가토에서 CCNU 로 유발된 골수 저형성증의 혈액학적 소견과 골수스캔의 변화에 관한 연구

김승택,이명철,최두혁,고창순,김병국,이문호,박선양,최성재,김노경,최영희 대한내과학회 1986 대한내과학회지 Vol.30 No.1

To understand systematically the hematological changes including the bone marrow changes in chemotherapeutic agent-induced bone marrow hypoplasia and to define the relationship between hematological and bone marrow scan findings and prognosis of the hypoplasia, CCNU (lomustine) was given orally to 44 rabbits to induce hypoplasia of the bone marrow. And serial changes of peripheral blood and bone marrow findings and (111)In Cl(3)((111)In scan)/(99m)Tc tin colloid bone marrow scan((99m)Tc scan) were checked before and after induction of hypoplasia. With assessment of 28 evaluable rabbits, the following results were obtained: 1) Significant hypoplasia of the bone marrow developed around day 4 of CCNU administration and recovered around day 14(cellularity 51,4±13.5% and 24. 5±14.97o before and after CCNU respectively, p<005). Megakaryocyte count was significantly depressed from 95.67,26% to 36.7$gt;31.82%(P$lt;0.005). M: E ratio was decreased from 162±1.19 to 0, 0.5$lt;0. 43(p±0.005). Shift to left(475), maturation a(40%), naked nucleus and degenerated cells(20%), increase of lymphocytes(47%), monocytes and reticulum cells were also found. 2) The uptake ratio of the 99(m)Tc tin colloid bone marrow scan was markedly increased in contrast to the depression of the bone marrow(4.4±2.12 and 14.1±7.06 before and 4 days after CCNU, respectively, p40. 005). Tc scan uptake ratio was inversely related to the cellularity(r=-0.442, p$lt;0.05) and megakaryocyte number of the bone marrow(r= 0.89, p< 0.01) and peripheral blood granulocyte (r = 0. 54. Pg0.01) and platelet count(r=0.40, p$lt;0.05). There was not significant correlation between (111)In scan uptake ratio and hematologic parameters. 3) The amplitude of the change of the (99m)Tc scan uptake ratio was significantly related to the prognosis of the rabbits with experimentally induced hypoplasia of the bone marrow(dead 5.1±2,67, survivors 2,5±0.96, P<0.01). The change of the (111)In scan uptake ratio was not related to the prognosis of these rabbits. In experimentally induced rrow hypoplasia, morphologic changes in addition to the numerical changes of the bone marrow elements were observed. And serial (99)Tc scan of the bone marrow appears to be helpful assessing the severity and predicting the outcome of bone marrow hypoplasia.

늑막조직생검으로 진단한 Pleural Paragonimiasis 1 예

김기영,이승환,박진현,이재갑,용석중,신계철,홍욱균,김향인,진춘조 대한내과학회 1991 대한내과학회지 Vol.40 No.5

We report a 28-year old female patient with pleural paragonimiasis who did not have the usual diagnostic triad for this parasitic disease. She did not have chronic hemoptysis, there were no pulmonary infiltrations, and stool, sputum and pleural fluid examinations did not yield paragonimus ova. The diagnosis was made on the basis of ova found in the pleural biopsy. Paragonimus pleural effusion was resolved with frequent thoracentesis and oral praziquantel therapy.

육성돈에서 Phytase 첨가가 Extrusion 한 쌀겨의 P 이용성에 미치는 영향

김영길,김인호,손중천,김은주,권기범,문태현 한국영양사료학회 1999 韓國營養飼料學會誌 Vol.23 No.3

본 시험은 육성돈에 있어 extrusion된 쌀겨에 대한 P의 이용성과 extrusion된 쌀겨에 phytase를 첨가하므로서 P의 이용성에 미치는 영향을 구명하고자 영양소 소화 시험을 실시하였다. Extrusion된 쌀겨와 extrusion된 쌀겨에 phytase을 첨가한 구간의 비교는 phytase의 첨가에 의해 건물 소화율이 약간 증가하는 경향을 보였다(P<0.04). N 소화율은 쌀겨구 보다는 extrusion된 쌀겨구에서 약간의 증가를 보였다(P<0.07). Ca(P<0.06)과 P(P<0.01)의 소화율은 모두 extrusion된 쌀겨에 phytase의 첨가수준이 다를 경우 500 unit보다는 1,000 mini에서 더 좋은 효과를 보였다. 분 중 P 배설량(2.72g/d vs 3.89g/d)은 extrusion된 쌀겨보다는 extrusion된 쌀겨에 phytase을 첨가하므로서 줄어들었다(P<0.08). 또한 phytase의 첨가수준이 증가할수록 P의 축적량이 증가함을 알 수 있었다(P<0.04). 한편 Ca 섭취량, 배설량 및 축적량은 모든 처리구 간에 통계적인 유의성을 찾아볼 수 없었다. 그러나 최종 Ca 축적량은 쌀겨에 비해 extrusion된 쌀겨의 경우 15%가 향상되었다(6.64g/d vs 5.77g/d). An experiment was conducted to determine the effects of microbial phytase and feed processing on production and phytate P utilization of pigs. Four crossbred barrows with average initial body weight of 30㎏ were used in 24-d metabolism experiment(4 x 4 latin square) to determine the effect of extruded rice bran and phytase supplementation on nutrient utilization. Digestibility of DM in pigs fed extruded rice bran with phytase improved compared to that in pigs fed extruded rice bran(P<0.04). N digestibility was greater for extruded rice bran than rice bran(P<0.07). However, there was no effect of phytase supplementation to extruded rice bran. Digeshbilities of Ca(P<0.06) and P(P<0.01) were greatest for extruded rice bran with phytase 1,000 unit. Fecal excretion of P(2.72g/d vs 3.89g/d) was less for extruded rice bran with phytase than without phytase(P<0.08). Also, when phytase supplementation was increased in diet, there was increased P retention(P<0.04). There were no treatment effects intake, excretion and retention of Ca. However, Ca retention improved by 15% in extruded rice bran compared to rice bran(6.44g/d vs 5.77g/d).

경막외마취 확산의 비교관찰 제 1 보 Bupivacaine-Lidocaine

김영석,김완식,김인규,김흥대,안기량,김교상 대한마취과학회 1980 Korean Journal of Anesthesiology Vol.13 No.1

Epidural anesthesia is widely practiced for lower abdominal operation and delivery in many hospital and its complication in minimal compared with spinal anesthesia. Lidocaine has been used extensively for epidural anesthesia with very satisfactory results. It has a very rapid onset of action, producing complete analgesia and has a reasonable duration of action(about 1-1½hr). A concentration of 1. 5% lidocaine causes effective sensory and autonomic blockade but it is unlikely to produce motor paralysis. More recently, bupivacaine(0.5%) has tended to supplement lidocaine as the drug of choice of epidural anesthesia. Firstly, the duration of action is longer. Secondly, it has better affinity for the tissue so that less will be absorbed into the circulation, thus reducing the risk of a toxic reaction. Thirdly, when used with a continuous technique, there is much chance of tachyphylaxis. Using a standardized anesthesia technic, we compared level of sensory anesthesia with a 0. 5% bupivacaine and 1. 5% lidocaine uder elective and emergency surgery. When equal volume of local anesthetic solution were injected(20 ml of 0.5% bupivacaine and l. 5% lidocaine) there were no statistically significant differences in sensory level in bupivacaine and lidocaine, but the duration of anesthesia in bupivacaine from 2 to 3 times longer than lidocaine.

기관지내 전이암

김현수,이상수,오미희,이재갑,원구태,홍희승,용석중,신계철 대한내과학회 1991 대한내과학회지 Vol.40 No.4

The lung is the most common site of metastasis of extrapulmonary malignant tumor. According to past reports, metastatic cancer of the lung has been found in about 2% of all patients at autopsy. But these days, a diagnosis of endobronchial metastatic cancer utilizing bronchoscopy only is not easy. Thus we need other means of gathering more informaction, such as past history, discovery of other metastatic sites, and pathologic findings with special staining and electronmicroscope, especially in cases of poorly differentiated adenocarcinoma and epidermoid cancer, which are common types of primary lung cancer. We present 5 cases of endobronchial metastatic cancer. We found endobronchial metastatic cancer 2 cases of cervix cancer (epidermoid, adenocarcinoma), 1 case of colon cancer (adenocarcinoma), hypernephroma (renal cell carcinoma), and bladder cancer (transitional cell carcinoma). Since it was impossiole to diagnose the metastatic adenocarcinoma from the cervix only with lightmicroscopic findings, we could use past history and unusual radiologic and bronchoscopic findings which was thought to be the specific endoscopic finding of metastic endobronchial cancer. The interval between the diagnosis of the primary cancer and endobronchial metastatic cancer was 25.7 months. In the future, development of immunohistochemistry, monoclonal antibody, and molecular biologic techniques will give us diagnostic clue for differential diagnosis of metastatic endobronchial cancer from primary bronchogenic lung cancer.

급성 골수성 백혈병(M6)에 합병된 중추성 요붕증 1 예

김성연,조보연,이홍규,고창순,민헌기,김병국,김노경,신찬수,이명식,강덕현,조종태 대한내과학회 1989 대한내과학회지 Vol.37 No.2

Leukemia is known to be an extremely rare cause of diabetes insipidus. We report a case of diabetes insipidus as a complication of leukemia. An 18 year-old man was admitted because of polyuria polydipsia and fever. Bone marrow aspiration and biopsy revealed the diagnosis of acute erythroleukemia (AML, M6). On the water deprivation test, the diabetes insipidus was confirmed to be of the central type. He was managed with intranasal vasopressin for diabetes insipidus with good response. Induction chemotherapy was administered without response, and the patient died of septicemia and respiratory failure 2 months after initial diagnosis. A short review of the literature related to this subject is also presented.

다른 광물질과 혼합된 크롬 피콜린산 급여가 비육돈의 성장 , 도체특성 , 혈액성상에 미치는 영향

김지훈,한인규,김진동,김대성,양종석,손현수,현영 한국영양사료학회 1999 韓國營養飼料學會誌 Vol.23 No.5

본 시험은 여러 가지 광물질과 혼합된 크롬 피콜린 산을 첨가한 사료의 급여가 비육돈의 성장, 도체특성, 혈액성상에 미치는 영향을 알아보기 위하여 수행되었다. 개시체중이 69㎏인 총 513두의 비육돈을 돈방당 16∼21두씩 수용하여 사양시험을 수행하였으며, 9마리가 대사시험에 사용되었다. 처리구는 2개의 단백질 수준별 대조구 (Con 12, Cen 14)와 외산 크롬 피콜린산 (CrP-CaCO₃ ; Prince사 제품). 크롬 제오라이트 (CrP-Zeolite 12, 14), 국산 크롬 피콜린산 1 (CrP-CaCO₃; KIST 개발), 크롬 피콜린산-산화아연 (CrP-CaCO₃-ZnO 12, 14) 그리고 국산 크롬 피콜린산 2 (CrP-CaCO₃ ; M. H. Lee 개발)이었다. 성장성적에 있어서는 일당중체량, 일당사료섭취량, 사료효율 등 모든 조사항목에서 처리구간의 차이가 발견되지 않았으나, 등지방 두께는 크롬 피콜린산 첨가에 의해 감소하는 경향이 발견되었고, 이러한 경향은 출하체중이 무거울수륵 뚜렷하게 나타났다. 도체등급은 크롬 제오라이트구와 크롬 피콜린산-산화아연처리구에서 높게 나타났으며, 혈액내 콜레스테를의 함량도 크롬 제오라이트구와 크롬 피콜린산-산화아연처리구에서 대조구에 비해 유의적으로 감소하였다 (p<0.05). 크롬 피콜린산-산화아연처리구와 크롬 피콜린산구에서 건물 및 단백질 소화율이 향상되었다 (p<0.05). This experiment was conducted to investigate the effects of chromium picolinate in different combinations with minerals on growth, carcass characteristics, serum traits and nutrient digestibility in finishing pigs. Five-hundred and thirteen pigs (69.0 ㎏ of initial weight) were assigned to 9 treatments, each containing three replicates of sixteen to twenty-one pigs each. Additional nine pigs were used in a digestion trial. Treatments were two controls (12% CP and 14% CP), foreign CrP-CaCO₃, two CrP-Zeolite (12% CP and 14% CP), domestic CrP-CaCO₃ 1, CrP-CaCO₃-ZnO (12% CP and 14% CP) and domestic CrP-CaCO₃ 2. ADG was not significantly different among the treatments. Tenth rib backfat thickness tended to be decreased by feeding diet with CrP. Carcass grade was improved by using zeolite and CaCO₃ + ZnO along with CrP in diets. Serum cholesterol level was significantly reduced by feeding diets containing CrP with CaCO₃ + ZnO or Zeolite compared with the control. Supplementation of Cr with CrP-CaCO₃ + ZnO or CrP-CaCO₃ in diets significantly improved the digestibility of crude protein and dry matter (p<0.05). The excretion of nitrogen was lower in pigs fed diets containing Cr regardless of the combinations with minerals. The excretion of phosphorus was lowest in the CrP-CaCO₃ + ZnO group which showed the highest phosphorus digestibility.

소장내용물의 위내역류 및 위내용물 배출시간에 관한 연구

김진호,박승철,이형호,안일민,박영태,김열흥,이창흥 대한내과학회 1986 대한내과학회지 Vol.30 No.2

Radionuclide enterogastric scintigraphy was done with (99m)Tc-DISIDA and (111)In-DTPA in 35cases; control group 5, gastric ulcer group 6, subtotal gastrectomy with Billroth g group 5, and functional gastrointestinal disorder group with or without grossly mixed bile in the gastric juice 19 cases. The results were: 1) Enterogastric reflux was very significantly increased in the subtotal gastrectomy with Billroth II group (p$lt;0, 001), 2) Gastric emptying was significantly delayed in the functional gastrointestinal disorder groups with or without grossly mixed bile (p$lt;0.05, p$lt;0. 001). 3) Enterogastric reflux was not significantly increased in the gastric ulcer group. 4) Enterogastric reflux was not significantly different between the functional gastrointestinal groups with or without grossly mixed bile in the gastric juice. 5) Inverse correlation between the gastric emptying indices and the enterogastric reflux indices was not proved (r=-0.37).

한국산 날치과(Beloniformes , Exocoetidae)어류 5 종의 분류학적 재검토

김종만,김진구,유정화,조선형,명정구,강충배,김용억 한국어류학회 2001 韓國魚類學會誌 Vol.13 No.2

Taxonomic review of the five flyingfishes, Parexocoetus mento (Valenciennes), Cheilopogon agoo (Temminck et Schlegel), Cheilopogon heterurus doederleini (Steindachner), Cheilopogon cyanopterus (Valenciennes), Hirundichthys oxycephalus (Bleeker) were carried out based on samples collected from the South sea and around sea of Jeju Island of Korea from 1996 to 1998. Parexocoetus mento (Valenciennes) and Cheilopogon cyanopterus (Valenciennes) were revealed as the unrecorded species in Korea, which were named as "Men-to-hwang-nal-chi" and "Ki-geom-nal-chi" respectively. Parexocoetus mento is differed from P. barchypterus in having no chin barbels in juveniles, and Cheilopogon cyanopterus is distinguished from C. agoo in the branched form of pectoral fin rays and from C. heterurus doederleini in the numbers of the dorsal fin ray and the color of pectoral fins.

한국형 출혈열 후유증으로 발생된 만성 신우신염

김연수,한진석,이정상,김성권,진호준,안규리,오국환,오윤규 대한내과학회 1997 대한내과학회지 Vol.52 No.4

It has been known that most patients with Korean Hemorrhagic Fever (KHF) were recovered without any significant renal complication. But several cases of renal hypertension, chronic pyelonephritis, and chronic renal failure after KHF have been reported. Recently, we experienced one case of chronic pyelonephritis as a sequela of KHF, which has been diagnosed at the 78th month of illness. This case showed reduced thickness of renal parenchyme, small and irregular shaped kidney, focal loss of normal cupping of calyces, and accumulation of radiacontrast media at distal calyes by IVP. This case suggested that chronic pyelonephritis may develop as a sequela of KHF,