급성하벽심근경색에서 전흉부유도 ST절 하강의 의의

정병천,배호상,곽동훈,김영태,배용학,황종현,임현주,류재근,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

목적 : 급성하벽심근경색증 환자에서 심전도상 흔히 동반되는 전흉부유도 ST절 하강의 의의를 알아보았다. 방법 : 심근경색후 24시간에서 48시간에 얻은 심전도를 기준으로 52명의 급성하벽심근경색증 환자를 전흉부유도에서 ST절의 하강이 있는 군과 없는 군으로 나누었으며 심도자, 관상동맥조영술, 심초음파도 및 방사성 핵종을 이용한 좌심구혈율 측정 등을 시행하였다. 결과 : 1) 좌심실확장기말압은 전흉부유도에서 ST절의 하강이 있는 경우에서 16.9±5.33mmHg로 없는 경우의 11.0±4.02mmHg보다 유의하게 높았다(p<0.05). 그러나 운동량 및 좌심구혈을은 흥부 유도상 ST절의 하강이 있는 경우 7.6±3.0 METs 및 53.9±9.1%로 없는 경우의 9.1±2.7 METs 및 54.6±9.5%보다 낮았으나 통계적 유의성은 없었다(p=0.180, p=0.823). 2) 관상동맥조영술상 전흉부 ST절의 하강이 동반된 군에서는 유의한 좌전하행지나 좌회선지의 협착이 있는 경우가 60.9% 및 57.9%로 ST절의 하강이 없는 군에서의 34.5% 및 7.7%와 비교해 좌관상동맥에 협착이 동반된 경우가 많았다(p=0.050, p=0.001). 3) 관상동맥조영술상 세 혈관질환의 빈도는 흉부유도상 ST절의 하강을 보인 23예에서 10예로 ST절 하강이 없었던 29예중 2예에 비하여 유의하게 많았고(P=0.007), 단 혈관질환의 빈도는 ST절의 하강을 보인 군에서 23예중 5예로 ST절 하강이 없었던 29예중 17예에 비하여 유의하게 적었다(P=0.002). 두 혈관질환의 경우에는 각각 8예와 10예로 양군간에 유의한 차이가 없었다. 4) 흉부유도상 ST절 하강의 빈도는 단 혈관질환 22예 중 5예에서, 두 혈관질환 18예중 8예, 세 혈관질환 12예 중 10예에서 관찰되어 협착이 있는 관상동맥의 수가 많을수록 ST절의 하강이 나타나는 빈도가 많음을 보였다(p=0.00308). 그러나 흉부유도상 나타난 ST절의 하강을 모두 합하여 구한 ST절 하강의 합은 협착이 있는 관상동맥의 수와 통계적인 유의성이 없었다. 5) 심초음파도상 좌심실 하벽의 벽운동은 ST절 하강을 보인 군에서는 akinesia가 83.3%, hypokinesia가 11.1%, 정상 벽운동이 5.6%로, ST절 하강이 없었던 군에서의 dyskinesia가 3.6%, akinesia가 39.3%, hypokinesia가 25.0%, 정상 벽운동이 32.1%와 비교하여 ST절의 하강이 있는 군에서 유의하게 벽운동의 장애가 빈번함을 보였다(p=0.03891). 그러나 좌심실전벽, 측벽 및 중격부위에서는 유의한 벽운동의 차이가 없었다. 결론 : 급성하벽심근경색증 환자의 전흉부유도에서 ST절의 하강이 동반되는 경우 다혈관 질환의 가능성이 높으며 좌심실확장기말압이 상승되었고 운동능력은 감소되어 있었다. 또한 심초음파도상 좌심실하벽의 벽운동장애도 심하였다. 따라서 전흉부 ST절의 하강을 동반한 급성하벽심근경색증 환자는 전흉부유도에 ST절 하강이 없는 경우보다 예후가 불량할 것으로 생각되며, 보다 적극적인 치료가 필요할 것으로 생각된다. The purpose of this study was to determine the significance of precordial ST segment depression appearing during acute inferior myocardial infarction and to assess the correlation of that with angiographic finding. 52 patients were allocated into two groups based on the existence of precordial ST segment depression : 23 patients with ST segment depression and 29 patients without ST segment depression. The extent of coronary artery disease as well as the prevalence of significant stenosis (≥70%) in left anterior descending artery were more frequent in patients showing precordial ST segment depression than in patients not showing them (p=0.050) and the result were similar in cases of left circumplex artery (p=0.001). On echocrdiographic examination of left ventricular (LV) wall motion, it showed more severely decreased inferior LV wall motion in patients showing precordial ST segment depression than in patients not showing them (p=0.03891) even though the other segment of LV wall motion didn't show the statistical difference between both groups. The other cardiac parameters such as LVEDP, exercise amount (METs) and ejection fraction were tend to showing bad profile in patients with precordial ST segment depression. From the above results, we could deduce that patients with precordial ST segment depression have relatively large infarction or concomitant left coronary artery disease, so they need more caution and intensive theraphy.

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

열안정형 카테콜-O-메틸전이효소 유전자의 클로닝

홍경만,최용복,정갑용,지은정,장현신,박현,백문기 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.2

Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is the enzyme which catalyzes the transfer of methyl group to the catecholamine neurotransmitters from its methyl donor S-adenosyl-L-methionine. Partially purified COMT from rat liver has been used to measure the concentration of catecholamines in the blood through solvent extraction and thin layer chromatography after converting ^3H-methyl derivatives of catecholamines. To improve this inconvenient and fluctuating method, an attempt was made to use COMT gene for the measurement of catecholamines. Specific primers, COMT5P (5'-TGC TCA GAG GTG CTT TGA AG-3') and COMT3P (5'-GGA GCC GCA GAA GGT CA G-3'), were used to amplify COMT gene from human placenta cDNA library. The amplified COMT gene through 35 cycles of polymerase chain reaction was cloned into T-vector and the nucleotide sequences are determined by automatic sequencer. Human COMT has two common variants, a thermostable high activity form which has valine at amino acid 158 and a thermolabile low activity form which Has methionine at the same position. The cloned COMT gene in this study has both variants. Clone 4 and 5 have valine at amino acid 158 (guanine at nucleotide 472) and clone 1-3 have methionine at this site (adenine at nucleotide 472). In addition to this, there are other DNA polymorphisms in COMT gene at nucleotide 101, 102 (amino acid 34, a structural mutation cysteine/serine) and nucleotide 186 (a silent mutation). All of the clones have cysteine at amino acid 34 (guanine and adenine at nucleotides 101 and 102) and cytosine at nucleotide 186 except clone 3 which has thymine at this nucleotide. Clone 4 and 5 are thermostable high activity variants, suggesting being more useful for the measurement of catecholamines after expressing the gene.

진화 알고리듬을 위한 객체지향 모델링과 클래스 라이브러리 구현

정호연,이수연,곽재승,김용주,박기태,현철주 한국경영과학회 2000 經營 科學 Vol.17 No.2

In evolutionary algorithm, there exist various models for the evolution of the population with respect to schemes and strategies for reproduction, in the application of the algorithm to a specific problem, one model suitable to the problem is to be properly chosen and a program expert or a software is needed to help implement and test a designed algorithm. In this study, object oriented modeling and the class library for simple evolutionary algorithms(SEA) with one population is developed. The library proposed here can be used as a generalized tool for solving problems in a wide range of domains.

야생 노랑제비꽃(Viola orientalis W.Becker)의 형태적 특성 및 Callus유도에 관하여

정용모,서정해,조만현,권오창 東亞大學校生命資源科學大學附設 農業資原硏究所 1996 農業生命資援硏究 Vol.5 No.1

부산근교의 고산 지대에 자생하는 야생 노랑제비꽃(Viola orientalis W. Becker)의 외부 형태적 특성과 줄기 조직으로부터 callus형성에 미치는 식물 생장조절제의 영양에 관한 실험을 실시하였던 바 그 결과를 요약하면 다음과 같다. 잎은 근생엽과 줄기상의 잎으로 구별할 수 있었으며, 엽장, 엽폭, 그리고 엽면적 각각 3.9㎝, 4.7㎝ and 15㎠로 모두 근생엽이 skjawl 줄기상의 잎보다 컸다. 그러나 엽형지수에 있어서는 근생엽이 0.83으로 가장 작았고 줄기상의 가장 작은 잎이 1.30으로 제일 크게 나타났다. 식물 생장조절물질의 단용에서 callus 유도는 Auxin의 NAA5×10??, 5×10??, 5×10??M에서 양호하였다. Auxin과 Cytokinin의 혼용에서 callus유도는 NAA 5×10??M 및 5×10??M에 BA 5×10??, 5×10??, 5×10??M의 전구에서 양호하였다. Callus 성장이 가장 양호한 조합은 NAA 5×10??M + BA 5×10??M 및 NAA 5×10??M + BA 5×10??M이었다. This experiment was conducted to study morphological feature and effect of plant growth regulators on callus induction of wild viola(Viola orientalis W. Becker). The results obtained were summarized as follows: In morphological feature, there was two distinctive leaf-forming types : one was rosette type derived from subterranean stem and the other was leaves formed on stem. Generally rosette type leaves were larger than others and the leaf length, leaf width, and leaf area were 3.9㎝, 4.7㎝ and 15㎠ on average, respectively. In the leaf shape index(the ratio of leaf length/width), the smallest value(0.83) was shown on rosette leaf while the greatest value(1.30) was determined from leaves on stems. Callus induction from the stem segments of wild viola was relatively higher at NAA concentrations of 5x10??M, 5x10??M or 5x10??M than at the same ones of other regulators used. The most effective combined concentrations of Auxin and Cytokinin for the callus formation were 5×10??M of NAA plus 5×10??M of BA or 5×10??M of NAA plus 5×10??M of BA.

광양만권의 유동장 및 대기오염농도예측

정용현 한국환경과학회 2000 한국환경과학회지 Vol.9 No.5

Numerical simulation model using nesting method and considering topographic features was developed to predict atmospheric environments, atmospheric flow, temperature and diffusion of air pollutants in Kwangyang bay where having complex areas of point sources, Korea. In addition, developed simulation model was used tracing of spreading range of pollutants when a gas leaks suddenly from Yeo-cheon industrial complex. By comparing the measured and calculated data on atmospheric flow, temperature and diffusion of air pollutants, the results showed that this model can be well applied and complicated topography affected the diffusion of air pollutants.

원위 대퇴골의 고립성 골연골종에서 발생한 속발성 연골 육종 1례 보고

정필현,황장수,강석,김용민,오형호,채동주,김종필 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

연골육종은 비교적 서서히 자라며 늦게 전이하는 악성 연골 종양으로 알려져 있다. 골 연골종에서 발생한 속발성 연골육종은 발생빈도는 드물며 타부위로의 전이가 적고 악성도가 낮은 경우가 많아 적합한 수술적 치료로서 좋은 예후를 보이는 것으로 보고되고 있다. 본 동국대학교 정형외과학 교실에서는 우측 대퇴골 원위부 골간단부에 생긴 고립성 골 연골종에서 이차적으로 발생한 연골육종을 치험한 바 문헌고찰과 함께 보고하는 바이다. A case of Secondary Chondrosarcoma Arising from Solitary Osteochondroma of the Distal Femur Department of Orthopaedic Surgery, College of Medicine, DongGuk University Phil Hyun Chung M.D., Jung Su Hwang M.D., Suk Kang M.D., Yang Mln Kim M.D., Hyung Ho Oh M.D., Dong Ju Chae M.D., Jong Pil Kim M.D. Chondrpsarcoma is a malignant cartilage-forming tumor that grows slowly and metastasis of this tumor occurs in late stage. Secondary chondrosarcomas arising from a solitary osteocartilaginous exostosis are rare and those have a better prognosis than other chondrosarcomas, and they rarely metastasize. We present our experience with a case of secondary chondrpsarcoma arising in solitary osteochondroma of distal metaphysis of right femur with clinical details.

Radiocobalt의 體內 汚染에 對한 除染效果

정인용,정현우,김태환,진수일,윤택구 대한방사선 방어학회 1988 방사선방어학회지 Vol.13 No.1

국내 原子力 産業의 施設增大로 放射線核種汚染의 가능성이 날로 증가되고 있음에도 불구하고 종사자 및 인근주민에 대한 診療對策에 관한 연구가 전무한 실정에 있어 이에 대한 기초자려마련의 일환인 應急處置方案을 수립코자 58CoCl2 1μCi를 마우스 (NIH-(GP))의 腹腔內에 投與한 후 CoNa3 DTPA 8.4mg/0.2ml saline, CoNa3 DTPA 8.4mg/0.2ml saline, saline 5ml등을 각각 投與하였으며, cobalt의 全身殘存量, 體內分布 및 尿內 含有된 量을 測定하기 위해 投與 後 4, 8, 12, 48시간, 그리고 7일에 MCA의 Ge-detector로 放射能을 計測하였고, 또한 각 實質臟器內 殘存된 cobalt의 放射能을 測定하기 위하여 각 group당 6마리의 마우스를 屠殺解體하여 測定하였던바 다음과 같은 결론을 얻었다. CoNa3 DTPA 處置群에서는 汚染된 放射性 cobalt의 全身殘存率의 減少 및 排泄率 增加에 유효한 效果가 있었으며, system contamination에 대한 방어효과는 CoNa3 DTPA, CoNa3 DTPA 그리고 saline 順으로 유효하였다. 결론적으로 본 실험결과로 볼 때 放射性 cobalt의 體內汚染에 대한 緊扱措置는 CoNa3 DTPA와 다량의 물을 동시에 投與함으로써 體內汚染된 放射性 cobalt의 排泄을 促進시킬 것으로 사료된다. In case of the acute intake of radionuclide, an early medical treatment may be necessary, but the little is established the procedures to decontaminate the victims of internal contamination in Korea. The purpose of the present investigation is to study chemical agents to remove radiocobalt from the victims and to provide a more reliable procedure for the treatment. The removals of radiocobalt from the NIH-(GP)mice injected intraperitoneally with lμCi of 58Co as CoCl2 were investigated with doses of either CaNa3 DTPA 8.4mg/0.2ml saline, CoNa3 DTPA 8.4mg/0.2ml saline, or saline 5ml. The radioactivity was determined by MCA and Ge-detector on 4, 8, 12, 48 hours and 7 days for the whole body, organ distribution and urine excretion. Six mice per each group were sacrificed for the measurement of cobalt retention in the parenchymal tissue. The cobalt trisodium chelate had a pronounced effect on reducing the whole body retention and increasing the excretion rate. Regarding to the systemic protective effects, CoNa3 DTPA, CaNa3 DTPA and saline were effected significantly in order. In conclusion, the extrapolations from these results to human were suggested that the rapid administration of cobalt trisodium chelate and an amount of saline to the contaminated person after internal contamination of radiocobalt were markedly increasing the decontamination effects.

역행성 골수강내 금속정을 이용한 대퇴골 과상-과간 골절의 치료

정필현,황정수,강 석,김종필,전용진 대한골절학회 2004 대한골절학회지 Vol.17 No.2

國內藥草의 抗癌成分硏究 (1) : 馬兜鈴, 石蒜, 三稜, 無花果皮, 碧梧桐皮, 人參 등 70餘種에 對하여

丁明鉉,李敦日,金永洙,朱興珪,劉永鐘,金成鎬,鄭鐘南 朝鮮大學校 1977 綜合論文集 Vol.1977 No.-

Alcohol, water, ether, and petroleum ether extracts of 75 species Korean medicinal plants have been tested for their antitumor activity. Most of the extracts had slight activity only. Some extracts had more pronounced acitivity. For antitumor activity, ddD-Mice of weighing 18-25g were used. 0.2 ml of cell suspension in 0.9% saline-glucose solution containing 10?? ascites tumor cells of either Sarcoma 180, Ehrlich carcinoma was transplanted intraperitoneally into each mouse. The control group animals in a given experiment consisted of 14 mices and the experimental group, 7 mices. The materials to be tested were administered once a day by intraperitoneal injection, commencing the day after tumor transplantation until the test animal died, and then the control group was received only 0.5% carboxy methyl cellulose (CMC). The mean survival time of each group was calculated according to the formula indicated in the protocols of the Cancer Chemotherapy National Service Center. In the antitumor activity screening, extracts had pronounced greater prolongation of survival time (50%-100%) were Aristo-lochia contorta, Lycoris radiata, Scirpus maritimus, Ficus carica, Firmiana platanifolia, Panax ginseng, Piper nigrum among the 75 species. The antitumor screening result were tabulated in Table II.