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이화영,강성윤,김경훈,김주희,류광희,민진영,박경희,박소영,성명순,이영수,양은애,지혜미,하은교,신유섭,이상민,정은희,최선희,고영일,김선태,남동호,박중원,심정연,안영민,한두희,한만용,이용원,최정희,대한천식알레르기학회 면역요법/알레르겐연구팀,Hwa Young Lee,Sung-Yoon Kang,Kyunghoon Kim,Ju Hee Kim,Gwanghui Ryu,J 대한천식알레르기학회 2024 Allergy Asthma & Respiratory Disease Vol.12 No.3
Allergen immunotherapy (AIT) is a causative treatment of allergic diseases in which allergen extracts are regularly administered in a gradually escalated doses, leading to immune tolerance and consequent alleviation of allergic diseases. The need for uniform practice guidelines in AIT is continuously growing as the number of potential candidates for AIT increases and new therapeutic approaches are tried. This updated version of the Korean Academy of Asthma Allergy and Clinical Immunology recommendations for AIT, published in 2010, proposes an expert opinion by specialists in allergy, pediatrics, and otorhinolaryngology. This guideline deals with the basic knowledge of AIT, including mechanisms, clinical efficacy, allergen standardization, important allergens in Korea, and special consideration in pediatrics. The article also covers the methodological aspects of AIT, including patient selection, allergen selection, schedule and doses, follow-up care, efficacy measurements, and management of adverse reactions. Although this guideline suggests the optimal dosing schedule, an individualized approach and modifications are recommended considering the situation for each patient and clinic.
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Characteristics of the Elderly Asthma
( Deok In Kim ),( Hyouk Soo Kwon ),( Woo Jung Song ),( Sang Min Lee ),( Sae Hoon Kim ),( Seong Wook Sohn ),( Chang Han Park ),( Heung Woo Park ),( Sun Sin Kim ),( Sang Heon Cho ),( Kyung Up Min ),( Yo 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.2
배경: 노인 천식은 한 보고에서 우리나라 유병률이 12.7%에 달하며 전세계에서 가장 빠르게 고령화 사회로 진입하고 있는 우리나라에서 점차 더 임상적으로 중요한 위치를 차지할 것이다. 노인 천식에 대한 다각적인 연구가 필요한 시점이다. 목적: 노인 천식에서 성별, 발병 연령 등에 따른 임상적 차이를 알아보고자 하였다. 방법: 분당서울대학교병원 천식 및 알레르기 클리닉을 방문한 65세 이상의 환자들을 대상으로 성별, 발병 연령에 따른 임상 양상에 대해 연구하였다. 65세 이전 발병의 경우를 조기 발병 천식, 65세 이후 발병의 경우를 후기 발병 천식으로 분류하였다. 결과: 총 180명 중, 81명이 조기 발병 천식, 99명이 후기 발병 천식이었다. 조기 발병 천식의 유병 기간은 18.8±17.1년, 후기 발병 천식은 3.4±3.5년이었다. 조기 발병 천식에서 천명음, 피부단자검사 양성, 기관지확장 소견이 더 높게 나타났으며, 기도 폐쇄 정도가 더 심하였으나, 천명 외의 다른 호흡기계 증상, 약물 요구 정도, 혈청 총 IgE에는 차이가 없었다. 일부 환자에서 유도객담을 분석하였고 후기 발병 천식에서 호중구 분율이 높았다. 결론: 65세 이상의 천식 환자를 일반적으로 노인 천식 환자라 부르고 있으나, 발병 연령에 따라 임상적인 차이가 있으며 후기 발병 천식에서는 호중구의 역할을 시사하는 연구결과를 보였다. 따라서 관련 연구 진행이나 진료에 있어 발병 연령에 따른 고려가 필요할 것으로 사료된다. (Korean J Asthma Allergy Clin Immunol 2008;28:98-104)
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류광희,지혜미,이화영,강성윤,김경훈,김주희,박경희,박소영,성명순,이영수,양은애,민진영,하은교,이상민,이용원,정은희,최선희,고영일,김선태,남동호,박중원,심정연,안영민,한만용,최정희,신유섭,한두희,대한천식알레르기학회 면역요법/알레르겐연구팀,Gwanghui Ryu,Hye Mi Jee,Hwa Young Lee,Sung-Yoon Kang,Kyunghoon Kim,J 대한천식알레르기학회 2024 Allergy Asthma & Respiratory Disease Vol.12 No.3
Allergen immunotherapy (AIT) has been used for over a century and has been demonstrated to be effective in treating patients with various allergic diseases. AIT allergens can be administered through various routes, including subcutaneous, sublingual, intra-lymphatic, oral, or epicutaneous routes. Sublingual immunotherapy (SLIT) has recently gained clinical interest, and it is considered an alternative treatment for allergic rhinitis (AR) and asthma. This review provides an overview of the current evidence-based studies that address the use of SLIT for treating AR, including (1) mechanisms of action, (2) appropriate patient selection for SLIT, (3) the current available SLIT products in Korea, and (4) updated information on its efficacy and safety. Finally, this guideline aims to provide the clinician with practical considerations for SLIT.
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대한천식알레르기학회 알레르기비염 진료지침: 파트 1. 약물치료의 업데이트
김민지 ( Minji Kim ),강성윤 ( Sung-yoon Kang ),양송이 ( Song-i Yang ),이일환 ( Il Hwan Lee ),류광희 ( Gwanghui Ryu ),김미애 ( Mi-ae Kim ),이상민 ( Sang Min Lee ),김현정 ( Hyun-jung Kim ),박도양 ( Do-yang Park ),이용주 ( Yong Ju Le 대한천식알레르기학회 2023 Allergy Asthma & Respiratory Disease Vol.11 No.3
The prevalence of allergic rhinitis (AR) and the socioeconomic burden associated with the medical cost and quality of life of AR have progressively increased. Therefore, practical guidelines for the appropriate management of AR need to be developed based on sci entific evidence considering the real-world environment, values, and preferences of patients and physicians. The Korean Academy of Asthma, Allergy and Clinical Immunology revised clinical guidelines for AR to address key clinical questions of the management of AR. Part 1 of the revised guideline covers the pharmacological management of patients with AR in Korea. Through a meta-analy sis and a systematic review, we made 4 recommendations for AR pharmacotherapy, including intranasal corticosteroid (INCS)/intra nasal antihistamine combination therapy, oral antihistamine/INCS combination therapy, leukotriene receptor antagonist treatment in AR patients with asthma, and prophylactic treatment for patients with pollen-induced AR. However, all recommendations are conditional because of the low or very low evidence of certainty. Well-designed and strictly executed randomized controlled trials are needed to measure and report appropriate outcomes. (Allergy Asthma Respir Dis 2023;11:117-125)
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메타콜린 기관지유발검사 시행방법: 대한천식알레르기학회 의견서
손경희 ( Kyoung-hee Sohn ),김환수 ( Hwan Soo Kim ),김병근 ( Byung-keun Kim ),김주희 ( Joo-hee Kim ),이상민 ( Sang Min Lee ),이재현 ( Jae-hyun Lee ),우성일 ( Sung-il Woo ),김철홍 ( Cheol Hong Kim ),정재원 ( Jae Won Jung ),김세훈 ( 대한천식알레르기학회 2023 Allergy Asthma & Respiratory Disease Vol.11 No.2
The Korean Academy of Asthma, Allergy, and Clinical Immunology task force report aims to provide new protocols for methacholine challenge test (MCT). Although new devices have different delivery system compared to old ones, previous protocols are still used, which cannot guarantee adequate diagnoses of asthma. Another important issue is the recent recommendation in European Respi ratory Society (ERS) technical standard guideline to use a delivered methacholine dose that causes a 20% decrease in forced expira tory volume in 1 second (FEV<sub>1</sub>) (PD<sub>20</sub>). Although the previous protocol based on the methacholine concentration causing a 20% de crease in FEV<sub>1</sub> (PC<sub>20</sub>) has been used globally, several studies have reported that PD<sub>20</sub> is more reliable and applicable for new proto cols of MCT. Indeed, a tidal breathing inhalation protocol using a breath-actuated or continuous nebulizer is recommended. Herein, we recommend 3 protocols for the MCT using new devices and provide a brief summary of the change in strategy based on the up dated ERS guideline. (Allergy Asthma Respir Dis 2023;11:56-62)
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이화영 ( Hwa Young Lee ),강성윤 ( Sung-yoon Kang ),김경훈 ( Kyunghoon Kim ),김주희 ( Ju Hee Kim ),류광희 ( Gwanghui Ryu ),민진영 ( Jin-young Min ),박경희 ( Kyung Hee Park ),박소영 ( So-young Park ),성명순 ( Myongsoon Sung ),이영수 대한천식알레르기학회 2024 Allergy Asthma & Respiratory Disease Vol.12 No.3
Allergen immunotherapy (AIT) is a causative treatment of allergic diseases in which allergen extracts are regularly administered in a gradually escalated doses, leading to immune tolerance and consequent alleviation of allergic diseases. The need for uniform prac tice guidelines in AIT is continuously growing as the number of potential candidates for AIT increases and new therapeutic ap proaches are tried. This updated version of the Korean Academy of Asthma Allergy and Clinical Immunology recommendations for AIT, published in 2010, proposes an expert opinion by specialists in allergy, pediatrics, and otorhinolaryngology. This guideline deals with the basic knowledge of AIT, including mechanisms, clinical efficacy, allergen standardization, important allergens in Korea, and special consideration in pediatrics. The article also covers the methodological aspects of AIT, including patient selection, allergen se lection, schedule and doses, follow-up care, efficacy measurements, and management of adverse reactions. Although this guideline suggests the optimal dosing schedule, an individualized approach and modifications are recommended considering the situation for each patient and clinic.
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부천지역 초등학생의 식품알레르기 발생 실태 및 다른 알레르기질환과의 연관성
박재영 ( Jae Young Park ),박가영 ( Ga Young Park ),한영신 ( Young Shin Han ),신미용 ( Mee Yong Shin ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.3
Purpose: This study was performed to evaluate the current status of food allergy (FA) and to analyze the relationship between allergy to individual foods and other allergic diseases in elementary school children. Methods: We performed a questionnaire survey for FA, asthma, allergic rhinitis, and atopic dermatitis using International Study of Asthma and Allergies in Childhood questionnaires. A total of 1,929 students in 3 elementary schools were enrolled. Results: A total of 324 students (16.8%) had ever suffered from FA symptoms more than once. Only 64 out of 324 students (19.8%) were diagnosed with FA by doctors. The presence of soy allergy was associated with the increased risk of bronchial asthma (adjusted odds ratio [aOR], 5.90; 95% confidence interval [CI], 1.87 to 18.59). The presence of egg (aOR, 1.91; 95% CI, 1.04 to 3.52) and wheat allergy (aOR, 5.45; 95% CI, 1.94 to 15.36) were associated with the increased prevalence of allergic rhinitis. The allergic symptoms to fruits/tomato was associated with the increased risk of allergic rhinoconjunctivitis symptoms (aOR, 2.98; 95% CI, 1.18 to 7.47). The allergic symptoms to egg (aOR, 2.29; 95% CI, 1.22 to 4.29), wheat (aOR, 4.91; 95% CI, 1.86 to 12.95), and shrimp/crab (aOR, 2.48; 95% CI, 1.37 to 4.49) were associated with the presence of atopic dermatitis. Conclusion: The prevalence of FA of elementary school students in Bucheon-city was 16.8%. A significant positive association between the suspected foods and the other allergic diseases was found. Soy allergy was significantly correlated to having bronchial asthma and fruits/tomato allergy correlated with allergic rhinoconjunctivitis. (Allergy Asthma Respir Dis 2013;1:266-273)
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