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정영철,Jeong, Yeong-Cheol 한국육가공협회 2000 肉加工 Vol.22 No.-
이 글은 지난 10월 13일 (사)한국양돈연구회가 주최한 「제19회전국양돈세미나」에서 정P&C 연구소의 정영철 소정이 발표한 내용을 발췌 수록한 것입니다.
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주정중독환자의 혈소판막과 $^{125}I-LSD$ 결합에 관한 연구
정영철,은홍배,Chung, Young Chul,Eun, Hong Bai 대한생물정신의학회 1996 생물정신의학 Vol.3 No.2
본 연구는 알코올사용장애 환자의 혈소판막에 있는 serotonin수용체가 대조군과 비교했을 때 어떤 차이가 있는지 알아보기 위해 시행되었다. $_{125}I-LSD$를 radioligand로 사용하여 포화반응을 해 봄으로서 다음의 결과를 얻었다. 1) 환자군과 대조군간은 $B_{max}$에 있어서만 유의한 차이를 보였다(P<0.0017). 2) Type 1군과 type 2군 사이 역시 $B_{max}$에 있어서만 유의한 차이를 보였다(P<0.0396). 3) 알코올남용군과 알코올의존군 사이의 $B_{max}$와 $K_d$는 모두 유의한 차이가 없었다. 위 결과들은 알코올사용장애의 serotonin 결핍가설을 지지해주며 혈소판의 serotonin 수용체 수의 증가가 알코올사용장애의 trait marker가 될 수 있음을 시사해 준다. This research was performed to find out the changes of serotonin receptors in the platelet of alcoholics. Using $_{125}I-LSD$ as a radioligand. We obtained the following results. 1) In the comparison of patients vs controls, $B_{max}$ of the former was significantly higher than that of the latter(P=0.0017). But there was no significant difference in the Kd between the two groups. 2) In the comparison of type 1 vs type 2, alcoholics by cloninger's classification $B_{max}$ of the latter was significantly higher than that of the farmer(P=0.0396). But there was no significant difference in the Kd between the two groups. 3) In the comparison of alcohol abuse vs alcohol dependence, there were no significant differences in the value of $B_{max}$ and Kd between the two groups. These results support the hypothesis of serotonin-deficit in alcoholism. Furthermore, it can be inferred that the increase of platelet serotonin receptors in alcoholics might be used as a trait marker.
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정영철 대한건축학회지회연합회 2007 대한건축학회지회연합회 학술발표대회논문집 Vol.2007 No.1
The attitude of the Korean for dwelling house and the viewpoints about nature are described in 'Shijo(a kind of short lyric poem)'. The purpose of this study is to find out the concepts of Korean traditional dwelling house through the 'Shijo'. The results of study are as follows. The concept of the traditional house is that the houses are regarded as a place of ideal seclusion, a part of nature, a resting place, a place of social life. The garden was composed of the natural and artificial element on principle of naturalness and introduction of the natural landscape, and the composition elements of the garden had the symbolic meanings.
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Erythema Dyschromicum Perstans 3예
정영철,임수덕,윤재일,허충림,한을남 대한피부과학회 1982 大韓皮膚科學會誌 Vol.20 No.6
We observed three patients who showed widespread macular ashy-colored eruptions. They fit clinically and histopathologically with the typical erythema dyschromicum perstans (ashy dermatosis). Erythoma dyschromicum perstans is a peculiar pigmented condition of unknown etiology characterized by persistent ashy-gray colored macule, refractory to any modality. All of them have similar skin lesions which are multiple, variable sized oval-shaped, ash-colored macular eruption on the trunk and extremities. Histologic findings of 2 patients reveal the characteristic feature of focal hydropic degeneration of the basal cell layer of the epidermis, perivascular infiltrates of lymphocytes and histiocytes and melanin-laden macrophages in the corium, however, merely pigmentary incontinence into the corium in 1 patient. Literatures are briefly reviewed.
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정영철,이춘용,현웅 대한정신약물학회 2006 대한정신약물학회지 Vol.17 No.6
Objective: Clozapine is known as an atypical antipsychotic drug which has less side effects in the extrapyramidal system than typical antipsychotic drugs and recommended as a treatment of choice in severe tardive dyskinesia (TD). However, it has been reported that the existing TD was worsened or new TD appeared in some cases where the antipsychotic drugs were switched to clozapine. Methods: We experienced a single case in which TD was appeared in the tongue and jaw 5 months after chlorpromazine was switched to clozapine. Results: The subject was 57 years old male patient with bipolar disorder. He had been treated intermittently with lithium and chlorpromazine for over 30 years. Five months after switching from chlorpromazine to clozapine, TD appeared in the tongue and jaw. Using Extrapyramidal Symptom Rating Scale (ESRS), the dyskinesia score was 10. Hence, clozapine was stopped and chlorpromazine was re-administrated resulting gradual improvement of TD. The dyskinesia score of ESRS was dropped to 6. Conclusions: It is speculated that this case is most likely a withdrawal tardive dyskinesia but other possibilities should be considered too. The question “Does withdrawal tardive dyskinesia occur more easily when switched to clozapine which has a weak dopamine antagonism?” should be addressed in future study.
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고도 호열성 Archaebacterium Thermococcus profundus가 생산하는 Amylolytic Enzymes
정영철,김경숙,노승환 한국식품영양학회 1994 韓國食品營養學會誌 Vol.7 No.4
심해 분화구에서 분리된 초고온성 archebacterium인 Pyrococcus furiosus DT5432는 α-1,4 또는 α-1, 6-glucoside 결합을 가진 탄수화물 함유 배지에서 균체외 amylase과 pullulanase, 균체내 α-glucosidase를 생성하였는데 0.5% maltose첨가시에 균체외 amylolytic효소의 생성능이 가장 우수하였다. DEAE-Toyopearl column chromatography와 활성염색의 결과가 2종류의 amylase가 생성되었는데, 이 효소들은 pH 5.5, 80℃에서 최적활성을 보였고, pH 5.5∼9.5, 80℃에서 30분간 안정하였다. 중온성 미생물 유래의 amylase와 빠르게 효소활성을 위해 Ca^2+ 이온을 요구하지 않았으며 SDS, Triton X-100과 같은 계면활성제에 1.0% 농도까지 안정성이 확인되었다. Amylase는 soluble starch, amylose, amyiopectin 및 glycogen등을 분해시켜 주생성물인 maltose와 maltotriose외에 미량의 glucose를 생성시켰으며 그리고 maltotetraose 이상의 oligosaccharide도 용이하게 분해시켰다. The hyperthermophilic archaebacterium Thermococcus profundus isolated from a deep-sea hydrothermal vent system, produced several amylolytic enzymes such as extracellular amylase and pullulanase, intracellular α-l,4-glucosidase in respone to the presence of complex carbohydrates in the growth medium. This strain showed high activities on 0.5% maltose than on complex carbohydrates One of the amylases was partially purified by ammonium sulfate precipitation, DEAE-Toyopearl chromatography. The amylase exhibited maximal activity at pH 5.5 and 80℃, and was stable in the range of pH 5.5 to 9.5 and up to 80℃ for 30min. The enzyme activity was no dependence on Ca^2+ and not inhibited by detergents. The amylase hydrolyzed soluble starch, amylose, amylopectin and glycogen to produce maltose and maltotriose with trace amounts of glucose, but not pullulan and α-, β-, γ- cyclodextrin. Malto-oligosaccharides ranging from maltotetraose to maltoheptaose were hydrolyzed in an endo fashion.
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