백서 심근경색모델에서 시간경과와 경색의 크기에 따른 심자도의 변화

김미성(Mi Sung Kim),박영선(Young Sun Park),권순길(Sun Gil Kwon),지정훈(Jeong Hoon Ji),신종성(Jong Sung Shin),오광식(Kwang Sik Oh),양용모(Yong Mo Yang),연태진(Tae Jin Youn),김동운(Dong Woon Kim),조명찬(Myeong Chan Cho),이용호(Yong Ho 대한내과학회 2002 대한내과학회지 Vol.62 No.1

N/A Background: Magnetocardiogram (MCG), which records the changes of magnetic fields generated by the heart`s electrical activity, theoritically can provide unique data for clinical application. To date, MCG has been investigated only at a single time point after myocardial infarction (MI) with severe left ventricular dysfunction in rats. The purpose of the present study was to investigate sequential changes of MCG after MI and to evaluate effects of infarct size on MCG. Methods: Acute MI were induced by the permanent ligation of left coronary artery in 22 rats. Magnetic fields were recorded just above a rat with Nb Superconducting Quantum Interference Device (SQUID) gradiometer inside a magnetically shielded room. MCG was measured before and immediately after surgery and it was subsequently recorded at the time points of 1, 4 and 6 hours post operatively. MCG was also measured at 1, 3, 7 and 21 days after surgery. Results: Elevation of ST segment and appearance of pathological Q wave on the MCG were evident immediately after the ligation of coronary artery and persisted to 6 hours after MI. On MCG, ST segment was depressed and T wave was inverted from 1 day after MI. In rats with small-and moderate- sized MI (infarct size〈30%), ST depression returned to near the isoelectric level and Q wave disappeared from 7 days after MI. However, ST depression and Q wave were still present in rats with larger infarct (infarct size≥30%). Conclusion: Evolutional changes of MCG were well-recognized up to 21 days after MI. Furthermore, the infarct size can be expressed by the extent of Q wave and ST segment depression on MCG. Taken together, these data indicate that MCG is a helpful modality for the diagnosis, evaluation of infarct size and follow up after MI.(Korean J Med 62:42-48, 2002)

의약분업 전후의 의약정보서비스의 질의응답과 질의자의 만족도 분석

신정인,김미애,허경희,김미정,신현택,오정미 한국병원약사회 2003 병원약사회지 Vol.20 No.2

Drug Information Centers(DICs) are responsible for providing updated and relevant drug information on the efficacy, safety and quality of drugs to health-care practitioners and finally to patients. After the establishment of new prescription law(Bunup)' on August 2000, the future direction for DICs is strongly needed to provide specified, appropriate and rapid information to health-card practitioners and patients. This project was undertaken to provide a future direction of DICs via comparing differences of Q&A before and after Bunup, based on the analysis of Q&A worksheets that were conducted from August 1999 to July 2001 at Drug Information Research Institute(DIRI) of Sookmyung Women's University. In addition, feedback sheets were collected from the users of DIRI from April 2001 to August 2001, to evaluate the satisfaction scores by '5-point Likert scale' on the response. The number of inquiries responded by DIRI was increase from 201 to 574 and the most frequently asked inquirers were pharmacists, specifically community pharmacists. The mean time to respond before and after Bunup was 5.35 and 4.68 hours, respectively. The method of inquiry utilized the most was electronic mailing system followed by telephone both before and after Bunup(66.2% vs. 65.7% via e-mail, from 32.8% vs. 32.4% via telephone). The most frequently asked category of question was on the 'clinical drug' category both before and after Bunup (79% vs. 73.6%). The tertiary literature was the most frequently used reference to answer the inquiries. Mean feedback result via questionnaires was good. That included accuracy, quality of information, time to respond, attitude of provider, accessibility, etc. The most increased inquirer after Bunup was general person, compared with before. Therefore DICs should provide separate responds according to inquirers, develop the systemic program to improve the response for each request, have systemic Q&A worksheet, and develop the educational program for drug information providers. DICs should continuously provide more appropriate and rapid information to health-care practitioners and patients.

대동맥 협착증과 동반된 출혈성 위장관 동정맥 기형에서 Estrogen-Progesterone 치료 1예

김도연,김화정,김효정,남준식,박수영,박영미,신정은,주미순,황민규,정혜경,손혜영,이선영,이한주 大韓消化器內視鏡學會 1999 Clinical Endoscopy Vol.19 No.부록2

교합 거상 금관이 어린이 교합 발육에 미치는 영향

신정근,백병주,김재곤,양연미,이선영 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.1

혼합 치열기에서 유치의 탈락 및 영구치의 맹출 과정이 순조롭게 이루어지는 것은 중요한 일이다. 맹출 중인 치아는 인접치유무, 유치의 흡수속도, 유치의 조기상실, 만기잔존, 국소병소나 입술, 혀, 저작근 등의 다양한 요인들에 의해 영향 받을 수 있으며, 이러한 요소들 사이의 균형이 깨지게 되면 인접치 간의 관계가 변하고 심각한 부정교합이 초래될 수 있다. 본 증례는 유치열 및 혼합치열을 가진 어린이들에서 상하악 구치부 교합면에 접착된 교합 거상 금속 스플린트(bite raising metal splint)가 치열에 미친 영향에 대해 보여주고 있다. 이들은 스플린트로 인한 유치의 만기잔존으로 영구치 맹출에 방해를 받거나, 전치부 개방교합, 제 1대구치의 저위 맹출 등 혼합 치열기 발달에 큰 영향을 받고 있었다. 치료로써 고속 핸드피스를 이용하여 스플린트를 제거하고 주기적 점검을 통해 교합변화 및 영구치 맹출 양상을 관찰하였다. Children are in mixed dentition during 6 years after 3 years old. this time is very important for sound permanent dentition. There are many factors of influence to tooth eruption stage ; adjacent teeth, tooth resorption, early loss or retention of deciduous tooth, local lesion, lip and tongue, masticatory muscles, ect. These factors should be in balance, if not, relation of adjacent teeth is changed, then severe malocclusion is occurred maybe. These cases revealed influences of resin bonded metal splint on occlusal surface of children's molar to mixed dentition. Splints interfere with falling off of deciduous tooth, tooth eruption, normal occlusion formation, and development of mixed dentition and occlusion. Therefore we removed the metal splint from teeth, follow-up checked occlusion and tooth eruption.

Periotron을 이용한 소아 치은 상태의 평가

신정근,백병주,김재곤,양연미,김성희 대한소아치과학회 2006 大韓小兒齒科學會誌 Vol.33 No.3

불량 단감을 이용한 속성 감식초의 제조와 품질 평가

정용진,신승렬,강미정,서지형,원충연,김광수 동아시아식생활학회 1996 동아시아식생활학회지 Vol.6 No.2

This study was performed to analyze general components such as, organic acids, alcohols and minerals in persimmon vinegar made with quick fermented using deteriorated sweet persimmon and four commercial vinegars(rice vinegar, apple vinegar, brewed vinegar, traditional persimmon vinegar) purchased in local markets for quality evaluation. The pH and total acidity of all vinegars were in the range of 2.02~3.02 and 4.62~9.78%, respectively. The pH of quick fermented persimmon vinegar(A) was relatively higher than that of others. Acidity was the highest in brewed vinegar. Total sugar content was in the range of 0.45~6.43%. These contents were high in were high in traditional persimmon vinegar wherase low in brewed vinegar. Total nitrogen and amino-nitrogen were in the range of 0.025~0.046% and 0.015~0.029%. Organic acids were identified as acetic acid, citric acid, tartaric acid, malic acid, succinic acid, formic acid and oxalic acid. While major minerals of all vinegars were Mg, Ca, and Na, minor minerals were Zn, Cu, Mn and Fe.

감과실 알코올 발효를 위한 효모의 분리

정용진,서권일,신승렬,서지형,강미정,김광수 동아시아식생활학회 1997 동아시아식생활학회지 Vol.7 No.4

To utilize abundant poor persimmon fruits effectively, it was studied on alcohol fermentation strains which were isolated and indentified from poor persimmon fruits. The strains which had exellent alcohol production ability were analysized morphogical, cultural characteristics and identified Saccharomyces cerevisiae YJK 20, Sacahroimyces kluveri DJ 97. Alcohol production ability between the isolated strains and industrial alcohol yeasts was compared in the YPD medium, persimmon extract medium. Isolated strains had high alcohol production ability in both of two medium, respectively. So it was expected that the strains, YKJ 20 and DJ 97 had good alcohol fermentation ability of persimmon fruits.

Cone Beam CT를 이용한 하악 제 1대구치 맹출 양상에 관한 연구

신정근,김재곤,백병주,양연미,정진우 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.3

건강한 정상 교합 어린이 83명(남자 42명, 여자 41명)을 대상으로 보호자 동의하에 cone beam CT 영상을 촬영하여, 하악 제1대구치의 맹출 양상을 연구하였다. 대상을 발육 정도에 따라 Nolla stage(4-10단계)로 구분한 후 삼차원 기준 평면인 전두면(frontal), 시상면(Sagittal), 수평면(horizontal)에서 각각 하악 제1대구치의 맹출 양상을 관찰하였다. 1. 전두면과 수평면에서, 하악 제1대구치간 폭경은 감소하였는데, stage 5에서 stage 8까지 가장 크게 감소했다가 약간 증가하였다. 2. 시상면과 전두면에서, 하악 제1대구치 맹출량은 교합평면을 기준으로 stage 5에서 stage 7까지 가장 많은 맹출 이동을 보였다. 3. 수평면과 시상면에서, 하악 제1대구치는 제2유구치 원심면으로부터 stage 4에서 stage 6까지 원심으로 이동하였고 이후 큰 변화가 없었다. 4. 시상면에서, 교합 평면과 하악 제1대구치의 근원심 치축이 이루는 각은 stage 4에서 stage 8까지 증가하였다. 5. 전두면에서, 교합 평면과 하악 제1대구치의 협설측 치축이 이루는 각은 지속적으로 증가하였다. 6. 수평면에서, 정중 시상면과 하악 제1대구치의 치축이 이루는 각은 stage 5부터 stage 8까지 증가하다 stage 8이후에는 다시 약간 감소하였다. The purpose of this study was to investigate the eruption pattern of the mandibular first molar in sagittal. frontal and horizontal views using the cone beam CT scanning. CT images were obtained from healthy 83 children(42 boys. 41 girls) between 3 to 10 years of age with a normal dentition according to Nolla stage. 1. In the frontal and horizontal view. the intermolar width decreased continuously with stage and slightly increased at the last stage. 2. In the sagittal and frontal view. eruption distances from occlusal plane were observed the largest change between stage 5 and 7. 3. In the horizontal and sagittal view. mandibular first molar from distal surface of primary second molar moved distally between stage 4 and 6. 4. In the sagittal view, angle from occlusal plane to mesio-distal axis increased between stage 4 and 8. 5. In the frontal view, angle from occlusal plane to bucco-lingual axis increased continuously during all stage. 6. In the horizontal view, angle from midsagittal plane to long axis increased between stage 5 and 8.

Hydrogen Peroxide 농도와 적용시간이 Hydroxyapatite discs의 미백과 물리적 성질에 미치는 영향

양연미,이두철,백병주,김재곤,신정근 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.1

법랑질의 주성분인 hydroxyapatite 분말을 성형하고 소결하여 착색을 유발한 다음 과산화수소의 농도와 적용 기간의 변화에 따라 나타나는 미세 조직과 기계적 성질의 변화 및 미백 효과 등에 관한 연구를 통해 다음과 같은 결론을 얻었다. 1. 과산화수소의 농도와 적용시간이 증가함에 따라 미백 효과가 증가되었다. 2. 표면조도는 15% 과산화수소 10일, 30% 과산화수소 7, 10일 적용 시 유의한 차이로 증가하였다(p<0.05). 3. X-선회절 분석결과 미백처리 전·후의 결정상의 변화는 관찰되지 않았으나, 주사전자현미경 관찰시 표면의 미세구조는 과산화수소 농도와 적용시간의 증가에 따라 미세기공이 증가하였다. 4. 2축 굽힘강도는 30%농도의 과산화수소로 7, 10일 적용하였을 때 유의한 차이로 감소되었다(p<0.05). 5. 미소 경도값은 15% 과산화수소 10일과 30% 과산화수소 3, 7, 10일 적용 후 유의한 차이로 감소되었다(p<0.05) The purpose of this study was to evaluate the effect that various concentration and application time of hydrogen peroxide had on tooth whitening and physical properties. The hydroxyapatite (HA) discs of 12 mm (Φ) x 1.2 mm (t) in dimensions were made by compression (100 kg/㎠) and sintering (at 1350℃ for 2 hours). All specimens were polished sequentially with #240 through #2000 emery paper and one side of each specimen was polished finally with 0.3 ㎛ alumina paste. The discs were placed in sterile whole stimulated saliva overnight at 37℃ in order to form an in vitro pellicle layer. Then the discs were rinsed with distilled water and soaked into staining broth at 37℃ for 7 days. These stained specimens were bleached with hydrogen peroxide according to the change of concentration (3∼30%) and application time (3∼10 days). The specimens were analyzed with a spectrophotometer, X-ray diffractometer (XRD), scanning electron microscope (SEM), surface roughness tester, microhardness tester and biaxial flexural strength. The results of present study can be summarized as follows: 1. The bleaching effect was increased with the increased concentration and the extended application time of hydrogen peroxide. 2. The surface roughness was significantly increased from the specimen bleached with 15% hydrogen peroxide for 10 days and with 30% for 7 and 10 days respectively (p<0.05). 3. The changes of crystal phase observed by XRD between before and after bleaching weren' t shown of any difference, but microporous structure of surface observed by SEM was shown of increase with the increased concentration and the extended application. 4. The biaxial flexural strength was significantly decreased from bleaching of specimen with 30% hydrogen peroxide for 7 and 10 days respectively (p<0.05). 5. Microhardness was significantly decreased from bleaching with 15% hydrogen peroxide for 10 days and with 30% for 3, 7 and 10 days respectively (p<0.05). Although the tooth bleaching effect was greater when the high concentration was applied, further in vivo experiment will be needed to prove it s safety.

K대학 여대생을 대상으로 한 치아우식활성검사 비교조사 연구

최은미,송윤신,장희경,최정이 경복대학 2002 京福論叢 Vol.6 No.-

본 연구는 치아우식증 발생요인 중 타액요인을 집중적으로 분석하고자 타액분비율, 타액점조도, 타액완충능, 스나이더, 구강내 포도당잔류검사를 조사하였으며, 특히 20내 남성의 치아우식증 발생요인에 대한 연구자료와 타액분비율과 타액내 pH 변화에 대한 조사 및 스나이더검사 간의 임상적 비교 조사 등의 연구를 통하여 자료를 비교 분석할 수 있었다. 또한 구강내 포도당잔류검사를 조사한 결과 등 수종의 실험연구의 경험적 연구 결과를 가지고, 한국의 여대생들과 상호관계를 비교 분석하고자 하였다. 본 연구의 조사대상은 여대생 160명을 대상으로 하였으며, 수집된 자료는 빈도, 백분율 분석으로 유의성을 검증하였다. 본 연구에서 조사된 결과는 다음과 같다. 1. 전체 조사대상자의 우식치아 수는 평균 3.23개로 조사되었고, 발거치아는 0.22개로 조사되었으며, 충전치아는 5.06개로 나타났다. 2. 전체 조사대상자의 평균 영구치 우식경험치아는 8.52개로 조사되었고, 평균 완충능력은 10.54로 나타났다. 3. 구강내 포도당잔류시간을 측정한 결과 평균 12.36 분으로 조사되었다. 4. 스나이더 검사방법 결과 조사대상자의 평균 치아우식활성 정도는 35.43 시간으로 판정기준에 의하여 중등도 활성으로 나타났다. 5. 자극성 타액분비량 및 타액점조도와 진행중인 치아우식증 보유집단과 집단간의 비교에서는 차이가 있음을 볼 수 있었다(P<0.01). 6. 비자극성 타액분비량, 자극성 타액분비량 및 구강내 포도당잔류시간 측정검사와 치아우식활성집단간에는 유의한 수준으로 나타났다(P<0.01). 7. 타액점조도에서도 치아우식활성집단간에는 유의한 수준으로 나타났다(P<0.05). 이와 같은 절과를 볼 때, 향후 연구논제에 세계보건기구(WHO)에서 기초조사로 조사되는 연령군인 12세 아동의 치아우식증과 치아우식활성과의 관계를 규명하고자 하는 노력이 있다면 치아우식증 발생요인을 구체적으로 제시할 수 있으리라 사료된다. This study was performed to investigate saliva flow rate, saliva buffer capacity, snyder test, glucose residuum test in the oral cavity in order to analyze 'saliva factor' intensively among the causing factor of dental caries. Especially through study data on causing factor of dental caries in male twenties, examination on pH changing rate in the saliva and saliva flow rate, clinical comparative study between Snyder tests, we have made a comparative analysis. Also, based on many kinds of exparimental study results from examination on glucose residuum test in the oral cavity, etc, we have intention to analyze comparatively interactive relationship of korean female college students. The subject of this study is 160 female college students, and we verified the confidence of our study data by the frequency, centesimal analysis. The results were as follows ; 1. Among the total subjects, the average of caries teeth were 3.23, extracted teeth 0.22, filling teeth 5.06. 2. Among the total subjects, the average of permanent teeth with experience of dental caries were 8.52, average buffering capacity 10.54. 3. The average minutes of glucose residual time in the oral cavity were examined 12.36 minutes. 4. On the result of Snyder examination method, the average activative degrees of dental caries were 35.43 hours rated medium level by the standard of decision. 5. There are some differencies between stimulative saliva flow, saliva adherence degree and the group of dental caries in progress. 6. There are significant results between non-stimulative saliva secretion, stimulative saliva flow, glucose remaining time test in the oral cavity and the group of dental caries in activation. 7. There are significant results between groups of dental caries in activation about saliva adherence degree. According to the results, if there is any effort in the future study theme to investigate the relationship between 12 year-old children's dental caries whose age WHO has made a basic surveying subject and activation of dental canes, we can present the causing factor of dental caries concretely.