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MicroSPECT and MicroPET Imaging of Small Animals for Drug Development
장범수 한국독성학회 2013 Toxicological Research Vol.29 No.1
The process of drug discovery and development requires substantial resources and time. The drug industry has tried to reduce costs by conducting appropriate animal studies together with molecular biological and genetic analyses. Basic science research has been limited to in vitro studies of cellular processes and ex vivo tissue examination using suitable animal models of disease. However, in the past two decades new technologies have been developed that permit the imaging of live animals using radiotracer emission, Xrays, magnetic resonance signals, fluorescence, and bioluminescence. The main objective of this review is to provide an overview of small animal molecular imaging, with a focus on nuclear imaging (single photon emission computed tomography and positron emission tomography). These technologies permit visualization of toxicodynamics as well as toxicity to specific organs by directly monitoring drug accumulation and assessing physiological and/or molecular alterations. Nuclear imaging technology has great potential for improving the efficiency of the drug development process.
은나노입자의 방사성 동위원소 운반체 적용 유효성 검증 연구
장범수,이주상,박해준,김화정,박상현 한국방사선산업학회 2011 방사선산업학회지 Vol.5 No.3
In this study, an Ag-polyaniline-silica (Ag-PANI-silica) nanoparticle was evaluated asa radioisotope carrier. An Ag-PANI-silica nanoparticle was incubated in the 125I solution for aduration of 24 hr to test its radioisotope absorptivity. During the incubation, radioactivity of thenanoparticle was measured at 3, 6, 12, and 24 hr. After a 24 hr incubation, 125I-Ag-PANI-silicananoparticle was incubated in a fresh saline for a duration of 48 hr to check its stability. Additionally,the 125I-Ag-PANI-silica nanoparticle was injected to the ICR mouse to investigate its in-vivodistribution characteristics. The 125I absorption yield of the Ag-PANI-silica nanoparticle was higherthan 95% after a 6 hr incubation period in the 125I solution. And 125I-Ag-PANI-silica was stablefor 48 hr at 80% yield at room temperature. The SPECT/CT image of a mouse that received 125IAg-PANI-silica complex showed that the 125I-Ag-PANI-silica complex was distributed in the lung,stomach and thyroid at 30 min post injection. From these results, the Ag-PANI-silica nanoparticlehas good radio-iodine carrying property and can be applicable for the purpose of diagnosis andtherapy.
Cannula를 장착한 돼지에서 Bacillus amyloliquefaciens DS11 Phytase와 Aspergillus ficuum Phytase의 역가 비교
장범수,박승춘,윤효인 한국임상수의학회 2001 한국임상수의학회지 Vol.18 No.1
In this study, we assessed the efficacy of a novel B. amyloliquefacience DS11 phytase (DS11 phytase) and that of a commercial Aspergillus ficcum phytase (AF phytase) through their bioavailabilities of phytin-posphorus and -calcium in the diet using cannulated pigs. For the purpose of evaluating the efficacy of the phytases in pigs, we determined phosphorous concentrations from serum and feces, in addition to ingesta obtained from the cannula at the terminal ileum. As results, phosphorus concentration was lower in feces from DS11 group and BASF group by 17% and 10%, and higher in serum from the respective groups by 34% and 20%, as compared to the control group. Both phytases are evaluated to enhance phosphorus availability to the great extent. Calcium concentration of feces were lower in DS11 group and BASF group by 31% and 10%, than that in the control. Calcium concentration of serum was higher in DS11 phytase group by 4% but lower in AF phyase group by 3%, then that in the control group.