Two Series of Familial Cases With Unclassified Interstitial Pneumonia With Fibrosis

이은,서주희,Hyoung-Young Kim,유진호,송진우,박영수,장세진,도경현,권지원,박성우,Jeong-hwan Park,홍수종 대한천식알레르기학회 2012 Allergy, Asthma & Immunology Research Vol.4 No.4

Several children presenting with mild symptoms of respiratory tract infection were diagnosed with unclassified interstitial pneumonia with fibrosis. Their clinical and radiological findings were similar to those of acute interstitial pneumonia, but there were some differences in the pathological findings. Unclassified interstitial pneumonia with fibrosis is characterized by histological findings of centrilobular distribution of alveolar damage and bronchiolar destruction with bronchiolar obliteration. This report describes two different series of familial cases of unclassified interstitial pneumonia with fibrosis, which developed almost simultaneously in the spring. Some of the individual cases showed rapidly progressive respiratory failure of unknown cause, with comparable clinical courses and similar radiological and pathological features, including lung fibrosis. Each family member was affected almost simultaneously in the spring, different kinds of viruses were detected in two patients, and all members were negative for bacterial infection, environmental and occupational agents, drugs, and radiation. These findings implicate a viral infection and/or processes related to a viral infection, such as an exaggerated or altered immune response, or an unknown inhaled environmental agent in the pathogenesis of unclassified interstitial pneumonia with fibrosis.

정서 사진에 대한 정서 반응성 : 평가 공간에서의 분포

이은,강지인,박성혁,전종희,최재혁,김재진,안석균 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.1

Objectives : To investigate the nature of emotional responsiveness in norma) adults, we exam the emotional responses to emotional pictures in an evaluative space defined by arousal and valence. Methods : Subjects were instructed to rate the arousal and valence that they experienced from the presentation of one of two sets of 60 emotional pictures. These two picture sets were comprised of 107 pictures : 101 selected from Intetnational Affective Pictures System and six pictures from our own collection. According to "evaluative space model", the authors set an evaluative space defined by the arousal scores as independent variable and the valence scores as dependent variable. In this evaluative space, one-hundred-and-seven pairs of coordinates representing respective emotional pictures were plotted. With regression analyses, the steepness of the regression lines on the plots with positive emotional responsiveness (n=51) and those with negative emotional responsiveness (n=56) were compared. Results : In the evaluative space, the regression line of negative emotional responsiveness was significantly different from that of positive responsiveness. The slope of negative responsiviveness was significantly steeper than that of positive responsiveness. At a low arousal level, the absolute valence of a positive stimuli was larger than that of a negative picture. Conclusion : This finding indicates that the function of the negative affective responsiveness might be different from that of the positive responsitiveness. IAPS also seems applicable to Korean subjects.

불면증 약물요법의 허와 실

이은 대한의사협회 2015 대한의사협회지 Vol.58 No.9

The consultation of personnel in relation to sleep disorders in Korea increased by 1.6 times between 2008 and 2012, and the related days of clinical practice increased by nearly 12 times during the same period. Among the sleep disorders, the most common diagnosis is insomnia, which is most commonly treated with medication. Medication is not only easy to access, but also effective immediately. However, the beneficial effect of hypnotic medication on sleep disorder for an extended period of time may be trivial. Tolerance is another barrier to treating chronic insomnia. In addition, such adverse effects as psychomotor slowing, memory loss, forgetfulness, and decreased sense of balance can heighten the risk of motor vehicle accidents and falling-related injuries. Recently, there have been reports about the association between the chronic use of sleeping pills and cancer mortality and dementia incidence. However, there are still many limitations to understanding whether it is the chronic use of hypnotics, or coexisting mental and physical illness, which increases the risk. Nevertheless, it is worthwhile to pay special attention to the abovementioned risks when using hypnotics and to consider alternative treatment options like cognitive behavioral therapy for insomnia.

용융탄산염 연료전지용 리튬첨가 Ni-Al 합금 연료극의 제조 및 특성

이은,윤성필,한종희,남석우,임태훈,홍성안,이호인 한국공업화학회 2004 한국공업화학회 연구논문 초록집 Vol.2004 No.1

급여사료의 질과 반추위내 섬모충의 일주변동과의 상호관계

이은,최무영 한국낙농학회 1992 韓國酪農學會誌 Vol.14 No.4

급여사료의 질을 달리한 조건에서 반추위내 섬모충의 총수, Entodinium, Diplodinium, Holotrichs 및 기타종들의 일주변동을 측정했다. 사료의 질에 관계없이 섬모충 총수, Entodinium의 수, Holotrichs의 수는 사료급여 후 수시간내에 하락하고 사료급여 직전에 회복되는 일주변동경향을 나타냈다. 그러나 경시적 증감폭과 변동시점은 사료의 질에 따라 상당한 차이를 보였으며 Diplodinium속 섬모충은 조사료 단일급여 조건에서 사료급여 후 5시간 후에 최고수치를 보여 사료의 질에 따라 일주변동경향에 상당한 차이를 나타냈다. The Diurnal fluctuations of total rumen ciliates, Entodinium, Diplodinium and Holotrichs were investigated in the various diet condition. The fluctuations of total rumen ciliates, Entodinium and Holotrichs were showed tendancy of marked decrease after feeding and began to increase several hours prior to following feeding in all the diet condition. However, the length of fluctuation and changing point were differed with the diet condition and the fluctuation of Diplodinium ciliates was differed from those of other ciliates in the roughage diet condition, which was showed maximum numbers at five hours after feeding.

Clinical characteristics and outcomes among pediatric patients hospitalized with pandemic influenza A/ H1N1 2009 infection

이은,서주희,김형영,나신,김성한,권지원,김병주,홍수종 대한소아청소년과학회 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.8

Purpose: The purpose of this article is to describe the clinical and epidemiologic features and outcomes among children hospitalized with pandemic influenza A/H1N1 2009 infection. Methods: We retrospectively reviewed the charts of hospitalized pediatric patients (<18 years) diagnosed with pandemic influenza A/H1N1 2009 infection by reverse-transcriptase polymerase chain reaction at a tertiary hospital in Seoul, Korea, between September 2009 and February 2010. Results: A total of 72 children were hospitalized with pandemic influenza A/H1N1 2009 infection (median age, 6.0 years; range, 2months to 18 years). A total of 40% had at least 1 underlying medical condition, including asthma (17%), malignancies (19%), and heart diseases (17%). Of the 72 patients, 54 (76%) children admitted with H1N1 infection showed radiographic alterations compatible with pneumonia. There was no significant difference in pre-existing conditions between pandemic influenza A/H1N1 infected patients with or without pneumonia. Children with pandemic influenza A/H1N1 pneumonia were more likely to have a lower lymphocyte ratio (P=0.02), higher platelet count (P=0.02), and higher level of serum glucose (P=0.003), and more commonly presented with dyspnea than did those without pneumonia (P=0.04). Conclusions: No significant differences in age, sex, or presence of preexisting conditions were found between children hospitalized with pandemic influenza A/H1N1 H1N1 influenza infection with pneumonia and those without pneumonia. Higher leukocyte count, higher glucose level, and a lower lymphocyte ratio were associated with the development of pandemic A/H1N1 2009 influenza pneumonia.

A case report of chronic granulomatous disease presenting with aspergillus pneumonia in a 2-month old girl

이은,오석희,권지원,김병주,유진호,박찬정,홍수종 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.6

Chronic granulomatous disease (CGD) is an uncommon inherited disorder caused by mutations in any of the genes encoding subunits of the superoxide-generating phagocyte NADPH oxidase system, which is essential for killing catalase producing bacteria and fungi, such as Aspergillus species, Staphylococcus aureus,Serratia marcescens, Nocardia species and Burkholderia cepacia . In case of a history of recurrent or persistent infections, immune deficiency should be investigated. Particularly, in the case of uncommon infections such as aspergillosis in early life, CGD should be considered. We describe here a case of CGD that presented with invasive pulmonary aspergillosis in a 2-month-old girl. We confirmed pulmonary aspergillosis noninvasively through a positive result from the culture of bronchial alveolar lavage fluid, positive serological test for Aspergillus antigen and radiology results. She was successfully treated with Amphotericin B and recombinant IFN-γ initially. Six weeks later after discharge, she was readmitted for pneumonia. Since there were infiltrates on the right lower lung,which were considered as residual lesions, voriconazole therapy was initiated. She showed a favorable response to the treatment and follow-up CT showed regression of the pulmonary infiltrates.

한국산 반추가축의 (反芻家畜) 제일위내 미생물상에 관한 연구 - I. 경북지방을 중심으로

이은,이학철 ( Eun Lee,Hak Chul Lee ) 한국낙농학회 1982 韓國酪農學會誌 Vol.4 No.1

頭位변환에 따른 회전성 현훈증에서 澤瀉湯加味方 투여 20例의 임상고찰

이은,박병욱,고흥 대한동의생리학회,대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.6

This study is to investigate the effect of Taksa-tang(Zexie-tang) on positional vertigo patients. we examined the degree of vertigo and divided 5 grade. In addition we made a diagnosis of vertigo's origin by clinical symptoms, brain-CT and nystagmus test. we divided patients two groups (A and B). A group(11 patients) was taken Taksa-tang (Zexie-tang)(three times a day), Dix-Hallpike maneuver, acupuncture(one time a day) and cupping (one time a day). B group(9 patients) was only taken Taksa-tang(Zexie-tang(three times a day). After treatment, 2 month later we rechecked the degree of vertigo, reattack and remainder symptoms in two groups. Benign positional paroxysmal vertigo was present in 85%, structural lesion of the cerebellum was founded in 10%. In A group, disappearance of symptoms was founded in 64%, improvement was founded in 36%, reattack was founded in 18%. On the contrast, in B group, disappearance of symptoms was founded in 44%, improvement was founded in 33%, reattack was founded in 22% and no response was founded in 11%. Taksa-tang(Zexie-tang) was efficacious against typical features of benign positional paroxysmal vertigo(BPPV) in the acute stage.

Prevalence and clinical manifestations of macrolide resistant Mycoplasma pneumoniae pneumonia in Korean children

이은,조현주,홍수종,이진아,성흥섭,유진호 대한소아청소년과학회 2017 Clinical and Experimental Pediatrics (CEP) Vol.60 No.5

Purpose: Macrolide resistance rate of Mycoplasma pneumoniae has rapidly increased in children. Studies on the clinical features between macrolide susceptible-M. pneumoniae (MSMP) and macrolide resistant-M. pneumoniae (MRMP) are lacking. The aim of this study was to identify the macrolide resistance rate of M. pneumoniae in Korean children with M. pneumoniae penupmonia in 2015 and compare manifestations between MSMP and MRMP. Methods: Among 122 children (0–18 years old) diagnosed with M. pneumoniae pneumonia, 95 children with the results of macrolide sensitivity test were included in this study. Clinical manifestations were acquired using retrospective medical records. Results: The macrolide resistant rate of M. pneumoniae was 87.2% (82 of 94 patients) in children with M. pneumoniae pneumonia. One patient showed a mixed type of wild type and A2063G mutation in 23S rRNA of M. pneumoniae. There were no significant differences in clinical, laboratory, and radiologic findings between the MSMP and MRMP groups at the first visit to our hospital. The time interval between initiation of macrolide and defervescence was significantly longer in the MRMP group (4.9±3.3 vs. 2.8±3.1 days, P=0.039). Conclusion: The macrolide resistant rate of M. pneumoniae is very high in children with M. pneumoniae pneumonia in Korea. The clinical manifestations of MRMP are similar to MSMP except for the defervescence period after administration of macrolide. Continuous monitoring of the occurrence and antimicrobial susceptibility of MRMP is required to control its spread and establish strategies for treating second-line antibiotic resistant M. pneumoniae infection.