구강점막 부착용 케토프로펜 고분자 필름의 제조 및 평가

박진석,이상은,강봉석,이경록,이은주,박정숙 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

Abstract – The objective of this study was to prepare ketoprofen-loaded buccal adhesive patch. The adhesive patch was formulated by casting method using aqueous soluble polymer povidone K17 (PVP 17PF) as film-forming agent and hydroxypropylmethylcellulose (HPMC) as adhesive agent. To compare the effect of HPMC type, different molecular weight of K4M and K15M HPMC was used. The physicochemical properties of patches such as appearance, thickness, in vitro release, and adhesiveness were investigated. The concentration of ketoprofen was determined spectrophotometrically at a wavelength of 233 nm. The appearance of prepared patches was semi-transparent, light-yellow or almost colorless, and odorless. Thickness of each patches (n=6) was 0.895 ± 0.033 mm for K4M patch and 0.727 ± 0.036 mm for K15M patch. In vitro release test, both K4M and K15M patches showed over 20% release within 30 min. At 120 min, K4M and K15M patches demonstrated 95% and 67.5% release of ketoprofen, respectively, and up to 240 min, both patches released drug completely. Maximum adhesive force of K4M and K15M patches was 6.571 ± 2.703 gf and 2.735 ± 1.151 gf, respectively. Moreover, it took 28.29 ± 0.38 sec and 28.30 ± 0.34 sec for K4M and K15M patch to peel off them after adhesion, showing no significant difference. In conclusion, thickness, in vitro release, and maximum adhesive force could be modulated by alteration of polymer types.

Inoue Balloon을 이용한 PMV의 장·단기 결과 분석

진은선,이연아,전숙,김현숙,정승묵,박상선,최락경,임달수,홍석근,황흥곤 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.11

Goldman's Algorithm을 이용한 비외상성 흉통 환자의 분석

조석진,유진현,김찬웅,어은경,정구영 대한응급의학회 1999 대한응급의학회지 Vol.10 No.4

Back ground : It is important to evaluate the patient presenting with non-traumatic chest pain in emergency department, and it is also difficult to classify appropriately. The purpose of this study is to predict probability of acute myocardial infarction(AMI) and assess the group for low probability of AMI that is target for observation-unit of chest pain in emergency department. Methods : A prospective, clinical study was performed from March 1998 to August 1998 at the department of emergency medicine, Ewha Womans University Mokdong hospital. We classified high-probability group and low-probability group of AMI according to Goldman's algorithm and then compared with the final diagnosis. Results : The study included 218 patients. 84 patients(39%) was the high-probability group and 134 patients(61%) was the low-probability group of AMI. As compared with final diagnosis, AMI was 47 patients(56%) among the high-probability group and 1 patient(0.7%) among the low-probability group. We observed sensitivity of 98%, specificity of 78% in predicting AMI. Conclusion : The classification according to Goldman's algorithm may be useful predictor of AMI and improve triage for emergency department patients with chest pain. It is also helpful for management of observation-unit of chest pain in emergency department.

가토 두정골 절단시 회전기구의 회전속도와 생리 식염수에 의한 냉각이 골 치유에 미치는 영향에 관한 연구

이은영,신영진,이의석 원광대학교 치과대학 학생회 1992 學生學術誌 Vol.1 No.1

The application of recently developed rotary instruments to oral and maxillofacial surgical procedures has interrupted the healing process by affecting the temperature rise during drilling the bones. To evaluated the effects of healing process on the rabbit's calvarial defects, we have drilled the 6 holes on the calvarial bone resulting in three groups respectively according to 38, 300 and 20000 rpm, which divided into another two different groups operated under saline irrigation, and others not. Each specimen was sacrified at 3 days, 1, 2, 4, and 6 weeks post-operatively and routine fixation, Hematoxylin & Eosin stains and examined under light microscopic findings. The obtained results were as follows; 1. In each rpm, the healing processes of the saline irrigation groups were faster than those of no saline irrigation groups. 2. The lower the rpm of rotary instrument was, the faster the healing process. 3. In groups of using rotary instrument below 20000 rpm, there was appeared the good healing process that was operated under the low rpm with saline irrigation.

정신보건법의 주요 쟁점 조항에 대한 선진국과의 사례 비교

홍진표,황순찬,박수빈,서동우,정은기,김진학,박종익,안주연,김수정,장홍석 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.2

Objectives The Mental Health Act is an initiative aimed at changing and shaping mental health services and protecting human rights of persons with mental disorders. Since the Mental Health Act was legislated in 1995, four amendments have been made according to the issues that arose from public concerns. However, there are still many debates about the human rights protection of the mentally iII. This study aimed to provide information regarding major aspects of the Mental Health Act by comparing them among several developed countries. Methods Current Mental Health Acts of the state of Michigan in the United States, Scotland in England, the state of Victoria in Australia, and Japan were reviewed. Issues regarding the Korean Mental Health Act were collected from seminar materials, news media contents, and mental health professionals Results The definition of subjects in Korean Mental Health Act was more inclusive than other countries and was derived from a medical classification of mental illness. Family members or guardians were granted important responsibilities for deciding the involuntary admission of mentally ill patients in Korea and Japan. In Western countries, Mental Health Review Tribunals or courts have the primary responsibility for important decisions about mentally ill patients. The regulation of immediate dis- charge after request by voluntarily admitted patients was not enacted in all countries except Korea. The mandatory procedure for involuntary admission in Western countries includes an individual case review with personal interview by a Mental Health Review Tribunal or court. Conclusion The Korean Mental Health Act appears to meet the basic standards of Guidelines from international organizations. Our traditional culture and inherent health systems seem to influence the legal regulation of mental health service and might be related to the problems of human rights protection of mentally ill patients in Korea.

수직적 안모유형에 따른 치료 후 교합평면 안정성에 관한 연구

박정은,차경석,이진우,정동화 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.5

본 연구는 수직적 안모유형에 따른 치료 후 교합평면 변화양상을 조사하여 향후 적절한 치료계획과 기전의 설정에 도움이 되고자 시행하였다. 골격성 1급 부정교합으로 진단되어 비발치로 치료받은 성인 60명(남자 28명, 여자 32명)을 대상으로 하였으며, Ricketts법의 facial axis, facial depth, mandibular plane angle, lower face height, mandibular arc의 5개 항목을 이용하여 한국 성인의 정상교합자 통계치의 기준에 따라 short face type (1군), average face type (2군), long face type (3군)으로 분류하였다. 각 군의 치료 전, 치료 종료, 종료 후 1년의 측모두부 방사선사진 계측치를 비교 분석하였다. 1군은 치료 종료 시와 비교하여 유지기간에 일반적 교합평면각, 기능적 교합평면각, L6/L1, MP-L6 항목이 유의하게 감소하였고 (p<0.01) L1-FOP 항목은 유의하게 증가하였다(p<0.001). 2군은 유지기간에 유의한 변화를 보이지 않았으며 3군은 유지기간에 기능적 교합평면각이 유의하게 증가하였다(p<0.05). 기능적 교합평면각의 치료 후 변화량은 각 군 간에 유의한 차이를 보였으며 특히, 1군과 3군 간에 매우 큰 유의성을 보였다. 따라서 치아의 압하, 정출 및 치료 후 전치부 피개 등에 있어 유지기간 중 교합평면각 변화의 고려가 필요하다고 생각된다. Objective: The purpose of this study was to find changes in the occlusal plane related to different vertical facial patterns and suggest treatment goals and conduct possible treatment mechanisms. Methods: 60 adult patients (28 males, 32 females) who had been diagnosed as Class I skeletal malocclusion and treated without extraction were selected. Patients were divided into three groups; short face type (group 1), average face type (group 2) and long face type (group 3), using the data on normal occlusion of Korean adults. Results: The results were achieved by analyzing cephalometric tracings of each group at pre-treatment, end-treatment and post-treatment (about 1 year recall check). The inclination of the occlusion plane tends to gradually increase as the face becomes longer. In group 1, COP-X, FOP-X, L6/L1, MP-L6 were significantly decreased, and L1-FOP was significantly increased during the retention period (T3-T2). Group 2 showed no significant change. In group 3, FOP-X was significantly increased during the retention period (T3-T2). During the retention period, FOP-X showed significant change among each group, especially between group 1 and group 3. Conclusion: These results suggest that changes of occlusal plane inclination according to facial vertical pattern need to be considered during the retention period for intrusion, extrusion, and incisor overbite.

스트레스 측정도구의 표준화 방안

장세진,차봉석,박종구,이은경 연세대학교 원주의과대학 1994 원주의대논문집 Vol.7 No.1

치과용 콤포머의 방사선 불투과성에 관한 연구

윤숙진,김은경 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.1

The Objective of this study is to measure and compare the radiopacities of dental compomers with those of resin-reinforced glass ionomer and dental composite resin and to compare radiographic densitometry with indirect digital image analysis. Disks of two different dental compomers(DR and CG) as the experimental group, one resin-reinforced glass ionomer(FL) and one composite resin(ZH) as the control group, 10mm in diameter and 2mm thick, were radiographed with intact human teeth and aluminum stepwedge standard. Radiopacity was evaluated by transmission densitometry and with an image analysis program following the digitization of the radiographs using a flatbed scanner with transparency unit. All material and tooth structure showed the significant difference except FL and DR, CG and ZH(p<0.005) by the densitometric evaluation. And all material and tooth structure also showed the significant difference except FL and DR, CG and ZH(p<0.005) by indirect digital image analysis. Two evaluation methods didn't show the difference among the materials, but showed the difference between enamel radiopacities and between dentin radiopacities.

「임원십육지(林園十六誌)」에 수록된 어패류의 향약성(鄕藥性)에 관한 연구

백숙은,최영진 동아시아식생활학회 2004 동아시아식생활학회지 Vol.14 No.3

This study was conducted to figure out the nutritional nature of seafoods categorized according to the medicinal effects and the usages introduced in Lim-Won-Sib-Rheuk-Ji, one of the well-known encyclopedias published during the Chosun Dynasty. They were compared with those introduced in other cooking books in order to find out how they were used in the diet of real-life. The seafoods of the book were first categorized into the fish 20, the mollusk 5. the crustacea 4, and the shellfish 7, and reptile according to the biological taxonomy, and then each one was reviewed in terms of the taste and the food-nature. Generally, the fishes has the sweet taste; the crustacea and the shellfish the salty or sour in addition to the sweet taste; none of them were bitter or hot. Most of them had the mild nature; seven of them were regarded as warm; four as cool; one as cold from the standpoint of the traditional medicine. The food-nature of seafoods was closely related with the medicinal effects on the human body. These seafoods were characteristically used in daily dietary life as well as the medical applications; used as the side-dishes rather than the main-dishes. The cooking methods of boiling, steaming, and baking were preferred to drying and stewing. The preservation methods favored were the fermentation, drying and salting. These cooking and preservation methods were believed to reflect the nature of the seafoods to manifest the medicinal effects.

ESPI 기법에 의한 하중을 받는 균열 박판의 진동 특성에 관한 연구

김경석,강기수,최지은,박찬주,홍진후 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.2

대부분의 실제구조물은 인장과 진동 등이 동시에 작용하는 복합하중 상태가 되며 이러한 환경에서 물체의 거동을 해석하는 것이 중요하다. 이 논문에서는 χ축에 대해 45˚결함이 있는 평판이 하중을 받고 있을 때, 진동 특성을 시간평균 electro speckle pattern interferometry(ESPI)를 이용하여 해석하였다. 결함이 있는 박판 시험편에 인장력을 증가하면서 물체의 고유진동수 변화와 모드의 형태 변화를 동시에 관찰하였다. 실험결과에서 결함은 저차모드에서는 진동모드에 영향을 주지 않았으나, 고차모드에서는 진동모드에 변화를 주었으며, 특정 진동모드에서 결함의 영향으로 현저하게 고유주파수가 낮아지는 경향을 보였다. 또한 실험결과는 유한요소해석과 비교하여 주파수 비교에서는 5%이내의 오차율을 보였으며, 진동모드 비교에서는 완전히 일치하였다. This paper presents the vibration characteristics of a rectangular plate with 45˚ oblique crack subjected to a uniaxial tension. The experiment is adopted by the time-average Electronic Speckle Pattern Interferometry(ESPI) method. The natural frequency and mode shape are considered accurately according to the increase of tensile load. When tensile load is zero, the vibration modes are agreed with the smooth and the 45˚ obliquely cracked plate. But according to the increasement of load, it is shown that vibration modes are extremely varied. The effects of the crack under the vibration are discussed in detail. It is indicated that the increase of load makes the variation of the frequencies and modes complicate in the range of even a small load. The results are agreed with the FEM analysis within 5%.