유전자 조작 , 균주분리 Yeast Thioredoxin System 의 발현 , 정제 및 특성조사

정진숙,김명희,김강화 한국미생물생명공학회 1998 한국미생물·생명공학회지 Vol.26 No.6

출판저널 칼럼

정진숙,Jeong, Jin-Suk 대한출판문화협회 1990 출판저널 Vol.66 No.-

좋아하는 날(FKD)을 통한 학대경험 타당화 연구

정진숙,김갑숙 한국예술심리치료학회 2011 예술심리치료연구 Vol.7 No.1

본 연구는 좋아하는 날(Favorite Kind of Day:FKD)이 아동의 학대경험을 파악하는 진단도구로 활용할 수 있는지 그 타당성을 검증하는데 목적이 있다. 연구대상은 부산, 대구, 경북지역의 시설아동 295명, 일반아동 282명으로 총 577명이고, 연구도구는 학대경험척도와 FKD그림검사를 사용하였다. 자료 분석은 SPSS 19.0 Program을 사용하였으며, 척도의 신뢰도 검증과 그림검사의 채점자간 일치도를 구하였다. 연구 문제와 관련하여 학대경험정도에 따라 FKD그림반응특성의 차이검증은 교차분석을, 타당성 검증을 위해서는 판별분석을 실시하였다. 본 연구의 결과는 다음과 같다. 학대경험정도의 신체학대, 정서학대에 따라 FKD그림반응특성은 형태요소에서 채색정도, 채색에너지, 색사용수, 공간사용도, 세부묘사, 선의질, 움직임과 날씨요소는 해 크기, 비 양, 해, 먹구름, 비, 번개 유·무, 그리고 색채요소에서는 검정을 제외한 9색에서 유의미한 차이가 있었다. 이들 변수들이 신체학대를 판별하는 정도는 87.2%, 정서학대를 판별하는 정도는 87.7%로 나타났다. 따라서 FKD그림은 아동의 학대경험정도를 진단하는 그림투사도구로서 타당성이 있다고 볼 수 있다. This study was conducted to see whether the FKD technique has diagnostic validity in identifying of signs of child abuse. For the research, “favorite kind of day(FKD)”drawings of 577 children from Daegu, Busan, and North Kyungsang provinces in Korea - 295 from institutions which facilitate abused children and 282 from children with no known history of abuse –were evaluated with various rating criteria. A software program, Statistical Package for Social Science(SPSS) version 19, was used to process and analyze data, testing the results for reliability of scales and inter-raters. With a discriminant analysis used to verify the validity of statistics gathered for the research, the study also applied the cross tabulation analysis to examine the differences in children’s responses to FKD depending on their severity of abuse. The results showed that the abused children drew significantly different FKDdrawings in how many colors and what colors they were predominantly using, what elements of weather movements such as the size of sun and the amount of rain, the existence of dull clouds and lighting they were drawing, and how much space they were filling and how they were filling the space in terms of the thickness and movements of lines. It was found that these variables accounted for 87.2% for the degree of physical abuse and accounted for 87.7% for the degree of emotional abuse. Consequently, the finding implies that the FKD drawing can be a valuable projective tool to detect the degree of abuse of children and adolescents.

규장각 정보화의 현황과 미래

정진숙 서울대학교 규장각한국학연구원 2023 규장각 Vol.62 No.-

Kyujanggak Institute for Korean Studies has been continuously carrying out digital transformation projects from the late 1990s to the present day. The projects can be divided into three phases depending on the main agencies involved, the purposes of the projects, and the amount of financial support provided. The first phase, from 1999 to 2007, was carried out as a public works project to cope with the economic downturn that continued after the IMF bailout, as part of the National Database Project of the Ministry of Public Administration and Security and National Information Society Agency. The annual budget executed for this project exceeded an average of about KRW 3 billion, which was a significant amount at that time. Through this project, Kyujanggak was able to digitize and provide services for images and texts of major Korean classical books, historical documents, and antique maps. However, Kyujanggak experienced significant trial and error during this period, particularly in terms of the purity of the texts data. This was due to the lack of project experience and long-term planning, as well as technological limitations. The second phase took place from 2008 to 2017. During this time, Kyujanggak carried out the National Archival Data Center project with the support of the Academy of Korean Studies. The Academy of Korean Studies project aimed to systematically collect, organize, analyze, and integrate various historical materials both domestically and internationally, including historical documents and books, into standardized formats to build Korean studies knowledge content. Kyujanggak performed the project to organize and process the Uigwe(儀軌) and the Jiriji(地理志), using them as historical materials. Kyujanggak received an annual budget of KRW 380 million to carry out the project. As a result of the project, Kyujanggak opened a comprehensive information site for the Uigwe and Jiriji. In particular, the project provided detailed information and explanations for the target materials and converted the image viewer to PDF to increase the convenience of service users. The third phase runs from 2014 to the present day, during which Kyujanggak has received support from the Cultural Heritage Administration to carry out its projects. From 2014 to 2016, Kyujanggak and Jangseogak received support to carry out its projects, and since 2017, Kyujanggak has been carrying out its projects independently with budgetary support. During this phase, Kyujanggak formulated a plan to separate its website from its collection search site, which was completed in 2020. Additionally, the Institute created its own management system for data maintenance. It is also conducting projects to modify and improve existing data, create and provide historical geographical information linked to geographical information systems and maps, and offer services using up-to-date geographical information systems. Over a long period of time, Kyujanggak has been working on an information technology project to open up its collection to Korean studies researchers and the public both domestically and internationally. However, the digitalization rate of the collection remains low, and it is not easy for the public to access and use the collection. Therefore, the Institute must continue to work for digitalizing its collection and devise ways to make it more accessible to the public. To achieve this goal, the Institute must provide a classification code for managing and viewing its collection, and digitally provide its collection using various classifications. It must also develop contents that are easily understood and of interest to the public, and offer them in the form of text, images, and videos.

조현병 환자에게서 RORA 유전자 다형성과 항정신병 약물과 관련된 하지불안증후군의 연관성

정진숙,조철현,윤호경,강승걸,박영민,이헌정,김린 대한조현병학회 2013 대한조현병학회지 Vol.16 No.2

Objectives : The previous studies have suggested genetic vulnerability to restless legs syndrome (RLS) development. The occurrence of antipsychotic-related RLS could also be attributable to differences in genetic susceptibility. This study aimed to investigate whether Retinoid-related orphan receptor A (RORA) gene polymorphism is associated with antipsychotic-related RLS in schizophrenia. Methods : We assessed symptoms of antipsychotic-induced RLS in 190 Korean schizophrenic patients and divided the subjects into two groups according to the International Restless Legs Syndrome Study Group diagnostic criteria : 1) subjects that met all of the criteria (n=44) and 2) the remaining subjects who were not considered to be RLS patients (n=146). Single-nucleotide polymorphism in the RORA gene was genotyped by PCR in 190 individuals. The χ2-test was conducted to compare differences between two groups. Results : The frequencies of genotype (χ2=0.066, p=0.968) of the RORA gene (rs11071547) did not differ significantly between schizophrenic patients with and without RLS. The difference of allele frequencies (χ2=0.008, p=0.927) of the RORA gene (rs 11071547) between the schizophrenic patients with and without RLS were not significant. Conclusion : These results suggest that RORA gene polymorphism does not play a major role in susceptibility to antipsychotic-related RLS in schizophrenia. RLS는 강한 유전성을 보이는 질환이며 증상이 주기적으로 발현되는 데 생체시계가 연관이 있다고 알려져 있다. 하루주기리듬을 만들어내는 데 중요한 전사인자인 RORA가 RLS의 발생 취약성에 있어서 좋은 후보 유전자가 될 수 있겠다. 본 연구에서는 RORA 유전자의 다형성과 항정신병 약물과 연관된 RLS의 관계를 살펴보고자 190명(44명의 RLS, 146명의 non-RLS)의 조현병 환자들을 대상으로 연구하였다. 결론적으로 RORA 유전자 다형성과 항정신병약제와 관련된 RLS의 연관성을 발견하지 못하였다. 그러나 본 연구는 RORA 유전자 다형성과 항정신병약물과 관련된 RLS의 연관성을 살펴본 연구로 의의가 있으며 향후 RLS와 다른 생체시계와 연관된 추가적인 후보 유전자들에 대한 연구가 진행된다면 RLS의 유전학적 병태생리를 이해하는데 큰 도움이 될 것이다.

아동의 학대경험 진단도구로서의 동적가족화(KFD) 활용

정진숙,김갑숙 한국미술치료학회 2011 美術治療硏究 Vol.18 No.2

본 연구는 동적가족화가 아동의 학대경험을 파악하는 도구로 활용될 수 있는지 그 타당성을 검증하는데 목적이 있다. 연구대상은 부산, 대구, 경북지역의 시설아동 295명, 일반아동 282명, 총 577명이었고, 연구도구는 ‘학대경험 척도’와 ‘동적가족화’를 사용하였다. 자료 분석은 SPSS 19.0 Program을 이용하여 처리하였으며, 척도의 신뢰도 검증과 그림검사의 채점자간 일치도를 구하였다. 연구 문제와 관련하여 학대경험유형별 정도를 파악하기 위하여 빈도분석을, 학대경험정도와 동적가족화 반응특성의 관계는 상관분석을, 학대경험정도에 따른 동적가족화 반응특성 차이는 t-test를 실시하였다. 본 연구의 결과는 다음과 같다. 첫째, 학대경험 유형별 정도는 신체학대에서는 손, 굵은 막대, 혁대 등으로 맞음이 많은 것으로, 정서학대에서는 수치심과, 모욕적인 말과 꾸짖음을 많이 받는 것으로 나타났다. 둘째, 신체학대, 정서학대와 동적가족화와의 영역 중 창조성, 행복감은 부적 관계가, 상처받음, 정서적 거리, 긴장/불안, 역할전환, 이상함, 포괄적 병리는 정적 관계가 있는 것으로 나타났다. 셋째, 신체학대, 정서학대를 평균, 표준편차를 이용하여 분류한 후 동적가족화의 반응특성 차이를 t-test한 결과, 두 집단 간에 통계적으로 유의한 차이가 나타났다. 따라서 동적가족화(KFD)는 학대 아동의 가족지각을 진단하는 그림투사도구로서 유용하다고 할 수 있다. This study was conducted to see whether the KFD technique has diagnostic validity in identifying of signs of child abuse. For the research, “Kinetic Family Drawing(KFD)”drawings of 577 children from Daegu, Busan, and North Kyungsang provinces in Korea-295 from institutions which facilitate abused children and 282 from children with no known history of abuse–were evaluated with various rating criteria. A software program, Statistical Package for Social Science(SPSS) version 19, was used to process and analyze data, testing the results for reliability of scales and inter-raters. Additionally, frequency test is carried out to find out the degree of abuse by the types of the abused experiences. Correlation analysis is carried out to find out the responsive characteristics of KFD with the degree of the abused experiences. And t-test is carried out to find out the difference in the KFD responsive characteristics to the degree of the abused experiences. The results of this study are as follows. First, in view of the degree of the types of the abused experiences, in the physical abuse, it was found out that there were a lot of hits by hands, a thick stick, a belt. And in the emotional abuse, there were a lot of abuses by humiliation, an insulting remark, a scolding. Second, among the subcategories of the responsive characteristics of KFD with the physical abuse and the emotional abuse, the creativity and the sense of happiness showed a negative correlation. And being hurted, the emotional distance, the tension and anxiety, the role reversion, the strangeness, the comprehensive pathology showed a positive correlation. Third, after sorting out the physical abuse and the emotional abuse by the average and the standard deviation, t-test was carried out to find out the responsive characteristics in KFD, which showed a significant difference between the two groups. Therefore, KFD is available as a projection tool to diagnose the family perception of the abused children.

A study on the synthesis of fluorinated polymers and application to photoresist for optical wave guide patterning

정진숙,위성유,이우균,김진봉 한국고분자학회 2007 한국고분자학회 학술대회 연구논문 초록집 Vol.2007 No.10

학대경험아동의 불안 감소 및 자기효능감 향상을 위한 활동중심 미술치료 사례연구

정진숙 한국아동발달지원연구소 2021 임상미술심리연구 Vol.11 No.2

본 연구는 학대경험아동에게 활동중심 미술치료를 적용하여 불안 감소 및 자기효능감 향상과 행동변화를 살펴보는데 목적이 있다. 연구대상은 초등학교 4학년에 재학 중인 11세 아동 1명이다. 연구대상에게 활동중심 미술치료를 주 2회, 50분, 사전 사후검사를 제외한 총 15회기 진행하였다. 활동중심 미술치료의 실시에 따른 불안 검사와 자기효능감 검사를 사전 사후로 실시하여 비교 분석하였으며, 행동변화를 살펴보기 위해 프로그램 진행을 회 기별 기록하여 기술하였다. 그에 따른 연구결과는 다음과 같다. 첫째, 활동중심 미술치료가 학대경험아동의 불안 감소에 효과가 있었으며 둘째, 활동중심 미술치료가 학대경험아동의 자기효능감 향상에 효과가 있었다. 셋째, 활동중심 미술치료를 실시한 결과 회기별 행동변 화에서는 눈 마주침, 물건을 챙기고 정리 정돈, 자발적인 활동하는 등의 변화가 있었다. 결 과적으로 활동중심 미술치료는 학대경험아동의 불안 감소 및 자기효능감 향상 등의 긍정 적인 영향을 주는 것을 확인할 수 있었고, 임상현장에서의 미술치료 프로그램 기초자료 제 공에 의의가 있다. The purpose of this study is to examine the reduction of anxiety, improvement of self-efficacy, and behavioral change by applying activity-based art therapy to abused children. The subjects of this study were one 11-year-old child in the fourth grade of elementary school. Activity-based art therapy was administered to the subjects twice a week, for 50 minutes, and a total of 15 sessions were performed excluding the preand post-test. The results of the study are as follows. First, activity-based art therapy was effective in reducing anxiety of abused children, and second, activity-based art therapy was effective in improving the self-efficacy of abused children. Third, as a result of the activity-based art therapy, there were changes in the behavioral changes for each session, such as eye contact, packing and organizing things, and voluntary activities. As a result, it was confirmed that activity-based art therapy had positive effects such as reducing anxiety and improving self-efficacy in children who experienced abuse, and it is significant in providing basic data for art therapy programs in clinical settings.

8주간의 걷기운동과 맨발걷기가 중년여성의 혈중 세로토닌, 코티졸, 에피네프린 그리고 노르에피네프린에 미치는 영향

정진숙,김병완,김창환 대전대학교 기초과학연구소 2019 自然科學 Vol.30 No.-

The purpose of this study is to inspect effects of regular walking and barefoot walking, which is the easiest way for middle-aged women to exercise in daily life, on serotonin, cortisol, epinephrine and norepinephrine in blood and probe the differences of hormonal changes between two groups. Both of two programs were performed three times a week and each program lasted for more than 30 minutes. The group of regular walking was set at 40-60%(HRmax) and the group of walking barefoot was set at level 10-12(RPE). This research is for reducing middle-aged women's stress and helping to promote their health. All the data is processed by using the arithmetical mean and standard deviation and two-way ANOVA is used to verify differences between groups and durations. In case that there is interaction, independent t-test is used for group comparison and dependent t-test is used for duration comparison to inspect details. Degree of hypothesis acceptance is set at p<.05, p<.01, p<.00l. Firstly, the serotonin rate is reduced in both groups after conducting the programs. Significant main effect of serotonin has differences related to durations at F(1.18)=8.281, p=.01 but there's no differences between groups at F(1.18)=.289, p=.597. There is no differences in interaction as well at F(1.18)=.432, p=.520. Secondly, significant main effect of the cortisol rate in both groups after conducting the programs has no differences related to durations at F(1,18)=.292, p=.595 and there's no differences between groups at F(1.18)=.121, p=.732. There is no differences in interaction as well at F(1.18)=.899, p=.356. Thirdly, the result of paired t-test shows that epinephrine rate of the group performing regular walking is reduced more than one of those who walk barefoot at t=2.326, df=9, p=.045 and there is a difference in interaction at F(1.18)=5.815, p=.027. Lastly, the norepinephrine rate of those who take usual walks shows a meaningful difference related to durations at F(1.18)=24.505, p=.00l which is more noticeable than one of the other. However, there is no difference between groups at F(1.18)=.175, p=.680 and there is also no difference in interaction at F(1.18)=.902, p=.355. The result says that both of the programs, regular walking and walking barefoot, don't influence the amount of middle-aged women's stress positively, which is against the previous studies. It is because this research exclude other factors which can influence hormone secretion of middle-aged women such as weather, time, diet and mental state in middle age. It can be deduced that future researches to promote middle-aged women's health and decrease the symptoms of depression should include changes caused by temperature, time to exercise, exercise intensity and subject's psychological state in middle age.

Selective regression of cancers expressing cytoskeleton associated protein 2-targeting RNA replacement by tans-splicing ribozyme, in vivo

정진숙,조경숙,주미하,김보경,반가이,이성욱,김인후 한국실험동물학회 2011 한국실험동물학회 학술발표대회 논문집 Vol.2011 No.2