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- 저자 : 조희정 ( Cho¸ Hee Jeong ) (검색결과 27 건)
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Anti-HIV agent VP-0501의 생체이용성 향상을 위한 아미노산 프로드럭 개발 및 약물동태연구
조희정,채경애,성지민,정상민,한진수,김진석,신호철,Cho, Hee-Jeong,Choi, Kyung-Ae,Sung, Ji-Min,Jeong, Sang-Min,Han, Jin-Soo,Kim, Jin-Suk,Shin, Ho-Chul 대한수의학회 2006 大韓獸醫學會誌 Vol.46 No.1
We have studied pharmacokinetics of a new anti-human immunodeficiency virus (HIV) agent VP-0501 and its amino acid prodrug VP-0501AL which is designed to improve oral bioavailability. After oral administration at 100 mg/kg dose in rats (n = 4), VP-0501 was not detectable in plasma (<50 ng/ml), while after the administration of VP-0501AL, VP-0501 was quantitatively detected, at least for 8 hrs, with Cmax of ca. $2.5{\mu}g/ml$ and AUC of $8hr^{\ast}{\mu}g/ml$. When VP-0501 was intravenously administered at 50mg/kg, this compound appeared at a marginal level in plasma with AUC of $2hr^{\ast}{\mu}g/ml$, $t_{1/2}$ of 2 hr, $C_0$ of $0.7{\mu}g/ml$, and MRT of 3 hr. On the other hand, with intravenous VP-0501AL at the same dose, both the prodrug VP-0501AL and its metabolite VP-0501 appeared comparatively at higher level in the plasma: pharmacokinetic parameters of VP-0501AL including $Vd_{\beta}$, AUC, $t_{1/2,{\beta}}$, $C_0$, $CL_{tot}$, and MRT were ca. 2 L/kg, $70hr^{\ast}{\mu}g/ml$, 2 hr, $180{\mu}g/ml$, 0.7 L/hr/kg, and 1 hr, respectively. These results demonstrate that attachment of amino acid alanine to VP-0501 is an effective approach for improvement of its oral bioavailability. Therefore, VP-0501AL is expected to become a new highly bioavailable and potent anti-AIDS drug candidate/lead compound.
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조희정 ( Cho Hee-jeong ) 한국실천유아교육학회 2014 실천유아교육 Vol.19 No.-
본 연구는 체계적인 수업의 전문성 향상을 위한 방안으로 ASSURE 모형의 유아교육적 적용을 이론적으로 탐색하였다. 이론적 탐색을 통해, ASSURE 모형의 적용 가능성을 알 수 있었다. ASSURE 모형은 교수ㆍ학습과정에서 효과적 적용을 통해 수업목적을 성취하도록 하며, 수업 설계 시 유용한 구조와 단계를 안내하는 모형이다. ASSURE는 6단계 교수절차로 수업설계를 할 때 유용한 구조와 단계적 안내를 하며, 매체 사용에 대한 적합한 방법을 구체적으로 제시해 준다. ASSURE 모형은 학습자의 특성을 충분히 파악하고 이해하게 하며, 기대되는 학습결과 즉 학습목표를 명백하게 제시하고, 적절한 교수전략과 자료를 선택하게 한다. 그리고 최적의 학습 제공을 위해 가장 유용한 공학과 매체를 적절히 사용하며, 적절한 연습과 피드백을 제공하여 학습자를 적극적으로 학습에 참여시킨다. 교수ㆍ학습 전 과정에서 학습자의 학습을 측정하고, 각 요소는 물론 수업 경험을 평가하여 필요한 경우 수정, 보완하게 한다. 따라서 ASSURE 모형에 기초한 수업모형의 적용은 유아교사들이 수업목표를 인지하면서 수업을 계획, 진행, 평가할 수 있도록 하여 효율적이고 체계적인 수업경험을 할 수 있을 것으로 기대된다. The purpose of this study was to investigate application of early childhood education using ASSURE model. ASSURE model that Heinich et al (1996) have developed makes achieve the purpose of the lesson in the process of teaching and learning through the effective application of instructional media, and provides guidance of useful structure and phase when the instructional design. Especially, ASSURE model facilitate writing lesson plan to use the instructional media and model that teacher can easily practice in the field of education. Whin the model, will allow you to make a advanced lesson plan by providing opportunity to think for teaching evaluation and improvement.
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ASSURE 이론에 기초한 예비유아교사의 모의수업 모형 개발 및 적용
조희정 ( Hee Jeong Cho ),이대균 ( Dae Kyun Lee ) 한국유아교육학회 2013 유아교육연구 Vol.33 No.3
본 연구는 ASSURE 이론에 기초하여 예비유아교사의 모의수업에서 효율적으로 실행할 수 있는 모의수업 모형을 개발하고 적용하여 그 효과를 분석하는 데 목적이 있다. 이를 위해, 관련 문헌고찰과, 모의수업에 대한 코멘트 기록지, 모의수업 평가지. 마이크로티칭에 의한 자기행동관찰, 저널분석, 피드백과 토의자료, 그리고 교수기술에 대한 사전·사후 t검증 자료를 수집, 분석하였다. 연구는 S시에 소재한 A대학교 유아교육과 3,4학년을 대상으로 2011년도 2학기에서 2012년도 2학기까지 실시되었다. ASSURE이론에 기초한 예비유아교사의 모의수업 모형은 예비연구과정과 1, 2차 모형 개발과정을 거쳐 개발되었으며, 모의수업 절차와 수업반성전략을 포함한다. 개발된 모형 적용의 결과는 다음과 같다. 질적 자료 분석 결과, 예비유아교사들은 모형 적용을 통해 짜임새 있는 계획안을 작성하게 되었고, 그동안 중요하게 생각하지 않았던 숨어있던 요소들을 발견하였다. 이러한 체계적인 계획안 작성이 수업을 잘할 수 있다는 자신감을 갖게 하였다. 또한 수업의 방향을 잡게 하는 목표와 교육과정에 근거한 계획안 작성이 유아중심의 수업을 생각하게 하고, 교구에 대해 새로운 생각을 갖게 하는 계기가 되었다. 마이크로티칭, 동료평가, 피드백, 토의와 같은 다양한 평가를 통해 자신의 수업을 반성하게 되었으며, 공감과 격려를 통한 성장의 계기를 갖기 되는 소중한 경험이 된 것으로 나타났다. 양적 자료 분석을 위해서 교수기술의 사전, 사후검사 자료를 t검증한 결과, 교수기술의 세가지 범주인 수업설계, 수업실행, 수업평가가 모두 통계적으로 유의미한 결과가 나타나 ASSURE이론에 기초한 모의수업 모형 적용이 예비유아교사들의 교수기술 향상에 도움을 준 것으로 분석되었다. Thought the ASSURE Model was originally designed for developing instruction utilizing media, its theory and design emphasize knowing the needs of the learner and for this reason this study chose ASSURE theory as guide for the development process of a simulated instructional model for early childhood teacher training. Following the components in the Assure acronym which are 1)Analyze learners, 2)State objectives 3)Select media/materials 4) Utilize media/materials 5)Require learner participation 6)Evaluate/revise, this study was conducted over a period of two semesters in 2011 and two in 2012 with 3rd and 4th year students in a 4 year university program. Data were collected through a review of related literature, recorded simulated instruction, self behavioral observations in microteaching and reflective journals,, the feedback and evaluation of the researchers and colleagues, lesson plans, discussion material and evaluation checklists. Statistical measures regarding efficacy were obtained from pre-and post-tests of teaching skills. The qualitative data from the application of the developed model reveal that pre-service teachers gained confidence as they systematically wrote lesson plans, finding heretofore gained confidence as they systematically wrote lesson plans, finding heretofore hidden elements. Statistically significant gains in teaching skills appeared in the categories of instructional design, instructional implementation and teaching evaluation. Thus ASSURE Model theory provides an adaptive blueprint for developing viable constructivist early childhood teacher training models.
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조희정 ( Cho¸ Hee Jeong ) 동국대학교 영어권문화연구소 2018 영어권문화연구 Vol.11 No.1
This paper aims to investigate Browning's generic experimentation taking place in Pauline. Although the poem has been entertaining relatively low critical attention due to its incoherence, it merits close analysis in the context of the generic development that transforms a conversation poem into a dramatic monologue. Browning’s Pauline resembles the conversation poem in that its speaker focuses on his own mental movement and invokes a female auditor in order to confess his feelings and thoughts. Yet, the speaker, who clearly shows the tendency toward self-supremacy in the beginning, increasingly realizes his own limit in connecting with the outer world. The speaker’s clear self-consciousness inserted later into the text renders the poem “double-voiced.” In addition, through the footnote added by Pauline in the middle of the text, the poem reveals a striking discrepancy between the speaker’s utterance and the female auditor’s reaction. Pauline in this poem does not function merely as a silent, passive recipient of the speaker’s monologue; rather, she becomes a reader and a critic, who possesses the potential to dialogize the poetic text. Pauline displays its author’s ambivalent view of Romanic poethood as well as the inherited poetic form. Diverging from the generic features of the conversation poem, it foreshadows the emergence of the dramatic monologue in Browning's later poetry.
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낭만주의 시 속의 여성 독자: 코울리지의 「나이팅게일」과 워즈워드의 「조애너에게」
조희정 ( Hee Jeong Cho ) 한국영미문학페미니즘학회 2007 영미문학페미니즘 Vol.15 No.1
The image of the reading woman as cultural consumer haunts the romantic imagination. The recurrent image of women as consumers in Romantic poetry is partially due to male poets` preoccupation with audience in an increasingly feminized literary market. The sympathetic female auditor of the conversation poem serves to mitigate the male poets` fears about the reception of their poetry. At the same time, unruly, disruptive images of women illuminate male anxiety about poetic reception. In Coleridge`s The Nightingale, the poet`s attempt to establish a poetic community is frustrated by the figure of the gentle maid. The nightingales` song becomes choral minstrelsy, indicating the fetishization of poetic identities in the contemporary literary market. To overcome this crisis, Coleridge defines his poem as a father`s tale, designating his son as the ultimate recipient of his poetry. Instead of the figure of the reading woman, Coleridge opts for the figure of the artistic heir as the idealized audience for his poetry. Wordsworth`s To Joanna shows how the poet`s fear of a feminine audience is translated in his dealings with the female character who threatens to subvert his authority. When Joanna`s laughter abruptly shatters the poet`s lofty, sublime vision of nature, Wordsworth feels the woman`s laugh is powerful enough to evoke echoes from all nature. The rest of the poem is an effort on the poet`s part to escape the influence of the feminine and establish his cultural authority. First by reducing Joanna to a woman in need of masculine protection, by designating her as a problematic other to be governed by the male community, and ultimately by inscribing her identity upon the natural scene, Wordsworth seeks to reclaim an authoritative poetic voice.
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N3WS : 키워드 및 요약문장 추출을 이용한 인터랙티브 신문기사 탐색
조희정 ( Hee-jeong Cho ),손지연 ( Ji-youn Son ),윤별이 ( Byeol-yi Yoon ),조아현 ( A-hyun Cho ),김명 ( Myung Kim ),박은정 ( Eun-jeong Park ) 한국정보처리학회 2017 한국정보처리학회 학술대회논문집 Vol.24 No.2
최근 인터넷 기사 중에는 부정확한 제목이나 자극적인 단어를 사용하는 경우가 많아 구독자에게 불편함을 준다. 본 논문에서는 이러한 기사들의 헤드라인을 삭제하고, 기사의 내용을 3 문장으로 요약해 주어, 구독자가 원하는 기사를 효율적으로 파악할 수 있게 하는 시스템을 제안한다. 제안하는 본 시스템은 파이썬 언어의 KoNLPy 패키지를 사용하여 기사의 단어들을 형태소 단위로 분석하며, 추출된 키워드를 토대로 워드 클라우드를 생성한다. 사용자가 클라우드의 특정 단어를 선택하면, 해당 신문기사들의 본문을 분석하여 각 신문 기사만의 핵심적인 문장을 3 문장으로 출력해준다.
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조희정 ( Hee Jeong Cho ),손상균 ( Sang Kyun Sohn ) 대한내과학회 2021 대한내과학회지 Vol.96 No.3
Chronic lymphocytic leukemia (CLL), characterized by monoclonal B-cell accumulation and highly variable clinical manifestations that range from an indolent to an aggressive course, is rare in Korea. Asymptomatic patients with early stage CLL can be followed up without treatment; however, those with active or advanced disease require treatment immediately after diagnosis, for symptom alleviation and prolonging survival. Previously, chemotherapy using cytotoxic agents was the only therapeutic option available for patients with CLL. Research has provided a deeper understanding of the pathophysiology of the disease, and novel agents such as monoclonal antibodies and small-molecule inhibitors that target specific sites on leukemic cells have been introduced. The advent of these new drugs has led to improved clinical outcomes in patients with CLL. Currently, Bruton’s tyrosine kinase inhibitors or B-cell lymphoma-2 inhibitors are recommended as frontline therapy, prior to the administration of cytotoxic agents or combination therapy with monoclonal antibodies. In this article, we review the diagnosis and prognosis of CLL, in addition to the clinical implications of the various therapeutic options. (Korean J Med 2021;96:195-208)
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