위의 유암종과 선종의 병발 1례

장재식,강혁주,이중현,서영범,윤병구,김용섭,이구,서정일,양창헌,이창우,김정란,윤환중 東國大學校醫學硏究所 2000 東國醫學 Vol.7 No.-

유암종은 전신에 퍼져 잇는 장크롬친화성 세포에서 기원하는데 위의 유암종은 비교적 드문 질환으로 모든 유암종의 1.9~2.2%에 해당하며 위에 발생하는 종양의 1% 미만에서 보고되고 있다. 유암종은 일반적으로 증상이 비특이적이고 면역조직화학검사에 의해서 진단되기 때문에 과거에는 드물게 발견되었으나 최근 내시경 기기 및 술기의 발전과 검사 빈도의 증가 및 면역조직화학검사의 발달로 진단율이 증가 추세에 있으며, 드물지만 유암종에서 선암과 공존하는 예들이 보고되고 있다. 저자들은 심와부 동통을 주소로 내원한 70세 남자 환자의 상부위장관내시경 검사에서 위체상부의 대만곡에서 0.4×0.4 cm 크기의 중간 함몰을 가진 Yamada 1형의 용종과 함께 전정부의 전벽에서 0.8×0.5 cm 크기의 융기된 점막 소견을 보여 조직학적으로 각각 위유암종 및 위선종임을 확진한 후 내시경적 용종 절제술로 치료한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Carcinoid tumors are arisen from enterochromaffin cells, which are scattered throughout the body. These tumors are composed of variable numbers of cells that contain endocrine granules in their cytoplasm, which can be identified by immunohistochemistry and electron microscopy. Gastric carcinoid tumors are relatively rare tumor, the reported incidence being 1.9~2.2% of all carcinoid tumors and less than 1% of all gastric tumors. Sometimes, composite carcinoid tumors and adenocarcinoma is reported. We experienced a case of the coincidence of carcinoid tumor and adenoma at the other site of the stomach in a 70 year old male patient. Gastrofiberscope showed 0.4×0.4 cm sized Yamada type I polyp with central depression on the greater curvature of the proximal body and 0.8×0.5 cm sized focal slightly elevated mucosa on the anterior wall of the antrum. The endoscopic biopsy specimens revealed carcinoid tumor and tubular adenoma with moderate atypism, respectively. The carcinoid tumor and adenoma were removed by endoscopic polypectomy. According to the follow-up gastrofiberoscopy after 7 month later, both lesions were nearly normal mucosa except whitish atrophic change after polypectomy.

크론병에 대한 CoPPLX의 방어효과에 대한 연구

이호학,김유림,문창기,이재일,양병윤,김종수,이정민,정재혁,안석진,박상준,김윤권,김소연,김영중,조민구,최영자,장성조 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351) 배경 : Gemcitabine, paditaxel, docetaxel, vinorelbine, ir-rinotecan 새로운 항종양제의 출현으로 일차 치료의효과가 증대 되고 있고 재발시에도 좋은 신체 활동도를 보이고 있어서 이차 치료의 대상군도 늘어나는 효과를 보이고 있다. 치료의 필요성은 증대 되고 있지만 현재까지 표준 치료가 확립되지 않은 상황에서 Gem-citabine과Vinorelbine모두 독성이 강하지 않아서 혼합 요법이 가능한 장점이 있고 비소세포 폐암에 대한효과도 입증이 되어있어서 본 연구는 반응이 없거나 반응을 보인후에 재발된 진행된 비소세포 폐암에 ge-mdtabine과 vinorelbine 흔합 요법을 시행하여서 치료 반응률과 생존율 그리고 부작용을 평가하였다. 대상 및 방법 :2000년 6월부터 2004년 3월까지 충남대학교병원에내원하여 진행성 비소세포 폐암 IIIA/IIIB, IV로 진단을 받고 일차 항암화학요법치료를 받은 환자중에 초기 치료에 반응이 없거나, 치료에 반응이 있었으나 병이 진행된 환자로 추적 관찰 기간이 6개월 이상인 환자를 대상으로 생존율과 반응률 그리고 독성을 분석하였다. 결과 : 총 치료 반응률은 17%. 반응 유지기간의 중앙값은 3.1개월(1-10개월)이었고 생존기간의 중앙값은 8.2개월 (1-23개월) 그리고 1년 생존율은 35%였다. 항암화학요법에 의한 독성은 3도 이상의 중성구 감소가 12%, 오심과 구토가 12.5% 였다. 결론 : 일차 치료에 반응이 없거나 재발한 비소세포 폐암환자의 이차 치료로 gemcitabine과 vinorelbine 혼합요법은 효과적이라고 생각되며 향후 3상 연구를 통한다른 약제와의 비교 연구가 필요하다고 생각된다.

韓國 地方自治團體 經營行政의 發展方案에 관한 硏究 : 先進國 地方經營行政의 벤치마킹을 中心으로 Benchmarks from the developed country

장인봉,정윤길 안양대학교 사회과학연구소 2000 社會科學硏究 Vol.7 No.-

Recently we meet the radical changes in local autonomous environment around Local Autonomy Authority. It is evident that these changes will be a factor to increase residents' administrative needs, furthermore to expand Local Autonomy Authority's functions. As a result, the main task of Local Autonomy Authority is the strengthening of competition power for the responsiveness of the increasing administrative needs and functions. Now, each Local Autonomy Authority is trying to find business which are suitable for the characteristics of their districts to promote welfare of local residents, to achieve the balanced development of district, and to increase local finance. The Management-oriented Administration of Local Autonomy Authority is something grafted with traditional public administration and the merits of private management in order to provide highquality administrative services by utilizing the limited sources efficiently. This idea applies economic principle, "minimum input, maximum output", to public administration and is based on an entrepreneur's management mind set.

주기억장치 데이타베이스를 위한 새로운 락 관리

장연정,김상욱,김진호,김윤호 강원대학교 정보통신연구소 1999 정보통신논문지 Vol.3 No.-

The locking is the most widely-used concurrency control mechanism for guaranteeing logical consistency of a database where a number of transactions perform concurrently. In this paper, we propose a new lock management method appropriate for main memory databases. Our method chooses the partition, a fixed-sized container for records, as a unit of locking, and directly keeps lock information within the partition itself. These make our method enjoy the following advantages: (1) it has freedom in controlling of the trade-off between the concurrency and locking overhead by considering the characteristics of given target applications, (2) it enhances overall system performance by eliminating the hashing overhead, a serious problem occurred in the traditional method.

액상가압성형법으로 제조된 탄소나노섬유 강화 Cu 기지 복합재료의 인장 거동

장영환,김상식,정윤철,이상관 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.5

In the present study, the unidirectionally aligned carbon nanofiber (CNF) reinforced Cu composite was fabricated by the liquid infiltration process, and the deformation behavior of the composite was evaluated. For the unidirectional alignment of the severely entangled CNFs, the mechanical drawing process was utilized. The bundle of drawn Cu tubes compacted with the unidirectionally aligned CNFs was placed on the specially designed mold, which was subsequently canned, degassed, evacuated, heated at 1100℃ for 10 minutes in the electric furnace to liquefy the Cu, and finally transferred to the press. The optical and SEM micrographic observations of the final product demonstrated that, even though the CNFs were not uniformly distributed throughout the specimen due to the molten metal flow during melting process, the local unidirectionality was found to be preserved in those areas where the CNFs were densely distributed. Tensile test results showed that approximately two-fold increase in the tensile strength was obtained with the CNF reinforced Cu composite. Based on the micrographic and fractographic observations, the strengthening mechanism of the CNF reinforced Cu composite fabricated by the liquid infiltration process was discussed. (Received March 2, 2004)

Powder Blasting을 이용한 Fused Silica Glass의 미세채널 가공

장호수,윤대진,전두성,이정원,박동삼 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

The old technique of sandblasting which has been used for paint of scale removing, de burring and glass decorating has recently been developed into a powder blasting technique for brittle materials, capable of producing micro structures larger than 100㎛. Recently, this technique is applied to fabrication of the microchannel for fuel cell processor and lab-on-a chip. This paper describes the performance of powder blasting in micromachining of microchannel of fused silica glass and the effect of blasting conditions such as the number of nozzle scanning and the size of abrasive on the erosion depth.

Ionized Calcium 과 Chitosan 정제의 안정성에 관한 연구

장윤정,김현주,김영일,양재헌 又石大學校 1998 論文集 Vol.20 No.-

Recently, chitosan has being fiocused on not only the role of a potential and natural resource with antibacterial or antifungal effect but also the natural controller of releasing of drugs or principle actives. Calcium is one of the most important minerals of human that concerned with the intra-or inter-cellular function. But ionized calcium, prepared from shell through the condition of high temperature, own the antibacterial effects. We prepared the mixed tablet of chitosan and ionized calcium with several additives such as starch paste, ethylcellulose(EC), hydroxypropylmethylcelullose(HPMC) or hydroxyprophylcellulose(HPC). Each formulation with a additive was adopted as a challenger to modify of release profiles of calcium. Finally following both cationic properties, chitosan & ionized calcium, the mucoadhesive effects in the oral cavity are favorable to introduce for chewable tablet. The similar patterns of contents of calcium, disintegration time, hardness, weigth variation were showed following the preparation with each additive. The dissolution profiles of starch paste preparation was more slower than other preparations. It was as the order as HPMC, HPC, EC. The stabilities of tablet of each formulation was creditable in the period of 4 weeks under the condition of 50℃ and 75% of humidity. The contents of calcium, disintegration time, hardness were not changed significantly. Ionized calcium and chitosan mixed tablet may increase the antibacterial effects and the release patterns of calcium could changed successfully by several addives.

뇌하수체 종양 제거술 시행 후 뒤늦게 발생한 횡문근 융해증과 동반된 중추성 열

장제혁,최규남,김일환,노은지,김윤정,유충헌,고정해,박봉수,김태균,권민정,이순희,박정현 인제대학교 2008 仁濟醫學 Vol.29 No.-

Body temperature is controlled by thermoregulatory center of the hypothalamus. We report a case of 24 years old man with central fever. He was subjected to a partial excision of pituitary tumor compressing optic chiasm four years ago. He has received hormonal therapy for panhypothyroidism after removal of pituitary tumor. And He received gamma knife operation for partially contrast-enhancing masses in suprasellar and both hypothalamic areas that is probably postoperatively remnant or recurrent tumor of pituitary adenoma. One year after gamma knife operation, he presented with a febrile syndrome of unknown origin including rhabdomyolysis. All usual investigations proved negative. We diagnosed him as central fever with rhabdomyolysis. He received medical ICU care with cooling bed, ice pack. And his symptom improved. Postoperative hyperthermia may result following resection of the pituitary tumor. When central fever is suspected taking note of past history, a quick recognition of course of fever can help reduce the using of unnecessary antibiotics and hospital stay.

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351)