프로 스포츠 활동에서의 윤리적 가치 일탈의 문제

정의권,임석원 중앙대학교 스포츠과학연구소 2003 體育硏究 Vol.- No.19

The essence of sportsmanship as applied to athletics can be determined by the application of the same principle. Honorable victory is the goal of the athlete and, as a reretended to a certain moral relevancy, although its precise place among the moral virtues has been uncertain. In spite of this confusion, distinguished advsult, the code of the athlete demands that nothing be done before, during, or after the contest to cheapen or otherwise detract from such a victory. Fairness or fair play, the pivotal virtue in athletics, emphasizes the need for an impartial and equal application of the rules if the victory is to signify, as it should, athletic excellence. Modesty victory and a quiet composure in defeat testify to an admirable and extraordinary self-control and, in general, dignify and enhance the goal of the athlete.

Loss of Primary Cilia Results in the Development of Cancer in the Murine Thyroid Gland

이정의,이신애,장준영,김정태,설혜정,박기철,Xuguang Zhu,Sheue-yann Cheng,Jukka Kero,김준,송민호 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.2

Communications at the interface between the apical membrane of follicular cells and the follicular lumen are critical for the homeostasis of thyroid gland. Primary cilia at the apical membrane of thyroid follicular cells may sense follicular luminal environment and regulate follicular homeostasis, although their role in vivo remains to be determined. Here, mice devoid of primary cilia were generated by thyroid follicular epithelial cell-specific deletion of the gene encoding intraflagellar transport protein 88 (Ift88 ). Thyroid follicular cell-specific Ift88-deficient mice showed normal folliculogenesis and hormonogenesis; however, those older than 7 weeks showed irregularly dilated and destroyed follicles in the thyroid gland. With increasing age, follicular cells with malignant properties showing the characteristic nuclear features of human thyroid carcinomas formed papillary and solid proliferative nodules from degenerated thyroid follicles. Furthermore, malignant tumor cells manifested as tumor emboli in thyroid vessels. These findings suggest that loss-of-function of Ift88/primary cilia results in malignant transformation from degenerated thyroid follicles.

지방산업활성화 정책과 벤처기업 육성대책

鄭義光 경성대학교 산업개발연구소 1998 산업혁신연구 Vol.14 No.-

Increased Primary Cilia in Idiopathic Pulmonary Fibrosis

이정의,오동현,박기철,최지은,권종범,이종호,박건,설해정 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.3

Primary cilia are solitary, non-motile, axonemal microtubule-based antenna-like organelles that project from the plasma membrane of most mammalian cells and are implicated in transducing hedgehog signals during development. It was recently proposed that aberrant SHH signaling may be implicated in the progression of idiopathic pulmonary fibrosis (IPF). However, the distribution and role of primary cilia in IPF remains unclear. Here, we clearly observed the primary cilia in alveolar epithelial cells, fibroblasts, and endothelial cells of human normal lung tissue. Then, we investigated the distribution of primary cilia in human IPF tissue samples using immu-nofluorescence. Tissues from six IPF cases showed an increase in the number of primary cilia in alveolar cells and fibroblasts. In addition, we observed an increase in ciliogenesis related genes such as IFT20 and IFT88 in IPF. Since major components of the SHH signaling pathway are known to be localized in primary cilia, we quantified the mRNA expression of the SHH signaling components using qRT-PCR in both IPF and control lung. mRNA levels of SHH, the coreceptor SMO, and the transcription factors GLI1 and GLI2 were upregulated in IPF compared with control. Furthermore, the nuclear localization of GLI1 was observed mainly in alveolar epithelia and fibroblasts. In addition, we showed that defective KIF3A-mediated ciliary loss in human type II alveolar epithelial cell lines leads to disruption of SHH signaling. These results indicate that a significant increase in the number of primary cilia in IPF contributes to the upregulation of SHH signals.

BRAFV600E 형질전환 마우스를 이용한 갑상선유두암 모델의 확립

이정의,정경혜,조영석,송민호 대한갑상선학회 2011 International Journal of Thyroidology Vol.4 No.1

Background and Objectives: The BRAF^(V600E) mutation has been regarded as the leading cause of papillary thyroid cancer (PTC). However, the multi-step carcinogenic process induced by BRAF^(V600E) has been remained to be elucidated in thyroid gland. In this study, to investigate staged development of papillary thyroid carcinoma, we observed the histo-pathological findings of thyroid gland from BRAF^(V600E) transgenic mice with a period of 60 weeks. Materials and Methods: We histologically inspected 3, 9, 20, 27, 39, 44, 48 and 60 week old BRAF^(V600E) transgenic mice derived from FVB/N background mice with a bovine thyroglobulin promoter which are providing thyroid specific BRAF^(V600E) expression. Results: Thyroid glands from 3 and 9 week old BRAF^(V600E)transgenic mice were enlarged and showed abnormal histologic feature such as distorted follicular architectures. The 20 and 27 week old BRAF^(V600E) transgenic mice showed irregularly enlarged thyroid gland sprouting out above the carotid arteries. Thyroid gland derived from 39 week old mice showed reduced formation of intact follicular structure and increased solid area. Thyroid glands were entirely replaced by firm tumor mass composed of poorly differentiated cell at 44 weeks. Interestingly, we could observe tracheal invasion, surrounding muscle invasion in thyroid gland from 48 week old mice and detect lung metastasis in 60 week old mice. Conclusion: Thyroid specific expression of BRAF^(V600E) induced staged development of thyroid cancer. This finding may support that BRAF^(V600E)have a role in entire carcinogenic process such as tumor initiation, development and progression.

해마 서식지 혼재 어류상

이정의,이윤호,최영웅,정민민,김재우,노섬,김성철 한국양식학회 2007 韓國養殖學會誌 Vol.20 No.1

NAD(P)H: Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 Polymorphisms in Papillary Thyroid Microcarcinoma: Correlation with Phenotype

이정의,김군순,이민호,김연수,이민희,이승은,김용경,유민정,김성정,최민정,조영석 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.5

Purpose: NAD(P)H:Quinone Oxidoreductase 1 (NQO1) C609T missense variant (NQO1*2) and 29 basepair (bp)-insertion/deletion (I29/D) polymorphism of the NRH:Quinone Oxidoreductase 2 (NQO2) gene promoter have been proposed as predictive and prognostic factors for cancer development and progression. The purpose of this study is to investigate the relationship between NQO1/NQO2 genotype and clinico-pathological features of papillary thyroid microcarcinoma (PTMC). Materials and Methods: Genomic DNA was isolated from 243 patients;and clinical data were retrospectively analyzed. NQO1*2 and tri-allelic polymorphism of NQO2 were investigated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Results: PTMC with NQO1*2 frequently exhibited extra-thyroidal extension as compared to PTMC with wild-type NQO1 (p=0.039). There was a significant relationship between I29/I29 homozygosity of NQO2 and lymph node metastasis (p=0.042). Multivariate analysis showed that the I29/I29 genotype was associated with an increased risk of lymph node metastasis (OR, 2.24; 95% CI, 1.10-4.56; p=0.026). Conclusion: NQO1*2 and I29 allele of the NQO2 are associated with aggressive clinical phenotypes of PTMC, and the I29 allele represents a putative prognostic marker for PTMC.

HIF-1α Expression in BRAFV600E-Positive Papillary Thyroid Microcarcinoma

이정의,김군순,설혜정,이동호,이관주,송민호,조영석 대한갑상선학회 2011 International Journal of Thyroidology Vol.4 No.2

Background and Objectives: Recent studies have reported that vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF)-1α are up-regulated in BRAF^(V600E)-positive papillary thyroid carcinoma (PTC). We investigated whether papillary thyroid microcarcinomas (PTMCs) also exhibited increased expression of VEGF and HIF-1α. In addition, we analyzed the relationship between BRAF^(V600E) mutation and clinicopathological parameters, as well as HIF-1α expression in PTMC. Materials and Methods: We retrospectively selected 225patients with PTMC. Immunohistochemical staining for HIF-1α and VEGF was performed using paraffinembedded PTMC tissue microarrays. BRAF^(V600E) mutation status was analyzed by dideoxy sequencing. Results:PTMCs larger than 0.5 cm tend to be related to aggressive clinicopathological features such as thyroid capsular invasion (p=0.023) and bilaterality (p=0.047). Immunoreactivity to HIF-1α (20.7%) and VEGF (30.2%) was more prominent in PTMCs as compared to normal follicular cells. However, HIF-1α and VEGF expression was not correlated with clinicopathological features. BRAF^(V600E) mutation was found in 70.7% (159/225) of the PTMC cases. PTMCs harboring the BRAF^(V600E) mutation exhibited larger tumor sizes as compared to PTMCs without the BRAF^(V600E) mutation (p=0.038). However, BRAF^(V600E) mutation status did not correlate with the expression of HIF-1α(p=0.623) or VEGF (p=0.990). Conclusion: HIF-1α and VEGF were more frequently detected in PTMCs as compared to normal thyroid tissues. However, BRAF^(V600E) mutation status was not correlated with the expression of HIF-1α or VEGF in PTMCs.

바다를 향한 새로운 도전!!!

이정의 한국수산과학회 양식분과 2005 韓國養殖 Vol.17 No.2

중고등학교 도서관 교육과정의 구성과 그 전개

정의순,Jeong, Ui-Sun 한국도서관협회 1967 圖協月報 Vol.8 No.7