Original Articles : Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients

( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3

Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)

전통누룩 진균류를 이용한 입국의 제조 및 입국곰팡이의 동정

김재호 ( Jae Ho Kim ),권영희 ( Young Hee Kwon ),이애란 ( Ae Ran Lee ),김혜련 ( Hye Ryun Kim ),안병학 ( Byung Hak Ahn ) 한국균학회 2012 韓國菌學會誌 Vol.40 No.4

다양한 향미를 가진 막걸리의 개발을 위해 전통누룩으로부터 분리한 곰팡이로 입국을 제조한 후 품질특성을 분석하여 입국의 규격에 적합하며 이취가 없고 관능이 우수한 9균주를 입국 제조용 우수균주로 최종 선발하였다. 선발된 균주는 Aspergillus oryzae(C1-5-2-2, C20-7-3, CN1.3.1-4, CN16.19.1-1, N152-1, N220-1), Mycocladus corymbiferus (N162-2), Rhizopus oryzae(N20), Lichtheimia corymbifera (N21)로 동정되었으며, 제조한 입국의 산도는 5.0~6.8, 당화력은 128~241sp이었다. Various koji were prepared by fungi isolated from traditional nuruk and their quality characteristics were investigated. Acidity and saccharification power of their koji were ranged in 5.0~6.8 and 128sp~241sp. Nine fungi which were showed good quality and sensory evaluation were identified by analysis of their nucleotide sequences with PCR-amplified 18S rDNA internal transcribed spacer-1(ITS-1) and ITS-4 genes. Among them, six strains were identified as Aspergillus oryzae and the other strains were identified as Mycocladus corymbiferus, Rhizopus oryzae, Lichtheimia corymbifera.

한약에 의해 유발된 급성 간질성 신염 2례

김덕윤,박동건,김응석,강영모,양창헌,이정호,이동철,이영현,김정란 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

간질성 신염은 신장의 간질을 선택적으로 침범하는 염증성 질환으로 여러가지 원인에 의해 유발되며, 이 중 약물에 의한 경우는 각종 항생제, 비스테로이드성 진통제, 항경련제, 이뇨제, 면역억제제등에 의한 증례들이 보고되고 있다. 현재 각종 질환-특히 만성질환-의 치료에서 한약이 차지하는 비중이 적지 않으나, 그 각각의 성분들이 유발할 수 있는 부작용들에 대한 연구는 거의 없는 실정이다. 저자들은 관절염 치료를 위해 중국산 한약을 복용한 후 복통, 피로감 및 육안적 혈뇨를 주소로 내원한 두 환자에서, 단백뇨와 신기능 장애를 보여 시행한 신조직 생검상 급성 간질성 신염에 합당한 병리학적 소견을 보이고, 한약 복용 중지 후 급속한 회복을 보여, 한약에 의해 유발된 것으로 사료되는 급성 간질성 신염 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Acute interstitial nephritis is a disease characterized by renal interstitial inflammatory cell infiltration and acute renal functional deterioration. This is caused mainly by antibiotics, NSAID and diuretics such as thiazide, but cases induced by herb medication are rare. We experienced two cases of acute interstitial nephritis after treatment with herb medication. One 71-year-old female patient and the other 60-year-old female were admitted to the hospital because of general weakness and gross hematuria. Microscopic hematuria, pyuria, and proteinuria were presented. After definitive diagnosis with a renal biopsy, we noted rapid recovery of renal function by drug withdrawal and steroid therapy. We report these cases with a review of the referenced literatures. Key Words : Herb medication, Acute Interstitial nephritis.

高天原 神話

李永蘭 대구효성가톨릭대학교 1992 연구논문집 Vol.45 No.1

19세기 말 중국 여성의식의 계몽 : 부전족운동(不纏足運動)

이영란 이화여자대학교 한국여성연구소 : 이화여자대학교 한국여성연구원 2014 여성학논집 Vol.31 No.2

20세기는 중국 여성의 권리가 신장되었던 시기로, 19세기 말 즉 청(淸) 말 중국에서도 여성들을 가정으로부터 사회로 이끌어내고자 하는 움직임이 있었다. 이러한 움직임에 따라 여성들은 점차 변화하는 시대에 맞게 전통의 굴레에서 벗어나 새로운 세계를 향하고자 하는 갈망을 갖게 되었다. 유교사상이 지배적인 명청(明淸) 시기에 여성들은 가부장적 사회 안에서 생활해야 했다. 전족(纏足)은 명대에 이르러 성행하였고, 청대는 전족이 최고 성행을 이룬 시기이다. 높은 신분에서부터 농민층에 이르기까지 전족의 풍습은 확산되었다. 고통을 감수하며 행한 전족으로 여성 자신은 주체적 인격이 상실되고, 남성 중심 사회의 관상 내지 성적 종속물로 기록되었다. 이러한 전족에 대한 반대는 이미 북송말엽 차약수와 정이로부터 시작하였다. 개항 이 후 지식인층 사이에서 전족문제를 제기하였고, 선교사들은 전족의 비인간적 풍습을 규탄하였다. 전족을 하지 못하도록 실천적 운동으로 옮기기 시작한 것은 바로 태평천국시기이다. 태평천국 시기 광서지역 여성들 스스로가 여성들에게 전족을 풀 것을 권유하면서 중국 여성들에게 전족이라는 악습에 대해 생각하게 하는 단서를 마련하였다고 할 수 있다. 국민의 한 구성원으로서의 여성 의식을 갖게 하기 위해 변법지식인은 계몽활동을 하였다. 여전히 남성들이 중심이 된 조직체를 운영하였지만, 전족을 한 여성들과 가족들에게 전족이라는 악습의 폐지로 여성이 국가의 한 일원인 국민으로서 자각할 수 있는 기회를 마련하였다. 결국 그들은 학회 및 보간(報刊)을 통해 여학을 강조하였고 여성을 위한 교육시설을 설립하여 중국 여성의식의 확대를 위한 노력으로 국민국가를 이루고자 하였다. The twentieth century was a period when the rights of Chinese women were enhanced. At the end of the 19th century, which was the end of the Qing Dynasty, there was a movement where women emerged out of their households and into the society. According to this movement, they had a desire to create a new world outside of traditional bridles in order to keep pace with changing times. During the Ming and Qing Dynasties, when Confucianism dominated the society, women had to stay within the framework of the family which limited the social activities of women. Foot binding prevailed during the Ming Dynasty and in particular, the Qing Dynasty experienced the peak in this foot binding custom. It had spread much farther from the upper classes to farmers in rural areas. Through painful foot binding, the subjective personalities of women were lost and they were regarded as objects of enjoyment or sexual subordinates in a male-oriented society. Opposition to foot binding began in Jiruoshui and Chengyi of the late Northern Sung. After the opening of ports to western forces, the issue of foot binding was presented by the intellectuals, and missionaries condemned the inhumane custom. It was during the Taiping Tien-kwoh period that the opposition to foot binding was developed into a practical movement. Women in Guangxi during the Taiping Tien-kwoh were recommended to release themselves from foot-binding, which was a chance for Chinese women to reconsider the evil custom of foot binding. Intellectuals in the Reform Movement led enlightenment activities to inspire women to become subjective women as members of the nation. Organizations involved with the women’s movement in that period were still centered on men, through which women with bound feet and their families could have the opportunity to understand the necessity for foot binding prohibition, and to become aware of themselves as members of their nation. Finally, women’s education was enhanced and welfare services were prepared through academies, newspapers, and magazines, which led to further development, and educational societies for women were established where the nation could make an effort to achieve and then enhance feminine awareness.

보건교사와 일반교사의 성교육 수업실태, 자료 활용도 및 문제해결 요구도 비교

이정란,안숙희,김영혜,조규영 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.2

Purpose : This descriptive study was conducted to compare the teaching status, utilization of the teaching materials, and the need to solve matters of sex education between the school health educators and teachers working in an elementary school in Busan. Method : 182 school health educators and 125 teachers participated in the research. Data was collected using a self-administered questionnaire, and analyzed by frequency and x2 .test using the SPSS WIN 10.0 Program. Results: While school health educators carried out most of the sex education in the extra curriculum and physical education class, teachers did in the regular curriculum and physical education class. Regarding the utilization of the teaching materials on sex education, although the majority of school health educators used the teacher's manual, only a few teachers used it. Most of the school health educators used the ICT teaching materials while only half of the teachers did. Regarding the methods to solve matters on sex education, school health educators responded that a sex-related subject should be combined with a health subject, and an independent sex-related subject was necessary. The teachers, however, responded that it was necessary to secure enough time for sex education, the sex-related subject combined with a health subject was necessary, and there is a need to designate a sex educator. Conclusion: School health educators utilized more teaching materials for sex education and suggested more active methods to solve matters related to sex education. Therefore, school health educators should be more active as sex educators, and the subject of sex education should be adopted as a regular course.

일측 부신 적출이 노화에 따른 백서 부신피질의 형태학적 변화에 미치는 영향

이영호,김수일,박경란,김원식 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

To observe the differences between the morphological changes of the remaining adrenal gland 2, 5, and 8 months after unilateral adrenalectomy and those of the shame-operated group, the adrenal glands were paraffin embedded and followed by H-E and PAS stain for the observation of general morphology, and epon embedded adrenal glands were stained by toluidine blue for the morphometry. The results were as follows. 1. The adrenal weight per 100g of body weight of the unilateral adrenalectomized-rats was heavier by about 85% than those of the shame-operated groups. 2. The thickness of the zona fasciculata of the adrenal gland 2 month after unilateral adrenalectomy increased prominently compared to that of the shame-operated group. And, the thickness of the zona fasiculata of the adrenal gland 5 month after unilateral adrenlectomy was decreased, but the thickness of the zona reticularis was increased compared to that of 2 month after unilateral adrenalectomy. 3. In case of groups were sacrificed 8 month after unilateral adrenalectomy and sham-operation, the thickness of the zona fasciculata of the shame-operated group was increased and the thickness of the zona reticularis was increased compared to the group 2 and 5 month after shame operation. The zonal proportions of the unilateral adrenalectomized-group was similar to those of the group 5 month after unilateral adrenalectomy. 4. The mean volumes of the zona fasciculata cells 2 month and 8 month after unilateral adrenalectomy were increased by 62% and 54% respectively compare to the those of the shame-operated group. 5. There were no significant differences in the lipofuscin amounts were accumulated in the adrenal cortex between the shame-operated and unilateral adrenalectomized-group.

Aflatoxin B_1과 Dexamethasone이 白鼠 肝 Kupffer 細胞와 內皮細胞에 미치는 影響에 關한 走査電子顯微鏡的 硏究

이영호,김수일,박경란,노승무,김원식 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.1

For the study on the effects of aflatoxin B_1 and corticosteroid to the Kupffer cells and endothelial cells of the liver, aflatoxin B_1(1mg/kg) and dexamethasone(4mg/kg) were administrated to the 3 groups of rats; the aflatoxin B_1-treated group, the dexamethasone-treated group, and the aflatoxin B_1 and dexamethasone-treated group. The liver tissues were fixed by perfusion with 0.5% glutraldehyde and 0.5% paraformaldehyde solution at 1, 12, and 24 hours after the administration. The fixed liver tissues were cracked and observed Kupffer cells and endothelial cells under scanning electron microscope. The results were as follows; 1. In aflatoxin B_1-treated group, the Kupffer cells were destructed severely and the endothelial cells were destructed partially. 2. In dexamethasone-treated group, the cytoplasmic processes of the Kupffer cells were shortened, but the endothelial cells showed no morphological changes. 3. Destructive changes of Kupffer cells and endothelial cells in the aflatoxin B_1-treated group were reduced after administration of dexamethasone. 4. The large Kupffer cells were destructed and disappered after administration of aflatoxin B_1, but small Kupffer cells were found until 24 hours after administration. 5. In aflatoxin B_1 and dexamethasone treated group, Kupffer cells were destructed severely but the capacity to catch foreign particles were remained. Accordingly, it is considered that aflatoxin B_1 will destruct Kupffer cells severely and the endothelial cells partially, but dexamethasone will reduce the destructive changes of the Kupffer cells and endothelial cells induced by aflatoxin B_1 respectively.

특발성 과호산구 증후군 환자의 치료 도중 발생한 간혈종 1례

이영태,김동기,박지훈,김윤정,김기향,박보민,권민정,김애란,이원식,주영돈,손창학 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Idiopathic hypereosinophilic syndrome is characterized by marked elevation of eosinophil count ( >1,500/㎣) in peripheral blood without explaining etiology. It shows tissue involvement in many organs such as liver, G-I tract, myocar dium, lung, skin, kidney and nerve. Some case of hypereosinophilic syndrome with hepatic involvement have been reported, but not much. We have recently experienced a case with idiopathic hypereosinophilic syndrome of a 40 year old man who presented with RUQ pain. By abdominal CT, ill- defined subcapsular hematoma was detected. Liver biopsy showed eosinophilic infiltration within the portal tract and sinusoid. Drain procedure and corticosteroid adminiiatbrought marked improvement of clinical manifestation, hematologic abnormality and radiologic abnormality.

日本天孫降臨神話考

李永蘭 대구효성 가톨릭 대학교 1988 연구논문집 Vol.36 No.1