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김호찬,이창영,오동원 고신대학교 의학부 1990 高神大學校 醫學部 論文集 Vol.6 No.2
The authors experienced a case of Wilson's disease coincidentally occured in brothers. The younger manifested grandiose delusion, elevated mood, visual hallucination and emotional lability, impulsive behavior. The elder showed non-specific symptoms. The patient was treated with small dosage of antipsychotics, D-penicillamine and oral zinc, low copper diet When sloped antipsychotics, the psychotic symptoms relapsed. We reported this patient and reviewed the related articles.
Cannabinoid Receptor Agonist가 만성 저산소환경에 의한 두뇌 겉질 신경세포의 자멸사에 미치는 영향
김호찬 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1
Chronic hypoxia has been associated with change in neurovascular behavior. The expression of cannabinoid receptors in brain has been well established and their agonists are thought to modulate neuronal activity and have the neuroprotective function in animal models of hypoxic-ischemia. In this work, we investigated the influence of cannabinoid receptor agonist (win 55.212.2) on cell death progress induced by chronic hypoxia. Rats were incubated in hypoxia conditions consisted of a mixture of 2% O2, 5%CO2, 93% N2. The solution containing WIN55.212.2 was injected into rats twice a day (every 12h) for 7 days. Synthetic cannabinoid receptor agonist, WIN55.212.2 inhibits the cell death by chronic hypoxia. Also it inhibits neuron apoptosis. These data support that WIN55.212.2 would rescues neurons from apoptosis by chronic hypoxia. Also it suggests that WIN55.212.2 may be therapeutic drug for neuronal death by chronic hypoxia.
김호찬 濟州大學校 産業技術硏究所 1998 산업기술연구소논문집 Vol.9 No.1
In this paper, an alternate method for state-covariance assignmer for SISO(sing1e input single output) linear systems is proposed. This method is based on the inverse solution of the Lyapunov matrix equation and the resulting formulas are similar in structure to the formulas for pole placement. Further. the set of all assignable covariance matrices to a SISO linear system is also characterized.
합성 카나비노이드 수용체 작용 물질인 WIN이 만성 저산소 환경에서 배양한 대뇌겉질 신경세포의 Caspase 3 활성화를 억제한다.
김호찬 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1
Synthetic cannabinoid receptor agonist, WIN55.212.2 may provide neuroprotection in damages of central nervous system, including hypoxia and ischemic diseases. Here I investigated the neuroprotective function of synthetic cannabinoid receptor agonist (WIN55.212.2) on death induced by chronic hypoxic damages in the primary cultured cortical neurons and tested the hypothesis that WIN55.212.2 modulates the caspase 3 activation, as key features induced by chronic hypoxia. WIN55.212.2 inhibits hypoxia-induced the activation of caspase 3 expression. Also it induces AKT phosphorylation in chronic hypoxia but not ERK phosphorylation. These data support that WIN would have a neuroprotective function in chronic hypoxia through the AKT intracellular signaling pathway. Also it suggested that WIN55.212.2 may be candidate for treatment of chronic hypoxia.
발모광 2례 : 정신역동적 측면을 중심으로 psychodynamic approach
김호찬 고신대학교 의학부 1998 高神大學校 醫學部 論文集 Vol.13 No.1-2
The author experienced two cases of trichotillomania, in an 11-year-old elementary schoolboy and a 13-year-old girl. In terms of psychodynamics, the cause of trichotillomania is discussed as follows : 1. The hair pulling is thought to begin as a rage reaction against mother and it appears that emotional deprivation in the maternal relationship contributes significantly to the development of hair pulling. 2. It is suggested that continuous hair pulling is closely related to transitional phenomenon. The literatures on trichotillomania were reviewed with discussion of the clinical and psycho dynamic aspects on hair pulling.
과모델된 선형시불변 시스템을 대상으로한 견실한 적응제어
金豪贊 濟州大學校工科大學産業技術硏究所 1996 尖端技術硏究所論文集 Vol.7 No.2
We design a robust adaptive controller based on the internal model control (IMC) structure for stable plants. The order of the controller can be lower than that of the plant. Some robustness properties of the IMC structure against modeling errors are presented and the concept of gain margin is utilized to make the adaptive system robust. In addition. we prove the stability of the proposed adaptive control algorithm. Simulation result shows the relation between performance and the order of the controller.
김호찬,이창영,오동원 고신대학교(의대) 고신대학교 의과대학 학술지 1990 고신대학교 의과대학 학술지 Vol.6 No.2
The authors expenenced a case of Wilson's disease coincidentally occured in brothers. The younger manifested grandiose delusion, elevated mood, cisual hallucination and emotional lability, impulsive behavior. The elder showed non-specific symptoms. The patient was treated with small dosage of antipsychotics, D-penicillamine and oral zinc, low copper diet. When stoped antipsychotics, the psychotic symptoms relapsed. We reported this patient and reviewed the related articles.