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설포베타인 키토산의 실크 블렌드 필름의 제조 및 그들의 성질
거자성(Ja Sung Koo),차재령(Jae Ryung Cha),오세행(Se Heang Oh),공명선(Moung Seon Gong) 한국고분자학회 2014 폴리머 Vol.38 No.1
Bombyx mori silk fibroin(SF)과 블렌드 필름을 만들기 위하여 키토산에 1,3-propanesultone을 반응시켜 수용성 sulfobetaine chitosan(SCs)을 제조하였다. 여러 가지 비율의 SF/SCs 블렌드 필름을 B. mori SF와 SCs의 수용액을 혼합하여 제조하였다. 수용액으로부터 얻어진 SF/SCs 블렌드 필름의 구조와 형태 변화는 분광학적 및 열적 분석을 통해 규명하였다. SF와 SCs의 혼합 비율에 따른 인공 피부나 화상치료 목적의 비이오재료로서의 물리적 및 기계적 성질에 미치는 영향을 조사하였다. X-선 분석으로 두 생체고분자 사이에 좋은 친화성을 보여주고 있음을 알 수 있었으며 기계적 성질도 SCs의 함량이 증가하면 크게 증가하였다. 37 oC에서 phosphate buffered saline solution용액 중에서 in vitro 분해 실험을 8주 동안 시행한 결과 46.4%가 분해됨을 알 수 있었다. MC3T3-E1 세포에 의한 독성 실험 결과 무독성을 나타내 주었으며, 3일의 배양 후 SF/SCs 필름의 상대 세포 수는 최적화된 tissue cultureplastic보다 약간 낮게 나타남을 알 수 있었다. Water-soluble sulfobetaine chitosan (SCs) was prepared for a blending film with Bombyx mori silk fibroin (SF)by reacting chitosan with 1,3-propanesultone. A series of SF/SCs blended films were successfully prepared by mixingaqueous solutions of B. mori SF and SCs. The SF/SCs blended films were examined through spectroscopic and thermalanalysis to determine the morphological changes of SF in the SCs. The effects of the SF/SCs blend ratios on physicaland mechanical properties were investigated to discover the feasibility of using these films as biomedical materials suchas artificial skin and wound dressing. X-ray analysis showed good compatibility between the two biopolymers. The invitro degradation behavior of the SF/SCs blended films was systematically investigated for up to 8 weeks in phosphatebuffered saline solution at 37 oC and showed a mass loss of 46.4% after 8 weeks. All films showed no cytotoxicity byMC3T3-E1 assay. After 3 days of culture, the relative cell number on all the SF/SCs films was slightly lower than thatof an optimized tissue culture plastic.
구자성,장재원,김상민,최지훈,장영우,김동진,Koo, Ja-sung,Jang, Jae-won,Kim, Sang-min,Choi, Ji-hoon,Jang, Young-woo,Ki, Dong-jin 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.2
Objective: This study reports on two patient cases with lower limb symptoms related to femoral nerve entrapment who were treated with traditional Korean medicinal treatments.Method: We used acupuncture and pharmacopuncture for several days and observed any changes in the patients’ symptoms.Results: After treatment, the numerical rating scale (NRS) of the first patient decreased from 7 to 1, while that of the second patient decreased from 10 to 1.Conclusion: The results of this study suggest that traditional Korean medicinal treatments may be effective in reducing symptoms related to femoral nerve entrapment.
픽셀 단위의 정밀한 방향성 보간을 이용한 공간적 에러 은닉 기법
김원기,구자성,진순종,정제창,Kim, Won-Ki,Koo, Ja-Sung,Jin, Soon-Jong,Jeong, Je-Chang 한국통신학회 2007 韓國通信學會論文誌 Vol.32 No.2C
본 논문에서는 전송 에러로 인해 발생하는 영상의 손실을 정밀한 방향성 보간(FDI: Fine Directional Interpolation)을 이용하여 복원하는 기법을 제안한다. 제안된 알고리즘은 공간 방향 벡터(SDV: Spatial Direction Vector)를 도입한다. 공간 방향 벡터는 손실블럭 주위의 영상 데이터의 에지 정보를 추출하여 구한다. 이 후 손실된 영상 블록은 공간 방향 벡터를 이용하여 픽셀단위로 적응적으로 보간함으로써 복원된다. 이러한 방식은 평탄한 영역뿐만 아니라 에지를 포함한 복잡한 영역도 우수하게 복원할 수 있다. 실험결과 제안된 방식은 기존의 공간적 에러은닉 방법과 비교하여 성능이 우수하다는 것을 알 수 있다. This paper presents a block loss recovery technique for the image block data corrupted by transmission losses through the employment of fine directional interpolation (FDI). The proposed algorithm introduces a spatial direction vector (SDV). The SDVs are extracted from the edge information of the neighboring image data. Subsequently, the SDVs are adaptively applied to interpolate lost pixels on a pixel-by-pixel basis. This approach improves the capability to more reliably recover high-detailed contents in the corrupted block. Experimental results demonstrate that the FDI method performs better as compared to previous techniques.
남정무,김병건,구자성,박종무,이정주,권오현,Nam, Jungmoo,Kim, Byung-Kun,Koo, Ja-Seong,Park, Jongmoo,Lee, JungJu,Kwon, Ohyun 대한임상신경생리학회 2007 Annals of Clinical Neurophysiology Vol.9 No.2
Spinocerebellar ataxia type 2 (SCA2) is characterized by progressive cerebellar ataxia and slow saccades. A 40-year-old woman presented with progressive gait disturbance and ataxia over 15 years. Neurologic examination revealed scanning speech, ataxia, and hyporeflexia. Brain CT showed diffuse atrophy of the cerebellum. Electronystagmography demonstrated slowed saccades with normal accuracy and delayed latency. The diagnosis of SCA2 was confirmed by the genetic test. Documentation of slow saccades may help differentiation among SCA subgroups.
다발성 섬유성 골이형성증 변형에 대한 나사못 맞물림 골수정을 이용한 치료
이광석,오종건,구자성,Lee, Kwang-Suk,Oh, Jong-Keon,Koo, Ja-Seong 대한근골격종양학회 1995 대한골관절종양학회지 Vol.1 No.2
The fibrous dysplasia is a progressive and disabling condition that lead to deformity, especially weight bearing bones. The morbidity that is associated with the polyostotic fibrous dysplasia is the recurrent fracture and deformity. Various methods of treatment had been failed to control this problem. We used osteotomy and reconstruction nailing for polyostotic fibrous dysplasia occured in the proximal part of right femur with varus deformity and reconstruction nailing in left femur without osteotomy, and interlocking intramedullary nailing in right tibia to prevent pathologic fracture. These methods brought a good result of bone union and full weight bearing ambulation after 1 year and 6 month follow up. We think these methods are useful methods to control refracture and deformity, so we reported this case with bibliographic reviews.
슬관절 통증 환자의 한의학적 치료 호전도와 BMI 와의 상관성
김상민,이순호,최지훈,김현중,구자성,장재원,이동현,유형진,Kim, Sang-Min,Lee, Sun-Ho,Choi, Ji-Hoon,Kim, Hyun-Joong,Koo, Ja-Sung,Jang, Jae Won,Lee, Dong-hyun,Yoo, Hyung Jin 척추신경추나의학회 2016 척추신경추나의학회지 Vol.11 No.1
Objectives : This study was designed to assess the general distribution, clinical effectiveness of Korean medical treatment on knee pain and the correlation between Korean medical therapy on knee pain and BMI. Methods : This is an observational study. 65 patients admitted to Daejeon Jaseng Hospital of Korean Medicine with musculoskeletal disorders were observed from July, 2014 to July, 2015. They were analyzed according to sex, age, pain lesion, body mass index(BMI) and treatment efficacy. All patients received a combination of treatments during hospitalization, including acupuncture, pharmacopuncture, herbal medicines and physical therapy. A zero to ten numerating rating scale (NRS) assessing pain, Western Ontario and McMaster Universities Arthritis Index(WOMAC) index and Range of Motion(ROM) was used before and after treatments. Statistical correlations among assessment measurements were evaluated by examining the paired t-test and the Pearson's correlation coefficients. Results : The average BMI of all patients was $24.03{\pm}2.95kg/m^2$. According to clinical definition of obesity by Korean Society for the Study of Obesity, 33.8% of all patients was within normal weight, 1.5% was underweight, 33.8% was overweight, 24.6% was obesity and 6.2% was morbid obesity. For knee pain patients, NRS (Numeric Rating Scale) decreased from $6.28{\pm}1.63$ to $3.94{\pm}2.03$(p<0.001). WOMAC index decreased from $48.14{\pm}17.63$ to $40.37{\pm}18.28$(p<0.001). But, there were no significant correlations in statistics among BMI, knee pain index and knee pain index improvement. Conclusions : Korean medical combination treatment might be effective in reducing pain and improving functional disorders for patients with knee pain. This study further confirmed the efficacy of Korean medical treatment on knee pain. But, more studies on correlation between knee pain and obesity and development of assessment measurement are needed.
고광묵(Kwang Mook Go),구자성(Ja Seong Koo),김영일(Young Il Kim),양재헌(Jae Heon Yang) 한국약제학회 1999 Journal of Pharmaceutical Investigation Vol.29 No.4
To protect β-carotene at the stomach and to release rapidly at the intestine we prepared alginate beads containing β-carotene. β-Carotene and alginate solution was homogenized and prepared o/w emulsion was prepared. It was poured into Ca^(2+) solution through syringe needle. The gel was formed spontaneously and alginate beads containing β-carotene were prepared. β-Carotene was incorporated into the beads more than 95%. The release rate of β-carotene was dependent on the concentration of Ca^(2+), β-carotene and surfactants. However, the concentration of alginate did not affect the release rate of β-carotene. The high concentration of Ca^(2+) slowed down the release rate of β-carotene. The addition of surfactants in the β-carotene beads increased the release rate of β-carotene in the order of Tween 80 > Cremophor > Span 20. The contents of β-carotene and diameter of β-carotene beads did not change significantly at 50℃ for 20 days.