정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

헬스클럽의 서비스 질과 고객만족 및 재 가입의사의 관계

성영호,김경식,권창기,정철규,신인숙 龍仁大學校 體育科學硏究所 2003 體育科學硏究論叢 Vol.13 No.1

This study was to analysis the relationship between service quality and consumer satisfaction, repurchase in health club. To attain the goal of the study described above paragraphs, the subject of this study were selected by cluster random sampling method. This study drew out and analyzed 310 people in total. The result of reliability check up was here below; Chronbach 'α=.82-91. To analyze materials, multiple regression and path analysis were used as statistic analysis techniques. The conclusion based on above study method and the result of material analysis are here below. First, the service quality influences on repurchase. Second, the service quality influences on consumer satisfaction. Third, the service quality does directly influences on consumer satisfaction and repurchase. Namely, consumer satisfaction is a variable connecting service quality and re-purchase.

조혈모세포이식환자에서 조혈기능의 회복과 관련된 인자들에 관한 연구

정기주,강명수,권기두,김경하,이상철,김현정,배상병,김찬규,이남수,이규택,원종호,홍대식,박희숙 순천향대학교 의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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당뇨병 환자에서 뇌간 청각신경 유발전위 잠복기의 연장- 기질적? 또는 대사성?-

김성민,권기한,이병철,엄근용,배종석 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3

Benz(a)anthracene이 마우스태자 간조직 세포의 소핵출현에 미치는 경태반효과

成耆天,張聖薰,車喆煥 고려대학교 의과대학 1989 고려대 의대 잡지 Vol.26 No.1

In order to adduce the cytogenic effect of Benz(a)anthracene(B(a)A) in pregnant mice through placental barrier to fetus, 125㎎/㎏, 250㎎/㎏, 500㎎/㎏, of B(a)A were administrated to groups of mice 16th pregnancy day About 20 hrs later, freauency of micronuclei in polychromatophilic normoblasts of liver tissues extracted from fetus was measured At the same time, 200 ㎎/㎏ and 400 ㎎/㎏ of Benzo(a) pyrene(B(a)P) were administered with same procedure to compare the frequencies between in cases of B(a)A and B(a)P administration. Especially incase of B(a)A administration, frequencies of their appearances in bone marrows of mother mice and livers of fetuses were compared. On the other hand, pathological changes of fetus liver caused by B(a)A and B(a)P in mothers were observed through microscopic examination in order to reconfirm and compare their transplacental effects. As the results, cytogenic toxicity for feture caused of B(a)A was confirmed. It means that some amount of B(a)A which was administered to pregnant mice could be transmitted to fetus through placental barriers Mutagenicity caused of B(a)A was higher in fetus than mother mouse. The cytogenic toxicity caused of B(a)A both for mother mouse and fetus was lower than that of B(a)p.

Tabes Dorsalis의 핵자기공명영상 및 전기생리학적 소견

권기한,김성민,권석범,이병철,조광호,주정희 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3

급성충소돌기염의 임상 : 병리학적 고찰

양기화,조준필,하영천,한진우,정학재,손수창,이성희,황재훈,신철호 최신의학사 1989 最新醫學 Vol.32 No.4

볼링 클럽활동 참가자의 유형별 만족도에 관한 분석

이기철,하성주 정보과학연구소부산외국어대학교 2001 情報科學論集 Vol.3 No.-

This research was to see the difernt opinions bowling players for the bowling satisfaction, facility satisfaction, service satisfaction, management satisfation and their group satisfaction. Questionaires were distributed to be filled to total 350 bowling players. 335 questionaires (96%) were returned and, eecept for 15 which were answered incompletely, 229 questionaires (85%) were valid for this research subject. 1. Satisfaction by ender It was shown that men more satisfied tan women with service, group and facility. Women were more satisfied with bowling. 2. Satisfaction by Age It was shown that people in their 30's were te most satisfied with teir groups, bowling and management. 40's were the most satisfied people with facility. 3. Satisfaction by Player's Occupation Company employee were the most satisfied with facilities and public workers were with the rest factors. 4. Satisfaction by Playing Period Every factors showed higher satisfaction as th subject's playing period was longer. The group satisfaction, especially, demonstrated significant difference by the playing period. 5. Satisfaction by Education It was shown that the subjects who had a relatively high education level were more satisfied with relation with their group members and didn't think much of the facilties. 6. Satisfaction by Score Level Playes who scored over 150 showed the highest satisfaction level overall. Bowling satisfaction exclude, subjects who mark score 80 showed the highest satisfaction. bowling players became the subjet of this research. Subjects were devided by their ender, age, accupation, playing period, euation and score level and heir opinion for the general facility satisfaction (lane condition, computer system, locker room, resting room and parking space), service satisfaction (kindness of staff, house ball condition and game fee), their group satisfaction and bowling satisfaction were collected. This research took place for the basic information for bowling club management and effective operation. Several problems revealed during the research peocess and future study subjects are follows; 1) This research limited the independent factors to six, gender, age, occupation, playing period, sore level and education, and dependent factors to roup, bowling, service, management and faility satisfaction. Consideration regarding more factors, which help understand player futhermore, is required for future for future study. 2) This research showed more satisfaction in men's group. It suggests that various sevices for women players' satisfaction required. 3) As it is stated in, bowling alley managers and staff need to offer better service for women players. 4) For this research, only a few public workers and others were availabe for the research subject and so it is thought that more research and study need to take place with these group of players.

Cylinder 冷間壓接에 필요한 理論的 荷重 解析

朴炳星,安基元,李龍哲 울산과학대학 1985 연구논문집 Vol.10 No.1

冷間壓接(Cold Pressure Welding)은 주로 상온에서 壓力에 의해 두 금속간을 접합하는 方法으로, 본 연구에서는 상계이론(Upper Bound Method)에 의한 해석적인 방법을 이용하여, Cu-Cu, Cu-Al, Al-Al Cylinder 間의 壓接에 필요한 荷重을 결정하였다. A cold pressure welding is the method bonding between metals by pressure. In this study, the theoretical load necessary to cold Pressure Welding between Al-Al, Al-Cu and Cu-Cu cylinder is determined by the upper-bound method to analylize it.

만 19세 남자의 근시성 굴절이상 결정요인

이상준,안기수,유병철 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Background : Myopia is common condition affecting a significant proportion of the population, particularly in East Asian countries. Although the causes of myopia are unclear, evidence supports both genetic and environmental components among which are higher amounts of near work, years of education and intelligence. We conducted this study in order t o find i nfluencing f actors for myopia of 1 9 years old men who lived i n Busan, Ulsan and Gyeongsangnam-do using health checkup data of conscription. Methods : We screened 66,915 nineteen-years-old conscripts who lived in Busan, Ulsan and Gyeongsangnam-do using subjective visual activity test and noncycloplegic autorefraction test. All refractive data were converted into spherical equivalents and we finally diagnosed 21,445 myopia which defined under -0.5 diopter. At the same time we measured biometric data and collected informations of social factors such as education level and residence area. We estimated influencing factors on myopic refractive error using social factors and biometric factors. Data analysis was performed with descriptive analysis, ANOVA and multiple regression analysis using SPSS Win(ver 12.0K) program. Results : Refractive errors of study subjects are -4.62 ± 1.95D(OD) and -4.36 ± 2.20D(OS). Refractive errors were significantly high in conscripts who lived in small cities(p=0.000), had high education level(p=0.000) and high in stature(p=0.047), -5.10 ± 2.13D, -4.79 ± 1.95D and 4.66 ± 1.94D respectively. The influencing factors of myopic refractive error in 19 years old men who lived in Busan, Ulsan and Gyeongsangnam-do were educational level, residence area, stature and systolic blood pressure(p=0.000). Conclusion : Although genetic factors are significant in the development and progression of myopia, environmental factors are important in prevention of myopia. Our study showed that degrees of myopic refractive error in 19 years old conscripts were influenced by education level, residence area, stature and systolic blood pressure.