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전라남도 고흥 북부지역에 분포하는 편마암류의 변성작용에 관한 연구
박배영,신상은,조계복 한국지구과학회 2004 韓國地球科學會誌 Vol.25 No.6
In northern Gohung granitic gneiss, porphyroblastic gneiss and migmatitic gneiss are widely distributed. Gneisses were plotted in granodiorite domain on an IUGS silica-alkali diagram. The amounts of trace elements (Li, Zn, Sc, Sr, Ni, V, Y, etc.) vs. SiO2 somewhat decreased. Plagioclase showed a wide compositional range (An32-48). Xalm and Xsps were higher in garnet rim and Xpyp in garnet core. The rocks in the study area were formed from S and I-type magmas which generated from syn-collision and the late to post-orogenic tectonic environment. Metamorphic P-T conditions were low to medium pressure, high temperature (803-913oC, 6.1-7.3 kb) and overprinted by retrograde metamorphism (570-726oC, 2.2-5.1 kb) and chloritization.
박경화,윤소영,오상철,서재홍,최철원,연종은,김병수,신상원,김열홍,변관수,김준석,이창홍 대한암학회 2002 Cancer Research and Treatment Vol.34 No.4
Purpose: Hepatocellular carcinomas are one of themost common malignancies in the world. However, noeffective therapeutic modality has been proven to prolongthe survival of patients in an inoperable stage. The purposeof this study was to determine the response rateand the toxicities of a combination of pirarubicin, UFT andleucovorin in patients with non-embolizable hepatocellularcarcinomas, or who had progressed during theirtranscatheter arterial chemoembolization treatment.Materials and Methods: Of 23 patients with a hepatocellularcarcinoma, 11 had progressed during a transcatheterarterial chemoembolization, with the other 12being transcatheter arterial chemoembolization-naive. Allthe patients were treated with pirarubicin (70 mg/m2 i.v.,day 1), UFT (350 mg/m2 P.O., day 1~21), and leucovorin(25 mg/m2 P.O., day 1~21).Results: Twenty patients were able to be evaluated,with a partial response being achieved in four, giving anoverall response rate of 20% (95% confidence interval,7~44%). The median overall survival time was 6 months,and the median survival time of the transcatheter arterialchemoembolization-naive patients was significantly longerthan that of those treated by transcatheter arterial chemoembolization(p=0.012). The most significant dose-limitingtoxicity was leucopenia and thrombocytopenia.Conclusion: The combination of pirarubicin, UFT andleucovorin therapies showed marginal antitumor activityand significant toxicity in patients with non-embolizableor failed transcatheter arterial chemoembolization hepatocellularcarcinomas. (Cancer Res Treat. 2002;34:280-283)
유방의 과립구성 육종으로 재발한 급성 골수성 백혈병 1 례
박경배,서원석,신상만 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Granulocytic sarcoma is a malignant neoplasm composed of poorly differentiated cells of the myelogenous series. Granulocytic sarcoma are reported in 3.1-9.1% of patients with myelogenous leukemia and occur concomitantly, following or rarely antedating the onset of leukemia. Granulocytic sarcomas can occur at various sites of the body and frequently at multiple sites. Involvement of the breast is uncommon. We experienced a case of acute myelogenous leukemia. 12 months earlier, she was diagnosed as acute myelogenous leukemia(M2) and acheived complete remission with KSPHOG ANL regimen. The patient was treated with KSPHOG ANL regimen without radiation therapy. An 20th day, left breast lesion disappeared and complete remission was obtained.
박원빈,임용수,김진주,조진성,이근,양혁준,신상도,So-Yeon Kong 대한의학회 2014 Journal of Korean medical science Vol.29 No.7
Stroke in young adults has been known to show a lower incidence and a better prognosis. Only a few studies have examined the epidemiology and outcomes of ischemic stroke inyoung adults and compared them with the elderly in Korean population. All consecutivepatients with ischemic stroke visiting 29 participating emergency departments wereenrolled from November 2007 to October 2009. Patients with less than 15 yr of age andunknown information on age and confirmed diagnosis were excluded. We categorized thepatients into young adults (15 to 45 yr) and elderly (46 yr and older) groups. Of 39,156enrolled all stroke patients, 25,818 with ischemic stroke were included and analyzed(young adult; n = 1,431, 5.5%). Young adult patients showed lower prevalence of mostchronic diseases but significantly higher prevalence in exercise, current smoking, andalcohol consumption. Hospital mortality was significantly lower in young adults thanelderly (1.1% vs. 3.1%, P < 0.001). Higher number of patients in elderly group (68.1%)showed worsening change of modified Rankin Scale than young adults (65.2%). Youngadults ischemic stroke showed favorable hospital outcomes than the elderly in Koreanpopulation.
신상원,김은영,노영일,양은석,문경래,박상기,박영봉 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3
Purpose: Respiratory tract infections are common in the first year of life. Severity of respiratory tract infection in infants is associated with early-life environmental factors, In recent, genetic studies suggest a role of heredity in susceptibility to severe respiratory tract infection(RTI) in infants. We designed a case control study to further investigate relative importance of familial influence in risk of respiratory tract infection in infants compared to environmental factors. Methods: We selected 126 children(44 cases; 82 controls) that admitted or visited to Chosun University Hospital. Cases were infants under age 1 year admitted to hospital with severe respiratory tract infection. Familial history and other factors were recorded in cases and controls by questionnaire. Results: Out of 126 infants, Patients admitted with severe respiratory tract infection are 44 cases. Diagnosis of patients with RTI are acute bronchitis 15 cases(34.1%), pneumonia 12 cases (27.3%), acute nasopharyngitis 7 cases (15.9%), acute bronchiolitis 5 cases (11.4%), infantile asthma 3 cases (6.8%), and croup 2 cases (4.5%). The crude odd ratio of repiratory tract infection of parental smoking is 3.35 and cow mik feeding 3.13, Prematurity & low birth weight 2.39, maternal allergic disease 2.13, and child allergy 1.92. Conclusion: Maternal allergic disease, parental smoking, Prematurity and low birth weight, and Allergic diseases increased the risk of respiratory tract infection in infants. Breast milk feeding decreased that. These results support the possibility that genetic factors play an important role in susceptibility to recurrent and severe respiratory infections in early life.