정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

레슬링 스타일에 따른 부상유형에 관한 연구

김정현,김창환,김병완 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.4

This study aims to investigate what types of injury frequently occur when wrestlers perform their exercise and what cause their injury and propose an efficient scheme to prevent injury. The subjects consist of 59 Greco-Roman and 53 Free-style wrestlers. The results are as follows: (1) Locations of Sports Injury In the case of Greco-Roman wrestlers, the most frequent locations of injury were in the following order: the knee joints, the wrist joints, followed by the neck, the ankle joints, the hands, the shoulder, the head, the elbow joints, the face, the breastbone, ribs, the waist, hip joints, the upper arms, the abdomen, the head, the hip, the forearms, the femoral region and trunk. In the case of Free-style wrestlers, they were in the following order: the head, the wrist joints, the face, the knee joints, the neck, the waist, the elbow joints, the ankle joints, the breastbone, ribs, the hands, hip joints, the forearms, the shoulder, the abdomen, the upper arms and trunk. (2) Types of Sports Injury In the case of Greco-Roman wrestlers, the most frequent injury types were in the following order: scratch, muscle contusion(96.6%), muscle stiffness(94.9%), muscle sprain(93.2%), sprain(91.5%), fracture(88.1%), aural hematoma(86.4%), fissure(84.7%), bone contusion(83%), incised wound or cut, collateral ligament tension and fracture(79.6%), joint sprain(76.2%), tendon fracture(64.4%), dislocation(59.3%), arthritis, disc(57.6%), cerebral concussion(50.8%), proliferous bone change(49.1%), chronic joint change(45.7%), periostitis(38.9%), nerve contusion(37.2%) and cerebral contusion(27.1%). In the case of Free-style wrestlers, they were in the following order: scratch(98.1%), muscle contusion(96.6%), muscle sprain(92.4%), sprain(91.5%), collateral ligament tension and fracture(88.6%), muscle stiffness(86.7%), joint sprain(84.9%), fissure(81.1%), fracture(79.2%), incised wound or cut, aural hematoma(71.6%), disc(69.8%), tendon fracture(56.6%), chronic joint change(49%), arthritis(47.1%), dislocation, proliferous bone change(45.2%), periostitis(41.5%), nerve contusion(37.7%), cerebral concussion(33.9%) and cerebral contusion(30.1%). (3) Times of Sports Injury According to 96.6% of Greco-Roman wrestlers and 98.1% of Free-style wrestlers, the most frequent time of injury occurrence was exercise time. While 38.9% of Greco-Roman wrestlers reported the experience of an injury on defense, 37.7% of Free-style wrestlers reported the experience of an injury both on offense and defense. While 100% of Greco-Roman wrestlers reported the experience of an injury on a cloudy day, 94.3% of Free-style wrestlers reported the experience of an injury on cloudy or raining days. The experience of an injury in the winter season was reported by 54.2% and 39.6% of Greco-Roman and Free-style wrestlers, respectively. The experience of an injury during afternoon exercise time was reported by 71.1% and 81.1% of Greco-Roman and Free-style wrestlers, respectively. (4) Causes of Sports Injury 'carelessness', 'an excessive desire to win' and 'the inability of coaches' were cited as the major causes of sports injury by 67.9%, 33.8% and 25.4 % of Greco-Roman wrestlers, respectively. Meanwhile, 'an excessive desire to win', 'lack of warm-up' and 'the inability of coaches' were cited as the major causes of sports injury by 64.1%, 37.7% and 30.1% of Free-style wrestlers, respectively. (5) Treatment of Sports Injury Both Greco-Roman and Free-style wrestlers reported that, when they had an injury, the emergency treatment was given by coaches and subsequent treatments were administered in hospital and that hot fomentation was applied as an emergency treatment. (6) Psychological state at time of sports injury Both Greco-Roman and Free-style wrestlers reported that, in case of an injury, they were thinking "I'm going to get better soon." Greco-Roman wrestlers' psychological reaction to injury was "What if I can't do as well as before? while that of Free-style wresters was "I'm afraid I will get hurt again." The most frequently recommended by both Greco-Roman and Free-style wrestlers as a solution to reduce injury was 'enough warm-up and finishing'. (7) To the question how many times they had an injury on the same location after treatment, 55.9% of Greco-Roman wrestlers and 47.1% of Free-style wrestlers answered "two to five times". Most of them reported they had experienced an injury in the same location after treatment. (8) Greco-Roman and Free-style wrestlers reported they participated in national tournaments 67 and 70 times respectively and they have ever given up an important match at least once due to injury.

가토의 외상성 슬관절염의 자연적 치유 경과에 대한 고찰

김동헌,장병춘,김상윤,김동혁 건국대학교 의과학연구소 1998 건국의과학학술지 Vol.8 No.-

Articular cartilage is a highly differentiated tissue, lacking a vascular supply and having only limited regenerative capability. It has been well documented that articular cartilage of mature animals has little capacity for repair after traumatic injury. Cuts or other mechanical damage restricted to the cartilage alone do not repair. However, it has been observed both experimentally and clinically that articular defects extending to the subchondral bone eventually are resurfaced with a form of fibrous, fibrocartilagenous or hyaline like cartilagenous tissue. Author's study was designed to evaluate the healing process of osteochondral defect of the knee of rabbit. Partial thickness defect of cartilge and full thickness osteochondral defect of 30 rabbits were made with 3mm diameter of drill-bit. Experimental animals were divided into three groups : 1) Group Ⅰ: Control group 2) Group Ⅱ: Partical cartilage defect group 3) Group Ⅲ: Osteochondral defect group The healing of the defect was assessed at 1weeks, 3weeks, 5weeks, 12weeks after operation by gross and histological examination. The principal findings were as follows. 1. The initial formation of repair tissue was variable, but it ocurred in most cases. 2. In partial cartilage defect group, degenerative change was more severe. 3. There is evidence of healing of small (1-4 mm diameter) but not of large full thickness articular defect. 4. Microscopically, resurfacing of the cartilage holes repaired mainly with fibrocartilage at 5 weeks of injury.

慶尙南道 南海岸地域의 개미相

김창효,崔炳文,金康一 慶尙大學校 1989 論文集 Vol.28 No.2

慶尙南道 南海岸地域의 島嶼 외 海水浴場 周邊등에 棲息하는 개미의 分布相을 調査하는 同時에 南海道의 錦山과 尙州海水浴場 周邊에 分布하는 개미의 高度別 및 季節的 變動을 調査한 結果를 要約하면 다음과 같다. 1. 慶尙南道 南海岸地域의 南海島를 비롯한 15個 地域에 分布하는 개미의 總 種構成은 4亞科 25續 48種이였다. 그리고 優勢種은 왕침개미(Brachyponera chinensis),주름개미(Tetramorium caespitum), 곰개미(Formica japonica), 일본왕개비(Camponotus japonicus)및 스미드개미(Paratrechina flavipes) 등 7種이였고 稀少種은 배굽은침개미(Proceratium itoi),밑드리개미(Crematogaster sordidula),이빨개미(Strongylognathus koreanus), 이도왕개미(Camponotus itoi). 갈색발왕개미(Camponotus kiusiuensis), 황개미(Lasius flavus) 및 두더쥐털개미(Lasius talpa)등 11尊이었다. 2. 南海道의 尙州海水浴場 周邊의 山地와 錦山의 頂上(666m)에서 採集된 남해호리가슴개미(Leptothorax sp.)는 韓國未記錄種으로 確認되었다. 3. 蛇梁島의 琴坪里에서 採集된 이빨개미(Strongylognathus koreanus PISARSKI,1966)가 南漢에서는 最初로 採集되었다. 4. 南海岸地域에 分布하는 개미는 두마디개미亞科(Myrmcinae)에 屬하는 種이 12屬으로 22種으로서 그 種構成이 가장 多樣하였다. 5. 地域別 개미群集의 種構成을 比較해보면 南海道에서 4亞科 23屬 42種으로서 가장 多樣하였다. 6. 南海島의 尙州海水浴場 周邊과 金山에 分布하는 개미의 總 種構成은 4亞科과 232屬 39種이였고, 개미의 高度別 種構成은 尙州海水浴場 周邊에 比하여 金山(660m)에서 약간 多樣한 것 같았다. 그리고 개미의 種構成은 季節的으로 變動하는데 특히 季節에는 海邊에 比하여 山地(金山)에서 그 變動이 심한 것 같았다. 7. 巨濟島에 分布하는 개미의 總 種構成은 4亞科 21屬 29種이였고, 優勢種은 검종꼬마개미(Monomorium minutum), 주름개미(Tetramorium caespitum), 곰개미 (Formica japonica), 일본왕개미(Camponotus japonicus), 고동털개미(Lasius niger)및 스미드개미(Paratrechina flavipes)등 6種이였다. 그리고 巨濟島에서도 南海島에서와 같이 개미의 種構成은 海岸地에 比하여 山地에서 多樣한 것 같았다. The following report is to summarize the results of investigating the height-fluctuation and the season-fluctuation of the ant fauna that lives around Gumsam and the Sangju swimming beach in Namheado(an island on the southern sea in Korea), and of investigation the ant fauna that lives around the swimming beaches, in islands and on the southern shore in Gyeongsangnamdo. 1. The total species structure of the ants which distributes in 15 areas as well as in Namhaedo on the southern sea in Gyeongsangnamdo was 4 sub-families, 25 genera, and 48 species. And the dominants of them were 7 species : Brachyponera chinensis, Monomorium minutum, Pristomyrmex pungens, Tetramorium caespitum, Formica japonica, Camponotus japonicus and Paratrechina flavipes. And the rare species were also 11 : Proceratium itoi, Crematogaster sordidula, Strongylognathus koreanus, Camponotus itoi, Camponotus kiusiuensis, Lasius flavus and Lasius talpa. Ⅱ. The Leptothorax sp. collected at the hilly areas around the Sangju swimming beach and at the top of Gum-san(660m) was confirmed as unrecorded species in Korea. Ⅲ. The Strongylognathus koreanus(PISARSKI,1966) collected at Gumpongli-Saryangdo(an island on the southern sea in Korea) was first in South Korea. Ⅳ. The species structure of the ants belonging to Myrmicinae was 12 genera and 22 species, which was the most diverse of the ants distributing on the southern shore. Ⅴ. Compared whith the species structure of the ants, Namhaedo was more diverse than any other area on the southern shore, which had 4 sub-families, 23 genera and 42 species. Ⅵ. The total species structure of the ants distributing around the Sangju swimming beach and at Gumsan was 4 sub-families, 23 genera and 39 species. The species structure of the height was likely to be a little more diverse at Gum-san than around the Sangju swimming beach. And the species structure of the ants changes according to season, especially in summer, the hilly area(Gumsan) was likely to be more changeful than the seashore. Ⅶ. The total species structure of the ants distributing in Gojedo(an island on the southern sea in Korea) was 4 sub-families, 21 genera and 29 species. And the dominants of them were six species : Monomorium minutum, Tetramorium caespitum, Formica japonica, Camponotus japonicus, Lasius niger and Paratrechina flavipes. In Gojeo as well as in Namhaedo, the species structure of the ants was likely to be more diverse at the hilly area than on the seashore.

반복매매모형을 활용한 아파트 매매가격지수

이창무,김병욱,이현 한국부동산분석학회 2002 不動産學硏究 Vol.8 No.2

Stock price index type of housing price indices were commonly used in Korea. However, this type of indices are not suitable for Korean housing market experiencing rapid changes in stock including both new constructions and demolitions. Especially, the recent Korean housing market has experienced substantial changes in housing characteristics. Basically, the stock price index type of housing price index requires a constant survey stock over time in order to maintain the comparability in total housing values. However, the constant stock concept is hard to accept in the Korean housing market accompanying with rapid increase and qualitative changes in housing stock. An alternative is a hedonic price index. However, the basic data requirements for the application of the hedonic model cannot be fulfilled in the Korean housing market where actual sale information is mostly unknown. In order to overcome this structural deficiency, the price indices in Korea are based o periodical price survey with the help of real estate brokers. If we accept the assumption that the whole condominium units belonging to a basic survey unit (an area type in an condominium complex) share the same housing characteristics and the surveyed price, we can use the repeat sale index concept with some modifications. The persistent price survey generates a perfect form of repeat sales data. This paper proposes a practical method for the application of repeat sale index to condominium sales price indexing.

8주간의 걷기운동과 맨발걷기가 중년여성의 혈중 세로토닌, 코티졸, 에피네프린 그리고 노르에피네프린에 미치는 영향

정진숙,김병완,김창환 대전대학교 기초과학연구소 2019 自然科學 Vol.30 No.-

The purpose of this study is to inspect effects of regular walking and barefoot walking, which is the easiest way for middle-aged women to exercise in daily life, on serotonin, cortisol, epinephrine and norepinephrine in blood and probe the differences of hormonal changes between two groups. Both of two programs were performed three times a week and each program lasted for more than 30 minutes. The group of regular walking was set at 40-60%(HRmax) and the group of walking barefoot was set at level 10-12(RPE). This research is for reducing middle-aged women's stress and helping to promote their health. All the data is processed by using the arithmetical mean and standard deviation and two-way ANOVA is used to verify differences between groups and durations. In case that there is interaction, independent t-test is used for group comparison and dependent t-test is used for duration comparison to inspect details. Degree of hypothesis acceptance is set at p<.05, p<.01, p<.00l. Firstly, the serotonin rate is reduced in both groups after conducting the programs. Significant main effect of serotonin has differences related to durations at F(1.18)=8.281, p=.01 but there's no differences between groups at F(1.18)=.289, p=.597. There is no differences in interaction as well at F(1.18)=.432, p=.520. Secondly, significant main effect of the cortisol rate in both groups after conducting the programs has no differences related to durations at F(1,18)=.292, p=.595 and there's no differences between groups at F(1.18)=.121, p=.732. There is no differences in interaction as well at F(1.18)=.899, p=.356. Thirdly, the result of paired t-test shows that epinephrine rate of the group performing regular walking is reduced more than one of those who walk barefoot at t=2.326, df=9, p=.045 and there is a difference in interaction at F(1.18)=5.815, p=.027. Lastly, the norepinephrine rate of those who take usual walks shows a meaningful difference related to durations at F(1.18)=24.505, p=.00l which is more noticeable than one of the other. However, there is no difference between groups at F(1.18)=.175, p=.680 and there is also no difference in interaction at F(1.18)=.902, p=.355. The result says that both of the programs, regular walking and walking barefoot, don't influence the amount of middle-aged women's stress positively, which is against the previous studies. It is because this research exclude other factors which can influence hormone secretion of middle-aged women such as weather, time, diet and mental state in middle age. It can be deduced that future researches to promote middle-aged women's health and decrease the symptoms of depression should include changes caused by temperature, time to exercise, exercise intensity and subject's psychological state in middle age.

Effect of epidural corticosteroid injection on magnetic resonance imaging findings

( Min Soo Kim ),( Tae Yoon Jeong ),( Yu Seon Cheong ),( Young Wook Jeon ),( So Young Lim ),( Seong Sik Kang ),( In Nam Kim ),( Tsong Bin Chang ),( Hyun Ho Seong ),( Byeong Mun Hwang ) 대한통증학회 2017 The Korean Journal of Pain Vol.30 No.4

Background: Magnetic resonance imaging (MRI) of the spine is the preferred diagnostic tool for pathologic conditions affecting the spine. However, in patients receiving epidural corticosteroid injection (ESI) for treatment of spinal diseases, there is a possibility of misreading of MR images because of air or fluid in the epidural space after the injection. Therefore, we defined the characteristics of abnormal changes in MRI findings following an ESI in patients with low back pain. Methods: We reviewed the medical records of 133 patients who underwent MRI of the lumbar spine within 7 days after ESI between 2006 and 2015.All patients were administered an ESI using a 22-gauge Tuohy needle at the lumbar spine through the interlaminar approach. The epidural space was identified by the loss of resistance technique with air. Results: The incidences of abnormal changes in MRI findings because of ESI were 54%, 31%, and 25% in patients who underwent MRI at approximately 24 h, and 2 and 3 days after ESI, respectively. Abnormal MRI findings included epidural air or fluid, needle tracks, and soft tissue changes. Epidural air, the most frequent abnormal finding (82%), was observed in 41% of patients who underwent MRI within 3 days after injection. Abnormal findings due to an ESI were not observed in MR images acquired 4 days after ESI or later. Conclusions: Pain physicians should consider the possibility of abnormal findings in MR images acquired after epidural injection using the interlaminar approach and the loss of resistance technique with air at the lumbar spine. (Korean J Pain 2017; 30: 281-6)

Investigation of high contrast and reversible luminescence thermochromism of the quantum confined Cs₄PbBr₆ perovskite solid

Choi, Jin Woo,Cho, Namchul,Woo, Hee Chul,Oh, Byeong M.,Almutlaq, Jawaher,Bakr, Osman M.,Kim, Sung-Hoon,Lee, Chang-Lyoul,Kim, Jong H. The Royal Society of Chemistry 2019 Nanoscale Vol.11 No.12

<P>Thermochromism of organic/inorganic halide perovskites has attracted particular interest due to their potential applications as photoluminescence (PL)-based temperature sensors. However, despite the outstanding PL characteristics, their use as a thermochromic material in practical temperature ranges has been limited because of their poor thermal stability. In this study, we used the quantum confinement effect and exceptional PL quantum efficiency of the Cs4PbBr6 perovskite to demonstrate their high on/off ratio (20) and reversible PL thermochromism in the solid state in practical temperature ranges including room temperature (RT). Systematic photophysical and optical characterization studies, including exciton-phonon scattering, exciton binding energy, exciton decay dynamics, and crystal structure change, were performed to investigate the origin of this unique thermochromic PL property. The results showed that the efficient and highly reversible thermochromic PL emission of the Cs4PbBr6 perovskite is due to its desirable optical properties such as highly luminescent emission, efficient PL quenching at high temperatures, and thermally reversible structural changes.</P>

위용종의 내시경적 생검과 내시경적 절제술 후 병리학적 진단의 불일치

윤원재 ( Won Jae Yoon ),이동호 ( Dong Ho Lee ),이국래 ( Kook Lae Lee ),장동경 ( Dong Kyung Chang ),김병관 ( Byeong Gwan Kim ),김지원 ( Ji Won Kim ),정지봉 ( Ji Bong Jeong ),김나영 ( Na Young Kim ),김진욱 ( Jin Wook Kim ),황진혁 ( 대한내과학회 2005 대한내과학회지 Vol.69 No.5

목적 : 위용종이란 위의 내강으로 돌출한 종괴를 의미한다. 거의 90%에서 조직학적으로 과형성 용종이며 이러한 경우 암으로의 진행은 매우 적은 것으로 알려져 있다. 그러나 위선종은 일부에서 국소적으로 암성 병변을 동반하거나, 동반하고 있지 않더라도 시간이 지남에 따라 암으로 진행하는 것으로 알려져 있다. 그러나 내시경적 겸자 생검과 전체 병변의 절제 후 조직 소견에서는 차이가 있는 것으로 알려져 있다. 저자들은 내시경검사에서 위용종이 발견된 후 내시경적 절제술을 시행받은 74명의 환자, 85예의 위용종을 대상으로 임상적 및 병리학적 특성을 알아보고 겸자 생검과 내시경적 절제술 후 병리학적 진단의 불일치를 알아보고자 하였다. 방법 : 1996년 4월부터 2003년 2월까지 내시경검사에서 위용종이 발견된 후 내시경적 생검과 내시경적 절제술 후 조직학적 진단이 모두 이루어진 74명의 환자를 대상으로 내시경 사진, 의무 기록 및 병리 기록을 분석하였다. 결과 : 74명의 환자에서 총 85개의 용종을 관찰할 수 있었다. 위용종은 전정부에서 가장 호발하였으며(58.8%) 그 다음으로는 체하부(18.8%)에 호발하였다. 내시경적 겸자 생검에서 관상 선종은 48.2%, 과형성 용종은 30.6%, 염증성 용종은 15.3%, 위저선 용종은 2.4%, 이형성증은 2.4%, 관상융모 선종은 1.1%였다. 내시경적 절제술 후 조직학적 검사상 관상 선종은 45.9%, 과형성 용종은 31.8%, 염증성 용종은 9.4%, 과오종은 3.5%, 위저선 용종은 2.4%, 관상융모 선종은 2.4%, 선암은 2.4%, 이형성증은 1.1%, 점막 위지방종증은 1.1%였다. 내시경적 겸자 생검 결과와 내시경적 절제술 후 조직학적 진단의 불일치율은 27.1%였다. 용종의 크기에 따른 진단 일치율의 차이는 없었다(p>0.05). 결론 : 위용종의 겸자 생검과 내시경적 절제술 후 조직검사 소견은 차이가 있을 수 있다. 용종의 크기는 진단 일치율에 영향을 미치지 못했다. 따라서 특히 선종이 의심되는 경우에는 크기에 상관없이 내시경적 절제술을 통한 전체 병변의 조직검사가 필요할 것으로 생각된다. Background : Gastric polyp is a descriptive term referring to mucosal prominence that protrudes beyond the flat lining of the stomach. Almost 90% of gastric polyps are hyperplastic polyps. Adenomatous polyps may contain focal carcinomatous foci or undergo carcinomatous changes. It is known that there is some degree of discordance between the results of endoscopic forceps biopsy and pathology of resected specimens. The aim of this study was to investigate the discordance in pathologic findings between endoscopic forceps biopsy and endoscopic resection specimen of gastric polyps. Methods : We reviewed endoscopic photographs and medical records of the patients who underwent endoscopic resection from April, 1996 through February, 2003. Results : A total of 85 cases of gastric polyps from 74 patients were reviewed. Male-to-female ratio was 1:1.96. Mean age was 59.9±10.8 years. Multiple polyps were observed in 10.8%. Gastric polyps occurred in the antrum most frequently (58.8%). Pathology results on resected specimens were as follows: tubular adenoma 45.9%, hyperplastic polyp 31.8%, inflammatory polyp 9.4%, hamartoma 3.5%, fundic gland polyp 2.4%, tubulovillous adenoma 2.4%, adenocarcinoma 2.4%, dysplasia 1.1%, and mucosal pseudolipomatosis 1.1%. Discordance rate between endoscopic biopsy and pathology of resected specimens was 27.1%. There was no relationship between the size of the polyp and concordance rate. Conclusions : There was considerable discordance in pathologic findings between endoscopic forceps biopsy and resected specimens. Approaches to review the histology of an entire polyp should be performed, especially when an adenoma is suspected.(Korean J Med 69:481-486, 2005)

SM45C강의 Tempering 온도 변화에 따른 상온 및 300℃에서의 피로균열전파특성

장천수,김현철,임병수 成均館大學校 科學技術硏究所 1993 論文集 Vol.44 No.2

The effect of micros tructural and tempering temperature change on ΔK_th has been investigated at room temperature and 300℃ For the experiments, using SM4OC steel, specimens of different grain sizes, spacings between ΔK_th particles and tempering temperatures were prepared. Some of the conclusions obtained are as follows ; 1. ΔK_th values were greater at 300℃ when compared with those at room temperature and the crack growth rate decreased as test temperature increased. 2. ΔK_th was observed to increase with tempering temperature. However, ΔK_th value of 450℃ tempered specimen was very low, which is believed to be the result of Tempered Martensite Embrittlement(T.M.E.).