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      • KCI등재

        유리체절제술과 백내장 동시수술에서 네지지부인공수정체의 안정성

        김재우,양지욱,지동현,Jae Woo Kim,Ji Wook Yang,Dong Hyun Jee 대한안과학회 2010 대한안과학회지 Vol.51 No.6

        Purpose: To evaluate the stability of intraocular lenses (IOLs) according to the haptic design in combined surgery (phacoemulsification, intraocular lens insertion, and vitrectomy) by comparing early IOP elevation and the accuracy of IOL power. Methods: A retrospective study was conducted for 85 eyes of 85 patients who had undergone combined surgery. IOP elevation one week postoperatively and the difference between target refraction and postoperative refraction after two months were evaluated in all patients. All eyes were allocated to either a 2-haptic IOL group or a 4-haptic IOL group, and then each group was divided into three subgroups: gas-filled, silicone oil-filled, or balanced salt solution-filled. Results: In the balanced salt solution-filled group, the early IOP increase was significantly less in the 4-haptic IOL group than it was in the 2-haptic IOL group (3.24 mmHg vs. 6.15 mm Hg, p=0.025). The myopic shifts of the 2-haptic IOL group were significantly greater than those of the 4-haptic IOL group for all of the subgroups (gas subgroup -0.71D vs. -0.31D, p=0.045; balanced salt solution subgroup -0.66D vs. -0.16D, p=0.018). Conclusions: In combined surgery, 4-haptic IOL implantation showed significantly less early IOP elevation and less myopic shift than those of 2-haptic IOL implantation. J Korean Ophthalmol Soc 2010;51(6):829-834

      • KCI등재

        Near-IR Photometric Properties of HB, MSTO, and SGB for metal poor Galactic globular clusters

        김재우,강아람,손영종,신인구,천상현 한국우주과학회 2007 Journal of Astronomy and Space Sciences Vol.24 No.1

        We report photometric features of the HB, MSTO, and SGB for a set of metal-poorGalactic globular clusters on the near-IR CMDs. The magnitude and color of theMSTO and SGB are measured on the ducial normal points of the CMDs by apply-ing a polynomial t. The near-IR luminosity functions of horizontal branch stars inthe classical second parameter pair M3 and M13 indicate that HB stars in M13 aredominated by hot stars that are relatively faint in the infrared,whereas HB stars in M3are brighter than those in M13. The luminosity functions of HB stars in the observedbulge clusters, except for NGC 6717, show a trend that the fainter hot HB stars aredominated in the relatively metal-poor clusters while the relatively metal-rich clusterscontain the brighter HB stars. It is suggestive that NGC 6717 would be an extremeexample of the second-parameter phenomenon for the bulge globular clusters.

      • < 전시-P-79 > 계절별 구상나무 잎 정유의 성분 및 항산화 활성 분석

        김재우,박미진,정민지,양지윤,이성숙 한국목재공학회 2018 한국목재공학회 학술발표논문집 Vol.2018 No.1

        정유는 같은 수종이라도 지리적 위치, 채취시기에 따라 구성성분의 차이가 있는 것으로 알려져 있다. 본 연구에서는 계절에 따른 구상나무 잎 정유의 성분과 항산화활성의 변화를 조사하고자 하였다. 공시시료는 국립산림과학원 산림유전자원부 내에 위치한 구상나무를 사용하였다. 채취시기는 1월, 4월, 7월, 11월에 각각 채취 후 -5℃이하에서 보관하여 사용하였다. 구상나무 정유는 hydrodistillation법을 사용하여 추출하였다. 추출한 정유는 GC-MS로 분석하였으며, 항산화 활성을 검정하기 위해 DPPH radical 소거능 분석을 수행하였다. 구상나무 잎 정유는 camphene(20.73%), d-limonene(20.41%), boynyl acetate(18.73%), a-pinene(14.21%), borneol(7.49%)이 주성분으로 확인되었다. 가장 많은 함유량으로는 camphene으로 1월과 7월에는 21%, 4월과 11월에는 20%의 함유량을 보였다. 계절별 정유성분 분석결과 1월과 7월에는 주요물질인 camphene, d-limonene, bornyl acetate의 함량이 61%이상이였으며, 4월과 11월은 58%로 함량이 떨어지는 것을 알 수 있었다. DPPH free radicals를 50% 소거시키는데 요구되는 효과농도(EC50 value)는 1월에는 13.92%, 4월에는 17.06%, 7월에는 14.93%, 11월에는 16.36%로, 1월 구상 나무 잎 정유의 radical 소거능이 가장 높은 것으로 나타났다. 선행연구에서 잣나무 잎 정유의 경우 7월(1.09%)에 채취된 잣나무 잎 정유가 항산화활성이 높음을 알 수 있었는데 구상나무의 경우 항산화활성이 잣나무에 비해 항산화활성이 낮음을 알 수 있었다.

      • SCIESCOPUSKCI등재

        Cyclosporin A가 in vitro에서 조골세포에 미치는 영향

        김재우,이현정,강정화,옥승호,최봉규,유윤정,조규성,최성호,Kim, Jae-Woo,Lee, Hyun-Jung,Kang, Jung-Hwa,Ohk, Seung-Ho,Choi, Bong-Kyu,Yoo, Yun-Jung,Cho, Kyoo-Sung,Choi, Seong-Ho 대한치주과학회 2000 Journal of Periodontal & Implant Science Vol.30 No.4

        Cyclosporin A(CsA) is an immunosuppressive agent widely used for preventing graft rejecting response in organ transplantation. The basic properties of CsA to osteoblast has not been well known yet. A better understanding of the mechanisms of CsA function on bone could provide valuable information regarding basic properties of bone remodeling, pharmacotherapeutic intervention in metabolic bone disease, and the consequences of immunosuppression in bone physiology. The purpose of this study was to investigate the effect of CsA on osteoblast by evaluating parameters of proliferation, collagen synthetic activity, alkaline phosphatase activity, and ALP mRNA expression in mouse calvarial cell. 1. CsA ($3{\mu}g/m{\ell}$) treated mouse calvarial cell showed statistically significant increase in cell proliferation.(P<0.05) 2. CsA($1,\; 3{\mu}g/m{\ell}$) treated MC3T3 cell line showed statistically significant increase in cell proliferation. 3. The amount of collagen of CsA($3{\mu}g/m{\ell}$) treated mouse calvarial cell was decreased statistically significantly. 4. Alkaline phosphatase activity was increased statistically significantly in CsA treated group($1{\mu}g/m{\ell}$). 5. mRNA expression of ALP was increased in CsA treated group These results suggest that CsA could affect bone remodeling by modulating proliferation & differentiation of osteoblast.

      • KCI등재후보

        청신경초종 수술 후유증 환자 증례 1례

        김재우,현진오,현민경,신원용,임성우,최은영,Kim, Jae-Woo,Hyun, Jin-Oh,Hyun, Min-Kyung,Sin, Won-Yong,Lim, Seong-Woo,Choi, En-Young 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3

        The purpose of this study is to develop an aproach to diagnosis and treatment of sequelae after removal of vestibular schwannoma through Oriental Medicine. An eighty year-old woman with sequelae after removal of vestibular schwannoma was observed and treated. She had difficulty of hearing, facial nerve palsy, dizziness and was generally weak. She was treated with herb medications for these symptoms. Having been treated for 27 days in hospital her symptoms improved. This report provides evidence for application of herbal medicine in treatment of sequelae. However, more cases are required for an in depth study of oriental treatments for this ailment in order to open this method of treatment to general application.

      • SCOPUSKCI등재
      • KCI등재

        Topical Prostaglandin Analogue Drugs Inhibit Adipocyte Differentiation

        김재우 대한안과학회 2014 Korean Journal of Ophthalmology Vol.28 No.3

        Purpose: To investigate the effects of topical prostaglandin analogue drugs on the differentiation of adipocytes. Methods: Differentiation of 3T3-L1 preadipocytes was induced with isobutylmethylxanthine, dexamethasone,and insulin. 3T3-L1 cells were exposed to 0.008, 0.08, 0.2 mM of latanoprost and travoprost. Reverse transcriptionpolymerase chain reaction for mRNA expression of lipoprotein lipase and peroxisome proliferator-activatedreceptor γ 2 (PPARγ2), and glycerol-3-phosphate dehydrogenase (G3PDH) assays were performed toexamine the effects on early and late differentiation, respectively. Also, glycerol assays were done to evaluatethe effect of prostaglandin analogues on lipolysis after differentiation. Results: Both prostaglandin analogues inhibited differentiation of preadipocytes. Topical prostaglandin analoguessignificantly decreased G3PDH activity, a marker of late differentiation. However, topical prostaglandinanalogues did not change mRNA expressions of lipoprotein lipase and PPARg2, markers of early differentiation. The activities of the early markers of differentiation were not changed significantly before and aftergrowth arrest. Compared to latanoprost, travoprost decreased G3PDH activity more significantly (p < 0.05). Both prostaglandin analogues did not affect the lipolysis of differentiated adipocytes (p > 0.05). Conclusions: Prostaglandin analogues display an inhibitory effect on the differentiation of adipocytes when thecells start to differentiate especially in the late stage of differentiation. Thus, commercial topical prostaglandinanalogues may decrease the fat contents of eyelids.

      • 근 긴장 이상증의 신경생리

        김재우 대한임상신경생리학회 1999 Annals of Clinical Neurophysiology Vol.1 No.2

        Dystonia is a movement disorder characterized by sustained, involuntary muscle contractions leading to abnormal postures. Using EMG recordings, three types of involuntary activity can be seen in dystonia. There are abnormalities in many different types of reflexes in dystonia. In view of the strong connection between the basal ganglia and motor areas of the cerebral cortex, there have been several investigations suggesting defects in cortical function including movement-related cortical potentials and contingent negative variation in patients with dystonia. Although dystonia is considered as a movement disorder, there are several phenomena relating to the sensory system that might suggest that dystonia could be primarily a sensory disorder. It is suggested that loss of inhibition from basal ganglia both at the cortical level and brainstem and spinal cord leading to defective control of interneuronal excitability be an important role for the pathogenesis of dystonia.

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