폐암의 표지자로써 Cyfra 21 - 1 의 유용성

박현덕(Hyun Duk Park),정현식(Hyun Sik Jeong),박정식(Jeung Sik Park),임성호(Sung Ho Lim),이은정(Eun Jung Lee),윤중원(Jung Won Yun),정수석(Su Suk Jung),신호철(Ho Cheol Shin),이승세(Seung Sei Lee) 대한내과학회 2002 대한내과학회지 Vol.62 No.4

목적 : 폐암에 대한 종양표지자로서는 암태아성 항원 (CEA), 편평세포암 항원 (SCC Ag), 신경원 특이성 에놀라제 (NSE) 등이 있으나 Cyfra 21-1은 최근에 발견된 종양표지자로서 비소세포성 폐암에 민감도가 우수한 것으로 보고되고 있다. 본 연구에서는 폐암에서 Cyfra 21-1의 민감도를 알아보고 폐암의 병기와의 관계를 알아 보았다. 대상과 방법 : 환자는 강북삼성병원에 입원하여 조직학적 및 세포병리검사상 확진된 폐암환자 110명을 대상으로 연구하였고 환자의 혈청에서 CEA, SCC Ag, NSE, Cyfra 21-1을 측정하였다. 결과 : 전체 폐암 환자에서 종양표지자의 민감도는 Cyfra 21-1이 51.8%였다. Cyfra 21-1의 양성율은 선암에서 63.2%, 편평세포암에서 54.1%, 소세포암에서 40.0%였고, 소세포암에 비해 선암과 편평세포암에서 통계학적으로 유의하게 (p<0.05) 높게 측정되었다. 병기에 따른 Cyfra 21-1의 민감도는 다른 종양표지자보다 양성율이 높고 T 병기가 진행하면서 높아지는 경향이 있었지만 통계적인 유의성은 없었고 림프절의 전이와 타장기로의 전이 유무에 따른 Cyfra 21-1의 양성율도 통계적으로 유의한 차이는 없었다. 선암과 편평세포암에서 병기에 따른 Cyfra 21-1의 평균치는 병소의 크기가 증가함에 따라 증가하지만 통계적인 유의성이 없었고 림프절 침범과 타장기로의 전이 유무에 따른 Cyfra 21-1의 농도의 변화도 통계적으로 유의한 차이는 없었다. 결론 : 본 연구에서 Cyfra 21-1은 폐암에서 기존의 종양표지자와 비교해 볼 때 상대적으로 가장 높은 양성율을 보이며 특히 비세포암에서 선별검사시 기존의 종양표지자와 함께 사용하면 더욱 유용하게 사용할 수 있다. 종양의 크기에 따라서 Cyfra 21-1 측정치도 증가하는 경향을 보이지만 통계적인 유의성은 없었고 조직학적인 아형에 따라서는 선암의 경우가 편평세포암의 경우보다 높게 나와 다른 기관의 연구와 상의한 결과를 보였다. Background : Cytokeratins are epithelial markers whose expressions are not lost during malignant transformation. The utility of cytokeratin fragment (Cyfra) 21-1, a new tumor marker, was investigated in 110 patients with lung cancer. The aims of this study were to confirm sensitivity of Cyfra 21-1 in detecting non-small cell cancer, to assess the potential relationship between Cyfra 21-1 and disease stage of the lung cancer. Methods : We measured serum levels of four tumor marker (NSE, CEA, SCC Ag, Cyfra 21-1) in 110 patients with lung cancer. The measurement of serum level of Cyfra 21-1 was performed with a cut off value of 3.3 ng/mL. An immunoradiometric assay was used to detect a fragment of the cytokeratin 19. The patients were grouped according to the stage of the disease and tumor type. Results : Overall sensitivity of Cyfra 21-1 was relatively high (51.8%) than others tumor markers. Sensitivity of this marker was especially high for adenocarcinoma (63.2%) and squamous cell carcinoma (54.1%). In contrast, sensitiviy of Cyfra 21-1 was relatively low for small cell lung carcinoma (40.0%). Serum levels of Cyfra 21-1 were higher in advanced nonsmall cell lung cancer than early stage disease. Conclusion : We conclude that Cyfra 21-1 is a sensitive tumor marker of nonsmall cell lung cancer, especially adenocarcinoma and also may be a useful adjunctive marker for disease monitoring.(Korean J Med 62:415-421, 2002)

도축돈의 호흡기질병에 관한 연구

이은정 ( Eun Jeong Lee ),박경재 ( Kyung Jae Park ),이청산 ( Cheong San Lee ),손현수 ( Hyun Soo Son ),김원설 ( Won Seoul Kim ) 한국가축위생학회 2000 韓國家畜衛生學會誌 Vol.23 No.3

A survey on pneumonic lungs and its histopathological changes of the slaughtered pigs from the southern area of Chungbuk province was carried out during the period from January to December 1999. Pneumonic lungs were attempted bacteriological findings and antibiotic susceptibilities. The results obtained were as follows; 1. Of 158 slaughtered pigs, 97(61.4%) pigs had pneumonic lesions in the lung, and the prevalence was high in winter, spring, autumn, and summer in order. 2. The bacteria isolated from pneumonic lesions were pasteurella spp, 13 heads(34.2 %), streptococcus spp, 6(15.8 %), actinobacillus spp, 3(7.9 %), coliform 4(10.5 %) and the other bacteria, 12(31.6 %). 3. These isolates were highly susceptible to the antibiotics of enrofloxacin 30(78.9 %), cephalothin 28(73.6 %) and ceftiofur 27(71 %). 4. Histopathologically, swine enzootic pneumonia and pleuropneumonia lesions were observed. The swine enzootic pneumonia lesions were consisted of peribronchiolar lymphoid hyperplasia and exudate in alveolar lumen. The pleuropneumonia lesions were consisted of thrombosis, alveolar wall thickened by mononuclear cells and neutrophil deposition.

국어교사의 비대면 쓰기 지도 실태 조사 연구

이은정 ( Lee¸ Eun-jeong ),박현 ( Park¸ Hyun ),백유진 ( Baek¸ Yu-jin ) 한국어교육학회 2021 국어교육 Vol.- No.174

This study suggests effective ways to teach writing in the post COVID-19 era by analyzing the condition of non-face-to-face writing instruction in Korean class. For doing this, the study analyzed the results of a survey of 130 in-service Korean language teachers on the status, method, content of writing instruction and their perception on the writing instruction. The results are as follows. First, Korean language teachers mainly instructed writing by using face-to-face and non-face-to-face methods parallelly amid the COVID-19 pandemic. Second, in non-face-to-face situations, Korean language teachers mainly instructed writing by using videos in online classes. Third, Korean language teachers addressed “writing expressing friendship and emotions” the most in non-face-to-face writing instruction. Fourth, in non-face-to-face situations, Korean language teachers tended to perceive the reviewing process as the most difficult process and the content generating process as the easiest process to instruct in the writing process. Finally, Korean language teachers tended to perceive face-to-face writing instruction as the most effective method for writing instruction.

TENG 기반 회전 마찰발전에서 외부환경 잡음 최소화 방안 연구

박현문(Park Hyun-moon),조영민(Cho Youngmin),용마리나(Yong Marina),이은정(Lee eun jeong),최주호(Choi Juho) 한국통신학회 2023 한국통신학회 학술대회논문집 Vol.2023 No.6

조갑하 편평 상피세포암

박현정,박철종,이종육,김형옥,이은정 ( Hyun Jeong Park,Chul Jong Park,Jong Yuk Yi,Hyung Ok Kim,Eun Jeong Lee ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4

Subungual squamous cell earcinoma is an uncommon disease. Diagnosis of this condition is often delayed because of a resemblance to a variety of benign inflammatory conditions such as onychomycosis, chronic paronychia, eczema, and verruca vulgaris. The importance of an early skin biopsy for a chronic nonhealing subungual lesion is stressed. We present a case of subungual squamous cell carcinoma iri a 75-year-old man who had a 3-year history of intermittent swelling, erythema, and tenderness on the left 5th toe. The patient complained of a tender whitish verrucous 1.5cm-sized mass which had been present for a few months. A Histopathological study revealed invasive, well differentiated squamous cell carcinoma. (Kor J Dermatol 1997;35(4): 790-793)

퇴행성무릎관절염 변증도구 개발에 관한 기초연구

전동휘 ( Dong Hwi Jeon ),이은정 ( Eun Jung Lee ),소현우 ( Hyun Woo So ),황만석 ( Man Suk Hwang ),유정은 ( Jeong Eun Yoo ),박양춘 ( Yang Chun Park ),정인철 ( In Chul Jung ),오민석 ( Min Seok Oh ) 대한한의학회 한방재활의학과학회 2017 한방재활의학과학회지 Vol.27 No.2

Objectives The aim of this study was to develop a standard tool of pattern identification for Knee Osteoarthritis, which will be applied to clinical research. Methods The advisor committee for this study was organized by 11 panel of experts (Korean Rehabilitation Medicine professors, Acupuncture and Moxibustion professors belonging to Korean Medicine colleges, Principal Researcher of Korea Institute of Oriental Medicine, Doctor of Korean medicine). The pattern identifications and symptoms for this tool were extracted from published Korean and Chinese literature. Through the discussion among internal experts and consultation from advisors, the Instrument on Pattern Identifications for Knee Osteoarthritis was developed. Results 1) Five pattern identifications (The Wind, Chill, and Moisture, The Moist-Heat, Blood Stasis, Yang Deficiency of Spleen and Kidney, Yin Deficiency of Liver and Kidney) were set for the tool. 2) The mean weights which represent the importance of each symptom and scored on a hundred-point scale was obtained. 3) The Instrument on Pattern Identifications for Knee Osteoarthritis was designed in the self-reporting format composed of 46 questions. Conclusions The Instrument on Pattern Identifications for Knee Osteoarthritis was created through this study. Though this study is not proved about validity, reliability, the instrument of pattern identification for Knee Osteoarthritis is meaningful and expected to be applied to the subsequent. (J Korean Med Rehabil 2017;27(2):77-91)

돼지 생식기호흡기증후군 바이러스의 Nucleocapsid 단백질 발현 및 진단적 응용

박효선,한태욱,김현수,최강석,이은정,강신영,Park, Hyo-Sun,Hahn, Tae-Uook,Kim, Hyun-Soo,Choi, Kang-Seuk,Lee, Eun-Jeong,Kang, Shien-Young 대한수의학회 2003 大韓獸醫學會誌 Vol.43 No.1

Porcine reproductive and respiratory syndrome (PRRS) is characterized by reproductive failures in sows and respiratory problems in piglets. The nucleocapsid(N) protein, encoded by the open reading frame 7 (ORF7) gene, is known to be the most abundant and antigenic protein in PRRS virus. Therefore, it was suggested that the N protein could be a suitable candidate for the detection of PRRS virus-specific antibodies and diagnosis of PRRS. In the present study, the ORF7 gene encoding the N protein was cloned and expressed as a fusion protein with the glutathione S-transferase (GST) in Escherichia coli. The resulting GST-N recombinant protein was used as an antigen for an indirect sandwich enzyme-linked immunosorbent assay (i-ELISA). Expressed GST-N recombinant protein was migrated at 41 kDa and reacted with ORF7-specific monoclonal antibody by Western blotting. In order to increase the specificity of the ELISA for the detection of PRRS virus-specific antibodes, an i-ELISA was developed using an anti-GST antibody as a capture antibody. The sensitivity and specificity of developed i-ELISA were 92% and 96%, respectively. Based on these results, it was suggested that the i-ELISA is a simple and rapid test for screening a large number of swine sera for the anti-PRRS virus antibodies.

자발적으로 발생한 재발성 간의 피막하 혈종 1예

최재신 ( Jae Shin Choi ),김유진 ( Youjin Kim ),박소영 ( So Young Park ),이수연 ( Su Yeon Lee ),이은정 ( Eun Jeong Lee ),신동현 ( Dong Hyun Sinn ) 대한내과학회 2017 대한내과학회지 Vol.92 No.2

외상 또는 응고 장애 등이 동반되지 않는 상태에서 자발적인 피막하 혈종의 발생은 드문 경우이다. 드문 원인이지만 증례로 보고된 경우는 임신과 연관된 자간전증 또는 전자간증 및 hemolysis, elevated liver enzymes, low platelets (HELLP)증후군 등이 있으며 간세포암종, 간샘종 및 간의 악성 및 양성 종양의 파열과의 연관성이 보고된 바가 있다. 또는 의학적 시술, 감염, 약물에 의한 간자색반병도 일부 보고되어 있다. 본 증례는 외상이나 응고 장애 등이 동반되지 않는 상태에서 반복적으로 피막하 혈종이 발생하였으며, 여러 문헌고찰을 통해 확인된 가능한 원인들에 대해 감별하였으나 뚜렷한 원인을 밝혀낼 수는 없었다. 다만, 가능성을 완전히 배제하기 어려웠던 기생충 감염에 대해 항구충제 치료 및 타목시펜 복용과 연관된 간자색반병의 가능성에 대해 타목시펜 중단 등의 조치를 취하였으며, 이후 반복적으로 발생하던 경과가 임상적으로 호전되는 양상을 보였다. 이에 비록 관찰 기간이 충분하게 길지 않지만, 문헌고찰과 함께 보고하는 바이다. A spontaneous subcapsular hematoma of the liver is an unusual clinical phenomenon and is usually associated with trauma, surgery, tumor or pregnancy. We report a case of a recurrent spontaneous subcapsular hematoma of the liver without an identifiable cause. A 52-year-old female presented to the emergency room with acute abdominal pain localized in the right upper quadrant area. Diagnostic workup revealed a subcapsular hematoma in the segment 8 area. The laboratory evaluation was also normal. She was managed conservatively. However, two months later another episode of abdominal pain in the right upper quadrant recurred. Diagnostic workup showed recurrence of a subcapsular hematoma in the segment 6 area. Follow-up evaluation revealed resorption of the previous subcapsular hematomas, as well as a new lesion in the segment 1 area. Herein, we discuss potential causes of this spontaneous subcapsular hematoma of the liver. (Korean J Med 2017;92:177-181)