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RAW 264.7 세포에 대한 중국산 천연 광물성 섬유 TAFMAG의 독성효과
임영,한진구,김지홍,김현욱,김은경,김경아,장황신 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.3
Objectives : This study was designed to evaluate cytotoxicity of TAFMAG, which is a trade name of natural mineral fiber mined and produced in China. Methods : The cytotoxicity of TAFMAG was evaluated by measuring iron content, lipid peroxidation, erythrocyte hemolysis, and cytotoxicity in vitro. These results were compared with the data of chrystotile and wollastonite as a positive and negative control, respectively. Results : There was significant increase of Fenton activity in TAFMAG and chrysotile with dose-response pattern. The iron chelating agent, desferrioxamine, significantly decreased Fenton activity of the particulates except wollastonite. TAFMAG and chrysotile fibers significantly increased malondialdehyde concentration from lipid peroxidation of the red blood cell membrane. In erythrocyte hemolysis test, TAFMAG & chrysotile had stronger effect on erythrocyte hemolysis than wollastonite with the concentration of 1,000g/ml. Furthermore, TAFMAG was more hemolytic than chrysotile with the concentration of 5,000g/ml. There was a significant cytotoxic effect in TAFMAG and chrysotile on RAW cell compared with wollastonite. Conclusions : In vitro study suggested that TAFMAG may have a similar health hazard as usual asbestos.
Vitamin D and carotid subclinical atherosclerosis in SLE
( Chang Bum Bae ),( Ju Yang Jung ),( Bo Ram Go ),( Hyun Ah Kim ),( Chang Hee Suh ) 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1
Vitamin D and carotid subclinical atherosclerosis in SLE Chang-Bum Bae, Ju-Yang Jung, Bo-ram Go, Hyun-Ah Kim, Chang-Hee Suh Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea Introduction Atherosclerosis develops earlier in systemic lupus erythematosus (SLE) and is the important cause of mortality. It has been suggested that vitamin D deficiency contributed cardiovascular disease and immune dysregulation in SLE. Methods One-hundred two female patients with SLE and 52 normal controls (NC) were recruited. The carotid artery intima-media thickness (cIMT) and plague were assessed by B-mode ultrasound at the carotid artery level. Vitamin 25(OH)D3 levels were checked by immunoradiometric assay using the Bio-Line 25(OH)D3-Ria CT kit (Bio-Line S.A., Belgium). Disease activity markers were checked at the time of enrollment. Results The cIMT of SLE is 0.41±0.08mm, which is higher than NC (0.37±0.11 mm, p=0.012). Also, carotid artery plague index (PI) of SLE is higher than NC (0.68±1.39 vs 0.26±0.87, p=0.026). The cIMT was correlated with age (r=0.442, p<0.001), body mass index (r=0.246, p=0.013), waist-hip ratio (r=0.245, p=0.013), SLE disease activity index (r=0.239, p=0.016), taking aspirin (r=0.244, p=0.013), and the carotid artery PI was correlated with renal involvement (r=0.224, p=0.023) in patients with SLE. Vitamin 25(OH)D3 was not showed correlation with cIMT and carotid artery PI. Also, it was not correlated with disease activity markers. Conclusion In patients with SLE, the risk of cardiovascular disease measured by cIMT and carotid artery plaque was higher than NC, which may be derived from systemic inflammation. However, vitamin D levels were not showed significant correlations with carotid subclinical atherosclerosis. It may be not suitable to assess vitamin D as marker of disease activity or subclinical atherosclerosis.
김현아,전명남 연세대학교 통일연구원 2003 통일연구 Vol.7 No.2
The purpose of this study is to find out psychological traits of North Korean refugees through MMPI. The variables related to the psychological traits of North Korean refugees included sex, age, experience of compulsive repatriation, unit of family or individual, refugee's motivation. The hypothesis of study are as follows; First, psychological traits through MMPI is significant differences in the North Korean refugee's sex. Second, psychological traits through MMPI is significant differences in the North Korean refugee's age. Third, psychological traits through MMPI is significant differences in the North Korean refugee's experience of compulsive repatriation. Fourth, psychological traits through MMPI is significant differences in the North Korean refugee's family or individual unit. The Fifth psychological traits through MMPI is significant differences in the North Korean refugee's motivation. In this study, MMPI test was taken among 821 North Korean refugees in Hanawon from 2001 to 2003 for the personal counseling or group test. They examined the difference among those groups using one-way analysis of variance and post-hoc analysis of Scheffe verification. For statistics, SPSS 10.0 for the window was used. The results of examining psychological trait is as follows; First, the group of woman scored higher than the group of man on the L, Hs, Mf subscales and the group of man scored higher than the group of woman on the D, Pd, Pt, Si subscales (p<.05) on MMPI. Second, the group of forty scored higher than the group of twenty on the L scales and the group of teenager scored higher than the group of sixty on the K subscales on the MMPI scale. The group of fifty scored higher than the group of teenager, twenty on the Hs subscales and scored higher than the group of twenty on the D subscales, and scored higher than the group of teenager on the Hy subscales. the group of twenty scored higher than the group of teenager on the Ma subscales (p<.05). Third, the unit of individual scored higher than the group of unit of family on the F, Pd, Sc, Ma subscales. On the other hand, scored lower than unit of family on the Si subscale (p<.05). Fourth, the experience of compulsive repatriation scored higher than the not experience of compulsive repatriation on the Ma subscales (p<.05) on MMPI scale. The Fifth, Refugees' motivation is not significant difference on the MMPI.
김명아,김현수,김은정 노인간호학회 2005 노인간호학회지 Vol.7 No.2
Purpose: To estimate the prevalence of and identify the associates of cognitive function and depression among people over 65 years of age, and to examine the relationship between cognitive impairment and depression. Method From a total of 1,027 inhabitants, aged over 65 years, in a community in Seoul, 605 were accessible and constituted the subjects. The trained health visitors interviewed all study subjects with a socio-demographic character- istics, the Korean version of Mini Mental Scale Examination instrument (MMSE-K), and Short Form of Geriatric Depression Scale (SGDS). Results The prevalence of cognitive impairment (MMSE-K≤24) was 41.4%, and that of depression (GDS≥8) was 20.2%. Female gender, increasing age, lower education, separation by death, and no work experience were associated with cognitive impairment. Lower education, no work experience, and separated by death were associated with depression. Depression in demented group was 43.8%, in suspect dementia group was 19.9%, and in non-demented group was 14.4%. Conclusion The prevalence of cognitive impairment and depression in elderly was high and depression was in association with cognitive impairment.
Meckel 게실의 합병증으로 수술 받은 환아의 임상양상
김현아,최금자,한후재 이화여자대학교 2003 EMJ (Ewha medical journal) Vol.26 No.2
Objectives : The purpose of study is to assess the clinical characteristics of complicated Meckel's diverticulum in children. Methods : A retrospective review of pediatric cases of complicated Meckel's diverticulae that were surgically treated at Ewha Womans University Hospital from 1985 was performed. The charts were reviewed for the age and sex of the patients, operation finding, treatment, and outcome. Results : A total 13 patients with a complicated Meckel's diverticulum were identified. There were 8 boys(61.5%) and 5 girls (38.5%) with a mean age of 5.3 years (range, 1month to 14years). Presenting signs and symptoms included digestive hemorrhage (6), intestinal obstruction(4), perfora-tion (1), intussusception due to inverted Meckel's diverticulum (1) and diverticulitis (1). A ^(99m) technetium pertechnetate scintiscan was positive in 3 of 4 patients. Barium contrast studies and colonoscopys were not diagnostic. The mean distance from the ileocecal valve to the diverticulum was 47.0±15.7cm. Average length of the diverticulum was approximately 4.7±3.0cm. Segmen-tal small bowel resection including Meckel's diverticulum (84.6%) or wedge excision(15.4%) was done for treatment. In the bleeding group, ectopic gastric mucosa was present in 5 of 6 patients. Postoperative morbidity and mortality was each 0%. Conclusion : The results of this study draw attention to the fact that the complicated Meckel's diverticulum must be suspected in children with acute abdomen or gastrointestinal bleeding. 목적: Meckel 게실의 합병증의 원인이 되어 수술적 치료를 받은 소아 환자들의 임상적 증상과 수술소견, 병리학적 소견을 분석하여 이들의 특징을 알아보고자 하였다. 방법 : 1985년 이후 이화대학교의료원에서 Meckel 게실의 합병증으로 수술을 받은 15세 이하의 소아들 대상으로 하여 의무기록과 조직병리 검사 결과를 조사하였다. 결과: 총 13명의 환아가 Meckel 게실의 합병증으로 수술을 받았으며 남녀의 비는 1.6:1로 남아에서 호발하는 경향을 보였으며, 수술 시 평균 연령은 5.3세였다. 수술의 원인이 된 Meckel 게실의 진단은 장출혈 6예, 장폐색 4예,Meckel 게실의 천공 1예, 장중첩 1예, 게실염 1예였다. 회맹판에서 게실까지의 평균길이는 47.0±15.7cm이었으며, 소장부분절제술과 쐐기절제술이 각각 84.6%와 15.4%에서 시행되었다. 장출혈을 나타내었던 환아 6명 중 5예에서 병리조직에서 이소성 위 점막이 관찰되었다. 술 후 합병증과 사망예는 없었다. 결론 : 소아에서 외과적 급성 복증이나 장출혈의 증상이 나타날 경우, Meckel 게실의 합병증의 가능성에 대한 외과의의 인식이 필요하다.
김현아,김문숙 服飾文化學會 2003 복식문화연구 Vol.11 No.3
This study first denfines the fashion convention industry as an idea that includes international conventions, exhibitions and collections mainly dealing with fashion (fabric·material, clothing·fashion, and machinery·equipment). It then infers constituents of the industry based on preceding studies on service quality and satisfaction, and analyzes their importance and the structural relation between constituent performance, satisfaction and ex post behaviour. Also it analyzes perception difference of the organizer and participators on constituent importance, performance, and satisfaction. n the survey, a total of 500 questionnaires were distributed to the organizers and participants of 2001 Seoul Fashion Week, and among them, 259 questionnaires from the participants and 18 from the organizers were used as data for the demonstrative analysis. LISREL 8 program and SPSS WIN V. 8.0 were used for a statistical process of collected of collected data.
제조업체 광물성분진의 총분진, 흡입성분진, 흉곽성분진과 호흡성분진의 농도
김용우,피영규,김현욱,김형아 가톨릭대학교 산업의학센터 2000 韓國의 産業醫學 Vol.39 No.2
This study was designed to estimate particle size distribution of airborne dust by an 8-stage cascade impactor, to compare concentrations of total dust by 37mm closed-face cassette with total dust, thoracic particle mass(TPM), inhalable particle mass(IPM) concentrations by an 8-stage cascade impactor and to estimate concentrations of respirable dust collected by cyclone in manufacturing factories. Total 85 sites in 44 factories were sampled from August 1, 1996 to December 31, 1997. The results were as follows: 1.The geometric mean concentration of total dust collected by 37mm closed-face cassette were 0.27-1.44 mg/㎥. The GM concentrations of total dust by impactor were 0.82-2.85 mg/㎥, of inhalable dust 0.63-2.24 mg/㎥, and of thoracic dust were 0.31-1.40 mg/㎥, respectively. 2.The analysis of particle size distribution showed bimodal patterns for almost all sampling sites studied. Geometric mean(GSD) diameters of the small mode were 0.515(1.577) ㎛ - 3.032(13.698) ㎛, while the large mode were 11.873(2.460) ㎛ - 19.774(2.606) ㎛, respectively. 3.The geometric mean(GSD) concentrations of respirable dust collected by cyclone were 0.08-0.46 mg/㎥. To evaluate health hazards from mineral dusts occurring in manufacturing industries, these results suggest the necessity of promulgating particle size-selective limit values and sampling methods such as IPM, TPM, and RPM.
광중합형 글래스아이오노머 시멘트의 전단결합강도에 대한 연구
김현양,태기출,국윤아,김상철 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.5
법랑질의 표면처리에 따른 광중합형 글래스아이오노머 시멘트의 전단결합강도를 알아보고자 사람 소구치 80개를 선택하여 8개군으로 나누어 전단 결합 강도를 측정하고, 접착 파절의 양상을 평가하여 다음과 같은 결과를 얻었다. 1. 37% 인산용액으로 부식한 후 건조상태에서 글래스아이오노머 시멘트, 광중합형 레진, 화학중합형 레진으로 각각 부착한 실험군에서 글래스아이오노머 시멘트 실험군의 전단결합강도는 두 군과 유의한 차가 없었으나 화학중합형 레진군의 그것은 광중합형 레진군에 비해 유의성있게 낮았다 (P<0.05). 2. 37% 인산 실험군, 10% 폴리아크릴산 실험군, 1.23% APF 실험군, 산처리하지 않은 실험군의 습한 상태에서 부착한 글래스아이오노머 시멘트의 전단결합강도에서 산처리하지않은 실험군의 그것이 유의성 있게 낮았으며, 그 외 군간에는 유의성 있는 차이가 없었다 (P<0.05). 3. 글래스아이오노머 실험군에서 습기의 존재가 전단결합강도에 유의성 있는 영향을 미치지 않았다 (P<0.05). 4. 산부식처리를 하지않은 군의 접착제 잔류지수가 가장 낮았으며 37% 인산용액으로 처리한 군의 접착제 잔류지수가 가장 높았다. The purpose of this study was to evaluate the shear bond strength of light cured glass ionomer cement to enamel surface which treated with 37% phosphoric acid, 10% polyacrylic acid, 1.23% acidulated phosphate fluoride gel and no etching agent. To compare the shear bond strength of glass ionomer cement, light-cured composite resin and chemically-cured composite resin were empoloyed as controls. Eight experiments groups were composed. 10 specimens of each group were bonded by metal bracket by tested in universal testing machine for shear bond strength, in stereoscope for adhesive remnants index. The data were evaluated statistically by SPSS/PC+. The results were as follows. 1. Among the groups of 37% phosphoric acid treated and dry and bonded with light cured glass ionomer, light cured composite resin, and chemically cured composite resin, the shear bond strength of glass ionomer group showed no significant difference to the others, but the shear bond strength of chemically cured resin showed statistically lower than that of light cured resin (P<0.05). 2. The shear bond strengths of glass ionomer cement to enamel treated group with 1.23% acidulated phosphate fluoride gel and 10% polyacrylic acid and 37% phosphoric acid showed statistically higher than that of no etched enamel group(P<0.05). 3. In the glass ionomer cement, the presence of moisture was not significantly effect to the shear bond strength (P<0.05). 4. After debonding, no etched enamel group showed less residual materials on the enamel surface than the group of enamel etched with 37% phosphoric acid.