수술 전 심장기능 평가에 있어 심근관류 SPECT의 유용성

신대희,조한표,최성일,이숙진,이 상,이재웅,김경수,김순길,김정현,임헌길,이방헌,이정균,최윤영 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.2

Background/Aims: The preoperative cardiac evaluation is important to predict perioperative cardiac event in patients who planned for non-cardiac operation. However, the usefulness of cardiac SPECT and/or evaluation of patient with clinical criteria is not clear. Therefore we evaluate the prognostic value of cardiac SPECT in surgical patients. And also compare the result of clinical risk stratification using the ACC/AHA guidelines with those of cardiac SPECT. Methods: 75 patients(M:F=31:44, 62.8±9.2 years), who have chest pain, EKG abnormality or history of ischemic heart disease were enrolled to the study. According to the result of cardiac SPECT, they were divided to 3 groups: normal perfusion(n=51), reversible perfusion defect(n=31), irreversible perfusion defect(n=3). Also we divided 3 groups according to clinical predictors of the ACC/AHA guidelines: minor risk group(n=51), intermediate risk group(n=21), and major risk group(n=3). I compare predictive power of perioperative cardiac event between cardiac SPECT and clinical predictors of the ACC/AHA guidelines. Results: Cardiac event occurred in 9.2% of patient. Prevalence of cardiac event in reversible cardiac perfusion group(19.0%) and irreversible cardiac perfusion group(33.3%) was higher than normal group(3.8%)(p〈0.05). By clinical predictors according to the ACC/AHA guidelines, I could not predict the postoperative cardiac event. Conclusion: Cardiac SPECT is more useful than clinical predictors according to the ACC/AHA guidelines in preoperative cardiac evaluation in patients with chest pain, EKG abnormality or history of ischemic heart disease.

방풍통성산이 비만인에 미치는 영향에 대한 임상적 연구

신대희,조국현,이혁,문미경,강대길,윤용갑,박도심,정선관,이호섭,Shin, Dae-Hee,Cho, Guk-Hyun,Lee, Hyuck,Moon, Mi-Kyung,Kang, Dae-Gill,Yun, Young-Gab,Park, Do-Shim,Juhng, Seon-Kwan,Lee, Ho-Sub 대한한의학방제학회 2008 大韓韓醫學方劑學會誌 Vol.16 No.2

Recently, people are becoming fatter in most parts of the world. Obesity is regarded as an important risk factor to adversely affect the health of humans, associated with hypertension, hyperlipidemia, diabetes, and cardiovascular diseases. In the present study, therefore, we tested the short time efficiency and safety of Bangpoongtongsungsan as a drug to decrease body weight in subjects with obesity. A total 48 volunteers (24 man, 24 woman) with body mass index (BMI : weight in kg divided by square of height in meters) of $23㎏/m^2$ participated in clinical study for 12 weeks, from 2008, March 01 to 2008, Jun 30. The subjects was received a dietary supplement of 12 pieces hard capsules per day (4 pieces in one, 3 times in a day) during the clinical study. At the end of clinical study, body weight of subjects was significantly decreased from $72.21{\pm}11.44\;kg$ to $70.53{\pm}11.67\;kg$ (p<0.05). Waist circumferences of subjects were reduced $91.58{\pm}6.43\;cm$ to $85.25{\pm}7.70\;cm$ (p<0.05). Also, a BMI of subjects was significantly decreased $26.07{\pm}2.35\;kg/m^2$ to $25.63{\pm}2.63\;kg/m^2$ (p<0.05). Particularly, a decrease in body weight, waist circumferences, and BMI was more significant in woman than man. But, other biochemical levels including lipid and glucose in plasma had no changes at the end of clinical study. In conclusion, administration of Bangpoongtongsungsan in subjects with high body weight fat could inhibit obesity associated with a decrease in body weight, waist circumferences, and BMI.

원인 불명의 실신 환자에서 Implantable Loop Recorder의 임상 경험

신대희,김준수,박정왜,임혜란,김준형,이선미,김기선,이창희,정동채,온영근,김덕경,이상훈,홍경표,박정의 대한심장학회 2008 Korean Circulation Journal Vol.38 No.4

Background and Objectives: Possible mechanisms of syncope often remain unknown despite the performance of extensive cardiological and neurological tests. An implantable loop recorder (ILR) has been introduced to monitor the heart rhythm continuously over a year. We evaluated the diagnostic value of the use of the ILR for unexplained syncope. Subjects and Methods: Between 2006 and 2007, an ILR was implanted in 9 patients (7 male, 2 female, mean age 55±17 years) where syncope remained unexplained after extensive diagnostic tests. We analyzed the recorded electrocardiogram signal in the memory of the ILR. Results: During a follow-up period of 8.8±7.3 months, arrhythmia was detected in five patients. Two patients had a sinus pause and received a permanent pacemaker, and one patient had sustained ventricular tachycardia and fibrillation and received an implantable cardioverter defibrillator. One patient had micturition syncope with sinus pause and is waiting for permanent pacemaker implantation, and one patient had symptomatic paroxysmal atrial fibrillation and was administered anticoagulation therapy. Inappropriate auto-activations such as a pseudopause or a decreasing signal were also noted. Conclusion: ILR monitoring seems to be a useful diagnostic tool to identify the arrhythmic cause in patients with unexplained syncope. Background and Objectives: Possible mechanisms of syncope often remain unknown despite the performance of extensive cardiological and neurological tests. An implantable loop recorder (ILR) has been introduced to monitor the heart rhythm continuously over a year. We evaluated the diagnostic value of the use of the ILR for unexplained syncope. Subjects and Methods: Between 2006 and 2007, an ILR was implanted in 9 patients (7 male, 2 female, mean age 55±17 years) where syncope remained unexplained after extensive diagnostic tests. We analyzed the recorded electrocardiogram signal in the memory of the ILR. Results: During a follow-up period of 8.8±7.3 months, arrhythmia was detected in five patients. Two patients had a sinus pause and received a permanent pacemaker, and one patient had sustained ventricular tachycardia and fibrillation and received an implantable cardioverter defibrillator. One patient had micturition syncope with sinus pause and is waiting for permanent pacemaker implantation, and one patient had symptomatic paroxysmal atrial fibrillation and was administered anticoagulation therapy. Inappropriate auto-activations such as a pseudopause or a decreasing signal were also noted. Conclusion: ILR monitoring seems to be a useful diagnostic tool to identify the arrhythmic cause in patients with unexplained syncope.

IMU 센서 데이터를 활용한 LSTM 기반 매니퓰레이터 고장예지 구현

신대희(Dae-Hee Shin),김태현(Tae-Hyeon Kim),옥승호(Seung-Ho Ok) 한국정보기술학회 2024 Proceedings of KIIT Conference Vol.2024 No.5

최근 인공지능을 활용하여 장비의 이상을 감지하고 고장을 사전에 예측하는 고장예지 및 건전성 관리 기술들이 연구되고 있다. 본 논문에서는 6축 매니퓰레이터 조인트 이상을 감지하고 고장을 예지하기 위해 IMU 센서를 사용하여 매니퓰레이터 Pick&Place 동작의 시계열 데이터를 수집하였다. 고장예지를 위한 인공지능 모델은 수집한 시계열 데이터의 학습이 가능한 LSTM으로 선택하여 지도학습으로 학습을 진행하였다. 인공지능 모델의 학습과 평가를 위해 네 가지 종류의 이상 징후를 수집한 데이터와 결합하여 이상 데이터를 생성하였으며, 학습 모델이 고장예지가 가능하도록 구현하였다. Recently, failure prediction and health management technologies that use artificial intelligence to detect equipment abnormalities and predict failures in advance are being researched. In this paper, time series data of manipulator Pick&Place operations were collected using an IMU sensor to detect abnormalities and predict failure of 6-axis manipulator joints. For the artificial intelligence model for failure prediction, an LSTM capable of learning from collected time series data was selected and trained through supervised learning. In order to learn and evaluate the artificial intelligence model, abnormal data was generated by combining four abnormalities in the collected data, and a learning model was implemented to enable failure prediction.

유한요소해석을 이용한 채널 I 형 잠호 맞대기 용접부의 변형 및 잔류 응력 예측에 관한 연구

신대희(Dae-Hee Shin),신상범(Sang-Beom Shin),이주성(Joo-Sung Lee) 대한조선학회 2007 大韓造船學會 論文集 Vol.44 No.6

새로운 짧은 경로로의 dl-Muscone 합성(Ⅰ)

임대식,신대희,박대규,Im, D.S.,Shin, D.H.,Park, D.K. 대한화학회 1996 대한화학회지 Vol.40 No.4

Cyclopentadecanone(2)으로부터 2-cyclopentadecen-1-one(4)까지의 일반적인 합성경로는 여러가지가 있을 수 있다. 본 실험에서는 우선 $C_2$-위치의 선택적인 브롬화반응을 위하여 $AlCl_3$를 써서 엔올산 염화하여 위치선택성을 증가시켰으며, 브롬화 수소 이탈반응에서의 시약 $Li_2CO_3$-LiBr-DMF 조건을 적절히 조절함으로써 화합물(4)를 쉽게 얻을 수 있었다. 이 과정에서 생기는 트랜스형 및 시스형 화합물(4)를 E.Ether 용매속에서 $CH_3MgI-Cu_2Cl_2$ 복합체에 적하하여 반응시킬 경우, 모두 1,4-첨가반응되어 dl-Muscone(1)를 생성함을 결과로 얻었다. 본 실험에서 Cyclopentadecanone(2)으로부터 dl-Muscone(1)까지의 3단계 과정을 통해 순수한 dl-Muscone(1)을 총 85%의 높은 수율로 얻었으며, 별다른 화학적 분리단계를 거치지 않아, 합성단가를 기존의 어느 방법보다 현격히 낮출수 있었다. New routes have been developed for the practical syntheses of dl-Muscone(1) employing cyclopentadecanone(2) as the starting material. In this experiment, addition of bromine to cyclopentadecanone in dried E. Ether solution with a trace of $AlCl_3$ as the catalyst were produced 2-bromocyclopentadecanone(3). This process was enhanced formation of regioselective enolate anion at $C_2$ position. 2-Bromocyclopentadecanone was put into $Li_2CO_3$-LiBr-DMF solution at 140∼150$^{\circ}C$, were produced trans- and cis-2-cyclopentadecen-1-one(4) mixture. Other by-products were reduced by control of reaction temperature and time. Trans- and cis-2-cyclopentadecen-1-one(4) mixture was directly put into dried E. Ether solvent and induce to react dropwise with $CH_3MgBr-Cu_2Cl_2$ complex, all of them got into 1,4-addition, dl-Muscone (1) was formed as the result. Conculsion, through three steps procedure from cyclopentadecanone(2) to dl-Muscone(1), the pure dl-Muscone was obtained with the high proportion of 85%, and synthetic cost was able to be much lower than any other conventional methods as there were no chemical separating steps.

A Case of Aortic Root Abscess Causing Fatal Myocardial Infarction

최성일,신대희,신진호,이재웅,김순길,김경수,임헌길,김정현,이방헌 한국심초음파학회 2006 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.14 No.2

포스터 전시 : 순환기 ; 경흉부 색도플러심초음파로 관찰된 관동맥-좌심실간 미세루 1예

최성일,신대희,박의순,신진호,김정현,김경수,이방헌,임헌길,김순길,이재웅 대한내과학회 2005 대한내과학회 추계학술발표논문집 Vol.2005 No.1

Progressive Familial Heart Block Type I in a Korean Patient

이창근,신대희,장진근,장경희,김은경,정상식,유상용 대한심장학회 2011 Korean Circulation Journal Vol.41 No.5

A 29-year-old man was referred to the emergency department with a complaint of abdominal pain and dizziness. He had ex-perienced two previous syncopal episodes. His family history revealed that his mother and his two uncles had received permanent pacemaker implantation. His initial heart rate was 49 beats per minute. The electrocardiography (ECG) showed atrial flutter and right bundle branch block (RBBB) with left anterior fascicular block (LAFB). On admission, 24-hour Holter show-ed ventricular pause up to 16 seconds during syncope. Radio frequency catheter ablation (RFCA) of atrial flutter was performed. The ECG revealed bifascicular block (RBBB and LAFB) and first-degree atrioventricular block. He received a perm-anent pacemaker implantation. His brother’s and his sister’s ECGs also showed trifascicular block and the pedigree showed autosomal dominant inheritance. This patient was diagnosed with a progressive familial heart block (PFHB) type I. This would be the first report of a PFHB type I case documented in Korea

변이형 협심증 환자의 장기 예후 및 임상적 특징

유상용,신대희,정정임,윤준영,하동천,조성원,정상식 대한심장학회 2008 Korean Circulation Journal Vol.38 No.12

Background and Objectives: The overall prognosis of patients with vasospastic angina (VA) is relatively good. However, the long-term prognosis and its influencing factors are not well understood in Korean patients. Subjects and Methods: Between August 1996 and January 2007, 256 consecutive patients with VA were reviewed (215 men, 53±9 years). Coronary spasm was confirmed via intravenous ergonovine provocation in all study patients during coronary angiography. Major adverse cardiac events (MACEs) were defined as myocardial infarction (MI), resuscitation from cardiac arrest, or repeat hospitalization due to recurrent angina. Results: The 256 patients were followed for an average of 59 months (range, 5 months to 11 years). Thirty-one patients (12.1%) were lost to followup. Cardiac deaths occurred in 6 patients (2.3%), non-fatal MIs occurred in 3 patients (1.2%), and MACEs occurred in 52 patients (20.3%). The rates of survival at 1, 3, and 5 years were 99%, 97%, and 97%, respectively, and the rates of MI-free survival at 1, 3, and 5 years were 99%, 96%, and 95%, respectively. Rates of MACE-free survival at 1, 3, and 5 years were 91%, 81%, and 62%, respectively. MI at initial presentation and current smoking were factors significantly associated with MACEs; these factors were also independent predictors of MACE-free survival. Conclusion: Despite treatment with calcium channel blockers, recurrent episodes of angina were frequently observed, whereas sudden cardiac death and non-fatal MI were rare. Smoking and myocardial infarction at admission were independent risk factors for cardiac death, non-fatal MI, and repeat hospitalization due to recurrent angina in patients with variant angina. Background and Objectives: The overall prognosis of patients with vasospastic angina (VA) is relatively good. However, the long-term prognosis and its influencing factors are not well understood in Korean patients. Subjects and Methods: Between August 1996 and January 2007, 256 consecutive patients with VA were reviewed (215 men, 53±9 years). Coronary spasm was confirmed via intravenous ergonovine provocation in all study patients during coronary angiography. Major adverse cardiac events (MACEs) were defined as myocardial infarction (MI), resuscitation from cardiac arrest, or repeat hospitalization due to recurrent angina. Results: The 256 patients were followed for an average of 59 months (range, 5 months to 11 years). Thirty-one patients (12.1%) were lost to followup. Cardiac deaths occurred in 6 patients (2.3%), non-fatal MIs occurred in 3 patients (1.2%), and MACEs occurred in 52 patients (20.3%). The rates of survival at 1, 3, and 5 years were 99%, 97%, and 97%, respectively, and the rates of MI-free survival at 1, 3, and 5 years were 99%, 96%, and 95%, respectively. Rates of MACE-free survival at 1, 3, and 5 years were 91%, 81%, and 62%, respectively. MI at initial presentation and current smoking were factors significantly associated with MACEs; these factors were also independent predictors of MACE-free survival. Conclusion: Despite treatment with calcium channel blockers, recurrent episodes of angina were frequently observed, whereas sudden cardiac death and non-fatal MI were rare. Smoking and myocardial infarction at admission were independent risk factors for cardiac death, non-fatal MI, and repeat hospitalization due to recurrent angina in patients with variant angina.