간호실무에서 신봉이론(Espoused theories)에 대한 탐색적 연구

서문자,김혜숙,이은희,박영숙,조경숙,강현숙,임난영,김주현,이소우,조복희,이명하,지성애,하양숙,손영희,권성복,김희진,추진아 성인간호학회 2001 성인간호학회지 Vol.13 No.1

As a nursing practice involves nurses' actions in a specific context of health care, this study has focused on exploring the espoused theories in nursing practice within the action science perspectives, Espoused theories are the belief, principles, and rationale expressed by the practitioner as guiding her/his actions in a situation of practice. The data were analysed qualitatively and 25 elements of espoused theories of nursing action were identified and clustered into 6 categories. The 25 elements of espoused theories are as follows: The clinical nurse worked in wholistic and individual nursing, focussed on the patient's needed, comfort and supportive nursing (5 theories of nursing goal) ; excellent skills, knowledge based, assessment and data collection, explaining, educating or a scientific basis(6 theories of nursing intervention): advocacy, value oriented, treatment, account- ability and commitment(4 theories of nursing ethics) ; human respect. partnership, trust(3 theories of patient-nurse relationship) : knowledgable, accumulated clinical experiences and personally lived experiences. positive perspectives(4 theories of nurse), role of intervention. rewarding peer relationship(3 theories of situations) The above mentioned espoused theories are similar to that of nursing textbooks which students learned through basic nursing education and almost the same as the Acts ofa Nurse in Korean. However, we are doubtful whether nurses actually do as they think. Therefore. it is recommended to review the theories-in-use in order to and any discrepancies between the espoused theories and the reality of nursing actions

최종당화산물이 혈관평활근세포 증식에 미치는 영향 및 그 기전

송진영,임성희,서지영,조영중,유형준,박성우,임자혜 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.26 No.2

연구배경:혈관평활근세포의 증식은 죽상경화증의 주된 변화로 당뇨병과 동반된 죽상경화증에서도 관찰된다. 최종당화산물(AGE)은 NO와 결합함으로써 이의 혈관평활근세포 증식 억제 작용을 차단한다고 알려져 있으나. 혈관평활근세포에도 최종당솨산물에 대한 수용체가 발견되었음에도 불구하고 최종당화산물이 혈관평활근세포의 증식에 직접 미치는 영향 및 기전에 대하여는 잘 알려져 있지 않다. 본 연구에서는 최종당화산물이 백서 대동맥에서 분리 배양한 혈관평활근세포 증식에 미치는 영향 및 그 기전을 알아 보고자 하였다. 방법:혈관평활근세포는 male Sprague­Dawley 백서의 대동맥에서 분리하여 10% FBS­DMEM 내에서 배양하였고, 세포 증식 실험은 24­well plate에 well당 1×10⁴세포를 0.1% FBS­DMEM(with or without AGE­BSA, anti­AGE antibody, MAP kinase inhibitor, antioxidants)내에서 배양하여 48시간후 MTT assay로 세포 증식을 측정하였다. 결과:AGE­BSA를 2.5, 5.0㎍/mL 농도로 첨가한 경우 혈과평활근세포 수는 AGE­BSA를 가하지 않은 대조군에 비해 1.5, 1.6배 증가되었다. 이러한 AGE­BSA에 의한 혈관평활근세포 증식 촉진 효과는 anti­AGE antibody(100㎍/mL), MAP kinase 억제제인 PD98509(50μM)및 항산화제인 N­acetylcysteine(1μM)이나 butylated hydroxyanisole(10μM)에 의해 차단되었다. 결론:이러한 결과는 AGE가 혈관평활근세포에서 산화 스트레스의 변화를 초래하고 MAP kinase 경로를 통해 혈관평활근세포의 증식 및 죽상경화증의 발생에 기여할 가능성을 뒷받침한다. Background : Diabetes mellitus is an epidemiologically proven risk factor for atherosclerosis. Advanced glycation end products (AGE) have been implicated in the pathogenesis of many diabetic vascular complications. AGE not only change the physicochemical properties of proteins, but also AGE on the vascular smooth muscle cells (VSMCs) have not been fully explained despite of presence of an AGE-receptor on the VSMCs. Methods : In order to test whether AGE promotes atherosclerosis by stimulation of the growth promoting signal transduction pathways in the VSMCs, the proliferation of rat aortic VSMCs cultured in the presence of AGE-BSA with/without anti-AGE antibodies, the MAP kinase inhibitor and antioxidants was measured. The VSMCs (1x10^4 cells in 24-well plates) isolated from the aorta of Sprague-Dawley rats were incubated for 48 hours and the proliferation was assessed by a MTT assay. Results : AGE-BSA increased the proliferation of rat aortic VSMCs by 1.5~1.6 fold at the ㎍/mL level. The stimulatory effect of AGE-BSA (5㎍/mL) was blocked by the anti-AGE antibodies (100 ㎍/mL). PD98059 at 50? inhibited the AGE-BSA-induced VSMC proliferative response of the VSMCs to AGE. AGE-BSA-induced VSMC proliferation was also attenuated by N-acetylcysteine (1?) and butylated hydroxyanisole (10?), implying that increased intracellular oxidative stress might be also involved in the proliferative response to AGE. Conclusion : These results suggest AGE play a role in diabetic atherosclerosis by stimulating of the growth promoting signal transduction pathways in the VSMCs (J Kor Diabetes 26:91~99, 2002).

2형 당뇨 환자에 있어서 C형 간염의 유병률에 관한 연구

김구영,서광섭,유광렬,임병욱,채선애,강남훈,김창훈,권영우,김희수,류성태,이정환,박성우,오웅식,김정한 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.1

Background: We have doubt about the truth that Type 2 DM is associated with chronic hepatitis C infection. The aim of our study was to prove a close relationship between chronic HCV infection and type 2 DM in korean patients. Methods: We reviewed the out-patient's medical records of 466 patients with type 2 DM who visit the Sung-ae hospital from March 2000 to August 2001. Diabetic patients were analyzed for the following variables: age, sex, waist circumference, weight, waist/hip ratio, using of self monitoring of blood glucose, method of therapy, duration of disease, experience of previous transfusion, major surgical procedure, accompanied disease, liver function tests (LFT), HbA1 c. We ruled out patients with liver cirrhosis. Results: Hepatitis C virus infection was observed more frequently in patient with Type 2 DM. Of 466 Type 2 DM patients, 13 patients were infected with Hepatitis C virus (2.79%). Compared with mean prevalence of Korean population (1.3~1.6%), it's value is very high. the other hand, 21 patients were infected with Hepatitis B virus (4.5%). Such results are similar to mean prevalence of the general public (4~5%). Conclusions: Prevalence of hepatitis C was closely associated in korean patients with type 2 DM. And an increased prevalence is independent of cirrhosis.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

두가지 故障形態를 考慮한 最適 交換政策에 관한 硏究

서용성,박영택 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.2

A replacement policy under two types of failures, repairable or irrepairable, is considered. In the policy, the system is replaced at the n-th failure if all the previous (n-1) failures are repairable; Otherwise it is replaced at the first irrepairable failure. Assuming that the j-th failure is repairable with probability a_j and minimal repairs are performed for repairable failures between replacements, we derive the expected cost rate through the application of NHPP in order to determine the optimal number n*. The policy includes some previous studies as special cases.

비만 환자에서 비만관련 유전자 다형성에 따른 체중감량차이 : 지방흡수억제제를 복용한 환자를 대상으로 In Cases of Subjects with Orlistat for Weight Reduction

서영성,김대현,이인규,이근미,김영훈 대한비만학회 2003 The Korean journal of obesity Vol.12 No.4

三斜晶系와 單斜晶系의 空間群에 對한 論解

徐日煥,李正秀,李珍昊,秋錦洪,成百石,林星秀,柳保盈 충남대학교 자연과학연구소 1992 忠南科學硏究誌 Vol.19 No.2

三斜晶系에는 2個의 空間群이 있고 單斜晶系에는 13個의 空間群이 있다. 本 論解에서는 이 空間群들을 誘導한후 各 空間群에 屬한 一般位置, 原點移動, 特殊座標 및 反射條件들을 說明 하였다. There are two and thirteen space groups in triclinic and monoclinic systems respectively. After derivation of the space groups, the general coordinates, the special coordinates and the reflection conditions of each space group have been discussed and change of origin of certain space groups is also shown.

規則的 反射條件으로 分類된 空間群

徐日煥,金光柱,秋錦洪,李珍昊,林星秀,柳保盈,金文執 충남대학교 자연과학연구소 1992 忠南科學硏究誌 Vol.19 No.1

各 結晶格子는 230個 空間群 中 하나로 記述되는 對稱性을 가지고 있으며 그 結晶의 構造를 밝히기 爲하여는 그 結晶이 屬한 空間群을 반드시 알아야 한다. 이 論文에서는 230個 空間群을, 그 結晶이 가지고 있는 反射條件에 依하여 明白히 決定되는 空間群과 空間群間의 共通的인 反射條件 때문에 結晶의 構造가 밝혀진 後에야 밝혀지는 空間群으로 分類하여 놓았다. Every crystal lattice has a symmetry which is described by one of the 230 space groups and the space group of a crystal must be known in order to elucidate its structure. In this paper the 230 space groups are classified into two categories, i.e., the space groups that are explicitly determined by the reflection conditions the crystals have and the others that are determined only after the elucidation of the crystal structures because of the common systematic reflection conditions between the space groups.

비만 여성을 대상으로 한 해조류 추출물의 국부처치와 운동 병행을 통한 지방분해 효과의 임상적 검정

서태수,이인숙,변재철,김규호,박승한,김유영,김상국,김현정,김상기,신동철,성미영,박종석,김종기,박언휘 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.3

This study was carried out to test the body fat breakdown during topical seaweed extract treatment and in combination with the aerobic exercise. Of 20 female obesity subjects, ten treated a cream types of seaweed extract(control group) and ten treated a placebo cream(placebo group). Topical treatment of each sample was designed for 4 weeks, and treated with 2 times a day about 10ml on the abdomen and the thigh, respectively. All subjects were participated aerobic dance half hour a day and four times a week. After 4 weeks of topical treatment and exercise, they were measured body fat, skinfold thickness, body circumference. Then venous blood samples were taken and analyzed blood cells, serum enzymes, and serum lipids. There were reduction of body weight, % of body fat, antebrachium, brachium, chest, waist, thigh circumference and abdomen thickness between pre and post treatment in both group. Especially, body weight and % of body fat significantly reduced in the subjects treating the seaweed extract than those treating the placebo. There were significant decrement in total cholesterol and LDL whereas increment in HDL and TBIL in the control group, but no significant difference in the placebo group. In conclusion, there were 7.6% of body fat reduction during 4 weeks of aerobic exercise and 21% of body fat reducement in combination of topical seaweed treatment and exercise, respectively. These results suggest that the topical treatment of seaweed extract should be very effective for fat breakdown. Especially, the body fat breakdown maximized in the combination with the topical seaweed extracts treatment and the aerobic exercise.

振動寫眞과 Weissenberg 零層寫眞法으로 7個 結晶系와 11個 Laue群의 認知

徐日煥,秋錦洪,李珍昊,林星秀,柳保盈 충남대학교 자연과학연구소 1992 忠南科學硏究誌 Vol.19 No.2

As the function Ⅰ(hkl) of the X-ray intensity has a center of symmetry assuming anomalous scattering is negligible, Ⅰ(hkl) shows the symmetry of a centrosymmetric point group, i.e., a Laue group. The symmetry of each Laue group gives rise to its equivalent intensity relation, from which a scheme for identification of Laue group by means of oscillation and Weissenberg zeroth layer photographs has been obtained.