經營計劃의 長期的 樹立에 對한 經營學的 考察

김호철 전주대학교 산업경영연구소 1985 産經論叢 Vol.- No.3

결핵 치료 중 발생한 부작용으로 약제 변경한 환자들에 대한 임상적 고찰

김호철,김호철,김이형,송재욱,고원중,전경만,송준휘,류연주,김우열,권용수,최재철,박소영 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

목적: 일차 항결핵제 치료 중 부작용으로 약제변경을 한 환자들의 임상적 특성과 치료 경과에 대하여 알아보고자 하였다. 방법: 2009년 1월부터 12월까지 국내 10개 병원에서 일차 항결핵제 치료를 시작한 환자들 중에서 부작용으로 인해 약제를 변경한 환자들을 대상으로 변경 원인과 임상적 특성, 치료경과에 대하여 후향적으로 조사하였다. 결과: 일차 항결핵제치료를 시작한 환자는 총 2,601명이었고, 남자는 1438명(55.3%), 평균나이는 49.8±19.1세였다. 이 환자들 중 부작용으로 약제 변경한 환자는 230명(8.8%)이었고 남자는 116명(50.4%)이었고, 평균나이는 50.9±19.6세였다. 발생한 부작용으로는 간독성이 99명(43.0%)으로 가장 많았고 피부 이상반응은 63명(27.4%), 위장관 증상 46명(20.0%), 시력장애 31명(13.5%), 발열 23명(10.0%%), 백혈구 또는 혈소판감소증 15명(6.5%) 신기능장애 8명(3.5%), 손발저림 5명(2.2%) 순이었다. 나이, 체질량지수는 관련이 없었고, 당뇨(19%, p=0.02), 만성간질환(9%, p=<0.001) 및 폐외결핵(40%, p=0.047)이 약제부작용 발생과 관련이 있었다. 치료기간은 평균 294.5±189.7일로 더 길었으나 최종 치료성적과 재발여부에는 차이가 없었다. 결론: 일차 항결핵제 치료를 받는 환자들 중에서 기저질환으로 당뇨, 만성간질환이 있거나, 폐외결핵의 환자들에서 약제 부작용이 더 많았고 이로 인해 약제변경이 필요하였다. 그러나 약제를 변경한 경우에도 치료 성적에는 큰 차이가 없었다.

Clinical Characteristics and Prognostic Factors of Lung Cancer in Korea: A Pilot Study of Data from the Korean Nationwide Lung Cancer Registry

김호철,정지영,조덕곤,전재현,이정은,안진석,김승준,김영대,김영철,김정은,이보람,원영주,최창민 대한결핵및호흡기학회 2019 Tuberculosis and Respiratory Diseases Vol.82 No.2

Background: Lung cancer is a leading cause of morbidity and mortality worldwide, and the incidence continues to rise. Although many prognostic factors have been identified, the clinical characteristics and outcomes in Korean lung cancer patients are not well defined. Methods: Of the 23,254 new lung cancer cases registered at the Korea Central Cancer Registry in 2013, total 489 patients from 19 hospitals were abstracted by the Korean Central Cancer Registry. The clinical data retrospectively analyzed, patients were followed up until December 2015. Results: The median age was 69 years (interquartile range, 60–74 years); 65.4% were male and 62.1% were ever-smokers. Cough was the most common initial symptom (33.5%); 13.1% of patients were asymptomatic. While squamous cell carcinoma was the most common subtype in male patients (37.2%), adenocarcinoma was the most frequent histological type in all patients (48.7%) and females (76.3%). The majority of patients received treatment (76.5%), which included surgery, radiation therapy, and chemotherapy. Older age (hazard ratio [HR], 1.037), lower body mass index (HR, 0.904), ever-smoker (HR, 2.003), small cell lung cancer (HR, 1.627), and distant metastasis (HR, 3.990) were independent predictors of mortality. Patients without symptoms (HR, 0.387) and without treatment (HR, 0.364) were associated with a favorable outcome in multivariate Cox analysis. Conclusion: Lung cancer in Korea occurs predominantly in elderly patients, with adenocarcinoma being the most frequent subtype. The prognosis was poorer in ever-smokers and older, malnourished, and untreated patients with advanced lung cancer.

한약재 건강식품의 소재

김호철 한국식품영양학회 2005 한국식품영양학회 학술대회논문집(학술심포지움) Vol.2005 No.06

전통지식 보호와 지적재산권 관련 국제적 논의 : WTO TRIPS, WIPO, CBD를 중심으로

김호철 서울대학교 기술과법센터 2010 Law & technology Vol.6 No.1

종래 전통지식(traditional knowledge)은 지적재산권 보호대상이 아니라 누구나 자유롭게 이용가능한 공공영역에 속하는 정보로 이해되어 왔다. 그러나, 90년대 들어 인류학자 및 환경론자를 중심으로 이러한 전통지식에 대해서도 권리를 인정하고 보호해야 한다는 주장이 제기되어 왔고, 최근 들어서는 전통지식 보호를 위한 구체적 방안이 세계무역기구(WTO), 국제지적재산권기구(WIPO), 생물다양성협약(CBD) 등 다양한 국제포럼에서 활발하게 논의되고 있다. 전통지식 보호 관련 국제적 논의의 핵심은 전통지식에 대한 보유국의 권리와 개발에 따른 이익공유를 규정하는 독자적인(sui generis) 국제레짐 제정 여부이다. 현재로서는 이들 논의가 선진국과 개도국간 대립구도로 인해 매우 더디게 진행되고 있으며 언제 합의될 수 있을지에 대한 전망도 불투명한 것이 사실이다. 그러나, 전통지식 보호 주장이 국제적 논의의 장에서 점차적으로 힘을 얻어가고 있다는 점에 주목해야 한다. 특히, 2010.10월 타결을 목표로 하는 CBD ABS 국제레짐 협상이 가시적인 진전을 이룰 경우 결국 WTO TRIPS, WIPO에서의 논의 진전에도 상당한 모멘텀을 제공할 것으로 예상되는바, 전반적인 협상동향을 예의주시하면서 국가적인 협상대응전략을 재점검할 필요가 있다. It has been generally regarded that traditional knowledge is not an information subject tointellectual property rights protection system but an information freely available for use by anybodywhich belongs to the public domain. Meanwhile, since the early 1990s, there has been an emergingconsensus among many environmentalists and ethno-biologists that traditional knowledge needsto be legally protected; recently, the issue of international action to protect traditional knowledge isbeing seriously discussed in various international fora, including World Trade Organization (WTO),World Intellectual Property Organization (WIPO) and Convention on Biological Diversity (CBD). The core of the discussion surrounding the protection of traditional knowledge relates to theintroduction of international sui generis system that would provide legal rights for traditionalknowledge holders and encourage the equitable sharing of the benefits arising from the utilization ofsuch knowledge. It is true that such discussion has shown little progress due to considerabledisagreement between developing countries and developed countries and that the prospect of thenegotiations remains unclear. However, it is notable that the request for the protection of traditionalknowledge is gradually gaining supports. Particularly, if the current negotiation on internationalregime for protecting generic resources and associated traditional knowledge in the CBD showssubstantial progress, it might provide significant momentum for the progress of other negotiationsin the WTO and the WIPO as to the protection of traditional knowledge. Therefore, it is necessaryto carefully keep an eye on any progress in each international forum and thoroughly review tofurther develop our negotiation strategies.

金銀花의 基原에 關한 文獻的 考察

金頀哲,李尙仁 대한본초학회 1990 大韓本草學會誌 Vol.5 No.1

일본 발명계의 실체(1)

김호철 한국발명진흥회 1990 發明特許 Vol.15 No.12

금속 함유 팬텀에서 MR영상 기법 고찰 (Metal artifact에 대한 Pulse Sequence 비교)

김호철,정운용,우경숙,한아름 대한방사선사협회 2003 대한방사선사협회지 Vol.29 No.1

大黃과의 配合煎湯이 大黃 中 sennoside b의 抽出量에 미치는 影響

金頀哲,安德均 대한본초학회 1996 大韓本草學會誌 Vol.11 No.1

The prescriptions of traditional Korean medicine is on the basis of the differentiation of syndromes and the establishment of therapeeutic methods, to pick out proper drugs and organically constitute them in the light of the principles of formain a prescription. In this paper, we chose Rhei Radix which has purgative, heat-firing and blood circulating effects. And we obserbed the effects of mixture with rhei radix in various kinds of herbs on the extraction amount of sennoside b, one of the purgative compounds in Rhei Radix. In the mixture of Paeoniae Radix, Perciae Semen, Carthami Flos, Scutellariae Radix, the extracting amount of sennoside b is more than that of Rhei Radix itself orderly. On the other hand, in the mixture of Cinnamnomi Ramulus, Angelica Gigantis Radix, Aurantii Fructus, Natri sulfus, the amount is less than that of Rhei Rhizoma itself orderly.

A Staging System for Risk Prediction in Patients with Rheumatoid Arthritis-Associated Interstitial Lung Disease

김호철,이정석,이은영,채은진,한민규,( Gary Cross ),( Joseph Barnett ),( Jacob Joseph ),송진우 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

Background: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) has variable clinical course for which predicting prognosis is difficult. This study aimed to develop staging system to predict mortality in RA-ILD patients. Methods: Clinical prediction model was developed by using retrospective data from 158 patients with RA-ILD, and validated in the seperate RA-ILD cohort (n=150). Candidate variables for prediction models were screened by multivariate Cox proportional hazard models and the C statistics were calculated to predict the prognostic ability of each prediction model. Results: In the derivation cohort, the median follow-up period was 55 months and 38.0% showed a usual interstitial pneumonia (UIP) pattern on high resolution computed tomography (HRCT) images. In a multivariate Cox analysis, UIP pattern (hazard ratio [HR], 2.282), high fibrosis score (sum of reticulation and honeycombing extent, HR, 1.046), emphysema (HR, 2.707) and a short six minute walk distance (HR, 0.997) were significant poor prognostic factors. Of these, three HRCT variables were included in the final model: a UIP pattern, high fibrosis score (≥ 20% of total lung extent), and emphysema. The prediction model showed a good performance in predicting mortality (C-index, 0.792, P<0.001) and divided into three stages. Predicted and observed mortality at 1, 2, and 3 years was similar in the derivation and validation cohorts. Conclusions: Our results suggest that risk prediction model based on HRCT variables could be useful in RA-ILD patients.