심근 허혈-재관류 백서 모델에서 mitogen-activated protein kinase 활성화에 대한 α-lipoic acid의 효과

김연경,박은미,최준호,윤경호,유남진,이은미,김남호,정진원,김민선,박병림,오석규 圓光大學校 醫科學硏究所 2006 圓光醫科學 Vol.21 No.1

플라즈마 표지소자의 제작

이상윤,라병욱,박동수,황인헌,이덕동,신영남,박성배,이동욱,박용석,박형근,손상호,권태근,채경락,정경득 慶北大學校 自然科學大學 1986 自然科學論文集 Vol.4 No.-

An Ac-type Plasma Display Panel (PDP) operating with Ne-Ar(0.1%) Penning mixture gas is fabicated. The characterics of the panel with electrodes covered with thin and thick dielectric layers are studied. The brightness of the Neon-orange light emitted by the panel measured as function of applied voltage and frequency. As an application, a graphic display system equipped with PDP showing still and moving pictures is made.

정상체중군과 과다체중군 산업장 중간관리자의 건강증진 행위에 관한 비교연구

김정남(Kim Chung Nam),박경민(Park Kyung Min),류미경(Ryu Mi Kyung),장희정(Jang Hee Jung) 계명대학교 간호과학연구소 2001 계명간호과학 Vol.5 No.1

The purpose of this study was to identify and compare Health Promoting Behavior and its affecting factors between Normal and Over weight industrial middle manager. The subjects were 163 workers employed in factories in Taegu and Kyung-book were convenient sampling data the period for May 22th-26th, 2000 through self report methodby structured questionnaires. Collected data were analyzed by t, x2, Kendal tau, Pearson correlation, Stepwise Multiple Regression. The results of this study were as follows. 1. There were a significant difference in shift pattern(x2=7.89, P=0.005) and career. (x2=12.99, P=0.005) between normal weight and overweight group. 2. The average score of performance in health promoting behavior among overweight group(2.55) was higher than that of normal weight group(2.46), but not significant. 3. The average score of health status in overweight group(3.07) was lower than that of normal weight group(3.21), but not significant. 4. The average score of self-efficacy in overweight group(3.63) was significant lower than that of normal group(3.71). 5. The average score of the perceived barrier of in overweight group(2.44) was significant higher than that of normal group(2.24). 6. Health promoting behaviors in overweight group was significantly correlated with health status(r=.384, P<.05), health Concept(r= 458, P<.01) self-efficacy ( r=352, P< 01), perceived benefit(r=.386, P< .05), perceived barrier(r= -245, P< .05) Health promoting behavior in normal weight group was significantly correlated with health concept( r= .307, P< .050 and perceived benefit. 7. In consideration of variables that have an influence on Health promoting behavior among Normal weight group, health concept and perceived benefit account for 28.8% of health promoting behavior. In overweight group. The perceived benefit account for 13.7% of health promoting behavior. The suggestions are as follows on the basis of the results of this study. 1. It is required to develop health promoting program to improve health promoting behavior. In addition, there are special demands on developing nursing strategies for health promoting behavior of overweight industrial supervisors. 2. It is necessary to support exercise facility in occupational field for improving supervisor's health promoting behavior.

다발성 관동맥-좌심실간 미세루 1예

정성원,김남호,박은미,이상재,윤경호,유남진,이은미,박무림,오석규,정진원,박옥규 圓光大學校 醫科學硏究所 2003 圓光醫科學 Vol.18 No.1

국내 관세자유지역운영의 활성화 방안에 관한 연구

박노경,손용정,김남호 朝鮮大學校 經營經濟硏究所 2004 經營經濟硏究 = Management and economics research Vol.27 No.1

同一患者 醫務記錄과 診療費明細書의 傷病名에 關한 實態 調査 硏究

남영희,박경숙 중앙대학교 의과대학 간호학과 간호과학연구소 1997 중앙간호논문집 Vol.1 No.2

The Purpose of this study was to serve as a basis for the improvement of health care insurance's payment system and the elevation of public health statistics', quality, by comparing the name of injury or disease of a patient described in a medical record with that of the same patient described in a detailed medical treatment account to find out whether the names expressed on both papers agreed with each other. The subjects in this study were inpatients who were taken under health care insurance to a hospital with more than 300 sickbeds that was not equipped with computer system and to a hospital with more than 400 sickbeds that was equipped with computer system. The data were collected from 682 patients who were out of the hospital with more than 300 sickbeds for two months from December 1996 through January 1997, and from 1,020 patients who were out of the hospital with more than 400 sickbeds for a month, in October 1996. The collected data were processed using SPSS. The following findings were given as a result of conducting study on the name of the same patients's injury or disease recorded in a medical record and a detailed medical treatment account: The largest department in the hospitals investigated was the internal treatment department(29.2 percent), the general surgical department (17.5 percent), and the obstetrics and gynecology in the order. The injury or disease added in detailed medical treatment account in comparison with each sickbed's medical record was 402 cases(26%) for the 20 largest ones among total 1,495 cases's distribution frequencies at the hospital with more than 300 sickbeds and 985 cases(32%) for the 20 largest ones among total 3,366 cases' distribution frequencies at the hospital with more than 400 sickbeds. The injury or disease omitteed in medical treatment account in comparison with each sickbed's medical record was 181 cases(32%) for the 20 largest ones among total 600 cases' distribution frequencies at the hospital with more than 300 sickbeds and 145 cases(21%) for the 20 largest ones among 713 cases' distribution frequencies at the hospital with more than 400 sickbeds. The injury or disease totally agreed between each sickbed's medical record and medical treatment account was 226 cases(39%) for the 20 largest ones among, total 582 cases' distribution frequencies at the hospital with more than 300 sickbeds and 373 cases(32%) for the 20 largest ones among total 1,254 cases' distribution frequencies at the hospital with more than 400 sickbeds. The injury or disease partially agreed between each sickbed's medical record and medical treatment account was 292 cases(37%) for the 20 largest ones among total 857 cases' distribution frequencies at the hospital with more than 300 sickbeds and 339 cases(30%) for the 20 largest ones among total 1,320 cases' distribution frequencies at the hospital with more than 400 sickbeds. and then, the number of classification symbol of injury or disease was compared between each sickbed's medical record and medical treatment account. As a result, what medical treatment account had larger number of classification symbol than medical record did was 926 cases(178%) for the hospital with more than 300 sickbeds and 2,695 cases(242%) for the hospital with more than 400 sickbeds. The mean number of classification symbol in each medical record was 1.8, while that of medical treatment account was 3.9. The number of injury or disease recorded in detailed medical treatment account was two times on the average as many as that in medical record. The agreement ratio of each sickbed's classification symbol was that 60.1 percent showed a perfect agreement and 70.9 percent showed a partial agreement. The agreement rate of medical record was that 25.6 percent agreed and 74.4 percent disagreed. The disagreement rate was higher than the agreement rate.

자가 면역성 간염에서 자가항체의 발현 양상과 스테로이드 치료의 효과

박기오,채경훈,허원석,강윤세,정재훈,김연수,문희석,이엄석,김선문,이병석,김남재,이헌영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

목적 : 최근 8년간 본원에서 경험한 자기면역성 간염의 혈액학적 특징과 스테로이드의 치료효과를 알아보고자 본 연구를 시행하였다. 방법 : 1996년 이후부터 2002년까지 충남대학교 병원에서 1999년 International Autoimmune Hepatitis Group(LAHG)에서 제시한 수정 진단 기준안에 의거하여 총 진단점수가 probable 이상에 해당하는 환자들을 대상으로 임상적 특징, 검사실 및 조직 소견과 스테로이드와 azathioprine의 치료 효과를 후향적으로 조사하였다. 결과 : 9예의 환자들은 여성이 78%, 40대가 많았고, 급성 발병이 33.3%, 피로감, 식욕부진 및 황달 등이 나타났으며, 항핵항체가 55.6%에서 그리고 항평활근 항체가 77.8%에서 양성이었고, 동반 질환은 류마치스 관절염이 2예, 특발성 혈소판 감소증 1예, Henoch-Sch nlein 자반증 및 그레브스병이 각각 1예 씩이었다. 7예에 대해서 스테로이드와 azathioprine으로 치료하여 생화학적 임상적 완해가 이루어져서 유효한 치료 결과를 얻었다. 결론 : 자가면역성 간염은 우리 나라에서 원인을 찾을 수 없는 만성 간질환의 경우, 특히 중년여성에서 다른 자가면역성 질환이 동반되었을 때 자가면역성 간염을 의심하여 자가항체 선별검사를 시행해 보아야 할 것으로 생각된다. 향후 다기관 연구를 통하여 좀 더 많은 증례를 모으고 전향적인 연구를 시행하여야 할 필요가 있다. Although autoimmune hepatitis(AIH) is common in western contries, some studties have been reported in Korea. The aim of the study was to analyze the clinical and histological features and expression pattern of the autoantibody and to examine clinical course of AIH in Korea. For 9 patients diagnosed as having AIH in our hospital since 1996, we reviewed medical records and analyzed clinical and laboratory findings retrospectively. They had a probable or definite AIH according to the revised criteria of International AIH group. The mean age was 42.7(21∼68)years and 7(77.8%) were female. Three of them(33.3%) showed acute hepatitis and five of them showed cirrhosis. Fatigue and anorexia were the most frequently complained symptoms(55.6%). Four patients(44.4%) were accompanied with other autoimmune diseases. Antinuclear antibody was detected in 5(55.6%) and anti-smooth muscle antibody was detected in 7(77.8%). Three patients showed focal picemeal necrosis and four showed periportal fibrosis. Among 7 patients who received immunosuppressive therapy, six patients(85.7%) showed initial response. and biochemical and serologic remission were achived in 5(71.4%) and 3(42.8%) patients, AIH seems to be partly responsible for chronic liver disease of unknown etiology in Korea. AIH should be suspected in female patients with unknown chronic liver disease of unknown etiolgy, especially accompanied with other autoimmune disease. The clinical characteristics of AIH may not be quite different from those of Western countries.

초기 성공적인 심폐소생술후 혈청 Interleukin-6 농도의 발현양상

박규남,박승현,황두영,김형국,이환,최경호,이원재,정욱성,김학주,김세경 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.4

Objective : To investgate patterns of serial serum interleukin-6(IL-6) concentrations after initial successful cardiopulmonary resuscitation, and to access differences in serum IL-6 concentrations in patients with Cerebral Performance Category(CPC, 1-2) and CPC(3-5) at the 5th day after cardiacpulmonary resuscitation(CPR). Methods : We studied prospectively 12 patients with spontaneous circulation after cardiopulmonary resuscitation. Venous blood samples were taken 2, 4, 12, 24, 48 and 72 hours after restoration of spontaneous circulation to measure serum IL-6 levels by the enzyme-linked immunosorbent assay. Results : Serum IL-6 concentrations in the severe neurolgically disabled group(CPC, 3-5) were significantly increased at 2, 24 and 48 hours after restoration of spontaneous circulation compared with the less neurolgically disabled group. Also, serum IL-6 concentrations in the severe neurolgic disabled group showed dual peak at 4 and 24 hours. Conclusion : Our study demonstrates significant increase of serum IL-6 in patients with CPC(3-5) after successful cardiopulmonary resuscitation and the significant correlation between early increase of serum IL-6 and poor neurologic outcome. It suggests that early increase of serum IL-6 can be used as a prognostic marker after successful cardiopulmonary resuscitation.

FGF-mediated FGFR signaling 이 두개봉합부의 초기형태발생 및 유지기전에 미치는 영향

남순현,김영진,서경환,김현정,박미현,유현모 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.4

두개봉합부의 조기융합으로 알려진 Craniosynostosis는 두개봉합부 주위 조직들 사이의 조화로운 상호 작용이 파괴되었을 때 야기될 수 있다. 흥미롭게도 FGF receptor들, 특히 FGFR2의 point mutation은 여러 가지 형태의 craniosynostosis 증후군과 연관되어 있어, FGFR가 두개봉합부를 포함한 두개골 성장 발달과정에 중요한 유전자임을 시사하고 있다. Mouse 두개봉합부의 초기형태발생시 FGFR 유전자들의 기능을 알아보기위해, in situ hybridization 방법을 이용하여 FGFR2(BEK) 및 골아세포분화의 초기표지자인 osteopontin이, 태생기(E15-18)에서 출생후(P1-P3)까지, 두개골의 시상봉합부에서의 발현양상을 조사하였다. FGFR2(BEK)은 osteogenic front에 강하게 발현되었으며, osteopontin은 parietal bone의 exo-, endocranial부위에서 발현되었으나, parietal bone의 성장가장자리인 osteogenic front에서는 관찰되지 않았다. 두개봉합부에서의 FGF-mediated FGFR signaling의 역할을 좀더 심도깊게 조사 하기위해 E15.5 mouse의 두개골을 이용하여 in vitro 실험을 시행하였다. 흥미롭게도 osteogenic fronts 및 시상봉합부의 간엽조직 중앙에 FGF2 - soaked beads를 점적하여 36시간 기관배양한 결과, bead주위 조직들의 두께 및 세포수가 증가되었으며, osteogenic fronts 상에 FGF4 beads를 올려놓은 경우, 시상두개봉합부 중앙에 점적된 FGF4 beads나 BSA control beads에 비해, 골성장이 촉진되어 시상두개봉합부의 부분적인 소멸을 관찰할 수 있었다. 이와 더불어 FGFR2 beads는 osteopotin 및 Msxl 유전자의 발현을 유도하였다. 이 결과들을 종합해 볼 때, FGF - mediated FGFR signaling이 발육중인 두개골과 두개봉합부에서 세포의 증식과 분화의 균형을 조절하는데 중요한 담당하고 있음을 시사해주고 있으며, 이 과정중 FGF signaling이 osteopontin 및 Msxl 유전자의 발현을 조절하므로써 막내골 성장 및 두개봉합부의 유지기전에 기여할 것으로 사료된다. Craniosynostosis, the premature fusion of cranial sutures, presumably involves disturbance of the interactions between different tissues within the cranial sutures. Interestingly, point mutaions in the genes encoding for the fibroblast growth factor receptors(FGFRs), especially FGFR2, cause various types of human craniosynostosis syndromes. To elucidate the function of these genes in the early morphogenesis of mouse cranial sutures, we first analyzed by in situ hybridization the expression of FGFR2(BEX) and osteopontin, an early marker of osteogenic differentiation, in the sagittal suture of calvaria during embryonic (E15-E18) and postnatal stage (P1 - P3). FGFR2(BEK) was intensely expressed in the osteogenic fronts, whose cells undergo differentiation into osteoprogenitor cells that ultimately lay down the bone matrix. Osteopontin was expressed throughout the parietal bones excluding the osteogenic fronts, the periphery of the parietal bones. To further examine the role of FGF-mediated FGFR signaling in cranial suture, we did in vitro experiments in E15.5 mouse calvarial explants. Interestingly, implantation of FGF2 soaked beads onto both the osteogenic fronts and mid-mesenchyme of sagittal suture after 36 hours organ culture resulted in the increase of the tissue thickness and cell number around FGF2 beads, moreover FGF4-soaked beads implanted onto the osteogenic fronts stimulated suture closure due to an accelerated bone growth, compared to FGF4 beads placed onto mid-mesenchyme of sagittal suture and BSA control beads. In addition FGF2 induced the ectopic expression of osteopontin and Msxl genes. Taken together, these data indicate that FGF-mediated FGFR signaling has a important role in regulating the cranial bone growth and maintenance of cranial suture, and suggest that FGF-mediated FGFR signaling is involved in regulating the balance between the cell proliferation and differentiation through inducing the expression of osteopontin and Msxl genes.

죽상경화 혈관 합병증의 예측 인자로서의 경동맥 내중막 두께 및 대동막 판막 두께

박은미,김연경,송미진,최준호,윤경호,오석규,정진원,김남호 圓光大學校 醫科學硏究所 2006 圓光醫科學 Vol.21 No.1