담도계 담석과 십이지장 유두 주위부 게실과의 관계

김남재,이경태,김진희,이상우,이승민,성재규,서광식,김석현,이병석,이헌영 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.4

Background/Amins: Juxtapapillary duodenal diverticuli are often associated with biliary stones. The aim of this study was to investigate the prevalence of juxtapapillary duodenal diverticuli in biliary stones. Methods: Three hundred and thirteen patients underwent endoscopic retrograde cholangiopancreatography were studied prospectively. Results: Seventy-five patients had juxtapapillary duodennl diverticuli(24%). The occurrence of diver- ticuli increased with age and more commomly in female patients. The prevalence of diver- ticulii was higher in patients with commom bile duct stones(35.6% vs 17.6%; P 0.002) and gallbladder stones(33.3% vs 17.6%; P=0,001) than in patients without biliary stones (17.6%). Conclusions: We conclude that biliary stones are associated with juxtapapillary diverticuli.

우울과 대인불안의 인지적 특성 비교

김남재 德成女子大學校 1996 德成女大論文集 Vol.25 No.-

Connitive theories and data on depression and social anxiety empathized the maladaptive cognitions. Many researchers have proposed that depressed individuals have cognitions overempathizing negative information. Negative cognitions also have been reported in social anxiety. Typical cognitive features in depression are as follows: excessive self-focused attention, negative self-concept, negative automatic thought, information-processing consistent with negative self-schema, negative attributional style, and low performance expectancy. And typical cognitive characteristics in social anxiety are as follows: excessive public self-consciousness, irrational beliefs, negative self-statements, low self-presentation outcome expectancy, negative attributional style, and information-processing hypersensitive to social threat. In previous studies, many common cognitive features between depression and social anxiety have been found. And that the cognitive specificity in depression and social anxiety can be identified by cognitive contents rather than cognitive processes has been suggested. Critical cognitive features differentiating social anxiety from depression can be condenced into the schema preoccupied with negative evaluations of others in social situations. Finally, necessity for research exploring cognitve specificity in depression, general anxiety, and social anxiety is discussed.

감초 함유 처방의 글리치리진 대사와 몇가지 효소저해효과

김남재,배은아,한명주,김동현,Kim, Nam-Jae,Bae, Eun-Ah,Han, Myung-Joo,Kim, Dong-Hyun 한국생약학회 1999 생약학회지 Vol.30 No.3

To analyze scientifically the prescription principle of polyprescriptions (Gamchotang, Daewhanggamchotang, Jakyakgamchotang, Gamchogungangtang and Gilkyungtang) containing Glycyrrhizae Radix, the transforming rate of glycyrrhizin in these polyprescriptions to 18 ${\beta}-glycyrrhetinic$ acid and their inhibitory effect on ${\beta}-glucuronidase$, hyaluronidase, phosphodiesterase and trypsin were investigated. When Glycyrrhizae Radix containing polyprescriptions were extracted with water, the contents of glycyrrhizin in water extract of Glycyrrhizae Radix with Rhei Rhizoma or with Zingiberis Rhizoma were higher than that of Glycyrrhizae Radix only, but that in water extract of Glycyrrhizae Radix with Platicodi Radix was lower than that of Glycyrrhizae Radix only. By human intestinal bacteria, glycyrrhizin was metabolized to 18 ${\beta}-glycyrrhetinic$ acid. These metabolism of glycyrrhizin in polyprescriptions containing Glycyrrhizae Radix was inhibited by Rhei Rhizoma, Paeoniae Radix and Platicodi Radix, but was not affected by Zingiberis Rhizoma. The inhibitory activity of Glycyrrhizae Radix on hyaluronidase and ${\beta}-glucuronidase$, was synergistic with Rhei Rhizoma or Zingiberis Rhizoma, but was antagonistic by Platicodi Radix.

구기자나무의 약물활성

김남재,윤황금,홍남두,Kim, Nam-Jae,Youn, Whang-Geum,Hong, Nam-Doo 한국생약학회 1994 생약학회지 Vol.25 No.3

Pharmacological effects of water extracts of Lycii Fructus, Lycii Folium and Lycii Cortex Radicis from Lycium chinensis were investigated. Lycii Folium significantly protected the hepatic function from damages orally caused by $CCl_4 $administration in mice and had a strong hypoglycemic effect in hyperglycemic mice induced by streptozotocin. Lycii Fructus decreased the blood pressure rise associated with the growth of normal rats. Lycii Cortex Radicis had a strong hypoglycemic effect in hyrerglycemic mice induced by streptozotocin. Also, hypolipidemic effects in hyperlipidemic rats induced by 1% cholesterol fed-diet and 75% fructose were significantly observed by oral administration of water extracts of Lycii Fructus, Lycii Folium and Lycii Cortex Radicis.

대인불안 집단의 정보처리적 특성 연구

김남재 덕성여자대학교 학생생활연구소 1996 學生生活硏究 Vol.12 No.-

인지적 접근의 이론과 연구들은 대인불안 집단은 사회적 상황에서 공적 자기의식을 많이 하며, 사회적 위협 단서를 촉진하는 정보처리를 할 것이라고 가정한다. 사회적-평가적 스트레스가 없는 상황에서도 대인불안 집단의 자기도식이 활성화되어서 가정된 정보처리적 특성이 나타나는가를 알아보는 것이 본 연구의 목적이었다. 여자대학생들을 피험자로 하여 변형된 처리의 깊이 파라다임을 사용하였다. 제시된 단어들을 사회적 위협 단어들과 비위형 단어들로 나누었으며, 평정 과제는 의미적, 사적 자기관련적 및 공적 자기관련적 과제이었다. 연구 결과, 비 대인불안 집단은 사회적 위협 단어들에 비해서 비위형 단어들을 더 많이 회상하였으나. 대인불안 집단에서는 단어 내용에 따른 회상량의 차이가 없었다. 예언과 달리, 대인불안 집단은 공적 자기관련적 처리 조건에서 사회적 위협 단어들을 가장 많이 회상하지 않았다. 본 연구 결과는 대인불안 집단이 사회적-평가적 스트레스가 없는 상황에서는 공적 자기에 관심을 기울이지 않으며, 사회적 위협 단서에 과민한 정보처리를 하지 않음을 시사한다. 끝으로 본 연구 결과의 시사점과 몇가지 해석의 가능성을 논의하였다. Theoretical and empirical efforts suggested that socially anxious individuals concern over evaluation of others and are hypervigilant to social-eva-luative threat cues. The present study attempted to investigate information processing characteristics of socially anxious individuals in no social-eval-uative stress condition A modified self-referent depth-of-Processing Parad-igm was employed. Stimulus adjectives were classified into social threat words and non-threat words. For non-anxious students, there was more recall for non-threat words than for social threat words. While for socially anxious students, there was no difference between social threat words and non-threat words recall. Inconsistently with the prediction, socially anxious students did not show greater recall for social words in public self-refernt condition than any other conditions. The present result suggest that socially anxious individuals do not concern over evaluation of others and are not hypervigilant to social-evaluative threat cues in no social-evalua-alive stress condition. Additionally some implications and methodological issues were discussed.

전통약물의 약효 평가방법

金南宰 경희대학교 동서의학연구소 1991 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1991 No.3

The interpretation on the traditional herbal medicine(THM) has been changing with the lapse of time. Especially, THM is used in a single crude drug or compound form of tens of crude drugs, also it's constituents and effect are not precisely proved and it's using is also based on the traditional evaluation by tae past experiences. The studies on the action of THM are widely carrying in the fields of pharmacognogy, pharmacology, biochemistry and clinics. But the biological effect and pharmacological actions are not sufficiently understood yet. Recently the interest in the biological activities of THM is increasing and the main purposes are divided in two. The first is to success and develop the THM through the scientific and analytical demonstration of the pharmacological actions. The second is to screen the activities of THM in purpose of using the THM as the source of new drug development. There are two method in screening and proving the action of THM by the pharmacological methods. One is the in vivo experiment using the living whole animals and the other is the random screening using the in vitro bioassay. The pharmacological experimental methods which are used in the study of THM will be discussed on the basis of the former method.

최근 5년간 간경변의 원인과 합병증에 관한 고찰

김남재,김진희,서광식,이승민,이경태,이상우,성재규,이병석,김석현,이헌영 대한간학회 1997 Clinical and Molecular Hepatology(대한간학회지) Vol.3 No.3

Background/Aims: The causes and complications of liver cirrhosis are varied and increasing prevalence of alcoholic liver disease has been suspected. We tried to categorize the causes and complications of liver cirrhosis. Methods: We investigated the 159 patients who are diagnosed as liver cirrhosis at Chungnam National University Hospital during the recent 5 years. Results: 1) HBV infection was the most common cause of liver cirrhosis (48.1%), alcohol was next (42.9%). 2) Alcoholic liver cirrhosis was the most common cause in male (54.2%), postnecrotic cirrhosis (HBV) was the most common cause in female (66.7%). The difference was considered to come from the fact that male drinks more, constantly or habitually. 3) Alcohol was the most common cause of liver cirrhosis above the fifth decade of age and HBV is under 40 yeats of age. 4) The complications of liver cirrhosis are variceal bleeding, most common, splenomegaly and ascites in order. Hepatocellular carcinoma occumd also especially in HBV induced liver cirrhosis. Conclusion: Alcoholic liver disease is a common cause of liver cirrhosis. (Korean J Hepatol 1997;6:202 209)

地黃의 품질평가

김남재,정은아,김희정,심상범,김종우 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

The dried roots of Rehmannia glutinosa(RG) have been used in the traditional medicine for treatment of diabetes, fever and dysuria, etc. In order to investigate the quality evaluation of the dried roots of RG, we conducted the physico-chemical and biological evaluation method. The amount of catalpol from commercial samples is very diverse about 0.00~3.89% by using HPLC method, because it is easily decomposed by processing of RG. So, we should try to identify the correlation with the contents of catalpol and biological activities of RG. We chose 3 samples which were a wide difference of catalpol contents between each sample(Sample-I; 3.4%, Sample-II; 2.8%, Sample-III; 0.05%). Sample-I and Sample-II were found to be more effective than Sample-III on the DPPH free radical scavenging effect and inhibitory effect on H₂O₂-catalyzed lipid peroxidation in rat liver in vitro. And, Sample-I and Sample-II exhibited more significant effects than Sample-III on accelerating actions of the small and large intestinal transport, and diuretic action in mice. So, it is suggested that the quantitative determination of catalpol should be required for the standardization of the dried roots of RG.

한방처방구성원리의 과학적 해석연구(Ⅱ) : 상한론 처방의 통계적 분석연구 Statistical Analysis of Sang-Han Prescriptions

김남재,김동현,장준복,송병기 慶熙大學校 1997 論文集 Vol.26 No.-

This study was made to objectify the principle of oriental medical prescriptions so that we could obtain the principle and the formulation of them. For that purpose, we analysed the formula and rule of 113 prescriptions recorded in 「ShanghanLun」, which have a few of components, and re widely used in clinical from ancient times to these days. At first we classified those prescriptions by their effect. Then we re-classified the herbs of the effect groups into four natures(cold, hot, warm and cool) and five kinds of flavors(wour, bitter, sweet, acrid and salty). And we classified the herbs into three grades -superior, medium, and inferior which were used in Shen Nong's Herbal Classic. By these means, we statistically evaluated the prescriptions recorded in 「ShanghanLun」based on the Four Regular Components(Monarch, Minister, Assistance and Laborer) According to the frequecy of the herbs used on the 108 prescriptions recorded in 「ShanghanLun」there are many concidences with the herbs used in these days. According to the effects, formulation of prescriptions and the effects have very colse relationship, and it might be related with the diseases on those days. The formulation of the prescriptions was carefully made by the for natures and five kinds of flavors. On the study of the three grades of Shen Nong's Herbal classic the superior and medium herbs mostly used, and the inferior herbs were very seldom used.

OSMU를 위한 MMORPG 캐릭터 특성 분석

김남재,이동열 한국디지털정책학회 2012 디지털융복합연구 Vol.10 No.1