감식초가 고콜레스테롤 식이를 한 흰쥐의 혈중 지질 성분에 미치는 영향

정소형,김주현,정용진,최미자 동아시아식생활학회 1999 동아시아식생활학회지 Vol.9 No.4

This study was performed to evaluate the effect of persimmon vinegar on serum lipid components in the hypercholesterolemic Sprague-Dawley male rats. Forty rats were divided into four groups and fed diets containing 1% cholesterol for 4 weeks. Experimental diets added to distilled water, 1.5%, 3%, and 7% persimmon vinegar(PV) as drinking water. Concentration of total cholesterol, LDL and HDL cholesterol, triglyceride in serum and activity of AST, ALT in serum were assayed. Average food intake, weight gain and FER of experimental rats were not significantly different by contents of persimmon vinegar. Concentration of total cholesterol and LDL cholesterol in serum were lowest in 7% persimmon vinegar group. However concentration of HDL cholesterol in serum was highest in 3% persimmon vinegar group. Concentration of triglyceride in serum was significantly lower in persimmon vinegar group than control group. Activities of AST and ALT in serum were lowest in 7% persimmon vinegar group. The results in this study suggest that persimmon vinegar is effective in lowering serum triglyceride level.

조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)

알코올이 면역체계에 미치는 영향

김주현,정소형,강혜경 東國專門大學 1999 金龜論叢 Vol.7 No.1

술은 식품, 약품 또는 중독성 물질로 분류되며 기분 전환제 또는 정신자극 약품으로 작용한다. 술은 국민의 신체적 정신적 건강을 해치는 물질로 계속적으로 주목을 받고 있으며 이를 상습 하는 사람의 경우 영양장애뿐 아니라 간, 췌장, 소화기관, 뇌, 심장, 근육과 생식기관등 신체의 모든 기관에 손상을 입힌다고 한다. 술의 남용은 결핵(tuberculosis), 기회감염(oppotunistic infections), 뇌와 목의 종양, 자가면역질환(autoimmune disease)의 발생 정도가 높으며, 면역체계와의 관련성 역시 제기되고 있다. 알코올에 의한 면역부진은 세포 매개성 면역(cell-mediated immminity)에서 가장 두드러지며, 이로 인해 결핵의 이환이나 간염과 인체면역결핍바이러스(HIV infection)과 같은 비루스에 의한 감염이 쉽게 일어날 수 있다. 알코올에 의해 T cell의 기능은 손상되거나 분비 이상이 초래될 수 있으며, Natural killer cell의 활성이 감소되는 등의 면역 기능의 손상을 가져올 수 있다. 이러한 면역기능의 손상은 간질환, 암, 기타 감염에 쉽게 노출될 수 있는 환경을 제공하게 된다. 결국 알코올 섭취와 관련된 특정질환에서 알코올은 immnomodulator로서 작용하여 여러 질환의 원인 물질로 작용될 수 있다.

급식소의 조리기기 및 작업환경에 대한 미생물학적 위해분석과 HACCP 제도 적용 후 위생개선효과

배현주,전희정 한국조리과학회 2003 한국식품조리과학회지 Vol.19 No.2

The purpose of this study was to evaluate the effect of implementing the HACCP system on foodservice establishments. At first, the hygienic conditions were measured by microbiological hazard analyses of the cooking utensils and working areas. In order to solve the detected problems, the HACCP system was implemented, after what was considered a sufficient settlement period following the initial assessment, then microbiological verification was Performed again. In relation to the cooking utensils and equipment(kitchen knives. cutting boards, knives for shredding vegetables, refrigerators, baskets, barts, working tables, preparation tables, tungs, dish-clothes and drains) the microbiological inspection on the Total Plate Count, Coliforms, Staphylocaccus aureus and, Listeria monocytogenes, were conducted with regard to the working areas(working tables, preparation tables, seasoning's shelves, serving tables, drinking water tables. refrigerators, storage rooms and dining tables), the Total Plate Count and Fungi were also examined. According to the microbiological hazard analyses there were many problems. especially with cutting boards, baskets, barts, dish-clothes and sinkballs. However. by introducing the HACCP system, the microbiological hazard levels were able to be controlled and lowered, and the total aerial bacteria in the working areas of the foodservice establishments were detected at levels below 6 CFU/plate.

무증상적 현미경적 혈뇨의 진단

김현주,김광식,허정식 제주대학교 생명과학연구소 2002 제주생명과학연구 Vol.5 No.6

Hematuria is one of the most common problems to medical service. Blood in the urine (hematuria) may originate from any site along the urinary tract. Serious urologic lesions have been reported in 4.8% to 16.5% of patients referred for asymptomatic microscopic hematuria. The purpose of evaluating any patient with asymptomatic microscopic hematuria is significant urologic disease at an early stage when it is amenable to curative treatment and prior to it causing significant morbidity. The commonly accepted diagnostic algorithm for hematuria includes intravenous urograpy and cystoscopy. Full Urologic evaluation (IVP< or renal sonography>, urine cytology and cystoscopy) is warranted in the majority of patients referred to a urologist with asymptomatic microscopic hematuria. The most commonly recommended surveillance protocol includes urinalysis and urine cytology every 6 months with cystoscopy and intravenous urography either yearly or alternating biannually.

조리조건에 따른 마늘의 휘발성 함황화합물의 변화

배현주,전희정 한국조리과학회 2002 한국식품조리과학회지 Vol.18 No.3

This study was performed to find the changes in volatile sulfur compounds of garlic under various cooking conditions. The volatile sulfur compounds of garlic were identified with GC and GC/MS. The results of the study were summarized as follows : Chopped garlic boiled for 30min and 60min had more volatile sulfur compounds than that of fresh garlic, while 2-vinyl-4H-1,3-dithiin decreased by boiling. Whole garlic boiled for 30min and 60min had less volatile sulfur compounds than that of fresh garlic, while allyl methyl trisulfide and diallyl trisulfide increased by boiling. Analyzing the change of volatile sulfur compounds under cooking methods, the order that showed more volatile sulfur compounds was as follows : grilling > frying > steaming > boiling > microwave oven cooking > pressure cooking.

Pulsed ECR PECVD를 이용한 SiOx박막의 성장 및 특성분석

이주현,정일채,채상훈,서영준,이영백 선문대학교 1998 공과대학논문집 Vol.1 No.1

일반적으로 TFT(thin film transistor)의 유전체막으로 실리콘 실화막(Si_(3)N_(4))이나 실리콘 산화막(SiO_(2)) 을 200 - 300℃의 온도에서 증착을 하게되는데 본 연구에서는 비정질 실리콘과 유전체막사이의 계면 특성 특히 계면의 거칠기를 향상시키기 위해서 기존의 증착법이 아니라 비정질 실리콘(a-Si:H)과 산소 ECR 플라즈마의 반응 에 의한 산화막의 성장법을 시도했는데, 이 때 기판은 의도적으로 가열하지 않았으며 특히 본 연구에서는 기존의 시도와는 달리 ECR 플라즈마를 형성할 때 마이크로파 전력에 pulse콜 가하는 방법을 최초로 시도했고, 계면에 불 순물의 혼입을 최대한으로 줄이기 위해서 진공을 파괴하지 않은 상태로 산화막을 연속적으로 성장시키는 방법을 이용했다. Pulse를 가했을 경우에는 pulse를 가하지 않은 경우에 비해서 화학양론적 측면, 유전상수, 산화막의 표면 평탄도 등에서 우수한 산화막이 성장했으며, 특히 비정질 실리콘과 유전체막사이의 계면 특성을 반영하는 산화막의 표면 평탄도가 1/3정도로 획기적으로 줄어들었다. Dielectric thin films for TFT(thin film transistor)s, such as silicon nitride(Si_(3)N_(4)) and silicon oxide(SiO_(2)), are usually deposited at 200 - 300 ℃. In this study, authors have tried to form dielectric films not by deposition but by oxidation with ECR(Electron Cyclotron Resonance) oxygen plasma, to improve the interface properties between the dielectric films and semiconductor films(hydrogenated amorphous silicon(a-Si:H)). The substrate was not intentionally heated during oxidation. The oxidation was performed consecutively without breaking vacuum after the deposition of a-Si:H films on the substrate to prevent the introduction of impurities. In this study, especially pulse mode of microwave power has been firstly tried during ECR oxygen plasma formation. Compared with the case of the continuous wave mode, the oxidation with the pulsed ECR results in higher quality silicon oxide(SiO_(x)) films in terms of stoichiometry of bonding, dielectric constants and surface roughness. Especially the surface roughness of the pulsed ECR oxide films dramatically decreased to one-third of that of the continuous wave mode cases.

단기간 저장조건을 달리한 마늘의 휘발성 함황화합물의 변화

배현주,전희정 한국조리과학회 2003 한국식품조리과학회지 Vol.19 No.1

This study was performed to find the changes in volatile sulfur compounds of garlic under various storage conditions. The volatile sulfur compounds of garlic were identified with GC and GC/MS. Analysis on the detected volatile sulfur compound of garlic which is known to have medical effect was performed while storing for two days at room temperature and for 1, 3 and 7 days at 4℃ and -18℃, respectively. The results of the study were summarized as follows : Total amount of 7 volatile sulfur compounds was the highest in the sample stored at room temperature for on hour. During the storage of 1, 3 and 7 days at -18℃, chopped garlic contained more of volatile sulfur compounds than under any other storage conditions and the amounts of 7 volatile sulfur compounds increased gradually during the storage of chopped garlic.

고령 작업자를 위한 농작업 편이장비의 인간공학적 개선에 관한 연구

이창민,오연주,김대웅,유중현,신광현 東義大學校産業技術開發硏究所 2009 産業技術硏究誌 Vol.23 No.-

우리나라의 농업은 작업자의 고령화와 여성작업자의 증가 그리고 비정형화로 구성된 작업형태로 인해 근골격계질환의 위험성이 매우 높은 업종이다. 특히 과수업은 작업점이 작업자의 머리위에서 형성되어 지속적으로 이루어지고, 수확기에는 작업량이 집중되어 농업분야 중에서도 근골격계질환의 유병율이 가장 높게 나타난다. 본 연구에서는 고령농작업자에게 집중적으로 발생되는 근골격계질환을 예방하기 위해 수확기에 집중되는 대표작업 세 가지 운반 작업, 선별작업 그리고 포장작업을 선정하여 유해요인을 분석하고 공학적 개선책을 제시하고자 한다. 배농업의 수확기 작업에서 근골격계질환 유해요인으로 나타나는 중량물 운반 작업과 불필요한 작업 자세를 개선할 수 있는 자바라 컨베이어 벨트와 높이조절식 작업대의 도입을 통하여 고령 작업자뿐만 아니라 여성 작업자들이 효율적인 시스템에서 안전하게 작업할 수 있기를 기대하며 근골격계질환 발생으로 인한 사회․경제적 손실도 감소시킬 수 있을 것이다.

다발성 골수종에서 저용량 thalidomide, cyclophosphamide, dexamethasone (TCD) 요법의 효과

류충헌,정재현,고정해,장제혁,박영진,최규남,박봉수,이상민,주영돈 인제대학교 2008 仁濟醫學 Vol.29 No.-

Background and Objectives : The immunomodulatory drug thalidomide can inhibit angiogenesis and induce apoptosis in experimental models. It can also induce marked and durable response in newly diagnosed myeloma patients. Thalidomide has been used at doses ranging from 200 to 800 mg with significant toxicity. No data are available on the impact of low-dose thalidomide, cyclophosphamide and dexamethasone as initial therapy for myeloma patients. Design and Methods : To address this issue, newly diagnosed myeloma patients were treated with 50 mg/day thalidomide continuously and cyclophosphamide 150 mg/m², days 1-4 and dexamethasone 20 mg/m², days 1-5 and day 15-19, every month. Between October 2005 and October 2006, 14 patients (median age 54.5 years) were treated with low-dose thalidomide, cyclophosphamide and dexamethasone. Results : After a minimum of two cycles of treatment, 5 patients (55.5%) showed a partial remission. After four cycles of treatment, 10 patients (83.3%) showed a partial remission (n=6) and complete remission (n=4). After a median follow-up of 15.4 months, 1 year overall survival rate was 82.0%. Thalidomide was well tolerated without serious toxic effects. Conclusions : The combination of low-dose thalidomide, cyclophosphamide and dexamethasone demonstrates favorable response rate and 1 year overall survival rate in newly diagnosed myeloma. Severe toxicities were not seen with this combination.