하악골에 발생한 골막 골육종

김태우,김승범,권혁찬,문선재,윤정훈,김형준,차인호,육종인,김진 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Periosteal osteosarcoma is a distinct entity of malignant bone tumor with characteristic clinical, morphological, and histological features within the group of juxtacortical osteosarcoma. Periosteal osteosarcoma is predominantly located in the tubular long bones, and extremely rarely involving the jaws. A case of periosteal osteosarcoma of the right mandible is presented. A 27-year-old woman complained of the gingival swelling and bleeding tendency of the right posterior mandible. Clinical examination revealed a reddish brown strawberry-like swelling on the affected mucosa, which measured 1.5㎝×1.5㎝. The tumor was located on the lingual cortex of the mandible and extended into the surrounding soft tissues. Microscopically, the tumor consisted exclusively of atypical chondroblastic cells with a small osteoblastic area. A minimal bone marrow involvement was noted and the adjacent cortex was free of tumor. These findings suggested that the tumor originated from the periosteal cambium layer, which lies between the periosteal fibrous layer and the cortex of mandible.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

老齡者의 建康을 위한 生活習慣 實態調査

申東敏,長鳳愚,李揆文,金賢俊,金昌範,崔宗洙,崔鍾晥,李鍾珏,金圭碩,趙庚旭,金鍾聲,朴鍾振 平生體育硏究所 論文集 1987 平生體育硏究所 論文集 Vol.2 No.-

With a view to examining the habit and method in which old people maintain and improve their health, we consulted 551 men and 444 women who were over 65 years old, and concluded as follows: 1. Habit of eating It's been revealed that most of the old people keep a regular eating hour, control the quantity of meal or eat a little food, and prefer vegetables to meat. 2. Mental health Old people feel the necessity for mental health and most of them (about 80%) keep good mental health without becoming pessimistic. Their chief concenrs have turned out to be about their sons and daughters and their own health and finance. 3. Managing Good Health It has been revelaed that old people do not possess any special kind of secret to keep good health but taking plenty of rest, regular meal, and proper exercise, and many of them (about 60%) have been shown to eat invigorant food that they can easily get around their living area. 4. Physical Functions It has been revealed that many old people are conscious of some symptoms about their parts of body and about to percent of them suffers from neuralgia. Some measures like medical aid especially for old people need to be taken as soon as possible. As we have found that the health-keeping method of old people consists plenty of rest, proper exercise, and appropriate nutrition, we can conclude that the recreatonal and culture facilities and programs for keeping old people in good health should be developed. It is also necessary to study food that contribute to their health and develop ways to get rid of the stresses to which they are exposed in their daily life. Presides, it is natural that government found an administrative department to deal with these matters effectively.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

운동특성에 따른 체구성과 골조성의 비교

김창범,박종진 충북대학교 평생체육연구소 2000 平生體育硏究所 論文集 Vol.12 No.-

This study was to analyze the body and bone compositions according to exercise characteristics. 32 subjects attending universities consisted of 8 track players, 8 tennis players, 8 wrestling players, and male students. A whole body scanner (model:dual X-ray absorptiometry, LUNA) was used to measure body composition components, bone mineral content, total bone calcium, bone mineral density, Comparisons of each group's bone densitometry numerics revealed following results. First, %body fat and fat body weight were significantly lower in track players, while lean body weight was significantly higher in wrestling and track players. Second, bone mineral content was significantly higher in wrestling players arms and body and track players' leg. Third, total bone calcium was significantly higher in wrestling players. Fourth, bone mineral density was significantly higher in track, wrestling and tennis players' pelvis and wrestling players' all the other parts. In sum, endurance training like track play had positive effects on developing appropriate body composition, while wrestling characterized by heavy weight, excessive and continuous exercise, and high loading had positive effects on developing appropriate bone composition. Hence, endurance training involving high loading and dynamics would be effective sports for developing appropriate body compositions.

마우스에서 전기자극 스트레스의 면역조절 효과

김정범,박종욱,배재훈 대한생물치료정신의학회 1996 생물치료정신의학 Vol.2 No.2

전기자극 스트레스가 마우스의 면역계에 미치는 영향을 조사하기 위해 체액성과 세포성 면역반응을 조사하고, 이 면역반응 결과에 대한 면역조절 기전을 이해하기 위해 전기자극 스트레스가 사이토카인의 유전자 발현에 미치는 영향을 조사하였다. 생체내 면역반응을 평가하기 위하여 흰쥐 적혈구에 대한 특이항체생성반응은 스트레스군에서 대조군보다 항체생성반응이 감소하였다. DNFB에 대한 접촉성 과민반응 실험에서 T24는 스트레스군과 대조군 간에 차이가 없었으나 T48는 T24에 비해 스트레스군에서 증가를 보였다. Phytohemagglutinin으로 자극된 비장 단핵구의 증식에 미치는 영향을 알아보기 위해 ³H-thymidine incorporation 검사를 실시한 결과 스트레스군에서 대조군보다 세포증식반응이 증가되었다. 전기자극 스트레스에 의한 면역조절 기전을 이해하기 위하여 사이토카인의 유전자 발현을 조사한 결과 스트레스군에서 대조군에 비해 IL-2, IL-6의 유전자 발현이 억제되고 IL-1, IL-12,GM-CSF,MIF등의 유전자 발현에는 대조군과 차이가 없음을 보였다. 이상의 결과를 볼 때 전기자극 스트레스에 의해 체액성 면역반응이 저하된 현상은 면역반응 활성화와 항체 생성에 중요한 IL-2및 IL-6 유전자 발현의 억제와 연관이 있을 것으로 생각되며, 스트레스군에서 IL-2 유전자 발현의 억제에도 불구하고 mitogen에 의한 세포증식반응이 증가한 현상을 해명하기 위해서는 보다 다양한 실험조건의 적용이 필요하며 더 나아가 스트레스에 의한 동물의 행동반응 또는 신경내분비계에서 나타날 수 있는 변화들과의 연관성에 대한 계속적인 연구가 필요할 것으로 생각된다. To explore the molecular mechanisms by which electric footshock has immunomodulatory effects, the effects of electric footshock, on the humoral and cell-mediated immune responses of ICR mice and then the gene expression of cytokines in splenocytes, including interleukin-1(IL-1), IL-2, IL-6, IL-12, the migration inhibitory factor(MIF), and the granulocyte macrophage-colony stimulating factor(GM-CSF), were investigated. Mice were subjected to electric footshock for 3 days(two sessions a day, 11 footshocks a 31-min session). The humoral response was measured using ICR mice immunized with rat RBC. The cell-mediated immune response was evaluated by contact. hypersensitivity to 2,4-dinitrofluorobenzene(DNFB) and by phytohemagglutin(PHA)-stimulated splenocytes proliferation assay. In the stressed group, electric footshock suppressed significantly the anti-rat RBC antibody(P<0.05), but enhanced significantly T48 relative to T24 in contact hypersensitivity(P<0.01) and T-cell proliferation response(P<0.05) by PHA stimulation relative to the control group. The gene expression of IL-2 and IL-6 were suppressed significantly in PHA-stimulated splenocytes, but that of IL-1, IL-12, GM-CSF and MIF were not. In conclusion, suppressed IL-6 gene expression seems to account for suppressed humoral immune response. In spite of enhanced cell-mediated immune response, the result is that IL-2 gene expression was suppressed, which suggests the two putative mechanisms. Firstly, while in the stressed group production of IL-2 occurs rapidly and thereafter declines abruptly, in the control group that of IL-2 occurs slowly and thereafter declines gradually. Secondly, there may be certain detouring circuits extending the signal conduction system by IL-2 except the usual signal conduction system.

Intentional Replantation에 의한 상악 제 1 소구치 치료의 증례보고

김종범,한세현,정우진,이상훈 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.3

Intentional replantation of the posterior teeth has been performed as a last resort except extraction when it is impossible to perform the conventional endodontic or surgical endodontic treatment. Many studies have done with the prognosis, and root resorption, of which the responsibility might have been injury of periodontal ligament and remaining periodontal lesion, proved to be major cause of failure. Intentional replantation, however, can exclude anatomic difficulty, risk of nerve injury, and maxillary sinus trauma that surgical access can raise, especially in posterior teeth, and it is reported that success rate is not less than surgical endodontics, independent of replantation of traumatically avulsed teeth. The success of intentional replantation can be evaluated with, clinically, ruduction of pocket depth, pain and mobility(physical mobility), and, radiographically, hard tissue formation, reduction of periapical radiolucency. In this case report, for the maxillary left first bicuspid with dens evaginatus that had periapical lesion, painfulness, mobility and showed no reduction of mobility after even extirpation and a number of irrigation, extraction followed by extraoral root filling with calcium hydroxide and replantation was performed. Based on many studies, it is concluded that hard tissue formation capacity of calcium hydroxide, preceded exterpation before extraction, and careful extraction without injuring periodontal ligament affected successful results of this case.

여드름 환자에서의 경구 레티노이드(Roaccutane^(�))의 치료 효과

김종율,김성진,이지범,이승철,원영호 全南大醫大 2000 전남의대학술지 Vol.36 No.2

전리수에서의 STS304의 부식

이종권,박소연,김범식 순천향대학교 산업기술연구소 2006 순천향 산업기술연구소논문집 Vol.12 No.1

.

혐기성 소화에 대한 식종원 및 암모니아 농도의 영향

김양지,김성일,신범식,안기섭,김종수 한국환경농학회 2004 한국환경농학회지 Vol.23 No.1

혐기성 소화에서 미생물에 저해/독성 물질로 알려진 암모니아의 농도와 식종원에 따른 영향 을 회분식 반응기를 이용하여 분석하였다. 식종원은 고농도의 암모니아에 장기간 적응된 축 산농가 축산폐수 집수조의 슬러지 그리고 저농도의 암모니아에 노출된 하수종말처리장 혐기 성 소화조 슬러지를 사용해서 COD 제거율과 biogas 발생량으로 측정된 혐기성 미생물의 활성에 저해영향을 주기 시작하여 3,500 ㎎-N/L에서는 더욱 심하였다. 암모니아 저해 농도 범위에서 휘발성 유기산의 농도는 50㎎/L 범위로 유지되므로 메탄생성균 뿐만 아니라 산생 겅균도 저해영향을 받는 것으로 나타났다. 축산폐수 집수조 슬러지로 식종된 경우 암모니아 농도가 TAN으로 2,500∼3,500 ㎎-N/L 범위에서도 COD 제거율과 biogas 발생량의 감소폭 은 미미하였으나, 하수종말처리장 혐기성 소화조 슬러지로 식종된 경우 암모니아 농도가 증 가할수록 COD 제거율과 biogas 발생량은 큰 폭으로 감소하였다. 결과적으로 암모니아에 장 기간 순응된 슬러지로 식종한 경우 암모니아의 저해 농도에 대하여 적응도 빨랐으며 저해영 양도 적었다. The seeding sources and concentration of ammonia on anaerobic digestion were investigated by batch culture bioreactors. The sourcces of seeding on anaerobic digestion were from swine wastewater collection pit of a hog raising farm and from anaerobic digestion sludge of a municipal sewage treatment plant. The inhibition of ammonia on anaerobic microoganisms was initiated at ammonia concentration of 1,500 ㎎NH₄-N/L and it s effect was increased by increasing ammonia concentration up to 3,500 ㎎NH₄-N/L, regardless the sources of seeding as evidenced by decreases in COD removal efficiencies and biogas yields. The inhibition occurred to not only methanogens but also acidogens since the concentration of volatile fatty acids was maintained at 50 ㎎/L. The COD removal efficiency and biogas yield were maintained constantly while increasing ammonia concentration up to 3,500 ㎎NH₄-N/L when swine wastewater collection pit was used as a seeding; however, those were decreased while increase ammonia concentration when anaerobic digestion sludge was used as a seeding. The results indicate that the seeding acclimated to high concentrations of ammonia for long time was easy in adaptation to high ammonia concentration and less subjective to ammonia inhibitory effects.