지난 2년간의 학회지 "신경정신의학" 심사 평가보고

김찬형,김세주,김도관,김성곤,박원명,송동호,박용천,이영문,오강섭,정영철,이상열,김주한,이동영,이헌정,함병주,김율리,김문두,김정진,이강욱,천근아,김재진,홍진표,홍승철 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

신규 3작용성 메타크릴레이트의 치과용 광중합형 콤포짓트 레진용 단량체로서의 응용 연구

김중곤,정찬문,김민성,김광만,김경남 大韓齒科器材學會 2001 대한치과재료학회지 Vol.28 No.4

Tris[4-(2-hydroxy-3-methacryloxypropoxy)phenyl]methane(THMPM) was prepared easily from triphenylolmethane triglycidyl ether in good yield. As compared with composite resin formulated with difunctional bis-GMA, the physical properties of a newly developed composite resin formulated with trifunctional THMPM was evaluated. Cytotoxicity and acute toxicity of composite resin based on trifunctional THMPM evaluated according to ISO standard method. The depth of cure of the composite resin based THMPM was higher than that of the bis-GMA composite. There were no significant differences in flexural strength and water sorption between the composites resin based on THMPM and bis-GMA. The water-solubility value for the light-activated composite resins formulated with THMPM was much lower than that for a control bis-GMA composite. According to cytotoxicity evaluation, the composite resin based on THMPM showed very mild cytotoxicity with the response index of between 0/0 and 1/0. No acute toxicity of composite resin formulated with trifunctional THMPM was also observed. It is believed that THMPM is promising candidate for application as a photocurable dental composite resin.

위 MALT 림프종에서 다발성 림프절 전이로 오인된 동시성 림프절 결핵 1예

김성은,김규종,김도현,송준영,문대성,장리라,유찬희,문원,박무인,박선자,김영옥 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

28세 남자가 내시경적 점막절제술을 통해 저등급 위MALT 림프종으로 진단되었다. 병기설정을 위해 18F-FDG PET 검사를 시행하였고 우측 쇄골상부, 우측상/하부 기관주위, AP window 부위에 강한 섭취가 관찰되어 전이성 림프절로 판단하였다. 그러나, 우측 쇄골상부 림프절에서 시행한 절제생검에서 만성육아종성염증소견이 관찰되었고 조직의 결핵 중합효소연쇄반응에서도 양성 반응을 보였다. 2개월간 항결핵제의 사용 후 시행한 추적 컴퓨터단층촬영 검사에서 림프절 크기의 감소를 보여 최종적으로 위 MALT 림프종에서 광범위 림프절 전이로 오인된 동시성 림프절 결핵으로 진단되었다. A 28-year-old man was diagnosed as gastric MALT lymphoma in diagnostic EMR (endoscopic mucosal resection). He subsequently underwent an 18F-FDG PET. 18F-FDG PET showed intense multifocal uptake in right supraclavicular, right upper and lower paratracheal, and AP window areas that was considered radiologically to represent widespread metastatic lymphadenopathy. Excisional biopsy of a supraclavicular lymph node, however, revealed chronic granulomatous lymphadenitis with a positive reaction of Tb-nested PCR. After antituberculosis treatment for 2 months, a follow-up CT scan showed complete resolution of the lesions. Intense 18F-FDG uptake could be due to an infectious process such as synchronous tuberculous lymphadenitis. Therefore, this could mimic a malignant condition such as lymphoma with extensive lymph node metastasis due to a false-positive finding, which may lead to a misdiagnosis.

실리카흄을 흔입한 고강도 콘크리트 개발

홍창우,김태경,김경진,김성환,김남윤,심도식,이정호,윤청호,백민경,원치문,박제선,이주형,정경일 강원대학교 석재복합신소재제품연구센터 1996 석재연 논문집 Vol.1 No.-

콘크리트 구조물이 대형화됨에 따라 설계단면이 증대되어 상대적으로 많은 경제적 손실을 부담하게 된다. 따라서 단면을 감소시키면서도 소요의 하중에 안전한 구조물을 건설하기 위해서는 우선적으로 구조물 건설에 기초가 되는 고품질, 고내구성의 고강도 콘크리트 개발이 절실히 요구된다 본 연구에서는 일정 시멘트비 및 혼화재 비율하에서 소요의 워커빌리티가 확보되는 고강도 콘크리트를 시간과 온도의 변화에 따라 증기 양생하여, 압축, 인장, 휨강도 뿐만 아니라 파괴특성을 실험적으로 연구하였다. 시료 제작시 시멘트 입자 사이의 공극 및 불연속 영역을 충전하여 고밀도화하기 위한 콘크리트용 혼화재로 시멘트 비표면적이 상당히 작은 초미립 분말인 실리카흄을 이용하였다. 또한 AE감수제 및 고성능 유동화제를 사용하여 혼화재의 첨가에 의하여 발생될 수 있는 워커빌리티의 감소를 방지하였다. 실험결과에 의하면 일정 양생 지속 시간하에서 온도의 증가에 따라 콘크리트의 압축, 인장 및 휨강도가 전반적으로 증가하였다. 동일하게 일정 온도하에서 양생 지속시간이 커짐에 따라 강도들이 증가됨을 알 수 있었다. 따라서 상대적으로 높은 온도와 긴 지속 양생 조건하에서 파괴에 대한 저항력이 크게 나타났다. The compressible, tensible, and flexibleresistance of the high strength concrete is analyzed by the experimentation in the present study. For the test, we cure several samples with the silica fume as a mixture being become dense the spaces between the particle of cement under the variation of both the temperature and the curing-interval. Then, the superplasticizer and the ezcon are also used to satisfy the required workability for construction. The compressible, tensible, and flexible resistances to a stress are increased as increasing the temperature and the time interval for the curing. Therefore it is concluded that the overal fractural and mechanical properties is improved by mixing the silica fume into the cement.

自然科 相互作用 槪念 形成의 評價資料 開發에 관한 硏究 : 物體의 均衡과 電流와 磁氣場 單元을 중심으로

文燦祜,金相玉 淸州大學校 科學敎育硏究所 1977 淸州大學校 科學敎育硏究所 Vol.1 No.-

The newly developed science program is being carried out in our elementary school science. However, the materials evaluating children's formation of the basic concepts of science are not developed enough. Learning and teaching in our elementary schools are misled now by the evaluation materials which are made without understanding the elementary science curriculum sufficiently. The purpose of this study is to develop the evaluation materials with which we could find how much and accurately Korean children build up the the interaction concept of science. The concept in a child is formed by the individual experiences and operational thinking, and is accommodated and developed by understanding the relation among the concepts. Thus, we conclude that the interaction concept is formed by perceiving change of objects, by classifying the evidencies of interaction into several groups, by abstracting the common feature from them, and by understanding the relation between the interaction intensity and the conditions of arrangement of objects in the interaction medium. According to this viewpoint, we analyzed the behavioural objects for use in evaluating the children's formation of interaction concept as follows: 11. Knowledge on the scientific terms and symbols. 12. Knowledge on the special facts of interaction. 21. Knowledge on the evidencies of interaction. 22. Knowledge on the interacting objects. 23. Knowledge on the time and space of the interaction. 31. Interpretation of the interaction laws. 32. Understanding the organized factors of the interaction law. 33. Understanding the relations among the interaction variables. 34. Solving the interaction problem and applying the interaction law. Based upon the subject contents and the behavioural objects, we tried to develop the evaluation materials which have the validity for the science teaching objects and the utility in the large class size in Korean elementary schools. We made 64 items for evaluating the concept formation of the equilibrium of objects', and those items are divided into two parts: A and B, and are put to the test by the third garde students in the Attached Elementary School to Cheong Ju Junior Teachers College. The arithmetic mean score of that test is 68.0 Pearson r of the A and B is 0.63, and the total reliability coefficient is 0.77. We made also 74 items for evaluating the concept formation of ‘the electric current and magnetic field', and those are tested in two parts: A and B by the sixth grade students in the same school. The arithmetic mean score of the test is 78.4, Pearson r is 0.67, and the total reliability coefficient is 0.80. We calculated the item difficulty (P) and discriminating index(D.I.) for each item. These values are shown in the table of item analysis. (See Table <5> and <6>). The number of the good items, which meet the conditions that P value is from 20 to 80 and D.I. is larger than+0.20, is 29 in ‘the equilibrium of objects' and 34 in ‘the electric current and magnetic field'. Most of the items being not met the conditions have a large P value, and have a small D.I. value because of the large P value, but some of them may have a smaller p value and a larger D.I. value than the value shown at the Tale <5>and <6> in other schools, since the students chosen for testing our evaluation materials were selected through the entrance examination, and have been taught under the better science facilities of the school than the other school students, and most of them are in the good family background and have comparatively high I.Q. (i.e., mean score, about 115.7). We analyzed the items having very small P and D.I. values. As a result of the analysis, we will conclude that the reason that the items have such small values may be in the children's wrong concept formation. We think that even the some items being not met the condition it is reasonable to use for finding out the process of the children's concept formation and the effective teaching methods.

Helicobacter pylori가 만성위염과 위종양에 미치는 영향에 관한 면역조직화학적 밑 초미세구조적 연구

문경래,정순봉,이미숙,이미자,서재홍,김만우,박찬국 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : Helicobacter pylori (H. pylori) is accepted as a principal cause of chronic gastritis and an important factor in the pathogenesis of peptic ulcer and gastric malignancy. The aim of our studies is to investigate relationships between H. pylori and gastric epithelial cells. Materials ðods : One hundred and eighty one H. pylori positive cases of gastric biopsy specimens were studied immunohistochemically and ultrastructurally. Results : p53 positive staining exhibited foveolar epithelial hyperplasia in 1 out of 32 cases, regeneration in 2 out of 12 cases, incomplete intestinal metaplasia in 5 out of 41 cases, complete intestinal metaplasia in 3 out of 18 cases, chronic ulcer in 1 out of 9 cases, tubular adenoma in 2 out of 14 cases and intestinal type of adenocarcinoma in 16 out of 21 cases. Ultrastructurally, H. pylori was observed to be in direct contact with the microvilli of the target cells and was demolishing the surface microvilli. The organisms were in close contact with the uncoated cell membrance. Penetration into the gastric cells by a few organisms was associated with marked cell damage and ultimately to cell disintegration. Conclusion : Our results suggest that H. pylori plays a role in the pathogenesis of gastric cancer, leading a relatively slow, long lasting process that induces chronic active gastritis, intestinal metaplasia, dysplasia, and adenocarcinoma of intestinal type.

Pseudomonas sp. 로부터 생산되는 phytase에 관한 연구

김대영,양시용,권문남,김찬길 建國大學校 自然科學硏究所 2002 建國自然科學硏究誌 Vol.13 No.2

Phytase (myo-inositol hexakisphosphate phosphohyrolase) is found naturally in plants and microorganisms. It catalyses pydrolysis of phytate to release inorganic phosphate, which would decrease the addition of phosphorus to feedstuffs for monogastric animals and thus reduce environmental pollution. this study was carried out for examination of characteristic of phytase from Pseudomonas sp. The phytase from Pseudomonas sp. was partially purified by DEAE-Sepharose chromatography and its molecular weight was estimated to 45kDa by SDS-PAGE Partially purified phytase was stable at pH values ranging from 5.0~7.0, and it was stable to 40℃.

濟州韓牛의 飼養管理와 繁殖狀況에 관한 硏究 : 第Ⅱ報; 濟州韓牛에 있어서 舍飼期間中 飼養管理가 體重變化와 隔年分娩에 미치는 影響 Ⅱ. The Effect of Winter Feeding on Body Weight Changes and Alternate Year Calving Rate in Jeju Native Cows and Heifer

金重桂,金文哲,金承贊 제주대학교 1983 논문집 Vol.16 No.-

舍飼期間中 濟州韓牛의 飼料給與狀態가 體重變化, 繁殖狀況 및 隔年分娩牛에 미치는 影響을 調査하기 爲하여 濟州道內 六個部落에서 飼育되고 있는 供試畜 400餘頭를 調査한 結果는 다음과 같다. 冬期間 飼料給與狀態에서는 各部落別 큰 差異는 없었고 補充飼料를 1kg以上 給與하는 戶數는 全體의 4.8%로 매우 낮았으며 糠類飼料(單用)을 每日 若干씩 주고 있는 農家는 46.6%로 過去보다 增加르 보였으나 乾草만으로 飼育하는 農家는 48.6%로서 漸次減少 現象을 보이고 있다. 冬期間 月別體重變化는 大部分 一月에서 四月까지는 大體로 20∼30kg 減少 趨勢를 보이다가 放牧場에 入殖된 五月에는 約 10∼20kg 增加되는 傾向을 보였으며 濟州韓牛와 交雜種間의 比較에서는 Brahman 交雜種이 體重變化가 가장 적은 反面 韓牛와 Santa 交雜種은 體重 減少幅이 極甚하였다. 未經産牛에서 初分娩月齡은 가장 빠른 地域이 38.2個月이 었고 늦은 地域은 40.5個月로 2個月差異가 있었으며 經産牛의 分娩後 初發情 再歸日에에서 隔年分娩牛를 除外했을 때는 平均 90.4日이고 地域別 10-20日差가 있었는데 反하여 隔年分娩牛를 包含시켰을때에는 平均 174.2日로 상당히 길었으며 地域別 差異도 甚하였음을 보여 주었다. 隔年 分娩牛의 發生率은 地域別로 볼 때 平均 13%에서 23%의 差異를 나타내고 있었으나 年度別로 比較할 때는 1980年度 9.5%, 1981年度 33.5%, 1982年度 11.9%로 隔差가 甚하였다. To investigate the effect of giving different feeds, during the winter, on body weight changes, reproductive performence and alternate year calving cows. 400 Jeju native and cross bred cows and heifers housed in villages were studied. Results showed no appreciable difference amongst the 6 villages feeding different foods during the winter period. Percentage of farms feeding various brans, over 1kg per day, was 4.8% ; a small quantity(0.5kg) of various brans was fed daily to 46.6% and those feeding only natural hay, 48.6%. The number of villages feeding various brans is increasing and those feeding hay decreasing. Cattle weights decreased by 20-30kg monthly per head during the winter feeding period(January-April) but by May increased in the range of 10-20kg per head with arrival of the new grass. Comparison of monthly body weight changes of Jeiu native cows and cross breds, Brahman cross breds showed the least body weight changes during winter while Native and Santa cross bred cows the weight changes were considerable. The average age at first calving, in the regional groups, varied by two months and when averaged out was 38.2 and 40.5 months in the early and late regions respectively. There was an average of 90.4 days from calving to first estrus excluding alternative year calving cows which had an avarage of 174.2 days from calving to first estrus. The alternate year calving percentages averaged from 13% to 23% in regional groups, and were 9.5% in 1980, 33.5% in 1981 and 11.9% in 1982.

저탄소강의 풀림 사이클에 대한 예측 프로그램 개발

김순경,이승수,김문경,전언찬 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.2

The cold spot of the coil is very important in the BAF(Batch annealing furnace) annealing process. Because of the annealing cycle time in the BAF, annealing was decided on the cold spot of the coil. So, we tested the temperature variation of cold spot and the correctness of computer simulation at the annealing furnace using the Ax atmospheric gas. As a result of several investigations. We confirmed the following characteristics ; Annealing cycle was changed under the influence of the strip surface condition and the strip tension. The cold spot of coil was the mid point of the B coil in the Ax atmospheric gas. And, the power of recirculation fan is very important in the high convection annealing furnaces.

Taylor 모델을 이용한 역동역학 뉴로제어기의 설계와 전력계통 안정화장치에 적용

김문찬,부창진,김호찬 제주대학교 공과대학 첨단기술연구소 2003 尖端技術硏究所論文集 Vol.14 No.2

This paper presents an implementation of power system stabilizer using inverse dynamic neuro controller. Traditionally. mutilayer neural network is used for a universal approximator and applied to a system as a neuro-controller. In this case. at least two neural networks are used and continuous tuning of neuro -controller is required. Moreover, training of neural network is required considering all possible disturbances, which is impractical in real situation. In this paper,Taylor Model Based Inverse Dynamic Neuro Model (TMBIDNM) is introduced to avoid this problem. Inverse Dynamic Neuro Controller(IDNC) consists of TMBIDNM and Error Reduction Neuro Model(ERNM). Once the TMBIDNM is trained. it does not require retuning for cases with other types of disturbances. The controller is tested for one machine and infinite-bus power system for various operating conditions.