근 긴장 이상증의 신경생리 = Neurophysiology of Dystonia

다국어 초록 (Multilingual Abstract)

Dystonia is a movement disorder characterized by sustained, involuntary muscle contractions leading to abnormal postures. Using EMG recordings, three types of involuntary activity can be seen in dystonia. There are abnormalities in many different types of reflexes in dystonia. In view of the strong connection between the basal ganglia and motor areas of the cerebral cortex, there have been several investigations suggesting defects in cortical function including movement-related cortical potentials and contingent negative variation in patients with dystonia. Although dystonia is considered as a movement disorder, there are several phenomena relating to the sensory system that might suggest that dystonia could be primarily a sensory disorder. It is suggested that loss of inhibition from basal ganglia both at the cortical level and brainstem and spinal cord leading to defective control of interneuronal excitability be an important role for the pathogenesis of dystonia.