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IgG1 및 IgG3 아형 결핍이 동반된 중증 아스피린 : 과민성 천식 환자에서 intravenous immunoglobulin 치료 1 례
박해심,김희연,한동석,남동호,안성균,유상용 대한알레르기학회 1999 천식 및 알레르기 Vol.19 No.4
Common complications in a patient with IgG subclass deficiency include recurrent respiratory infections and concomitant inflammatory lung disease. The most effective therapy in these patients is the administration of intravenous immunoglobulin. The authors report a case of severe aspirin-sensitive asthma and recurrent pneumonia with combined IgG1, and IgG3 subclass deficiency in a 19-year-old man. The patient was treated with 0.4g/kg at monthly intervals for 6 months, and is still receiving 0.2g/kg every 2 weeks at our clinic. After the replacement of in- travenous immunoglobulin, the patient has clinically improved.
Trichophyton 에 의한 천식 : 특이 lgE, lgG1 및 lgG4 측정
박해심,이수걸,남동호,김선신 대한알레르기학회 2001 천식 및 알레르기 Vol.21 No.2
Background and objective : Trichophyton may be the causative allergen in patients with severe asthma. This study was performed in order to confirm Trichophyton as a causative antigen in asthmatic patients in Korea and to understand the pathogenic mechanism of Trichophytoninduced asthma. Materials and method : Two groups of 33 asthmatic patients sensitized to Trichophyton antigen were enrolled. Group I included 12 patients showing positive results on Trichophyton bronchoprovocation test(BPT), group II included 21 patients showing negative results on Trichophyton-BPT, and group III included 19 controls showing negative results to Trichophyton antigen on skin prick test. Allergy skin prick test including Trichophyton as well as common inhalant allergens was done. To confirm bronchial sensitivity, BPT with Trichophyton extract was performed. Serum specific IgE, IgG1 and IgG4 antibodies by ELISA were done using Trichophyton mentagrophytes antigen and then compared with specific IgE results by RIA using Trichophyton tonsurans. Results : Although there were no significant differences in asthmatic duration, total eosinophil count and skin reactivity(p$gt;0.05, respectively), significant difference was noted in methacholine PC20 (p$lt;0.05) between group I and II. There were no significant differences in specific IgE and IgG4 level between group I and group II (p$lt;0.05). Specific IgE and IgG4 levels were significantly higher in group I than in group III (p$lt;0.05, respectively). Two of group I patients had high specific IgG4 without specific IgE. There was no relationship between skin reactivity to Trichophyton mentagrophytes and specific IgE level. Positive predictive value of RIA for Trichophyton BPT was higher than that of ELISA. Conclusion : These results suggest that Trichophyton inhalation induces bronchoconstriction by IgE mediated mechanism. Trichophyton antigen should be included in skin prick test battery to creen causative agents for asthmatic patients. Further studies will be needed to evaluate the roles of specific IgG in Trichophyton-asthma.
고양이 항원에 의한 호흡기 알레르기 - 고양이 항원과 집먼지 추출액과의 관계
박해심,이미경,홍천수 대한천식알레르기학회 1989 천식 및 알레르기 Vol.9 No.1
To evaluate the relationship between cat allergen and commercial extracts of house dust(Torii Co. Japan), bronchoprovocation tests and cat RAST inhibition test with cat fur, house dust extracts and cat serum were performed in 2 cat sensitive asthma and 1 allergic rhinitis patients with bronchial hyperreactivity. After the inhalation of cat fur extracts, all of them showed significant bronchoconstriction (2 dual, 1 early response). Two asthmatic patients showed positive response (1 early, 1 late only) after the inhalation of house dust extracts, and one of them showed early bronchoconstriction after the inhalation of cat serum. RAST inhibition tests of cat epithelium(el) revealed that significant inhibitions (over 90%) were noted with cat fur extract in each patient. Variable inhibitions (18g- 648%) were noted with house dust extracts and no inhibition with addition of Dermatophagoides farinae and cst serum. It is suggested that commercial house dust extracts contain significant quantities of cat allergen and this point may be considered for the identification of allergic etiology in house dust-induced asthmatic patients.
박해심,김재원,정덕희,김열자 대한천식알레르기학회 1991 천식 및 알레르기 Vol.11 No.3
The results of skin prick test, radioallergosorbent test and mukiple chemiluminescent assay (CLA) to 35 antigens including Dermatophagoides farinae (D. farinae), Dermatophagoides pteronyssinus(D pteronyssinus), mugwoit pollen, cat fur and some tree(alder and oak) and grass pollens(meadow fescue, timothy and rye grass) were evaluated in 43 respiratory allergic patients and 7 non-atopic asthmatic patients. All CLA had valid positive and negative control threads. The results of D, farinae, D pteronyssinus, cat fur and tree pollens showed good associations between three different methods. The sensitivities of CLA to mugwort, timothy and rye grass pollen were about 50g The results suggested that CLA could offer a valuable method for mass screening of serum specific IgE antibody to common inhalant allergens