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심근경색 모델 흰쥐에서 스트레스가 B-type Natriuretic Peptide 발현 및 심박변이율 변화에 미치는 영향
이삼윤(Sam Youn Lee),이미경(Mi Kyoung Lee),김남호(Nam-ho Kim),주민철(Min Cheol Joo),조항정(Hyang Jeong Jo),강지숙(Ji Sook Kang),김병숙(Byung Sook Kim),윤선식(Sun Sik Yoon),최을식(Eul Sig Choi),이문영(Moon Young Lee) 대한스트레스학회 2010 스트레스硏究 Vol.18 No.3
심박변이율의 감소는 심근 경색 환자에서 예후의 악화와 관련되어 있다. 심박변이율 중 very low frequency가 심부전환자의 예후를 판단할 수 있는 독립적 인자로서 사용이 가능하다고 보고된 바 있으며, 심실의 압력 증가에 반응해서 생성되는 B-type natriuretic peptide가 심근 경색의 예후 인자로서 사용할 수 있음 역시 보고된 바 있다. 본 연구에서는 심근경색 모델을 제작하여 일정의 회복 기간을 거친 다음 다시 일정 기간의 스트레스를 겪게 한 후 심박변이율의 변화 및 심실 조직에서의 BNP 발현 정도를 비교하여 스트레스에 의한 영향을 관찰하고자 하였다. Sprague-Dawley계 수컷 흰쥐 15마리를 대상으로 하였다. 실험동물은 인위적 스트레스 및 수술을 받지 않은 대조군(CON, n=5), 심근경색 수술을 받은 후 restraint stress를 받지 않은 군(MI+No Stress, n=5), 심근경색 수술을 받은 후 1주일 동안 restraint stress를 받은 군(MI+Stress, n=5)으로 분류하였다. 심근경색 모델 제작 직후 15분 이상 심전도의 변화를 기록하였으며, 2개월 정도 후 심근경색 수술을 받은 동물을 두 군으로 나누어 그 중 한 군에는 1주일 동안 restraint stress를 가한 후 restraint stress를 가하지 않은 동물과 심박변이율을 비교 분석하였다. 심실 조직은 좌심실 전벽 부위의 위축을 관찰할 수 있었고, 대식세포에 의하여 응고, 괴사된 심근세포의 탐식과 혈관이 풍부한 육아조직 및 섬유 변화를 볼 수 있었다. 심박변이율은 심근경색 수술을 받은 직후 심박수는 유의한 증가를 보였고, standard deviation of the normal to normal intervals (SDNN), very low frequency (VLF) 및 low frequency (LF)의 유의한 감소를 보였다. 심근경색 수술을 받았던 동물에서 두 달 정도의 회복 기간을 거친 후 스트레스를 받지 않은 군은 심박수 및 기타 심박변이율 분석에서 SDNN 값을 제외하고는 정상군과 유의한 차이를 관찰할 수 없었던 반면 1주일 동안 스트레스를 받은 군에서는 심박수가 다시 유의하게 증가했을 뿐만 아니라 SDNN, VLF 및 LF 역시 정상군과 유의한 차이를 보였다. 이상의 결과를 종합하면 심근경색 동물에 대해 1주일 동안 스트레스를 가한 결과 심박변이율이 감소하고 심실에서의 BNP 발현은 더욱 증가하여 악화함을 보여주고 있다. Diminished heart rate variability (HRV) is associated with less favorable prognosis after myocardial infarction (MI). It has been reported that very low frequency (VLF) power in HRV analysis is an independent risk predictor in patients with congestive heart failure and B-type natriuretic peptide (BNP) can be used as a prognostic factor of MI. The purpose of this study was to investigate whether stress has an effect to the changes of BNP expression and/or heart rate variability in MI model in rats. Male Sprague-Dawley rats were divided into 3 groups: control group (CON), MI group (MI+No Stress), and MI followed by stress group (MI+Stress). MI+Stress group rats were raised for a two month recovery period after the operation, followed by being exposed to restraint stress for 2 hours per day for 1 week. Electrocardiogram was recorded after the operation and the last day after 1 week of stress. The frequency components of HRV were calculated in the frequency domain such as VLF, low frequency (LF), high frequency (HF) and so on. In HRV analysis, standard deviation of the normal to normal intervals (SDNN) was significantly reduced in both groups compared to the control group. VLF and LF also were significantly reduced in MI+Stress group compared to the control groups. In addition, BNP expression in western blotting was shown the strongest bands in MI+ Stress group among experimental groups. These results suggest that BNP and HRV were aggravated by stress in MI rat model. (Korean J Str Res 2010;18:275∼285)
한국 전통장류가 한우 반힘줄모양근(M. Semitendinosus)으로 제조한 건염햄의 육질 특성에 미치는 영향
성필남,조수현,강근호,김동훈,박범영,강선문,박경미,Seong, Pil-Nam,Cho, Soo-Hyun,Kang, Geun-Ho,Kim, Dong-Hoon,Park, Beom-Young,Kang, Sun-Moon,Park, Kyoung-Mi 한국축산식품학회 2013 한국축산식품학회지 Vol.33 No.6
This study was conducted to develop a processing method for dry-curing beef ham with Korean traditional sauces and to investigate the quality properties of the dry-cured beef hams. Semitendinosus muscle from Hanwoo was spread with sundried salt (C), sun-dried salt mixed with red pepper paste (T1), and sun-dried salt mixed with soybean paste (T2), and inserted into washed Hanwoo large intestine. It was then dried and fermented for 75 d. Moisture contents of the hams were 46-48%, without any significant differences. T1 showed the lowest pH among the three dry-cured hams, while water holding capacity (WHC) of T2 was found the lowest (p<0.05). In mechanical color determination, C showed higher CIE $a^*$ and CIE $b^*$ than T1 and T2 (p<0.05), however CIE $L^*$ did not show any significant difference. In texture, T1 demonstrated significantly lower springiness than C (p<0.05). The sensory properties of all dry-cured hams did not show any significant difference, but T1 indicated a higher taste, saltiness and overall acceptability than others, whereas C gathered the highest score in color and flavor. In conclusion, the dry-curing by combination of sun-dried salt mixed with red pepper sauce (T1) showed higher quality properties of the Hanwoo dry-cured ham. 우리나라 전통장류를 건염햄 제조에 접목한 건염햄의 제품을 개발하기 위해 염지과정에서 첨가한 고추장과 된장이 건염햄 품질에 미치는 영향을 조사하고자 실시하였다. 천일염(C), 천일염+고추장(T1), 천일염+된장(T2)을 한우의 반힘줄모양근(m.emitendinosus)의 표면에 골고루 발라주고 세척한 한우 대장에 충진한 후 75일 동안 건조 및 발효시켰다. 한우 반힘줄모양근 건염햄 품질을 조사한 결과, 건염햄 수분함량은 46.45-48.04% 수준으로 유의적인 차이는 없었다. T1은 모든 처리구 중에서 pH가 가장 낮았고 T2는 WHC가 가장 낮았다(p<0.05). 기계적 육색 측정에서 C가 $a^*$와 $b^*$가 전통장류 처리(T1, T2)보다 높았으나(p<0.05), $L^*$은 유의적인 차이가 없었다. 조직감에서 T1은 C보다 탄력성이 유의적으로 낮았다(p<0.05). 관능평가 결과 모든 처리구에서 유의적인 차이가 없었고 C는 제품색과 향미가 높은 점수를 받은데 반해, T1은 높은 맛, 짠맛, 그리고 전체적 기호도가 다른 처리구에 비해 높았다.
남선숙,최미혜 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1
The purpose of this study was individual taking good care of primiparas and multiparas from comparison analysis of their nursing need. The subject of this study was a total of 133 puerpera who was within 3days from childbirth of three university hospitals in seoul. The data collected from questionnaire during the period from the first september to October 30, 2000, which were composed of during labor and delivery nursing need 27 item 5 point, puerpera self care nursing need and newborns care nursing need 38 item 5 point concerning puerpera's degree of nursing need on delivery room. The instruments used in this study were Ahn, H S(1993), Yeo, J H(1999), Kwang, Y H(1996), Jun, Y J(1997) it is modified The data were analyzed by t-test, ANOVA, x^2-test, Duncan's Multiple Range Test with SPSS Program The result of this study were as follows 1. The more nursing need wanted group were catholic group than the other religion group of during labor and delivery(F=3.001 p=.033), puerpera's self-care and newborns care(F=4.588 p=.004). 2. No different nursing need of primiparas and multiparas during labor and delivery, they were the mean score primiparas 4.04, multiparas 4.07 with a range of 1 to 5. 3. The more newborns care nursing need wanted group were primiparas than multiparas(t=4.688 p=.000). Therefore delivery room nurse think twice of a trend carelessly taking care of multiparas by reason of experienced one more delivery, puerpera self-care, newborns care. In order to start on effective education delivery nurse have to give lession in puerpera self-care, newborns care to primiparas and multiparas before they leave delivery room
일 지역 중학생들의 분노표현양식과 신체증상에 관한 연구
김남선,권미경 관동대학교 의과대학 의과학연구소 2005 關東醫大學術誌 Vol.9 No.1
The purpose of this study is to provide basic data needed in the nursing intervention for middle school students by examination of the level of anger expression style(anger-in, anger-out, anger control) and physical symptoms of the subjects and measurement of correlation between two. Data were collected from June 13, 2005 to June 17, 2005 and subjects were 200 middle school students in G city. Anger expression style were measured by the Korea adaptation of the State-Trait Anger Expression Inventory(STAXI-K) revised by Lee & Cho(1999) and it is comprised of total 24 questions. As a measuring instrument of physical symptoms was used by Moon(2003). Data were analyzed using the SPSS 10.0 program and included descriptive statistics, t-test, ANOVA and pearson correlation Coefficient. The results of this study are as follows: 1. The mean score for anger-control was 2.92±.42, anger-in was 2.46±.49, and anger out was 2.12±.61. 2. The mean score for physical symptoms was 2.28±.74. 3. There were significant differences in the anger control according to the seniority of brothers and sisters(F=3.286, p=.022) and records(F=4.939, p=.008). There were significant differences in the anger-in according to the grade(F=4.886, p=.009), religion(F=3.441, p=.0120 and records(F=3.380, p=.036). There were significant differences in the Anger out according to the records(F=3.666, p=.027) and friend relation(F=2.893, p=.037). There were significant differences in the physical symptoms according to the grade(F=7.254, p=.020). 4. The data shows significant correlations between anger expression style and physical symptoms(r=.219, p=.000), between anger-in and physical symptoms(r=.271, p=.000), between anger control and physical symptoms (r=.155, p=.038). As a result of this study, the level of anger expression style in the middle school students tends to be higher than comparative research outputs. And the results meant that the higher anger expression level, the more physical symptoms. Accordingly, nursing intervention to reduce the anger expression of middle school students are needed.