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조성환,손화영,김혜성,최종윤,류시윤,박배근,윤원기,홍성혁,김덕환 충남대학교 수의과대학 동물의과학연구소 2002 動物醫科學硏究誌 Vol.10 No.-
Pilomatricoma was histopathologically diagnosed in a 2.5-year-old male Alaskan malamute. The patient was referred to Chungnam National University, Veterinary Medical Teaching Hospital with solitary, firm and well-circumscribed mass at shoulder. Grossly, the mass was dome shaped to tumor like and 10 x 8 x 5㎝ in size. Some lesions had gritty or bony consistency and was chalky when sectioned Histopathologic feature included mumerous clusters of tightly arranged, basaloid cells with evenly distributed chromatin and ghost cells were characterized by a central unstained zone. The ghost cells often become calcified and osseous metaplasia was also present.
조은상,손화영,류시윤,조성환 忠南大學校 獸醫科大學 動物醫科學硏究所 2005 動物醫科學硏究誌 Vol.13 No.-
A dog which referred to animal hospital with chief compliment of left hindlimb lameness, was died under the examination, so we observed this case histopathologically. Clinical signs were hindlimb lameness, dyspnea, exercise intolerance, lethargy, hemoptysis, anorexia, and coughing. The gross findings were 5cm in diameters nodule in the caudal abdomen, swelling and milky nodules of the lung, swelling and gray-white patches of the liver, ovarian cyst and dirofilariasis in the heart. In histopathologic examination, metastatic tumors and microfilaria were observed in the lung, liver, spleen, adrenal gland and kidney.
情神分裂病 患者의 腦梁과 視床 : 腦 磁氣共鳴映像 硏究 Magnetic Resonance Imaing Study
조성연,강민희,이정섭 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.2
남성 정신분열병 환자에서 대조군에 비하여 뇌량무릎(genu)부위가 유의하게 작았으며 여성 정신분열병 환자군에서는 양군에서 차이가 없었다. 시상의 면적에서는 양군의 차이가 없었다. 이러한 결과는 남성 정신분열병에서 전전두엽의 크기가 작을 가능성을 시사하며, 또한 남성 정신분열병이 여성에 비하여 신경발달학적인 이상이 많을 가능성을 생각할 수 있다. Magnetic resonance imaging study about size of corpus callosum and thalamus of the shizophrenic patient. Many previous studies have been performed. But the result have been inconsistent. We studied with developed semiautomated measurement method. Using DSM-Ⅳ diagnostic criteria of schizphrenia, we selected 20 subjects and 22 controls. We measured area of corpus callosum and thalamus in midsagittal image with NIH image software. Divided 7 areas of corpus callosum as Witelson method and area of thalamus were measured. Significant difference was found in genu area of male corpus callosum, but no significant difference was found in female between schizophrenia and control. Above finding suggests that male schizophrenia may have neurodevelopmental abnormalities and prefrontal abnormalities.
돼지생식기호흡기 증후군(PRRS) 바이러스 감염시킨 돼지 기관의 병리학적 관찰
조성환,김현수,윤원기,전무형,류시윤,박배근,손화영,김무강 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-
The porcine reproductive and respiratory syndrome virus was inoculated into swine tracheal organ culture. The ballooning degeneration of the tracheal ciliated epithelium and a decrease of ciliary activity from the tracheal organs infected with PRRS virus were observed one day post-infection(PI). Tracheal epithelium showed degeneration and focal necrosis 2 days PI. Epithelial necrosis and loss of cilia and epithelial cells became more severe 3 and 4 days PI. An entire loss of cilia and epithelial cells were recognized 4 days PI, however, control tracheal organs were normal during the period of the experiment except a little decrease of ciliary activities with time..
한국형 출혈열 환자에서 분리한 한타 바이러스의 핵산 분석
조종태,윤성철,안규리,한진석,김성권,이정상 단국대학교 1998 論文集 Vol.33 No.-
Hemorrhagic fever with renal syndrome(HFRS)is an infectious disease showing diverse clinical manifestations according to different serotypes of hantavirus. On the assumption that the antigenicity, nucleotide and amino acid sequence diversity of hantaviruses, as well as immune response diversity of individual KHF patients may be present, this study was performed to analyse the genetic diversity of hantaviruses isolated from patients with KHF. In the 13 samples hantaviral RNAs were extracted, cDNAs of partial M segment were amplified by RT-PCR using genus-reactive primer, amplified cNNAs were analyzed by direct sequencing method, and then the nucleotide and deduced amino acid sequences were compared with previously known sequences of four serotypes of hantavirus isolated from rodent hosts and each other by the computer assistance. The results were as follows. The nucleotide and amino acid sequences of 11 samples among the 13 human isolates showed 90.3∼95.5%, 86.7∼97.9% the other 1 samples 82.7%, 71.9% homology respectively to those of Hantaan virus 76-118 strain, and another 1 sample showed 83.7%, 75.3% homology respectively to those of Seoul virus B1 strain isolated from rodent host. The nucleotide and amino acid sequences of 7 among 12 Hantaan samples showed differences within 5%, 10% respectively each other and high genetic similarities, but those of the oehr 5 among 12 Hantaan samples showed low genetic similarities each other. In conclusion, hantaviruese isolated from KHF patients showed genetic diversity compared with previously known hantaviruses isolated from rodent hosts.
엔로플록사신 액제의 닭 호흡기 및 소화기 감염증에 대한 예방 및 치료효과
윤효인,박병권,조준형,정상희,박경환,장범수,김종춘,황윤환,임종환,이내경,박승춘 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-
We evaluated the efficacy of the liquid form of enrofloxacin against poultry respiratory and digestive infections, the major problems in the poultry industry, from diverse diagnosis viewpoints. Results obtained through this study were as follows: 1. The liquid form of enrofloxacin showed good acceptability to poultry owing to no abhorrence to the drug by chickens, which indicated its suitability for mixing in drinking water. 2. The application of the enrofloxacin formulation improved the productivity of the chicken farm to a great extent by lowering the death toll of chicken raised in the farm. 3. The use of the drug shortened the days to the market, and increased the body weight at the time of marketing. 4. Preventive and therapeutic effects of the liquid enrofloxacin were observed higher than ampicillin, a major antibiotic used in poultry farming. From above results, the liquid form of enrofloxacin would find its use for the prevention and treatment of digestive and respiratory infections, let alone the growth promotion and feed efficiency, especially in the chicken farming practice.
입원환자 간호관리료 차등제 도입이후 간호사 확보수준의 변화
조성현,전경자,김윤미,박보현 대한간호학회 간호행정학회 2008 간호행정학회지 Vol.14 No.2
Purpose: To examine the changes in nurse staffing in hospitals after implementing the policy of differentiating inpatient nursing fees by staffing grades. Method: The study sample included 43 tertiary hospitals, 185 general hospitals, and 282 non-general hospitals that were operating in both 1999 and 2008. Nurse staffing grade was categorized from Grade 1 (highest) to 6 (lowest) in 1999 or Grade 7 in 2008, based on the nurse-to-bed ratio. Results: Tertiary hospitals at Grade 3 and Grade 4 accounted for 49% and 35%, respectively, in 2008, whereas 63% were Grade 6 in 1999. General hospitals at Grade 6 decreased from 87% to 48%. In non-general hospitals, little change was found in the staffing distribution, in that 92% still remained in Grade 6 or 7 in 2008. Forty tertiary hospitals (93%) and 45% of general hospitals improved their staffing grades, while only 7% of non-general hospitals did. Greater likelihood of improvement in staffing grades was found in general hospitals located in metropolitan areas or having 250 or more beds. Conclusion: Elaboration of the financial incentive system is needed to increase the policy impact on staffing improvement.
배추좀나방(Plutella Xylostella Linnaeus)에 대한 새로운 살충활성 분자의 설계
조윤기,최우영,성낙도 충남대학교 농업과학연구소 2007 농업과학연구 Vol.34 No.2
The new insecticidal active molecules from the based on the holographic quantitative structure-activity relationships (HQSAR) between a series of 1-(R₁)-2-(n-octyl)-3-(R₂), 3-(R₃)-pseudothiourea derivatives and their insecticidal activities against Diamond-back moth (Plutella Xylostella Linnaeus) were designed and discussed quantitatively. The most active molecule from the based graphical analyses of atomic contribution maps with the optimized HQSAR C-1 model (q²=0.764 & r²_(ncv)=0.942) was 1-(n-butyl)-2-(t-butyl)-3,3-diisopropylpseudothiourea (P1: pI_(50)=5.30, IC_(50)=1.397 ppm). Therefore, it is suggested that the new designed molecule would increased the activity as much as 23.5 times as compared to X=n-octyl substituent 17(pI_(50)=4.00, IC_(50)=32.86 ppm) which was the highest active molecule in training set compounds.