[뉴스부문_제158회 이달의 방송기자상] 절박한 순간, 112를 누르는 마음을 알기에 : 〈잇단 경찰 부실 대응 사건최초 연속보도〉 2021년 11월 16일~29일 보도 SBS 신정은, 최선길, 한성희 기자

신정은 (사)방송기자연합회 2022 방송기자 Vol.64 No.-

Optimal Pharmacologic Treatment of Chronic Constipation: Review and Recent Developments

신정은 대한소화기 기능성질환∙운동학회 2009 Journal of Neurogastroenterology and Motility (JNM Vol.15 No.2

Constipation is a common clinical problem that can be difficult to manage. Typical pharmacologic recommendations for patients with chronic constipation begin with bulking agents and then add osmotic agents followed by stimulants laxatives. However, almost half of all constipated patients were dissatisfied with their treatment for chronic constipation. Thus, there is a clinical need for new, more potent drugs particularly for patients who are not satisfactorily treated by conventional therapies. Lubiprostone, chloride channel activator acting on intestinal secretion, which is not available in Korea, may be an alternative option for patients with chronic constipation. And the new 5-HT receptor agonists are currently under investigation with the goal to improve the selectivity for their receptors and to minimize the incidence of cardiac side effects.

문학지리학적으로 보는 이효석의 도시소설연구 - “벽공무한”, “하얼빈”, “은은한 빛”을 중심으로 -

신정은 한국문화융합학회 2024 문화와 융합 Vol.46 No.2

The purpose of this paper is to examine Lee Hyo-seok's novels that focus on urban space and discuss the interrelationship between space and characters through the geopolitical specificity of the work. Urban space in the late 1930s was a mixture of various concepts. These spaces reveal an imbalance, and the characters within them show efforts for a new self. This paper aims to study the lives of characters in urban space and their perceptions of urban space through Lee Hyo-seok's “Byukgongmuhan,” “Harbin,” and “Silent Light” from the perspective of literary geography. From a literary geography perspective, we will focus on understanding how the city in literary works is perceived through the perspectives of various characters and examining ‘city-character-culture’ organically.

대장 선종과 대장암에서 MMP-2, HIF-1α 및 VEGF의 발현

신정은,정성애,김성은,주양희,심기남,김태헌,유권,문일환 대한소화기학회 2007 대한소화기학회지 Vol.50 No.1

Backround/Aims: This study was aimed to investigate the expression of matrix metalloproteinase-2 (MMP-2), hypoxia-inducible factor (HIF)-1α, and vascular endothelial growth factor (VEGF) in colonic adenoma-carcinoma sequence. Methods: Thirty-two tissue samples of colon adenoma, 11 of early colon cancer and 36 of advanced colon cancer were collected by colonoscopic biopsy. Normal colonic tissues were also collected from the same subjects. The mRNA expression levels of MMP-2, HIF-1α, and VEGF were quantitated using semiquantitative reverse transcription polymerase chain reactions. The protein expressions of activated MMP-2 and HIF-1α were examined by gelatin zymography and by Western blot in surgically resected cases, respectively. Results: The expression level of MMP-2 mRNA showed a progressive increase in the advance of the colorectal adenoma-carcinoma sequence (p<0.05). In colon cancer tissues, the expression level of MMP-2 mRNA showed an increasing trend according to differentiation, lymphatic invasion and Dukes' stage (p<0.05). The protein expression of activated MMP-2 was observed in 10 of 11 (91%) cases of cancer tissues. The mRNA expression levels of HIF-1α and VEGF were greater in tissues of early and advanced colon cancer compared with colon adenoma (p<0.05; p<0.001). The protein expression of HIF-1α was observed in 9 of 11 (82%) cases of cancer tissues. The mRNA expression level of HIF-1α showed a positive correlation with MMP-2 and VEGF, respectively (r=0.52, p<0.001; r=0.76, p<0.001). Conclusions: MMP-2, HIF-1α, and VEGF may be useful in detecting early carcinogenesis and progression of colon cancer. (Korean J Gastroenterol 2007;50:9-18) 목적: 대장암 발생 과정 중 초기 기저막 파괴에 관여하는 MMP-2와 신생혈관 형성에 관여하는 HIF-1α와 VEGF가 대장암 발생 및 각 진행단계에서 발현하는 양상 및 예후 관련 인자와의 연관성을 알아보고자 하였다. 대상 및 방법: 대장 선종 32예, 조기 대장암 11예와 진행 대장암 36례의 대장내시경 생검 조직에서 MMP-2, HIF-1α와 VEGF의 mRNA 발현을 역전사 중합효소 연쇄반응을 이용하여 주변의 정상 조직을 기준으로 반정량적으로 측정하였으며, 이 중 암 수술 조직 11예에서 gelatin zymography와 Western blot을 이용하여 활성형 MMP-2 단백과 HIF-1α 단백 발현을 관찰하였다. 결과: MMP-2 mRNA 발현은 대장 선종에 비해 진행 대장암에서 증가하였고(p<0.001), 대장 선종에서 조기 대장암과 진행 대장암으로 갈수록 증가하였다(p<0.05). 대장암에서 MMP-2 mRNA 발현은 림프관 침습이 있는 경우와 중등도와 저분화도일 때 및 병기가 진행함에 따라 증가하였다(p<0.05). Gelatin zymography 결과, 11예 중 10예(91%)의 암조직에서 활성형 MMP-2 단백이 발현되었다. HIF-1α와 VEGF mRNA 발현은 대장 선종에 비해 조기 대장암과 진행 대장암에서 증가하였으나(p<0.05; p<0.001), 조기 대장암과 진행성 대장암 사이에 차이가 없었다. Western blot 결과, 11예 중 9예(82%)의 암조직에서 HIF-1α 단백이 발현되었다. HIF-1α mRNA 발현은 MMP-2 mRNA 및 VEGF mRNA 발현과 유의한 상관관계가 있었다(r=0.52, p< 0.001; r=0.76, p<0.001). 결론: 이번 연구는 대장암 발생 및 진행에 있어서 MMP-2, HIF-1α와 VEGF의 발현 및 상호 연관성을 확인할 수 있었으며, 이들 인자들의 발현이 대장 내 신생물의 악성화 단계 및 악성 병변의 진행을 예측할 수 있는 한 방법이 될 수 있을 것으로 생각한다. 색인단어: Matrix metalloproteinase-2, Hypoxia-inducible factor-1α, Vascular endothelial growth factor, 대장 선종, 대장암

[내 마음속 목자] 그로부터 시작된 연착륙 주님의 손길

신정은 미래사목연구소 2017 사목정보 Vol.10 No.6

업무몰입을 위한 사무공간 디자인 요소에 관한 연구

신정은,임호균 대한건축학회 2022 대한건축학회논문집 Vol.38 No.3

The workplace is a physical environment that stimulates the five senses. The incorporated design elements are contributing factors that can influence employees to become more productive with their work. Although work responsibilities can be clearly defined, the classification and system of design elements in a workspace are unclear. This study aims to analyze the relationship between work commitment and design elements in an office space by systematically deriving design factors that directly affect work commitment through an Analytic Hierarchy Process (AHP). Design factors were classified into primary hierarchy involving structural and decorative elements, secondary hierarchy through literature review, and then their importance was evaluated by conducting expert surveys. Upon analyzing these surveys, the factors not related to work commitment were disregarded; there were 15 primary hierarchies and 85 secondary hierarchies of design elements derived. By conducting an AHP survey on the primary hierarchy, experts placed more importance on the structural elements of the workplace than on the decorative elements that contribute to work commitment. Also, the walls among the structural elements and the furniture surrounding the decorative elements were deemed most important. This research proved to be meaningful in providing a framework for classifying design elements while offering evaluation tools especially for workplaces where there is no such system in place. Additionally, through this research expert opinions were identified regarding the priorities placed on design elements in a workplace as it relates to work commitment. 사람들의 오감을 자극하는 물리적 환경인 사무공간과 사무공간을 구성하는 디자인 요소들은 사무실에서 직원들이 업무에 몰입할 수 있도록 영향을 끼치는 중요한 요소이다. 따라서 업무몰입과 사무공간 디자인 요소간의 관련성을 연구해볼 필요성이 있는데, 업무몰입에 대한 정의는 명확하지만 사무공간 디자인 요소에 대한 분류 및 체계는 불명확한 실정이다. 이에, 본 연구는 업무몰입에 영향을 미치는 사무공간 디자인 요소들을 체계적으로 도출하는 것을 연구의 목적으로 하였다. 먼저, 선행연구를 통해 사무공간 디자인 요소들을 상위항목(구조적 요소와 장식적 요소)과 하위항목으로 구분하여 정리한 후, 전문가 설문을 진행하여 그 중요도를 평가하였다. 설문을 통해서 업무몰입과 연관성이 없다고 평가되는 항목들을 삭제하였고, 최종적으로 업무몰입을 위한 사무공간 디자인 요소 상위항목 15개와 하위항목 85개를 도출하였다. 뿐만 아니라, 상위항목에 대한 AHP 설문도 함께 진행하여 전문가들은 업무몰입을 위해 사무공간의 구조적 요소를 장식적 요소보다 더 중시하고 있고, 구조적 요소 중에서는 벽을, 장식적 요소 중에서는 가구를 가장 중시하고 있음을 파악하였다. 이렇듯 본 연구는 사무공간 디자인 요소에 대한 명확한 분류가 없는 현 상황에서 사무공간 디자인 요소를 상위항목과 하위항목으로 세분화하여 도출하고, 업무몰입과 사무공간 디자인 요소간의 관련성을 연구하기 위한 평가도구의 기틀을 마련하였다는 데 의의가 있다. 또한, 전문가가 생각하는 업무몰입을 위한 사무공간 디자인 요소의 우선순위도 파악하였다는 데 의미가 있다.

Transcriptional Regulation of Proteoglycans and Glycosaminoglycan Chain-synthesizing Glycosyltransferases by UV Irradiation in Cultured Human Dermal Fibroblasts

신정은,오장희,김연경,정지용,정진호 대한의학회 2011 Journal of Korean medical science Vol.26 No.3

Various kinds of glycosaminoglycans (GAGs) and proteoglycans (PGs) have been known to be involved in structural and space-filling functions, as well as many physiological regulations in skin. To investigate ultraviolet (UV) radiation-mediated regulation of GAGs and PGs in cultured human dermal fibroblasts, transcriptional changes of many types of PGs and GAG chain-synthesizing enzymes at 18 hr after 75 mJ/cm2 of UV irradiation were examined using quantitative real-time polymerase chain reaction methods. Hyaluronic acid synthase (HAS)-1, -2, and -3 and hyaluronidase-2 mRNA expressions were significantly increased by UV irradiation. Expressions of lumican, fibromodulin, osteoglycin,syndecan-2, perlecan, agrin, versican, decorin, and biglycan were significantly decreased by UV irradiation, while syndecan-1 was increased. Expressions of GAG chain-synthesizing glycosyltransferases, xylosyltransferase-1, β1,3-glucuronyltransferase-1, β1,4-galactosyltransferase-2, -4, exostosin-1, chondroitin polymerizing factor, and chondroitin sulfate synthase-3 were significantly reduced, whereas those of β1,3-galactosyltransferase-6, β1,4-galactosyltransferase-3, -7, β-1,3-N-acetylglucosaminyltran sferase-2, and -7 were increased by UV irradiation. Heparanase-1 mRNA expression was increased, but that of heparanase-2 was reduced by UV irradiation. Time-course investigation of representative genes showed consistent results. In conclusion, UV irradiation may increase hyaluronic acid production through HAS induction, and decrease other GAG productions through downregulation of PG core proteins and GAG chainsynthesizing glycosyltransferases in cultured human dermal fibroblasts.

Increased risk of refractory Mycoplasma pneumoniae pneumonia in children with atopic sensitization and asthma

신정은,천보람,심재원,김덕수,정혜림,박문수,심정연 대한소아청소년과학회 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.6

Purpose: A nationwide outbreak of Mycoplasma pneumoniae pneumonia (MP) refractory to macrolideantibiotics occurred in Korea during 2011. Steroid therapy has been reported to be both efficacious andwell tolerated in pediatric patients with refractory MP. We compared clinical features and laboratorycharacteristics between children with refractory MP requiring steroid treatment and those withmacrolide-responsive MP and evaluated the risk factors associated with refractory MP. Methods: We investigated 203 children who were admitted to our institution with MP from June toNovember 2011. Refractory MP was defined by persistent fever over 38.3℃ with progressive pulmonaryconsolidation or pleural effusion despite administration of appropriate macrolide antibiotics for 5 daysor longer after admission. Steroid therapy was initiated on the fifth day after admission for refractorycases. Results: There were 26 patients with refractory MP requiring steroid therapy. The mean duration ofsteroid therapy was 5.4 days and most of the patients were afebrile within 24 hours after initiation ofsteroid therapy. The prevalence of refractory MP was higher in patients with pleural effusion, lobarpneumonia affecting more than 2 lobes, higher levels of serum lactate dehydrogenase, increasedoxygen requirements, and longer duration of hospitalization. Atopic sensitization and history of asthmawere also associated with refractory MP after adjusting for age and gender. Conclusion: Children with refractory MP had more severe pneumonia. Atopic sensitization and historyof asthma may be risk factors for refractory MP requiring steroid therapy in Korean children.

Dose Irritable Bowel Syndrome and Dysmotility Have an Autoimmune Origin?

신정은 대한소화기 기능성질환∙운동학회 2012 Journal of Neurogastroenterology and Motility (JNM Vol.18 No.1

Linked Twitter Data between Korean Tourists Perception and Australia Tourism Industry

신정은,김도훈 한국지능정보시스템학회 2017 한국지능정보시스템학회 학술대회논문집 Vol.2017 No.11