급성하벽심근경색에서 전흉부유도 ST절 하강의 의의

정병천,배호상,곽동훈,김영태,배용학,황종현,임현주,류재근,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

목적 : 급성하벽심근경색증 환자에서 심전도상 흔히 동반되는 전흉부유도 ST절 하강의 의의를 알아보았다. 방법 : 심근경색후 24시간에서 48시간에 얻은 심전도를 기준으로 52명의 급성하벽심근경색증 환자를 전흉부유도에서 ST절의 하강이 있는 군과 없는 군으로 나누었으며 심도자, 관상동맥조영술, 심초음파도 및 방사성 핵종을 이용한 좌심구혈율 측정 등을 시행하였다. 결과 : 1) 좌심실확장기말압은 전흉부유도에서 ST절의 하강이 있는 경우에서 16.9±5.33mmHg로 없는 경우의 11.0±4.02mmHg보다 유의하게 높았다(p<0.05). 그러나 운동량 및 좌심구혈을은 흥부 유도상 ST절의 하강이 있는 경우 7.6±3.0 METs 및 53.9±9.1%로 없는 경우의 9.1±2.7 METs 및 54.6±9.5%보다 낮았으나 통계적 유의성은 없었다(p=0.180, p=0.823). 2) 관상동맥조영술상 전흉부 ST절의 하강이 동반된 군에서는 유의한 좌전하행지나 좌회선지의 협착이 있는 경우가 60.9% 및 57.9%로 ST절의 하강이 없는 군에서의 34.5% 및 7.7%와 비교해 좌관상동맥에 협착이 동반된 경우가 많았다(p=0.050, p=0.001). 3) 관상동맥조영술상 세 혈관질환의 빈도는 흉부유도상 ST절의 하강을 보인 23예에서 10예로 ST절 하강이 없었던 29예중 2예에 비하여 유의하게 많았고(P=0.007), 단 혈관질환의 빈도는 ST절의 하강을 보인 군에서 23예중 5예로 ST절 하강이 없었던 29예중 17예에 비하여 유의하게 적었다(P=0.002). 두 혈관질환의 경우에는 각각 8예와 10예로 양군간에 유의한 차이가 없었다. 4) 흉부유도상 ST절 하강의 빈도는 단 혈관질환 22예 중 5예에서, 두 혈관질환 18예중 8예, 세 혈관질환 12예 중 10예에서 관찰되어 협착이 있는 관상동맥의 수가 많을수록 ST절의 하강이 나타나는 빈도가 많음을 보였다(p=0.00308). 그러나 흉부유도상 나타난 ST절의 하강을 모두 합하여 구한 ST절 하강의 합은 협착이 있는 관상동맥의 수와 통계적인 유의성이 없었다. 5) 심초음파도상 좌심실 하벽의 벽운동은 ST절 하강을 보인 군에서는 akinesia가 83.3%, hypokinesia가 11.1%, 정상 벽운동이 5.6%로, ST절 하강이 없었던 군에서의 dyskinesia가 3.6%, akinesia가 39.3%, hypokinesia가 25.0%, 정상 벽운동이 32.1%와 비교하여 ST절의 하강이 있는 군에서 유의하게 벽운동의 장애가 빈번함을 보였다(p=0.03891). 그러나 좌심실전벽, 측벽 및 중격부위에서는 유의한 벽운동의 차이가 없었다. 결론 : 급성하벽심근경색증 환자의 전흉부유도에서 ST절의 하강이 동반되는 경우 다혈관 질환의 가능성이 높으며 좌심실확장기말압이 상승되었고 운동능력은 감소되어 있었다. 또한 심초음파도상 좌심실하벽의 벽운동장애도 심하였다. 따라서 전흉부 ST절의 하강을 동반한 급성하벽심근경색증 환자는 전흉부유도에 ST절 하강이 없는 경우보다 예후가 불량할 것으로 생각되며, 보다 적극적인 치료가 필요할 것으로 생각된다. The purpose of this study was to determine the significance of precordial ST segment depression appearing during acute inferior myocardial infarction and to assess the correlation of that with angiographic finding. 52 patients were allocated into two groups based on the existence of precordial ST segment depression : 23 patients with ST segment depression and 29 patients without ST segment depression. The extent of coronary artery disease as well as the prevalence of significant stenosis (≥70%) in left anterior descending artery were more frequent in patients showing precordial ST segment depression than in patients not showing them (p=0.050) and the result were similar in cases of left circumplex artery (p=0.001). On echocrdiographic examination of left ventricular (LV) wall motion, it showed more severely decreased inferior LV wall motion in patients showing precordial ST segment depression than in patients not showing them (p=0.03891) even though the other segment of LV wall motion didn't show the statistical difference between both groups. The other cardiac parameters such as LVEDP, exercise amount (METs) and ejection fraction were tend to showing bad profile in patients with precordial ST segment depression. From the above results, we could deduce that patients with precordial ST segment depression have relatively large infarction or concomitant left coronary artery disease, so they need more caution and intensive theraphy.

Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans

Song, Mi-Young,Kim, Sang Hoon,Ryoo, Ga-Hee,Kim, Mi-Kyung,Cha, Hye-Na,Park, So-Young,Hwang, Hong Pil,Yu, Hee Chul,Bae, Eun Ju,Park, Byung-Hyun Nature Publishing Group UK 2019 Experimental and molecular medicine Vol.51 No.5

<▼1><P>Adipose tissue inflammation is a reproducible feature of obesity and obesity-linked insulin resistance. Although sirtuin 6 (Sirt6) deficiency has previously been implicated in diet-induced obesity and systemic insulin resistance, the adipocyte-specific role of Sirt6 in the regulation of adipose tissue inflammation and systemic metabolic dysfunction in mice fed normal chow and in humans remains elusive. Here, using <I>Adipoq-Cre</I>-mediated adipocyte-specific Sirt6 knockout (aS6KO) mice, we explored whether adipocyte Sirt6 inhibits adipose tissue inflammation and its underlying mechanism. aS6KO mice fed normal chow gained more body weight and fat mass than wild-type mice and exhibited glucose intolerance and systemic insulin resistance. Measurement of plasma and tissue cytokines and flow cytometric analysis of adipose stromal vascular cells indicated a decrease in alternatively activated M2 macrophages in the adipose tissue of aS6KO mice. Mechanistically, Sirt6 regulated the expression of the canonical type 2 cytokine IL-4 by adipocytes in a cell autonomous manner, which in turn affects M2 macrophage polarization. Consistent with animal experimental data, the degree of obesity and insulin resistance demonstrated by the body mass index, fasting blood glucose and HbA1c correlated negatively with the expression of Sirt6 in human visceral fat tissues. Collectively, these results suggest that adipocyte Sirt6 regulates body weight gain and insulin sensitivity independent of diet, and the increased IL-4 production by Sirt6 and resultant M2 polarization of adipose tissue macrophages may attenuate proinflammatory responses in adipose tissue.</P></▼1><▼2><P><B>Obesity and diabetes: A control protein in fat</B></P><P>A protein in adipose tissue (composed of fat cells) helps protect against inflammation and the development of resistance to insulin that develops in obesity and can lead to type 2 diabetes. Researchers in South Korea, led by Eun Ju Bae at Woosuk University, Wanju, and Byung-Hyun Park at Chonbuk National University, Jeonju, investigated the role of Sirt6 in mice and in human adipose tissue. Deleting the mouse gene that codes for Sirt6 in adipocytes promoted the impaired response to insulin and associated increase in blood glucose levels that are two key aspects of diabetes. Changes in biochemical signaling pathways controlling immune cells called macrophages were implicated in these effects and suggest an anti-inflammatory role for Sirt6. Analysis of human adipose tissue supported these findings. The research will help understand how obesity promotes type 2 diabetes.</P></▼2>

국내에서 분리된 Esherichia Coli 와 Klebsiella pneumoniae의 CTX-M형 Extended-Spectrum β-Lactamase 생성 현황

배일권,우건조,정석훈,박광옥,조병규,김둘만,권수봉,김현주,강현경 대한임상미샐물학회 2004 Annals of clinical microbiology Vol.7 No.1

오차드그래스(Dactylis glomerata L.)의 품종에 따른 종자유래의 캘러스 형성률과, 캘러스 크기 및 식물체 재분화 효율의 비교

배은경,이인애,김기용,이병현,손대영,이효신,정민섭,조진기 Plant molecular biology and biotechnology research 2002 Plant molecular biology and biotechnology research Vol.2002 No.-

Comparison results of callus formation ratio from seed explants, callus sizes, regeneration ratios from callus and regeneration efficiency [calculated by following formular; callus formation ratio(%) × regeneration ratio(%)/100]for 27 ochardgrass (Dactylis glomerata L.)varieties imported and Hapsung 2 developed in Korea are as follows; 1. Among ochardgrass varieties showing more than 50% callus formation ratios, the descending order of callus formation ratio after bedding the seed explants for 4 weeks was 93>Sparta>Pizza>Condor>Lidaglo>Glorus>Hapsung2>Frode. 2. The callus sizes after bedding for 4 weeks were in the range of φ 0.43cm~4.2cm in which there was 10 times size difference between the largest one and the smallest one but most of them were between φ2.5cm~4cm. 3. The regeneration ratio from callus among varieties were in the range of 0~36% and descending order of the upper 6 varieties was Plano>Akimidori>Justus>Lidacta>Currie>Hall mark. 4. The regeneration efficiency which is calculated by the ratios of regeneration from seed explant numbers was between 0 to 17.4% among which Justus showed the highest value in the 4-week treatment. 5. The correlation between callus formation ratios and the callus sizes, callus formation ratios and regeneration efficiency, and callus sizes and regeneration efficiency were r=0.5765, r=0.6365 and r=0.6246, respectively in 4-week callus and all the correlations were significant on the 1% level. 6. In 6-week callus, the descending order callus formation ratios from seed sxplants for the best 6 varieties was Condor>Sparta>93M>Justus>Potomac>Lidaglo>Frode. 7. The callus sizes formed were between φ1.5~5.7cm in which Sparta, the largest one of φ5.7cm was five times larger than the smallest one. The callus size of the control variety. Hapsung 2 was φ3.8cm, which belonged to larger size. 8. Regeneration ratio showed a great deviation among varieties from 6-week old calli by showing from 0% to 100% in which all the calli were regenerated in Plano while no callus was regenerated in Juno, 9. The range of regeneration effciency was between 0~28% among varieties in which the values from 6-week callus treatment were larger than those from 4-week callus treatment. Especially, the value of Potomac in 6-week was 3 times larger than that in 4-week. 10. The correlation between callus formation ratios and the callus sizes, callus formation ratios and regeneration efficiency, and callus sizes and regeneration effciency were r=0.8369, r=0.6683 and r=0.5937, respectively in 6-week callus, and all the correlations were significant on the 1% level.

백서 하악골의 기능적 전방위가 악관절 원판에 미치는 영향

배용철,경희문,장병천,성재현 대한치과교정학회 1994 대한치과교정학회지 Vol.24 No.4

This study was conducted to examine the changes in the shape of the Sprague-Dawley rats' articular disk following postural hyperpropulsion by observing their articular specimens through light and electronic microscopes after following 2-week and 4-week postural hyperpropulsion from their four weeks of age. The findings of this study are summarized as follow. It was shown that as compared with the control group, the experimental group indicated a significant increase in thickness of the 2-week groups' anterior and posterior portion of the articular disc. The experimental group showed statistically more significant increase in thickness of the 4-week groups' anterior portion of the articular disc than the control group. Light micrograph showed that the experimental group had more fibroblast in the anterior portion of the 2-week and 4-week groups than the comparing group. The 2-week groups showed in the findings through the electronic microscope that there were found the well developed and dilated RER which see-ms to actively synthesize the extracellular matrix including collagen, the cells with the well developed RER without distention which seems to actively synthesize the intracellular microfilaments due to the well developed free ribosome, and the typical chondroid cells. In addition, there was more fibroblast cell with the distended and well developed RER in the anterior area of the experimental group than that of the control group while fibroblast with the well developed RER and free ribosome was quite abundat. Based on the above result of this study, it was shown that the functional hyperpropulsion of the mandible causes the changes in the nature of the mechanical load to the certain portion of the articular disk. As a result, it seems that there may be occurred some changes in morphology of the disc by adaptation or confrontation with these changes at the cellular level.

팽이 톱밥 人工栽培時 培地微生物相의 經時的인 密度變化

배태웅,文炳周,辛元敎,宋模烈,李鉉旭,曺東進 東亞大學校生命資源科學大學附設 農業資原硏究所 1996 農業生命資援硏究 Vol.5 No.1

팽이 재배에 있어 가장 큰 문제 중의 하나는 雜菌에 대한 汚染, 특히 細菌에 의한 피해가 극심하므로 作業段階와 栽培過程 전반에 걸쳐 培地徵生物相의 經時的인 密度變化에 따른 雜菌의 培地內 流入時期를 조사하여 汚染菌의 發生消長을 알아보기 위해 現地農家에서 시험해 본 결과 接種후 培養室에서 菌絲培養을 시작한 5일후부터 細菌이 檢出되기 시작하여 菌긁기전까지 약 25일간 0.5∼3.1×10⁴cfu/g의 密度를 보였으나 經時的인 密度增加는 없었고, 菌絲培養이 끝난 뒤 菌긁기직후부터 細菌의 密度는 118.3×10⁴cfu/g으로 급격히 높아졌으며 子實體生育 기간동안에 시간이 경과함에 따라 密度가 현저하게 증가되는 경향을 나타냈다. 이는 培養室 안으로 흐르는 空氣를 통하여 甁內로 細菌이 流入되고 또한 菌긁기 직후 培地表面에 灌注하는 물과 加濕機에서 噴霧되는 물粒子가 細菌의 密度增加에 절대적으로 영향을 미치는 것으로 판단되므로 이때가 細菌性褐斑病菌에 感染되기 가장 용이한 시기로 생각된다. 眞菌은 菌긁기후 子實體生育 기간동안 1.17∼7.87×10⁴/g의 密度로서 菌絲培養 기간동안의 密度보다 다소 높게 檢出되었으나 대체로 經時的인 密度增加는 보이지 않았으며, 放線菌은 거의 검출되지 않거나 菌絲培養 후 5일째부터 다소 검출되기 시작했으나 밀도가 매우 낮았고 經時的으로도 증가되지 않았다. One of the most serious problem on the Enoki mushroom cultivation is the infection by pathogenicitic microorganisns, especially bacterial diseases causing serious economical losses in the mushroom production. It was carried out to find the tendency of the development of mushroom diseases by temporal changes and variation of the densities of media microflora through the cultivation periods and working stages in a mushroom farm. According to the results, several bacteria were detected from the fifth day after the inoculation and incubation of mycelium in the incubation room, and the density of bacterium was 0.5∼3.1×10⁴cfu/g media for 25 days before the inoculum-removing, although there was no increment of the density. Since the inoculum-removing after the spawn run, the density of bacterium was rapidly increased as 118.3×10⁴cfu/g media, and was significantly increased by time during the growth period of fruitbodies. It was hypothesized that it is the most suitable period for the pathogen infection because the bacterium might be introduced by the air in the incubation-room, and the increment of bacterium density might be affected by moisture supplied through watering or humidifier in the growing room after the inoculum-removing. Fungi were detected as the density as 1.17∼7.87×10⁴/g media and the density was slightly higher than that during the incubation period of hyphae, although there was no significant increment. Generally, the density of Actinomycetes was disregardfully low, or Actinomycetes were hardly ever found, although there was found some 5 days after incubation hyphae in few cases.

규조토로부터 β-Sialon의 합성

배원태,전병세,최태현,문종수 慶南大學校 附設 工業技術硏究所 1989 硏究論文集 Vol.7 No.-

카올린에 비하여 Al₂O₃의 함량이 낮은 규조토로부터 β-Sialon을 합성하였다. 불순물의 함량을 저하시키고, 반응을 증대시키기 위하여 규조토를 산처리하였다. 산처리하므로써 알카리 함량이 저하되고, 비표면적은 증가하며, 또한 Al₂O₃의 함량이 낮은 규조토를 사용한 β-Sialon에서는 미반응 Al₂O₃가 존재하지 않았다. β-Sialon was synthesized from diatomaceous earth which had the lower content of Al₂O₃ than kaolin. Diatomaceous earth was treated by acid in order to reduce impurity level and to increase reactivity. Contents of alkali were reduced and specific surface area was increased in acid treated samples. Free Al₂O₃ did not exist in the final samples which were synthesized from the low Al₂O₃ contented diatomaceous earth.

혈관성 파킨슨증의 경사에코 자기공명촬영 소견 : 환자-대조군 연구 A Case-Control Study

배희준,김병건,구자성,김현숙 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.2

Background & objective : Changes of signal intensity in the various Structures of basal ganglia(BG), Which can be detected by gradient echo MRI(GE-MRI). have been reported in different kinds of parkinsonism Altered iron content in these structures may be a possible explanation of above phenomenon Vascular parkinsonism is a kind of parkinsonism syndrome and is common However. There have been no reports about the BG signal changes on GE-MRI in vascular parkinsonism Methods : We investigated the difference of signal intensity in various BG and midbrain structures between 36 patients with vascular parkinsonism. which was defined as clinical parkinsonism+evidence of relevant vascular lesion on MRI+poor or no response to levodopa, and age-& sex- matched controls. The intensity of BG on GE-MRI was graded as 0-3 relative to cortical gray matter Results : There were no significant differences in clinical characteristics between two groups Among patients with vascular parkinsonism, hypointensity was observed in globus pallidus in 94.4%. in putamen in 58.3% in head of caudate in 33.3%, in substantia nigra in 72.2%,& in red nucleus in 52.8% There was no significant linear trend in the association between signal intensity of above structures and the presence of vascular parkinsonism (p>0 05 on Mantel-Haenszel chi-square test) However, the correlation between the degree of white matter lesions and the presence of vascular parkinsonism was statistically significant (p=003). Conclusions : Our GE-MRI study fails to prove that iron content of various BG structures in patients with vascular parkinsonism is different from controls.

偏心荷重을 받는 基礎構造物의 安定性에 關한 信賴度 解析

裵主星,吳秉炫 全北大學校 1994 論文集 Vol.38 No.-

In the stability analysis of eccentrically loaded foundation, soil properties and loads involve many uncertainties so it is necessary to do stability analysis of foundation that considers the probabilistic properties of each variable. This study is performed to reliability analysis for bearing capacity and settlement of eccentrically loaded foundation by using Monte Carlo Simulation Method. To consider the uncertainty of variables, the soil properties and loads and eccentric length are assumed to be normal distribution random variables. Then it is performed to do sensitivity analysis which is involved to failure probability of bearing capacity and excess probability of allowable criteria of settlement according to varity of each variable. It is thought to be proper that the stability analysis of eccentrically loaded shallow foundation should be analyzed considering uncertainty of variables.

Alum계 응집제를 이용한 고탁도 원수의 응집효율 평가

배병욱,김선태,김현영 대전대학교 산업기술연구소 1999 산업기술연구소 論文集 Vol.10 No.1

고탁도 원수의 효율적인 응집을 위해 세 종류의 응집제(Alum, PACl, PACS)를 대상으로 응집실험을 수행하였다. 대청 원수에 카오린을 첨가하여 제조한 고탁도 고알칼리도 인공원수(탁도 510±10 NTU, 알칼리도 33±1 mg/l)의 경우, 무기고분자 응집제가 Alum 보다 우수한 결과를 나타내었으며, UV254는 응집제 종류에 따라 다소 차이가 있지만 57~66 % 정도 제거되었다. 고탁도 중알칼리도 인공원수(탁도 500±10 NTU. 알칼리도 20±2 mg/l)의 경우에는 탁도제거 측면에서 PAC이 가장 효과가 좋았으나, 유기물제거 측면에서는 Alum이 가장 양호한 결과를 보였다. 고탁도 저 알칼리도 인공원수(탁도 520 NTU, 알칼리도 11±1 mg/1)의 경우에는 고알칼리도나 중알칼리도 원수에 비해 잔류탁도가 전반적으로 높았으며, PACS가 Alum이나 PAC보다 높은 Al투입량 구간에서 양호한 잔류탁도를 나타내었다. 강우시 금강 중하류에 위치한 부여정수장 고탁도 중알칼리도 원수(탁도 85±5 NTU, 알칼리도 34mg/l)의 경우에는 잔류탁도가 1 NTU를 상회하였으며, Alum이 가장 우수한 UV254 제거율을 보였다. 결론적으로 기존 정수장에서 고탁도 원수에 대응하기 위해서는 개개 수계별로 존재하는 탁질과 천연유기물의 물리화학적 특성에 가장 적합한 응집제를 선정하는 것이 바람직한 것으로 판단된다. For the better coagulation of high turbidity water which comes to happen during the rainy season, Jar tests were made using three kinds of Al-based coagulants, such as Alum, PACl, and PACl. In case of the synthetic high-turbidity and high-alkalinity water made by adding kaolin into the raw water from the Daechung Reservoir(turbidity 510±10 NTU, alkalinity 33±1 mg/1) , PACl and PACS showed better results than Alum with respect to the residual turbidity and UV254 removal efficiency. In case of the synthetic high-turbidity and medium-alkalinity water(turbidity 500±10 NTU, alkalinity 20±2 mg/l), PACl produced the lowest residual turbidity, but Alum showed the highest removal efficiency of UV254. Comparing to high- and medium-alkalinity water, the low alkalinity water(turbidity 520 NTU, alkalinity 11±1 mg/l) showed higher residual turbidity after Jar tests. In this case, PACS showed lower residual turbidity than Alum and PACl at the higher Al dosage. When the raw water(turbidity 85±5 NTU, alkalinity 34 mg/l) taken from Puyo water treatment plant was coagulated, the residual turbidity was maintained more than 1 NTU and Alum showed the highest UV254 removal rate. In conclusion, in order to cope with the high turbidity water in the conventional water treatment facility, it might be the most important to select the proper coagulant which is appropriate to the physicochemical characteristics of both colloidal particles and natural organic matters present in the specific water supply.