스몰오버랩 충돌 시 하지상해 발생 메커니즘 규명

김현철,남윤식,김병철,김기일,김기성,Kim, Hyun Chul,Nam, Yun Sik,Kim, Byoung Chul,Kim, Ki Il,Kim, Ki Sung 한국자동차안전학회 2017 자동차안전학회지 Vol.9 No.1

Small Overlap test decided on IIHS (Insurance Institute for Highway Safety) evaluates a robustness of the car body and a passenger injury protection. A current vehicle is satisfied with a robustness of the car body for Small Overlap test but not meet the requirements of passenger injuries because it is difficult to inquire into the actual state of injury mechanism for Small Overlap test. The study shows the new injury mechanism which represents the relation between a structure of the vehicle placed with the lift foot and the low extremity injury.

우리나라 중고등학교 청소년의 성별 및 학교 종류별 흡연 결정요인

김현철,김은경,최은실,김유정,이현주,김정주,장형숙,심경선,전상남,강요한,강현석,오주환,조경숙,Kim, Hyun-Cheol,Kim, Eun-Kyong,Choi, Eun-Sil,Kim, Yu-Jeong,Lee, Hyun-Ju,Kim, Jong-Ju,Jang, Hyung-Suk,Shim, Kyung-Seon,Jeon, Sang-Nam,Kang, Yo-Han,Ka 대한예방의학회 2006 예방의학회지 Vol.39 No.5

Objectives: This study assessed the influences of various factors that are related to youth smoking such as gender, age and type of school, and we wanted to provide supporting data for tailored and effective policy initiatives to reduce adolescent smoking. Methods: A self-report survey was conducted on 14,910 teen-age students who were selected based on the nationwide distribution of students in large and small cities and counties, the gender ratio of the students and the ratio of students attending various type of school at 38 middle and high schools in six representative areas of each province. The survey was handled and managed by a health education teacher at each school. Binary and multinomial logistic regression was used in the analyses. Results: Smoking by adolescents was associated with gender, age and even height. Male high school students tended to smoke more than female high school students, but this differences was not significant for middle school students. The older the adolescents were, the more likely that they smoked, except for the female high school students. Height was meaningful for all adolescents, except for the boys at the vocational high schools. Monthly allowance was significant for all adolescents. School factors such as type of school and the students' school performance were also crucial factors. Attending a vocational high school was strongly related to smoking, especially for girls. Students' school performance and the perceived level of stress were strongly associated with smoking, especially for boys. Home factors such as the relationship with parents and conversation time with family members were closely related to smoking behavior. Knowledge about the health hazard of smoking was also found to be strongly related to adolescent smoking. Conclusions: In conclusion, demographic factors, school factors, home surroundings and the perception on the harmfulness of smoking are strongly related to adolescent smoking behavior, but these differ from gender and type of school.

쑥갓세포의 현탁배양에 의한 ${\beta}-sitosterol$ 생산

김현철,정하영,이소연,정호용,김유정,백남인,김성훈,최근원,김대근,권병목,박미현,정인식,Kim, Hyun-Chul,Chung, Ha-Young,Lee, So-Youn,Chung, Ho-Yong,Kim, You-Jung,Baek, Nam-In,Kim, Soung-Hoon,Choi, Geun-Won,Kim, Dae-Keun,Kwon, Byoung-Mok,Park 한국응용생명화학회 2005 Applied Biological Chemistry (Appl Biol Chem) Vol.48 No.4

[${\beta}-sitosterol$]은 식물 스테롤로서 인간의 전립선암과 대장암 세포의 성장을 억제하고 생체내 콜레스테롤 농도를 감소시킨다. 본 연구에서는 쑥갓세포 배양에서 ${\beta}-sitosterol$ 생산의 최적화 연구를 수행하였다. 그래서 쑥갓(Chrysanthemum coronarium L.)으로부터 캘러스 유도는 NAA와 BAP의 농도가 각각 1 mg/l의 조합에서 최적이었으며 이들 캘러스로부터 현탁배양 세포주를 확립하였다. 현탁 배양시 초기 세포농도 2 g DCW/l에서 조성이 각각 1배인 탄소원(30 mg/l), 질소원(1900 mg/l $KNO_3$, 1650mg/l $NH_4NO_3$), 무기인산원(170 mg/l)을 포함하는 MS 배지에서 ${\beta}-sitosterol$ 생산이 최적으로 나타났다. Shake-flask를 이용한 현탁배양에서 ${\beta}-sitosterol$의 최대 생산량은 $150{\mu}g/g$ DCW이었다. 그리고 공기부유식 생물반응기의 배양에서는 100 cc/ml의 통기량에서 ${\beta}-sitosterol$의 생산이 $142.8{\mu}g/g$ DCW으로 나타났다. [${\beta}-sitosterol$] is a plant sterol that reduces cholesterol levels and inhibits the growth of human prostate and colon cancer cells. Optimal conditions for ${\beta}-sitosterol$ production were examined from cell suspension cultures of Chrysanthemum coronarium L. The callus induction was optimal in MS medium containing 1 mg/l NAA and 1 mg/l BAP. Cell suspension culture was also established from the callus. Optimal ${\beta}-sitosterol$ production was obtained when the cells were cultured at an initial density of 2 mg DCW/l in MS medium containing 1 X sucrose (30 mg/l), 1 X nitrogen (1900 mg/l $KNO_3$, 1650 mg/l $NH_4NO_3$), and 1 X phosphate source (170 mg/l). In cell suspension cultures of C. coronarium L. using shake flasks, the peak content of ${\beta}-sitosterol$ was $150{\mu}g/g$ DCW. In cell suspension cultures of C. coronarium L. using an air-lift bioreactor, the maximum ${\beta}-sitosterol$ content of $143.8{\mu}g/g$ DCW was obtained at an air-flow rate of 100 cc/min.

악성 흑색종과 멜라닌 세포성 모반의 bc1 - 2 단백의 발현 양상

김현철,김윤규,채영수,서기석,김상태 ( Hyun Cheol Kim,Yun Kyew Kim,Young Soo Chae,Kee Suck Suh,Sang Tae Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2

Background; The bcl-2 is a newly known oncogene involved in tumorigenisis by blocking apoptosis or programmed cell death. Overexpression of bcl-2 protein has been detected in a variety of human malignancies. However, recent studies of the expression of bcl-2 protein in human melanoma and melanocytic nevus have been controversial. Objective : The purpose of this study was to examine whether there are any differences in the expression of bcl-2 protein between melanocytic nevus and rnalignant melanoma. Methods : Immunohistochemical analysis of bcl-2 protein expression was performed on the formalin-fixed, paraffin-embedded tissue sections of 22 melanocytic nevus and 29 malignant melanomas(20 primary and 9 metastatic) using anti bcl-2 monoclonal antibody with an avidin-biotin peroxidase complex procedure. Results : The results were as follows. 1. The positive rate for bcl-2 protein was observed in 95.4% (21/22) of melanocytic nevus and 95.0%(19/20) of primary malignant melanomas. Therefore, there was no significant difference between the two groups in the positive rate for bcl-2 prtoein. 2. The percentage of stained cells and the staining intensity of bcl-2 protein were significantly increased in melanocytic nevus compared to malignant melanoma(p<0.05). 3. The positive rate for bcl-2 expression of metastatic malignant melanoma[44.4% (4/9)] was significantly decreased compared to that of primary malignant melanoma[95.0%(19/20) ](p<0. 05). But, there was no significant difference betweeen tumor thickness and histological type of malignant, melanoma in the expression of bcl-2 protein. 4. In melanocytic nevus, immunoreactivity of bcl-2 protein gradually diminished or even disappeared towards the deep dermis Conclusion : the bcl-2 expression was decreased in malignant melanoma compared to melanocytic nevus. It. suggests that the loss of bcl-2 expression may play a significant role in the progression and metastasis of malignant melanoma. (Kor J Dermatol 1997;35(2): 284-291)

이미지 딥러닝을 통한 컨텐츠와 관련 반응 동영상의 감정 분석 시스템 설계

정윤영(Yoonyoung Jeong),김봄(Bom Kim),류소정(Sojeong Ryu),권나현(Nahyun Kwon),손규진(Gyujin Son),이소정(Sojeong Lee),김윤희(Yoonhee Kim) 한국정보과학회 2019 한국정보과학회 학술발표논문집 Vol.2019 No.12

점막하 구개열 환자 공명장애의 스펙트럼 특성 연구

김현철,임대호,백진아,신효근,김오환,김현기,Kim, Hyun-Chul,Leem, Dae-Ho,Baek, Jin-A,Shin, Hyo-Keun,Kim, Oh-Hwan,Kim, Hyun-Ki 대한악안면성형재건외과학회 2006 Maxillofacial Plastic Reconstructive Surgery Vol.28 No.4

Submucosal type cleft palate is subdivision of the cleft palate. It is very difficult to find submucosal cleft, because when we exam submucosal type cleft palate patients, it seems to be normal. But in fact, there are abnormal union of palatal muscles of submucosal type cleft palate patients. Because of late detection, the treatment - for example, the operation or the speech therapy - for the submucosal type cleft palate patient usually becomes late. Some patients visited our hospital due to speech disorder nevertheless normal intraoral appearance. After precise intraoral examination, we found out submucosal cleft palate. We evaluated the speech before and after surgery of these patients. In this study, we want to find the objective characteristics of submucosal type cleft palate patients, comparing with the normal and the complete cleft palate patients. Experimental groups were 10 submucosal type cleft palate patients and 10 complete cleft palate patients who got the operation in our hospital. And, the controls were 10 normal person. The sentence patterns using in this study were simple 5 vowels. Using CSL program we evaluated the Formant, Bandwidth. We analized the spectral characteristics of speech signals of 3 groups, before and after the operation. In most cases, the formant scores were higher in experimental groups (complete cleft palate group and submucosal type cleft palate group) than controls. There were small differences when speeching /a/, /i/, /e/ between experimental groups and control groups, large differences when speeching /o/, /u/. After surgery the formant scores were decreased in experimental groups (complete cleft palate group and submucosal type cleft palate group). In bandwidth scores, there were no significant differences between experimental groups and controls.

Aging Study with High-Level Radiation Sources for the CMS Forward RPCs

김현철,이경세,Byun Il Kim,홍병식,Chong Kim,D. H. Moon,Duk Gil Koo,E. Won,J. K. Lim,Ji Hyun Kim,Jun Tak Rhee,K. B. Lee,Kwang-Souk Sim,M. S. Ryu,Rong Jiang Hu,S. K. Nam,Sang Yeol Bahk,이석재,Seong Jong Hong,Sung Hw 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.3

An aging study with intensive radiation sources was performed for the forward resistive plate chambers (RPCs) of the Compact Muon Solenoid (CMS) detector in the Large Hadron Collider experiment (LHC). The expected rate of the radiation background to be induced in the forward RPCs ranges from a few tens of Hz/㎠ to as much as ~1 kHz/㎠. Therefore, the radiation hardness for the forward RPCs should be sufficient to ensure the safe operation of the CMS and successful achievement of the LHC physics. Two oil-coated and one plain double-gap RPCs were manufactured and tested with the neutron beam provided by the MC50 cyclotron of the Korea Institute of Radiological and Medical Science (KIRAMS) and with gamma rays from a 200-mCi137Cs source. The estimated radiation dose induced by the fast neutrons was approximately 50 Gy. No significant aging effect was found to be a consequence of the neutron irradiation, However, a degradation of the RPC performance was observed after intense gamma irradiation for a total of 32.5 days. The mean gamma-signal rate drawn in each RPC was 4.0 kHz/㎠, which was approximately two times the maximum rate expected in the highest η-region covering the particle trigger. Increases in the noise rates and the currents accounted for the degradation in the efficiencies for the RPCs. As a result, safe operation of the forward RPCs in the avalanche mode was ensured for signal rates up to 2 kHz/㎠.

양극화경제성장이 승용차수요에 미치는 영향

김현철,Kim, Hyun-Chul 한국통계학회 2010 Communications for statistical applications and me Vol.17 No.6

This paper investigates the relationship between the passenger car demand and business activities in the OECD. The positively linear relationships changed suddenly since 1990 and the reason was thought to be the polarized economic development of USA and Japan. The cases of other countries supports this conclusion. According to the conclusion, we modeled and estimated the car demand function of Korea. OECD에서 승용차판매와 경기 사이의 관계가 1990년까지는 양의 선형관계를 유지하다가 1991년 이후 극적인 변화를 보이며 달라졌다. 이런 변화의 원인이 미국과 일본을 중심으로 한 일부 국가들의 빈부격차에 있을 수 있음을 보였다. 이런정보들을바탕으로한국의승용차수요함수를제시하고추정하였다. 이 연구는 그동안 자동차업계의 연구자들이 막연하게 '승용차가 포화상태에 진입한 선진국에서 나타나는 수요정체현상'이라고 말했던 현상이 사실은 일부 선진국에서 나타나는 상대빈곤율의 증가때문이라는 점을 밝혔으며, 한국의 승용차 시장 세그먼트 별 수요예측에 확장 가능한 수요함수를 제시했다.

두부 외상 후 섬망의 자문 정신 의학적 고찰

김현철,이상철,김도훈,이상규,홍승관,손봉기,Kim, Hyon-Chul,Lee, Sang-Chul,Kim, Do-Hoon,Lee, Sang-Kyu,Hong, Seung-Gwan,Son, Bong-Ki 한국정신신체의학회 2004 정신신체의학 Vol.12 No.1

연구목적: 두부 외상은 신체적 후유 증상뿐 아니라 다양한 정신 증상을 야기한다. 본 연구에서는 두부 외상 후 섬망을 보이는 환자들을 대상으로 정신과 자문을 실시하고 과다행동 증상의 유무 등의 임상 양상과 회복 기간과의 관련성에 대해 평가하고자 하였다. 방 법: 1998년부터 2002년까지 두부 외상을 주소로 신경외과에 입원한 환자들 중 섬망이 발생하여 정신과에 자문 조정이 의뢰된 45명의 환자를 대상으로 하였다. 섬망 발생 4주 후 추적 자문에서 섬망의 회복 여부에 따라 완전 관해 된 군 및 잔류 증상이 남아 있는 군으로 나누고, 두 군간의 차이를 과다행동 유무와 사회 인구학적 변수, 두부 외상 부위의 빈도에 따라 살펴보았다. 결 과: 첫 자문 주소에서 과다 행동 유무에 따라 분류해 보았을 때 4주 후의 섬망의 관해와 유의미한 관계를 보였다(p<.01). 섬망의 잔류 증상이 남아 있는 군은 완전 관해 된 군에 비해 중환자실 입원 기간 및(p<.05), 전체 입원 기간이 길었다(p<.01). 섬망 발생 4주 후 잔류 증상이 남아 있는 군은 완전 관해된 군에 비해 사고보험과의 관련성이 많았으며(p<.05), 신경 영상학적 조사에서 피질 하 회백질의 손상의 여부와 유의미한 관계를 보였다(p<.05). 결 론: 본 연구를 통해 첫 자문 의뢰 시 과다행동 유무에 따라 섬망의 회복 기간에 유의한 차이가 있었다. 또한 섬망의 회복 기간이 지연될수록 재원기간이 길어짐을 알 수 있었다. 향후 두부 외상 후 섬망 환자의 정신과적 개입에 있어 과다행동의 유무를 비롯한 임상 변수들에 대한 다각적인 연구가 필요할 것으로 사료된다. Objectives: Delirium after head trauma results in various cognitive and behavioral dysfunction. This study aimed at developing and validating a predicitive model for clinical improvement after delirium based on precipitating factors during hospitalization Method: Data were collected on 45 patients who developed delirium after head trauma using 5 year retrospective design, based on reviews of medical charts including psychiatric consultation reports. The differences of the group who sustained residual symptoms of delirium(The RS group) and the group of full recovery(The FR group) at 4 week follow-up visits were compared by motoric type of delirium, socio-demographic variables, neuroimaging variables and clinical variables of interest. Result: There was significant difference in reason for initial consultation between two groups, in terms of hyperactivity(p<.01). The presence of compensation claim, subcortical gray matter lesion was significantly associated with the RS group(p<.05). Total length of intensive care unit(ICU) admission and of hospital stay were significantly longer in RS group than FR group(p<.01). Conclusion: This study shows that hyperactivity on initial consultation, compensation claims, specific brain lesion were altogether significant factors in explaining prolonged duration of delirium after head trauma. A simple predictive model based on the presence of precipitating factors might be used to identify delirious patients at high risk for prolonged cognitive dysfunction. Early psychiatric intervention would be required for evaluating efficacious management and shortening admission period.

변형된 현시비교 우위지수와 지역전략산업의 식별

김현철,Kim, Hyun-Chul 한국통계학회 2009 Communications for statistical applications and me Vol.16 No.6

이 연구는 기존의 현시비교우위지수 (RCA)를 지역에 적용한 후 지역불균형발전 정도를 반영하도록 수정한 지역현시비교우위지수를 제안하고 있다. 이는 한국의 산업입지가 전적으로 지역의 비교우위에만 기초해서 이루어지지는 않았다는 가정 아래 한국의 각 지역 간 비교우위를 평가하여 지역전략산업을 탐색하기 위한 것이다. 참여정부 이래 지속되고 있는 한국정부의 국가균형발전정책 역시 같은 가정에 기초하고 있다. 지역현시비교우위지수는 전통적인 현시비교우위의 지수에 국가균형발전의 역수인 불균형정도를 나타내는 요소를 반영한 것이다. 우리는 이 지수를 2007년 데이터에 적용하여 실제로 지역별 전략산업을 제시해 보았다. In this paper, we suggested a modified revealed comparative advantage(RRCA) index for identifying regional strategic industries. The index is developed under the assumption that the concentration of industries in Korea is not based entirely on the comparative advantages. The Korean government has set up balanced development strategies since 2003 under the assumption too. The index is the ratio between the comparative advantage index and economic imbalance of the region. By the index, we selected strategic industries for 15 regions under the rule of 1) relative ratio of the index is more than 15%, 2) 1 to 3 regions for a industry according to the industry's output.