한센병 환자의 족저궤양과 족저압력의 관계

김종필 고려대학교 대학원 2009 국내박사

한센병은 나균(Mycobacterium leprae)에 의한 피부와 신경의 육아종성 질환이며, 감염에 의한 말초신경병증의 가장 흔한 원인이다. 나균은 슈반세포에 친화력이 있어 그 세포 내에 침범하여 증식하면서 미엘린을 파괴시킨다. 2차적인 염증반응과 신경구조가 파괴되어 말초신경병증이 발생한다. 한센병에서 말초신경병증과 그에 의해 발생하는 합병증으로 불구와 장애가 발생하며, 장애로 인하여 사회적 편견을 받게 되어 아직도 공중보건학적 문제로 남아 있다. 감염 초기에 답손, 크로파지민, 리팜피신을 이용한 복합화학요법으로 장애발생을 줄일 수는 있지만, 조기 진단을 하지 못하거나, 신경손상을 유발하는 나반응이 발생할 수 있어, 불구나 장애를 일으키는 신경병증이 아직도 흔히 발생한다. 족저궤양은 신경병증에 의한 흔한 합병증이다. 족저압력은 족저궤양 발생에 중요한 요인이다. 족저압력은 한센병 환자의 족저궤양을 이해하는데 매우 중요함에도 불구하고, 이에 대한 보고가 없었다. 이에 저자는 한센병 환자에서의 족저압력의 특성과 이에 영향을 미치는 요인들을 조사하였다. 연구를 위해 최근 5년 내에 족저궤양 병력이 있는 환자 50명과 없는 병력이 없는 환자 50명을 대상으로 하였다. 한센병의 말초신경병증에 의해 감각소실이 소실되고 정상적인 구조가 파괴된 발에서 지속적인 손상의 중요한 요인인 족저압력의 여러 인자들에 대해 조사하고 족부 기형과 궤양 병력 유무의 차이와 이에 미치는 요인들을 phenolic glycolipid I(이하 PGL-I)항체값과 감각 유무에 따른 상관관계를 보아 분석하였다 갈고리발에서는 주로 전족부 중족골 두부에서, 중족골 손상에서는 주로 중족부에서, 족하수에서는 전족부, 중족부 외측, 후족부 등에서 궤양 발생과 연관이 있는 요인의 변화를 확인하였다. 또 PGL-I 항체값과 족저 궤양 발생과 연관이 있는 요인들과의 상관관계도 확인하였다. 본 연구결과가 향후 세계적으로 공중보건사업으로 수행되고 있는 한센사업 중 장애예방사업의 계획 수립과 수행을 위한 기초 자료로 이용되어 효율적인 한센사업 수행에 도움이 되기를 기대한다. The relations of the plantar pressure and plantar ulcer in patients with leprosy Kim Jong Pill Department of Medicine Graduate School, Korea University Thesis Advisor: Kang Yoon Kyou OBJECTS Leprosy is a chronic infection principally affecting the skin and peripheral nerves caused by the obligate intracellular organism Mycobacterium leprae. Complications secondary to the neuropathy can result in deformity and disability. Leprosy remains a stigmatizing disease, so it continues to be a significant public health problem. Multidrug therapy (MDT) cures the infection. MDT, which cures the infection, has led to the understanding that leprosy can be effectively treated before disability develops, but leprae reactions may occur and neuropathy may lead to disability and deformity. The plantar ulcer is a common complication in leprosy. And the plantar pressure is important factors developing plantar ulcer. Though the characteristics of planter pressure are very important for the understanding of the plantar ulcer, there is any report for them. So the author is studied about characteristics of planter pressure in patients with leprosy. SUBJECTS AND METHOD Subjects included 100 leprosy patients, divided two groups according to the plantar ulcer history. The author analyzed the significant factors of the characteristics of planter force and pressure participating of the provoking of plantar ulcer. And analyzed the relations between that significant factors and various factors(PGL-I titer, sensory level). RESULTS Most of significant factors were found in fore-foot on claw foot, mid-foot on mid?]foot injury, and all parts of foot, especially later side, on foot drop. And the interrelation between the PGL-I antibody titer and the above factors, above mentioned, were found. CONCLUSION The author ascertained that the plantar pressure were the important factors participating of the provoking of plantar ulcer and PGL-I antibody titer would be the possible tool for estimating the plantar ulcer of the Hansen disease program, especially the prevention of disability, in more ways than one. key word: leprosy, planter pressure, plantar ulcer, deformity

운항 정보전송 시스템 개발에 대한 연구

김종필 한국해양대학교 대학원 2018 국내석사

Autonomous vessels are becoming a hot topic in the global shipping industry. In the EU, Autonomous ship technology is rapidly developing. Autonomous vessels are expected to become a new paradigm to change and accelerate the digitization, platform connectivity and intelligence of the shipping industry. Over the past few years, the marine industry has maintained its competitive edge by securing operating competitiveness by reducing operating costs such as vessel size and oil costs. However, as with other industries, ICBM (Industry 4.0) IOT, Cloud, Big Data, Mobile), cyber security, simulation, etc., and to create new business by maximizing the unique capabilities of the shipping industry as defined in Shipping 4.0. Until recently, autonomous vessels were named as various types such as Smart Ship, Digital Ship, Connected Ship, Remote Ship, Unmanned Ship and Autonomous Ship. They were defined as MASS (Maritime Autonomous Surface Ship) by International Maritime Organization (IMO) This is a comprehensive product and service for the unmanned ship, autonomous transportation and efficient transportation in the stepwise upgrade for safety, reliability, and efficiency in ship operation. In this paper, the research background and research scope is described in chapter 1, discussion about autonomous ship related contents are in chapter 2. The design and implementation of a large scale ship data transmission system including method of ship communication, data protocol and messaging processing technology to transmit and display large amount of data are describe in Section 3. The configuration and results of the experimental environment are in Section 4. Then finally the conclusion and further studies are described. Chapter 2 - Autonomous vessels are that incorporate ship control systems and communication technologies that enable wireless monitoring and control, including improved decision support systems and remote control and autonomous navigation capabilities. The control function for the autonomous vessels is implemented in the Shore Control Center (SCC). In order to accurately recognize the situation of the ship at the remote land control center, the existing systems such as AIS and RADAR are equipped with thermal cameras, LIDAR an advanced sensor module is added to the vessel to replace the existing sailing company's watch keeping operations with the landlord and system. The land control center simultaneously monitors the safe operation of autonomous vessels, manages the voyage plan update and autonomous navigation system, and manages the maintenance plan for autonomous vessels. Chapter 3 - In this paper, we constructed and implemented a large capacity ship data acquisition and transmission system that can collect, process, and transmit data generated from ships. The required physical configuration is largely divided into onboard and onshore, and by design, it can have n ships and n land. On the ship side, data are collected from navigation equipment and AMS (Alarm Monitoring System) such as RADAR, Speed Log, Doppler, Gyro Compass and GPS, processed and stored for use on land and onboard service applications, The land consists of a server composed of modules capable of receiving data from various ships and transmitting them to a required place after processing, and servers for service application. The user is connected to the web browser on the PC and configured to use services such as flight information monitoring. Chapter 4 - Experiments were conducted on the large scale ship data acquisition and transmission system implemented in this paper by constructing an environment in the T/V Hanbada Lab. For each unit function, the experiment proceeded while the Kongsberg simulator and the training line were at anchor, and the integrated test for the stability and function of the data was conducted during the long voyage. Chapter 5 - In this study, the research was carried out in order to process the ship’s navigation data generated from various equipment for several number of vessels in terms of ship operation data and remote control center technology for this purpose. For the research on application system implementation and verify evaluation, an analysis of a data collection and process on ship and shoreside and design of data transmission has been studied. Also for this research, the basic research knowledge were achieved together with research results on ship data processing and transmission. The newly developed web based system can used to monitor ship’s data in real-time on the shoreside.

米穀生産의 適正營農規模에 關한 硏究

金鍾弼 忠南大學校 1998 국내석사

It is imperative to increase productivity through the structural adjustment of agricultural production and continuous management innovation in order for the Korean farmers to keep competitability in globalization and trade liberalization era; Especially, in rice enterprise it should be one of the alternatives to that to save production costs and realize a scale of economy through the increase of farm size and the consolidation of dispersed farmland. Such a typical example is the project of rice key-farmer fostering and farm size optimization which has been implemented by the government since 1988. The objective of the study is to give basic information for individual farm households to make decisions for optimizing their farm sizes and for the government to implement farm size optimization policies through the identification of combinations among rice production factors in plain areas like Cholwon county and the suggestion of the optimal farm sizes of individual farmers based on the scale of economy calculated. The data of agricultural production costs of 50 rice farmers in the plain area which is located in Dongsong-eup Cholwon county, Kangwon province were used in the analysis. The 'translog' cost function among various methods which is a flexible function type was adopted to calculate the scale of economy in rice production. Seemingly unrelated regression(SUR) method was used in forecasting functions and processing other statistics by SHAZAM which is one of the computer aid program for quantitative econometric analysis. The conclusions of the study be summarized as follows: First, it has been found that the least-cost scale of rice economy so called optimum farm size was estimated at 9.7ha and the marginal rate of scale of economy showing increase up to 5.0ha; Second, the Allen's partial substitution elasticity calculated by the traslog cost function method shows that there are substitution relationships among land, labor, and capital(agricultural machinery) because all of their elasticity values have positive values respectively. Among them, the substitution elasticity between labor and capital was the highest, which means the mechanized working condition of the surveyed area was best. Third, price substitutability of factor demand was calculated by using the distribution values of factor costs once Allen's partial substitution elasticities were calculated. The results of all the price elasticities were positively supported the demand law that the higher the factor price, the lower the demand level. There showed substitution relationships among production factors considering the positive value of crossed price elasticities. And the demand of land was sensitively responded to the price change of agricultural machinery and the demand of agricultural machinery was sensitively responded to the price of labor. These imply that it will be easier to expand farm sizes by substituting of labour for agricultural machinery in the surveyed area. Fourth, long-run average cost(LAC) curve showed 'U-shape ' which was different from 'L-type' one which was shown in the previous studies by others. The lowest point of the LAC was 9.764ha and the concerned production cost amounted to 633 Won/kg, Based on these results, it have to be suggested that around 10 ha of paddy is the target size for policy assistances to save costs under the present level of farming practices and technology. Fifth, the above results show that the rice production costs could be saved up to 10ha in Cholwon plain area which is a typical paddy field. However, there should be considered such variables as land use relationship, land condition, land ownership relationship and manager's ability .which may affect scale of economy. Furthermore, reasonable management will have to be realized by means of labor saving technology and cost saving management skill like enlargement of farm size of rice.

냉간압조 비조질강의 압연조건에 따른 미세조직과 기계적 특성

김종필 포항공과대학교 2000 국내석사

Bio-Health 소재를 이용한 버섯 청국장에 관한 연구

김종필 충주대학교 산업대학원 2008 국내석사

This study is to establish the stepwise fermentation conditions of medicinal mushroom mycelium, Bacillus sp. and lactic acid bacteria with soybean as a substrate and to investigate the biological activity of the material produced from the optimum fermentation condition established. 1. To establish the stepwise fermentation process, soybean was used as a substrate and solid fermentation method was applied to see the growth conditions of mycelium and intensity of mycelium. From the results we selected Phellinus linteus, Cordyceps militaris, and Ganodrema lucidum for this study. 2. The separation of Bacillus sp. was done from the Chungkukjang manufactured by traditional method and 4 strains including FEN 1, 2, 3, and 4 were separated. Three of them had a good fermentation ability except for FEN 2 strain. When the enzyme activity was compared with the strain obtained from the gene bank, FEN 3 was the best strain for our objective. 3. To investigate the optimum growth conditions for medicinal mushroom mycelium different amount of ground soybean solution was added. The results indicated that it was best condition for growth performance when the ground soybean solution was added at 15% for Phellinus linteus, 30% for Cordyceps militaris, and 10% for Ganodrema lucidum. 4. The total polyphenol content of the fermented material after the 1st step fermentation were 990 ㎍/mL for Phellinus linteus, 1,374 ㎍/mL for Cordyceps militaris, and 603 ㎍/mL for Ganodrema lucidum. Those of the fermented material after the 2nd step fermentation, 1,328, 1,185, and 2,168 ㎍/mL for Phellinus linteus, Cordyceps militaris, and Ganodrema lucidum, respectively. The amount of total phenol contents showed an increasing trend compared to the 1st fermentation. However, after the 3rd fermentation, the total phenol content was the highest in Ganodrema lucidum and those of Phellinus linteus and Cordyceps militaris were reduced to less than that of Lactobacillus bulgaricus fermentation. 5. The free radical scavenging activity of the fermented material after stepwise fermentation. The DPPH radical scavenging activity of the fermented material after the 1st step fermentation resulted in 45.53, 57.05 and 13.22,% in Phellinus linteus, Cordyceps militaris, and Ganodrema lucidum, respectively. After the 2nd step fermentation, the activity increased to 57.27, 65.47 and 16.72%, respectively. After the 3rd step fermentation, the radical scavenging activity showed 42.00, 53.36 and 28.03% in Phellinus linteus, Cordyceps militaris, and Ganodrema lucidum, respectively. In this case, the activity of Phellinus linteus and Cordyceps militaris decreased but that of Ganodrema lucidum increased. 6. The superoxide dismutase (SOD) activity of the fermented material after the 1st step fermentation were 57.67, 56.57 and 47.62% for Phellinus linteus, Cordyceps militaris and Ganodrema lucidum, respectively, which showed that Phellinus linteus and Cordyceps militaris were superior to Ganodrema lucidum. However, after the 2nd step fermentation, the activity of Ganodrema lucidum increased to 55.6% and was comparable to Phellinus linteus and Cordyceps militaris. After the 3rd fermentation, the SOD activity of fermentation materials of 3 samples showed no difference statistically. 7. The melting activity of blood clot was measured after 3 step fermentation including 1) grew the mushroom mycelium of Phellinus linteus, Cordyceps militaris and Ganodrema lucidum in ground soybean solution, 2) fermented by Bacillus subtilis using fermented material after the 1st fermentation, and 3) fermented by lactic acid bacteria using the fermented material after the 2nd fermentation. The blood clot melting activity of Phellinus linteus was the highest (89.4%) than those of Cordyceps militaris and Ganodrema lucidum after the 2nd step fermentation. However, after the 3rd step fermentation, the activity increased dramatically to 75.2, 75.2 and 82.6% for Phellinus linteus, Cordyceps militaris and Ganodrema lucidum, respectively. The results indicate that the blood clot melting activity of the medicinal mushroom mycelium grown in ground soybean can be increased after stepwise further fermentation using Bacillus subtilis and lactic acid bacteria. 본 연구는 대두를 기질로 하여 약용버섯 균사체, 바실러스균, 유산균 등의 단계적 최적 발효조건으로 발효시킨 배양물의 생리활성을 검토하였다. 1. 단계적 발효에 의한 생육조건을 확립하기 위하여 대두를 기질로 하고 고체 배양을 통하여 균사체 생육조건 및 균사체 조밀도 등을 관찰하여 상황버섯(Phellinus linteus), 밀리타리스 동충하초(Cordyceps militaris), 영지버섯(Ganodrema lucidum) 등을 선정하였다. 2. 바실러스균의 분리는 전통적인 방법으로 제조된 청국장으로부터 FEN 1, FEN 2, FEN 3 및 FEN 4 등 4개의 균주를 분리 하였으며, FEN 2를 제외한 세 균주는 발효능력이 우수하였으며, 유전자은행으로부터 분양받은 균주와 비교하였을 때 효소활성도는 FEN 3이 가장 우수한 것으로 나타났다. 3. 약용버섯 균사체가 생육하기에 적합한 조건을 검토하기 위하여 마쇄 대두액 첨가량을 달리하여 생육조건을 측정한 결과, 상황버섯의 경우 15%, 동충하초는 30%, 영지버섯은 10%의 마쇄한 대두를 첨가한 천연배지에서 균사체량이 가장 우수한 결과를 얻을 수 있었다. 4. 단계적 발효에 의한 발효물의 생리활성 물질 중 총 페놀성 화합물의 함량은 약용버섯 균사체를 배양한 1 단계 발효물의 경우, 상황버섯 990 ㎍/mL, 동충하초 1,374 ㎍/mL, 영지버섯 603 ㎍/mL으로 동충하초, 상황버섯, 영지버섯의 순으로 함량이 높게 측정되었다. 2 단계 발효물의 경우에는 상황버섯, 동충하초, 영지버섯이 각각 1,328, 1,185, 2,168 ㎍/mL으로 1단계 발효물과 같았으며 그 함량은 1 단계보다 증가한 경향이었다. 그러나 3 단계 발효물에서는 영지버섯의 총 페놀성 화합물 함량이 1,483 ㎍/mL로 가장 높았으며, 상황버섯과 동충하초는 2 단계 발효물보다 오히려 감소하여 876, 1,184 ㎍/mL로 측정되었다. 5. 단계적 발효에 의한 발효물의 DPPH free radical 전자공여능을 이용한 항산화성을 측정한 결과, 약용버섯 균사체를 발효시킨 1 단계 발효물 상황버섯, 동충하초, 영지버섯은 각각 45.53, 57.05, 13.22%로 동충하초, 상황버섯, 영지버섯 순으로 전자공여능이 우수하였다. 2 단계 발효물에서도 상황버섯, 동충하초, 영지버섯은 각각 57.27, 65.47, 16.72%로 1 단계 발효물보다 전자공여능이 상승하였다. 3 단계 발효물의 경우에는 상황버섯, 동충하초, 영지버섯의 전자공여능이 각각 42.00, 53.36, 28.03%로 영지버섯의 전자공여능은 소량 상승하였으나 상황버섯, 동충하초는 약간 감소하였다. 6. 단계적 발효에 의한 발효물의 superoxide dismutase(SOD) 유사활성을 측정한 결과는 약용버섯 균사체를 발효시킨 1 단계 발효물 상황버섯, 동충하초, 영지버섯은 각각 57.67, 56.57, 47.62%로 영지버섯보다 상황버섯, 동충하초의 SOD 유사활성이 우수한 것으로 나타났으며, 2단계 발효물에서는 영지버섯의 활성도가 증가하여 55.6%를 나타내어 상황버섯 57.67, 동충하초 56.57%와 유사한 활성도를 나타내었다. 3단계 발효물에서는 상황버섯, 동충하초, 영지버섯의 SOD 유사활성이 각각 50.84, 54.11, 51.52%로 세 실험군 모두 유의적인 차이를 보이지 않았다. 7. 마쇄대두에 영지버섯, 상황버섯 및 동충하초 균사체를 배양한 1 단계 발효물에 바실러스균을 발효(2 단계 발효물)시키고 여기에 유산균을 발효시킨 3 단계 발효물에 대한 혈전용해능을 측정한 결과, 2 단계 발효물에 대한 혈전용해 활성이 각각 상황버섯 89.4%, 동충하초 47.8%, 영지버섯 2.0%로 상황버섯의 혈전용해 활성이 가장 높게 측정되었다. 3 단계 발효물에 대한 혈전용해능을 측정한 결과, 상황버섯 75.2%, 동충하초 75.2%, 영지버섯 82.6%로 동충하초와 영지버섯은 2 단계 발효물보다 혈전용해능이 월등히 상승하였으며, 상황버섯은 2 단계 발효물보다 약간 낮아졌으나 큰 차이는 없었다. 이러한 실험 결과는 마쇄대두에 배양한 약용버섯 균사체에 바실러스균 발효와 유산균 발효의 2 단계 및 3 단계 발효과정을 거치면서 혈전용해능이 증가하는 것으로 나타났다.

한.일 프로축구 관중의 서비스품질 지각과 고객충성도의 관계

김종필 용인대학교 2004 국내박사

이차원 그물형 병렬 시스템의 개발

김종필 포항공과대학교 1997 국내석사

부여 부소산 문화재보호구역 경관개선방안에 관한 연구

김종필 公州大學校 大學院 2006 국내석사

혐기성 폐수처리 공정 중 인 성분 첨가에 의한 메탄가스 발생 효율 향상에 대한 연구

김종필 호서대학교 대학원 2023 국내박사

국제사회는 기후변화와 같은 환경문제에 변화로 전광석처럼 일어나고 있다. 환경규제의 강화에 따라 온실가스의 하나인 메탄을 대기로 배출하면 지구온난화를 가속화될 수 있으며 온실가스를 저감 하기 위해 에너지원으로 활용하는 연구가 진행되면서 국내에서는 바이오 시설의 효율 향상에 연구가 진행되고 있으며, 본 연구의 목표는 혐기성 폐수처리 공정에서 인 성분에 대하여 소화 기술 및 운영 조건을 도출하여 상용화 가능성을 판단하고자 하였다. 연구는 회분식 BMP-test 연속운전으로 유기물 부하가 증가할수록 알칼리도는 환원반응에 의해 증가로 SCOD 제거율과 VFAs의 농도는 고부하조건에서 매우 높은 메탄 생성량으로 혐기성 소화 효율을 나타내었다. 인의 농도에 따라 미생물의 활성도 및 폐수의 생분해 COD(CODBD) 농도와 산화 정도를 근거로 평가하여 그중에 산화 정도 세포 생산율에 미치는 영향에 따라 가스 발생량에 변화가 일어났다. 미생물의 활성도를 극대화함으로써 가수분해 단계에서 생성된 NH4+-N 농도는 400mg/L~465mg/L 범위에서 나타나며 유기물 안정화와 함께 미생물의 형태인 Org-N(C5H7O2N)으로 증식시켜 고효율의 바이오가스 생산 및 저농도 유출수 상징액이 배출되는 고효율 혐기성 소화가 형성되었다. 이 결과로 혐기성 소화 향상 연구에 활용으로 온실가스 저감을 위한 바이오가스 진공 온수보일러를 설치하여 급수탱크의 충수 온도 약 34℃를 가온하는 결과를 확인하였다. 이때 바이오가스 열량은 7,328kcal/㎡로 나타난다. 혐기성 소화 공정에서 바이오 메탄을 재이용하여 연간 LNG 사용량 저감으로 온실가스 CO2 배출량 감소 연구가 될 수 있을 것으로 사료 된다. With the tightening of environmental regulations, methane, one of the greenhouse gases, can be released into the atmosphere to accelerate global warming, and research is attracting attention to use it as an energy source to reduce greenhouse gases. Accordingly, research is being conducted on improving the efficiency of biogasification facilities in Korea, and the goal of this study was to determine the possibility of commercialization by deriving the characteristics and optimal conditions of fire extinguishing technology for phosphorus components in the anaerobic wastewater treatment process. The study showed anaerobic digestion efficiency with very high methane production under high load conditions, as the organic load increased with continuous operation of the batch BMP-test, alkalinity increased by reduction reaction. According to the concentration of phosphorus, the activity of microorganisms and the biodegradable COD(CODBD) concentration and oxidation of wastewater were evaluated based on the degree of oxidation, and among them, the amount of gas generation changed according to the effect of oxidation degree on cell production rate. By maximizing the activity of microorganisms, the NH4+-N concentration generated in the hydrolysis step appears in the range of 400 mg / L ∼ 465 mg / L and it is proliferated into the microorganism form Org-N (C 5H 7 O 2 N) with the stabilization of organic matter, high-efficiency biogas production and high-efficiency anaerobic digestion in which low-concentration effluent symbol liquid is discharged. As a result, it was confirmed that a biogas vacuum hot water boiler was installed to reduce greenhouse gases by using anaerobic digestion improvement research to warm the filling temperature of the feed tank about 34°C. At this time, the caloric content of biogas appears to be 7,328 kcal/㎡. It is believed that biomethane can be reused in anaerobic digestion processes to reduce annual LNG usage and be used for research on reducing greenhouse gas CO2 emissions.

성장-변형률법에 의한 유동시스템 형상의 최적 설계

김종필 한양대학교 대학원 2001 국내석사

유동시스템 형상의 최적 설계는 공학분야에서 요구되어지는 효과를 얻기 위하여 이루어지고 있다. 대표적으로 실험을 바탕으로 하는 경험적인 방법과 수학적으로 목적함수를 설정, 수치해석을 하는 방법이 있다. 본 연구에서는 후자의 수치해석적인 방법으로 Azegami가 제안한 성장-변형률법을 유동시스템에 적합하도록 수정하여 여러가지 유동시스템에 적용을 하였다. 또한 이를 Azegami의 기법에 의한 최적 형상과 비교하여, 비점성 유동인 포텐셜 관로유동에서는 성장비의 조절이 필요하지 않고, 점성 유동인 2차원 확대관에서는 분포매개변수가 보다 안정적이고, 빠르게 수렴함을 알 수 있었다. 그리고 다른 수치해석 기법인 Adjoint 방법과 비교하였을 때는 층류 평판 확대관의 경우, 각각의 Renolds 수에 대한 압력회복계수 와 최적 형상이 근사적으로 일치하며, 유동시스템 형상의 최적화에 효율적이며, 실용적으로 적용될 수 있음을 확인하였다. Shape optimization of a flow system is done to obtain the required effects, in the engineering fields. Most of these designs are accomplished by empirical or numerical analysis. In empirical analysis, it is difficult to obtain an optimal shape in the feasible design region. And, in numerical method, it usually needs much calculation expenses for shape optimization, because of design sensitivity analysis. In this study, we used the growth-strain method having only one distributed parameter such as a design variable. It optimizes a shape by making a distributed parameter such as dissipation energy uniform in a flow system, and then applied to two-flow systems. In order to overcome the stability occurred in numerical analysis performed by Azegami, the equation of volumic strain has been modified. Also, the shapes were compared with the known optimal shapes for the flow systems. Consequently, we confirm that the modified growth-strain method is very efficient and practical in shape optimization of the flow systems.