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일본문학의 특수성과 국제성 : 카와바타(川端)와 오오에(大江)문학의 세계화 과정
최재철 한국일어일문학회 2000 日語日文學硏究 Vol.36 No.1
文學の世界化の段階は一國の文化の總體的な水準を計る尺度であると言える. 本稿では日本文學の世界化の過程を考察し, 韓國文學の世界化に寄與する道を摸索してみた. まず, 日本文學の特殊性と國際性に關して, 二人のノ-べル賞受賞作家の場合を調べてみた. 川端文學の場슴は'四季'の表現を中心に日本的な傳統に根差した特殊性を, 大江文學の場合は'個人的な體驗'の普遍化という側面から一般化·國際化されやすい傾向があるという点を明らかにした. そして, このような川端と大江文學の世界化の過程について, ノ-べル文學賞受賞までの過程を海外への飜譯及び紹介, 海外との文學交流など具體的な資料を添附して檢討した. 以上により, 一國の文學がいろいろな國へ知られるようになるまでにはいくつかの複合的な段階を經なければならないということを確認することができた. 文學の世界化は良質の作品·作家·飜譯者·出版社·評者-の確保, 文化の紹介の擴充, 國家イメ-ジの改善, 外郭團體の支援などが渾然一體になってはじめて可能な, 一國の文化と精神, 力量の總合で成し遂げられる課業であると言えよう.
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최재철,오승환,이대동,김형회,이은엽 대한진단검사의학회 2005 Annals of Laboratory Medicine Vol.25 No.3
Background : Mutations of the tumor suppressor gene p53 cause subsequent cellular accumulation of p53 gene product and a specific immunologic response. Detection of circulating antibodies against p53 protein has been evaluated for a tumor marker or prognostic factor for several cancers including those of the breast, stomach, ovary and lung. Methods : Serum samples from 74 colorectal cancer patients were obtained preoperatively and anti-p53 antibody was measured by enzyme immunoassay (Anti-P53 ELISA II: PharmaCell, France). Carcinoembryonic antigen (CEA) and Carbohydrate antigen (CA) 19-9 were measured in parallel. Tissue p53 protein expression was examined by immunohistochemical staining. Results : Anti-p53 antibodies were positive in the serum from 34% (25/74) of patients, but normal controls were all negative. Anti-p53 antibodies were significantly associated with p53 protein overexpression. CEA and CA19-9 were detected in 38% and 11%, respectively. There was no correlation among anti-p53 antibody, CEA and CA19-9. No differences were found between the anti-p53 antibody positive and negative groups in the following parameters: tumor site, histologic grades, Dukes stages, margin invasion, vessel invasion, lymph node and distant metastasis, and survival duration. Conclusions : The measurement of serum anti-p53 antibody is not suitable for preoperative markers of prognostic significance, but can be used as a simple serological marker for detection of p53 alteration. There should be more studies of the serum p53 antibody as a possible marker for postoperative monitoring in colorectal cancer. 배경 : 종양억제유전자 p53의 돌연변이로 인해 축적된 p53 단백은 특이면역반응을 일으켜 혈청 내 p53 항체를 생성한다. 유방암, 난소암, 폐암 등에서 p53 항체가 종양표지자로서 예후와 관련되어 평가되어왔다. 대장암 환자에서 혈청 p53 항체를 측정하고다른 종양표지자와의 연관성 및 임상적 의의를 평가하고자 하였다.방법 : 74명의 대장암 환자에서 술전에 채취한 혈청을 사용하여효소면역법으로 p53 항체, CEA, CA19-9을 측정하였다. 동시에일부 절제된 종양 조직의 p53 단백발현을 면역조직화학학적으로염색하였다.결과 : 혈청 p53항체는 대장암 환자의 34% (25/74)에서 양성이었고, 정상인에서는 모두 음성이었다. 혈청 p53 항체 양성과조직 p53 단백 발현 사이에 유의한 관계가 있었다. CEA, CA19-9은 각각 환자군의 38%, 11%에서 양성이었고 이들 종양표지자들간에는 유의한 연관성이 없었다. p53 항체 양성과 음성군에서 종양의 위치, 크기, 조직학적 분류, 침범정도, 혈관 침범, 림프절 침윤, 절제 부위 침범, 원격 전이 유무, 생존 기간에서 유의한 차이는 없었다. 결론 : 혈청 p53 항체는 단독적인 예후 인자로 사용하기에는 부적절하며, 기존의 종양표지자와 달리 발생기전과 관련된 종양의 생물학적 표지자로서 p53 유전자의 변이를 반영하는 것으로 생각된다. 혈청 p53 항체는 높은 특이도를 가지고 있어 향후 이들 환자의 절제 후 p53 항체의 측정을 통해 경과관찰 용도의 사용가능성에 대한 연구가 필요할 것으로 생각된다.
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Are in-Hospital Delays Important Obstacles in Thrombolytic Therapy Following Acute Ischemic Stroke?
최재철,강사윤,강지훈,고여주,배종면 대한신경과학회 2007 Journal of Clinical Neurology Vol.3 No.2
Background and purpose: The advances in the diagnosis and treatment of acute stroke increase the importance of providing these patients with timely medical attention. This study was designed to assess time delays in neurological evaluation and neuroimaging and to determine whether they are important obstacles to performing thrombolytic therapy. Methods: Data were obtained between May 2004 and September 2006 from 195 consecutive patients who were admitted to Cheju National University Hospital for acute ischemic stroke within 24 hours of the onset of symptoms. We determined the time of the onset of symptoms, arrival time at the emergency department (ED), and times of neurology notification, neurology evaluation, and neuroimaging using interviews and by reviewing the medical record. Results: Short onset-to-door time, performing computed tomography rather than magnetic resonance imaging, presence of aphasia or motor weakness, and severe initial neurological deficit were significantly associated with reduced in-hospital delays. Seventeen (20%) of the 85 patients who arrived within 3 hours of the onset of symptoms received intravenous thrombolysis. Mild neurological deficit, rapidly improving symptoms, and insufficient time to workup were the main causes of the nonreceipt of thrombolytic therapy in these patients. Only one patient did not receive thrombolytic therapy due to delay in neurology consultation. Conclusions: Whilst in-hospital delays were not major obstacles to performing thrombolytic therapy in this study, there is still a high probability of missing patients with mild-to-moderate stroke symptoms. More effective in-hospital organization is required for the prompt evaluation and treatment of patients with acute ischemic stroke.
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