OPTIMAL CONTROL PROBLEM IN A TUMOR MODEL WITH IMMUNE SUPPRESSION EFFECTS

Kwang?Su KIM,Il-Hyo JUNG 한국산업응용수학회 2013 한국산업응용수학회 학술대회 논문집 Vol.8 No.1

용량별 죽력 투여가 생쥐의 간과 신장의 조직 및 혈액학적 변화에 미치는 영향

정종길,나창수,김경수,홍광표,김정상 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : Bambusae Caulis in Liquamen extracts (BE) has been used for various curative effect that remove intense heat from the heart, replenish deficiency Yin, nourish deficiency blood, resolve phlegm. This study was performed to investigate the toxicity of BE to mice according to the administered dosage. Methods : The experimental groups divided four. Control group treated saline, J1 group treated BE and distilled water in the ratio of 1:15(0.05ml/kg), F2 group treated BE and distilled water in the ratio of 1:7(0.05ml/kg), J3 group treated BE and distilled water in the ratio of 1:17(0.05ml/kg). We administered BE to the mice for 24 weeks at interval of 48 hours, and investigated the body weight, changes in hematological profile, activities of the transaminase(GOT, GPT) and two hepatic antioxidant enzyme(SOD, catalase), and histological changes of the liver and kidney. Results : Leukocytes of J3 group were increased in the administered for 12 weeks, but decreased in the administered for 24 weeks. Platelets were decreased about 36% in J3 group treated for 12 weeks, but increased about 50% in the same group treated for 24 weeks. Blood total proteins were decreased slightly in the all experimental groups compared with control group. The activities of the transaminase and superoxide dismutase(SOD) were increased, but decreased activities of catalase in the J2 and J3 groups administered for 12 or 24 weeks. In the light microscopical observation, ballooned and injured hepatocytes in portal vein area of J1 group occurred, and dilated hepatocytes and disoriented sinusoid observed in J2 group administered extracts to mice for 24 weeks. Apoptosis occured in the ballooned and injured hepatocytes of the portal vein area in J3 group. A agglutination of RBC in glomerular capsule of the kidney observed in the J2 group, and destructed convoluted tubule observed in the J3 group treated for 24 weeks. Conclusions : These results indicate that mice treated with high dose BE develop a hematological changes, dysfuncton of the liver and kidney.

廢棄物의 好氣性 堆肥化에 관한 硏究

鄭鳳守,黃光性 진주산업대학교 2000 산업과학기술연구소보 Vol.- No.7

This paper has compared experimenta1 values with the theoretical values of composting model to examine the possibility of putting the theoretical calues to actual use in the aerobic composting of the sewage sludge and hog manure. The results of the experiments are as follows : 1. In the ranges of 54∼60 % of moisture content of initial material, 7.3∼7.6 of pH, 27.3∼29.7 of C/N ratio and 0.35~0.37 gr / ㎤ of bulk weight, the experimental values of the periodical changes of moisture content, fermantation temperature and organic matter were approximately identical with the theoretical values of those. So those ranges were considered to be the optimum ranges. And it can be concluded that it is possible to plan an aerobic composting accdording to the theoretical formula. 2. When the ventilation volume was larger than 0.22 ㎥/hr·㎏, the evaporation loss of moisture content was great. When the ventilation volume was 0.0028 ㎥/hr·㎏, the anaerobic condition appeared. Thus we can judge the optimum range of venti1ation volume to be 0.02 - 0.06 ㎥/hr·㎏. 3. The CO^2 generation showed its maximum point of 0.85 mmole/day. g (VM) per organic matter between the temperature range of 58~66℃.

스트레스 대처방식이 조혈모세포 이식 환자의 우울과 불안에 미치는 영향

윤수정,이철,임성후,채정호,전태연,김광수 한국정신신체의학회 2002 정신신체의학 Vol.10 No.1

고탄력 팬티스타킹의 압력차이에 따른 피부온도의 변화 : The Change of Skin Temperature with different Pressure in Support Panty-Stocking

성수광,정연 대구효성가톨릭대학교 응용과학연구소 1995 응용과학연구논문집 Vol.4 No.-

In order to examine how much difference do they show skin temperatures when wear-ing, taking off and diferent pressure support panty-stocking(PS) under the cold environ-ment, skin temperature responses were observed on four females worn two types of Japan made PS that is 9 pressure PS(A) and 3 pressure PS(B) in environment 15.5±0.1℃ and 50±5% RH. The results were as follows ; 1) Mean skin temperature showed the difference of 0.4 ~ 0.9℃ temperature when wear-ing and taking off PS. It was higher in wearing A PS than B PS. 2) Forehead and trunk skin temperatures were higher in wearing A PS than B PS in every parts, and showed signifiant difference with stocking and wearing and taking off. 3) Upper extremity skin temperature was higher in wearing A PS than B PS and in tak-ing off B PS than A PS. Lower extremity skin temperature was higher in wearing B PS than A PS throughout every parts.

인간 재조합 인터루긴-32 면역조절작용에 대한 유세포 분석

이광수,김영관,채정일,심정현,김은미,강형식,김수현,윤도영,명평근 충남대학교 생물공학연구소 2006 생물공학연구지 Vol.12 No.-

Xenotransplantation of porcine organs has the potential to overcome the severe shortage of human tissues and organ available for human transplantation. however, it remains various hurdles for clinical xenotransplantation. In pig and mouse xenotransplantation, porcine xenograft evoke a strong cellular rejection response in immunocompetent host and grafts are destroyed within a week. This cellular immune response could involved both T cells and NK cells. A number of groups have shown that human NK cells can recognize and damage porcine endothelial cells. In addition, human T cells can respond to porcine endothelial cells through both direct and indirect mechanisms. Cellular rejection of porcine tissues requires T cells, particularly CD4^(+) cells. A new cytokine recombinant human interleukin-32α,β(IL-32α,β) has a role innate and acquired immune system. In order to investigate the role of recombinant mouse IL-18 and recombinant human IL-32α,β in xenograft rejection, we transplanted the PK(15) cells to C57BL/6 mice with or without intraperitoneal injection of recombinant mouse IL-18 or recombinant human IL-32 α,β. It was analyzed the population of NK cell, T cell and B cell in the C57BL/6 mice transplanted with PK(15) cells and recombinant mouse IL-18 or recombinant human IL-32α,β by flow cytometry analysis. As a result, lymph node and thymus of PK15/IL18, PK15/IL32α and PK15/IL32β injected group were increased to T cell activation population than normal injected groups. CD8^(+) T cells were decreased in lymph node of PK15/IL18, PK15/IL32α and PK15/IL32β injected groups. CD4^(+) T cells were increased in lymph node cell of PK15/IL32α and PK15/IL32β injected group and also, B cell population were increased in lymph node cell and spleen of PK15/IL18, PK15/IL32α and PK15/IL32β injected group. Therefore, we suggest that recombinant mouse IL-18 and recombinant human IL-32α,β suppress xenograft rejection in cellular xenotransplantation.

자기정렬된 TiSi2 접합을 사용한 MOSFET 소자의 I-V 특성 시뮬레이션에 관한 연구

崔廣洙,李政勳 水原大學校 1999 論文集 Vol.17 No.-

Self-aligned TiSi2 silicidation of shallow junctions in a 0.35 ㎛ MOSFET device is simulated with TSUPREM-4. The effect of resulting decrease in parasitic resistance at the source and drain junction was investigated by plotting Id vs. Vg and Id vs. Vd characteristics with the Medici simulation program. The doping profile in the source and drain regions show that out of 87.9 nm initial junction depth, Tisi2 was formed to the depth Of 36.2 nm after the silicidation process. With silicidation, the saturation drain current increased about 14% from 0.31458 mA/㎛ to 0.35938 mA/㎛ at Vg - Vt = 1.3 V. However, the on-off characteristic (Id vs. Vg) was found to be invariant under silicidation, contrary to the degradation in the on-off characteristic due to excessive Si consumption that is observed in real experiment.

대형 화재로 인한 사상자의 손상 유형과 합병증 : 동인천 라이브호프 화재를 중심으로

신중호,김재광,염석란,신종환,민순식,임용수,양혁준,이근,황성연 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Background: High risks of fire alway exist for buildings in urban areas, especially those in downtown. Crowds, as well as more complex and larger structures, may cause more victims in the event of fire; therefore, emergency medical service plans must be established for such disastrous events. Methods: On the evening of October 30,1999, a fire broke out in downtown, Dong-Incheon Live-Hof restaurant; 56 people were killed and 76 were injured. Most of them were teenagers. We retrospectively reviewed the medical records of the victims, Results: 1) Among the 56 dead, 54 died from smoke inhalation, one from extensive burns, and one from sepsis during treatment. 2) Among the 76 injured, 70 patients suffered from smoke inhalation, 53 from burns, and 9 from several types of trauma (sprains, contusions, lacerations, abrasions, fractures, etc.). 3) Later complications were laryngeal edema, pulmonary edema, scar contracture, and hypoxic brain damage, and so forth. 4) Post traumatic stress syndrome was unexpectedly more prevalent in mildly to moderately injured survivors and witnesses than in seriously injured survivors. Conclusion: Many complications exist after a fire. Some may be resolved in time, but others may result in permanent sequelae. Early rescue, early triage, and early management during transport by emergency medical service (EMS) personnel can result in fewer complications and a lower mortality rate. Therefore, we propose the establishment of plans to be followed during various major disasters.

20~30대 성인여성의 신체계측치와 체지방의 상관성

전정혜,성수광 한국의류산업학회 2004 한국의류산업학회지 Vol.6 No.5

The research is focused on relationship between body fat percentage and physical characteristics of women in age group between 20s and 30s who experience great deal of physical change such as marriage, pregnancy, delivery, breast-feeding, and etc. The research used physical measurement of two hundreds women: 50 women in their early twenties, 50 women in their late twenties, 50 women in their early thirties, and 50 women in their late thirties. The research provides base data for women clothing industry by observing relationship between physical figure and body fat percentage rate based on obesity study on body fat percentage, physical BMI, Rohrer Index, and Vervaeck Index. Followings are conclusion of the research. The older the ages, the shorter the height and the heavier the weight. Recognizable differences in circumference, thickness, and width rather than in length are found. Also recognizable increases in average body fat percentage and average physical characteristics by age have found. By observing body fat percentage and physical measurements, it was revealed that weight has more effect on body fat percentage than height in all ages. Circumference, width, and thickness have more impact than length measurements among physical measurements. Main body or upper body has more impact than legs and arms or lower body. Body fat percentage increase rapidly by ages. 2.0% of age 20-24, 20.0% of age 25?29, 28.0% of age 30?34, and 54.0% of age 35?39 were sorted as obesity.

CROSS 공법을 이용한 폐수의 생물학적 처리에 관한 연구

박광하,심재도,권영두,강동수,김인호,정태명,황갑성 7개 국립대학교 환경연구 논문집 공동발행 위원회 2003 공업기술연구 Vol.3 No.-

This study aims to develop using a continuous removal of organic and settling solid(CROSS) to increase the efficiency of aeration system for wastewater treatment. To solve many problems of the conventional activated-sludge process, authors suggested a new CROSS model in conjunction with aeration systems in 1996. This system is characterized by utilizing an intensive aeration pipe with inlets at the lower portion and outlets at the higher portion in an aeration tank. Through the experiments on CROSS process, the average removal efficiences of BOD, COD_(Mn), SS, T-N and T-P were showed 98.8%, 93.9%, 98.0%, 71.3% and 49.8%. The average DO (Dissolved-Oxygen) concentration was constantly maintained at 8.0 mg/L by the intensive aeration which was accompanied by rapid reduction of BOD. Degradation of the organic matters in sewage then continued for the whole aeration period. The process demonstrated that it was very adaptive without seeding and returning the sludge. Compared to the activated sludge system, the system was very flexible for the continuous flow treatment. This preliminary assessment showed that the porous media in CROSS reactor is viable for the sewage treatment, since the porous media under the intensive aeration achieves acceptable effluent quality.