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Chemical Interface Damping of Silver-coated Gold Nanorods Using Supramolecular Host–Guest Chemistry
Kyeong Rim Ryu,Ji Won Ha 대한화학회 2021 Bulletin of the Korean Chemical Society Vol.42 No.8
We present the chemical interface damping (CID) of single Ag-coated Au nanorods (AuNRs@Ag) using cucurbit[7]uril (CB[7])-based host?guest chemistry. The chemisorption of CB[7]-NH2 onto an AuNR@Ag surface resulted in a redshift of its localized surface plasmon resonance (LSPR) scattering peak, with a considerably increased linewidth. This LSPR broadening was ascribed to CID caused by the formation of a strong nitrogen?Ag interaction during the chemisorption of CB[7]-NH2 onto the AuNR@Ag surface. Furthermore, we observed additional broadening of the LSPR linewidth when the guest molecule (oxaliplatin) was encapsulated into CB[7]-NH2 chemisorbed onto the AuNR@Ag surface.
Use of inhaler devices in elderly patients with respiratory disease
( Ha Youn Lee ),( Jin Hwa Song ),( Yeonkyung Park ),( Ha-kyeong Won ),( Keun Bum Chung ),( Young Mee Ahn ),( Byoung Jun Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Introduction: We aimed to investigate inhaler device handling in elderly patients with respiratory disease. Also, we compared the differences between inhaler devices with respect to misuse and error correction. Methods: Participants were eligible if they were aged ≥65 years, using inhaler for at least 3 months, and received inhaler training previously. Patients were assessed for inhaler technique using standardized checklists at first and 90 day follow-up visit after face-to-face retraining. We compared five different types of inhalers. The primary outcome was the differences of adequate use ratio between inhaler devices. Secondary outcomes included comparison of error correction after training, patient satisfaction on each device and most common step of misuse. Results: A total of 256 patients (mean age 76.43±6.13, male 93.4%) were included and the handling of 320 devices (MDI, 75; DPI, 199; Respimat®, 46) was assessed in the study. All have been trained in the past, but only 24.7% of them use it correctly. Appropriate use were respectively 38.7%, 50.0%, 61.4%, 60.8% and 43.2% of inhalation assessment tests with Evohaler® (n=75), Respimat® (n=46), Turbuhaler® (n=44), Ellipta® (n=74), and Breezhaler/Handihaler(n=81) (p=0.026). After retraining, appropriate usage ratio increased and there was no significant difference between inhaler device types (Evohaler® (63.9%), Respimat® (86.1%), Turbuhaler® (74.3%), Ellipta® (64.6%), and Breezhaler/Handihaler (65.3%), respectively; p=0.129). Conclusion: New inhalers were developed, but the accuracy of inhaler use was still low. This study results suggest that repeat training is more important than inhaler type.
Ha-Kyeong Won,Ji-Hyang Lee,Jin An,손경희,Min-Gyu Kang,Sung-Yoon Kang,Alyn H. Morice,조상헌,송우정 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.6
Purpose: Chronic cough is a prevalent condition in the community and may pose considerable impairment to quality of life (QoL). However, its disease burden remains largely undefined in the general population. The present study investigated the relationship between chronic cough and health-related QoL in a Korean nationwide population database, with an emphasis on clinical conditions which may confound the impact of cough. Methods: This study analyzed cross-sectional datasets of adults (aged ≥ 40 years) in the Korean National Health and Nutrition Examination Survey 2010–2016. Health-related QoL was assessed using the 3-level EuroQoL 5-dimension component (EQ-5D-3L) index score. The presence of chronic cough and other conditions were defined using structured questionnaires. Results: The prevalence of chronic cough was 3.48% ± 0.17% among adults aged ≥ 40 years. The overall EQ-5D-3L index score was significantly lower in subjects with than without chronic cough (0.79 ± 0.01 vs. 0.86 ± 0.00, P < 0.001). In subgroup analyses by age and sex, chronic cough had a notably large impact on QoL in women aged ≥ 65 years (vs. those without chronic cough: 0.55 ± 0.04 vs. 0.70 ± 0.01, P < 0.001), although the mean difference in the scores exceeded the minimally important difference score of 0.05 in all subgroups. In multivariate analyses, chronic cough was significantly associated with QoL, independent of confounders including depression, arthritis, asthma, and chronic obstructive pulmonary disease. In dimension analyses, chronic cough was more associated with anxiety/depression, pain/discomfort, and usual activities than with self-care or mobility in the EQ-5D. Conclusions: The present study demonstrated significant associations between chronic cough and health-related QoL in a nationwide large general adult population aged ≥ 40 years, which were independent of clinical confounders. The impact of chronic cough was greater in women aged ≥ 65 years. These findings indicate a considerable burden of chronic cough in the general population and warrant further investigations to assess the disease burden of chronic cough in a global scale.
Kyeong Woo Lee,Sang Beom Kim,Min-Gu Kang,Jong Hwa Lee,Won Wook Ha 대한연하장애학회 2023 대한연하장애학회지 Vol.13 No.1
Premature infants often face oral feeding problems. The videofluoroscopic swallow study (VFSS) is a commonly used method to detect subglottic aspiration. However, there is no consensus to date regarding the association of aspiration observed on VFSS and incidence of aspiration pneumonia in preterm infants. This study investigated the occurrence of aspiration pneumonia in preterm infants on oral feeds after aspiration has been confirmed by VFSS. This study included 50 preterm infants who had undergone VFSS. Among them, 13 patients with no aspiration, two patients who were lost to follow-up, and nine patients with massive aspiration were excluded from the analysis. In VFSS, the frequency and amount of aspiration, nasal penetration, suck-swallow ratio, and sucking power were assessed. We analyzed 26 patients with aspiration confirmed on VFSS but who had initiated oral feeding. The frequency of aspiration (percentage of the number of aspirations to the total number of swallowing) was 10.22±3.62 (%). The mean amount of aspiration was 2.28±1.02 (%). One preterm infant, born with very low-birthweight developed aspiration pneumonia 10 days after the initiation of full oral feeding. He was diagnosed with respiratory distress syndrome and had weak sucking power. In the absence of massive aspiration, most infants with aspiration confirmed on VFSS tolerated oral feeding, especially when oral feeding was partially initiated.
S-665 Non-irritating concentration of skin test with commonly prescribed antibiotics in Kore an
( Ha-kyeong Won ),( Min-suk Yang ),( Woo-jung Song ),( Sea-hoon Kim ),( Heung-woo Park ),( Yoon-seok Chang ),( Kyung-up Min ),( Sang-heon Cho ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Backgrounds: Although the data on validity of skin test with drugs expect for penicillin is still scarce, positive skin reaction at non-irritating concentrations with relevant history is generally accepted for diagnosis of drug allergy. In this study, we investigated the maximal non-irritant drug concentrations for intradermal skin test with commonly prescribed antibiotics in Korean adults. Methods: Sixty one healthy volunteers were recruited. Seventeen parenteral antibiotics including beta-lactams and fluoroquinolones were evaluated. The maximal concentration of antibiotics was investigated by two steps as following; A) Intradermal skin test were repeatedly performed from full strength concentration of each drug and, if the result was positive, then serially diluted concentration till the result was negative in the first volunteer; B) establishing the nonirritating concentration identified in step A in 19 more subjects. All subjects were allowed to participate in multiple testing using different drugs. The established maximal nonirritating concentration for each type of antibiotics from this study were compared with a ‘known nonirritating concentration’ of each drug from the previous studies. Results: The mean age of the subjects is 35.0 and there were more females (77%) than males. The maximal nonirritating concentrations for ampicillin/sulbactam, aztreonam, ciprofloxacin, clindamycin, nafcillin and penicillin G from this study were comparable with the known nonirritating concentration of each agent. The maximal nonirritating concentrations of cephalosporins except for ceftriaxone were different from those from previous studies. In addition, the discrepancy between previous known concentrations and the values from this study was 10-fold and more for azithromycin, levofloxacin, meropenem, piperacillin/tazobactam, SMT/TMP, and vancomycin. The difference in nonirritating concentration among volunteers were greater than 100 fold for cefotetan, azithromycin, and vancomycin. Conclusions: To improve the reliability of skin test, study with the numerous subjects would be necessary to standardize non-irritating drug concentration for skin test.
Comparing Inhaler Use Technique Based on Inhaler Type in Elderly Patients with Respiratory Disease
( Ha Youn Lee ),( Jin Hwa Song ),( Ha-kyeong Won ),( Yeonkyung Park ),( Keun Bum Chung ),( Hyo-jeong Lim ),( Young Mee Ahn ),( Byoung Jun Lee ) 대한결핵 및 호흡기학회 2021 Tuberculosis and Respiratory Diseases Vol.84 No.1
Background: The aim of this study was to investigate inhaler device handling in elderly patients. Inhaler devices with respect to misuse and error correction were also compared. Methods: Inhaler use technique was assessed using standardized checklists at the first visit and 3-month follow-up visit after retraining. The primary outcome was difference in the acceptable use ratio among inhaler devices. Secondary outcomes included differences in error correction, the most common step of misuse, and factors affecting the accuracy of inhaler use. Results: A total of 251 patients (mean age, 76.4 years) were included. The handling of 320 devices was assessed in the study. All patients had been trained before. However, only 24.7% of them used inhalers correctly. Proportions of acceptable use for Evohaler, Respimat, Turbuhaler, Ellipta, and Breezhaler/Handihaler were 38.7%, 50.0%, 61.4%, 60.8%, and 43.2%, respectively (p=0.026). At the second visit, the acceptable use ratio had increased. There were no significant differences among inhaler types (Evohaler, 63.9%; Respimat, 86.1%; Turbuhaler, 74.3%; Ellipta, 64.6%; and Breezhaler/ Handihaler, 65.3% [p=0.129]). In multivariate analysis, body mass index, Turbuhaler, and Ellipta showed positive correlations with acceptable use of inhalers, whereas Chronic Obstructive Pulmonary Disease Assessment Test score showed a negative correlation. Conclusion: Although new inhalers have been developed, the accuracy of inhaler use remains low. Elderly patients showed more errors when using pressurized metered-dose inhalers than using dry powder inhalers and soft-mist inhalers. However, there were no significant differences in misuse among inhaler devices after individual training. Results of this study suggests that repeat training is more important than inhaler type.