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The Smad4/PTEN Expression Pattern Predicts Clinical Outcomes in Colorectal Adenocarcinoma
정유민,위영찬,김예슬,방성식,양정호,장기석,민경환,백승삼 대한병리학회 2018 Journal of Pathology and Translational Medicine Vol.52 No.1
Background: Smad4 and PTEN are prognostic indicators for various tumor types. Smad4 regulates tumor suppression, whereas PTEN inhibits cell proliferation. We analyzed and compared the performance of Smad4 and PTEN for predicting the prognosis of patients with colorectal adenocarcinoma. Methods: Combined expression patterns based on Smad4+/– and PTEN+/– status were evaluated by immunostaining using a tissue microarray of colorectal adenocarcinoma. The relationships between the protein expression and clinicopathological variables were analyzed. Results: Smad4–/PTEN– status was most frequently observed in metastatic adenocarcinoma, followed by primary adenocarcinoma and tubular adenoma (p < .001). When Smad4–/PTEN– and Smad4+/PTEN+ groups were compared, Smad4–/PTEN– status was associated with high N stage (p = .018) and defective mismatch repair proteins (p = .006). Significant differences in disease-free survival and overall survival were observed among the three groups (Smad4+/PTEN+, Smad4–/PTEN+ or Smad4+/PTEN–, and Smad4–/PTEN–) (all p < .05). Conclusions: Concurrent loss of Smad4 and PTEN may lead to more aggressive disease and poor prognosis in patients with colorectal adenocarcinoma compared to the loss of Smad4 or PTEN alone.
정유민,하지훈,박수남 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.35 No.-
Solid lipid nanoparticles consisting of cationic lipids were prepared for effective delivery of luteolin, andevaluated their physical characteristics and cytoprotective effects against ultraviolet A (UVA) radiationand H2O2 in HaCaT cells. This study reports that triple-tailed CSLN can enhance transdermal delivery ofluteolin with high entrapment efficiency, slow release kinetic without initial burst. Further, it showedhigh intracellular uptake, provided the highest degree of the cytoprotective effects of LT-CSLNs (83.10%,77.65%) as compared to non-treated groups (60.85%, 52.70%) against UVA and H2O2. These resultssuggested that LT-CSLN3 could be used as an effective transdermal delivery system for luteolin.
골수 줄기세포와 주사형 MPEG-PCL diblock copolymer를 이용한 조직공학적 골재생
정유민,이태형,박정균,김원석,신주희,이의석,임재석,장현석,Jeong, You-Min,Lee, Tai-Hyung,Park, Jeong-Kyun,Kim, Won-Suk,Shin, Joo-Hee,Lee, Eui-Seok,Rim, Jae-Suk,Jang, Hyon-Seok 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.1
Aim of the study: As an injectable scaffold, MPEG-PCL diblock copolymer was applied in bone tissue engineering. In vivo bone formation was evaluated by soft X-ray, histology based on the rat calvarial critical size defect model. Materials and Methods: New bone formation was evaluated with MPEG-PCL diblock copolymer in rat calvarial critical size bone defect. No graft was served as control. 4, 8 weeks after implantation, gross evidence of bone regeneration was evaluated by histology and soft X-ray analysis. Results: The improved and effective bone regeneration was achieved with the BMP-2 and osteoblasts loaded MPEG-PCL diblock copolymer. Conclusion: It was confirmed that MPEG-PCL temperature sensitive hydrogels was useful as an injectable scaffold in bone regeneration.
분변오염 기저귀에서 분리한 플라스틱과 펄프의 미생물 저감화
정유민,이호선,김경신,오한슬,주탁,강성태,Jung, You Min,Lee, Ho Sun,Kim, Kyung Shin,Oh, Han Seol,Joo, Tak,Kang, Sung Tae 한국미생물학회 2015 미생물학회지 Vol.51 No.2
분변이 오염된 기저귀의 플라스틱과 펄프를 재활용하기 위해서 기저귀에서 분리된 플라스틱과 펄프의 세척, 기저귀의 직접 가열 살균 후 세척, 분리된 플라스틱과 펄프의 세척 후 가열 살균의 3가지 방법으로 플라스틱, 펄프 중의 대장균군과 일반세균의 저감화를 시도하였다. 기저귀를 10% $CaCl_2$과 4% 해수염 용액에 반응시킨 뒤 1,000 ml의 희석액을 투입한 후 체에 걸러 플라스틱과 펄프 시료를 분리하였다. 분리된 플라스틱, 펄프의 미생물의 저감화에는 3회 세척이 가장 적당하였으며 3회 세척 시 플라스틱과 펄프에 잔존하는 대장균군은 92.8%과 99.8%가 감소하였고 일반세균은 97.3%과 98.5%가 감소하였다. 사용된 기저귀에서 플라스틱과 펄프를 분리하지 않고 직접 기저귀를 살균한 후 플라스틱과 펄프를 분리하여 잔존 미생물수를 측정한 결과, $60^{\circ}C$, $80^{\circ}C$, $100^{\circ}C$에서 12시간 동안 살균한 후 3회 세척 및 분리 과정을 거쳐 회수한 플라스틱과 펄프에서는 12시간 가열 후에도 $60^{\circ}C$, $80^{\circ}C$, $100^{\circ}C$에서 각각 2-3 log CFU/g, 1-2 log CFU/g으로 일반세균이 검출되어 완전 사멸이 되지 않았다. 한편 분변 오염된 기저귀로부터 얻어진 플라스틱과 펄프를 3회 세척한 후 가열하는 경우 $80^{\circ}C$에서 4시간으로 완전 살균이 되었으며, 이 방법이 분리된 플라스틱과 펄프 중의 미생물의 저감화에 가장 적합한 방법으로 확인되었다. Three different methods (simple washing of plastic and pulp sample, washing after direct heating of the diapers, and the heating after washing of plastic and pulp sample) were carried out to decrease total coliforms and heterotrophic plate count (HPC) in the diaper's plastic and pulp. Plastic and pulp samples were obtained from diaper by treatment with 10% $CaCl_2$ and 4% sea salt water, dilution with 1,000 ml tap water, and draining by using sieves. Three times washing was the most appropriate for the reduction of microorganisms in plastic and pulp. By three times washing, the number of total coliforms in the plastic and pulp samples showed 92.8% and 99.8% of decrease, respectively, and the number of HPC showed 97.3% of decrease in the plastic and 98.5% of decrease in the pulp. The washing after direct heating of the fecal contaminated diapers was not effective because HPC in the plastic and pulp samples were still detected about 2-3 log CFU/g in the plastic and 1-2 log CFU/g in the pulp, respectively, even after heating at $60^{\circ}C$, $80^{\circ}C$, $100^{\circ}C$ for 12 h. Meanwhile, total coliforms and HPC were completely sterilized at $80^{\circ}C$ for 4 h by heating after washing of plastic and pulp samples, suggesting that this method was the most appropriate method for the reduction of microorganisms in plastic and pulp obtained from fecal contaminated diapers.
Inhibitory Effects of Mung Bean (Vigna radiata L.) Seed and Sprout Extracts on Melanogenesis
정유민,하지훈,노근영,박수남 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.2
Inhibitory effect against melanogenesis and the in vitro tyrosinase inhibitory activity of ethyl acetate (EtOAc) and methylene chloride fractions of 80% methanol extracts of mung bean (Vigna radiata L.) seeds and sprouts were determined. EtOAc extract fractions from mung bean sprouts germinated for 12 h (33.5%), 1 day (56.5%), and 2 days (47.9%) inhibited melanogenesis more effectively than arbutin (16.3%). The in vitro tyrosinase inhibitory activity was higher in an EtOAc extract fraction from mung bean sprouts germinated for 2 days (70.5%). EtOAc extract fractions from mung bean sprouts germinated for 1 day showed excellent whitening effects due to the flavone vitexin. Extracts from mung bean sprouts germinated for 1 day can be used as a novel whitening cosmeceutical ingredient.