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CONSTRUCTION, ASSEMBLY AND COMMISSIONING OF KSTAR MAIN STRUCTURES
Yang, Hyung-Lyeol,Bak, Joo-Shik,Kim, Byung-Chul,Choi, Chang-Ho,Kim, Woong-Chae,Her, Nam-Il,Hong, Kwon-Hee,Kim, Geung-Hong,Kim, Hak-Kun,Sa, Jeong-Woo,Kim, Hong-Tack,Kim, Kyung-Min,Kim, Sang-Tae Korean Nuclear Society 2008 Nuclear Engineering and Technology Vol.40 No.6
The KSTAR device succeeded in first plasma generation on $13^{th}$ June of 2008 through comprehensive system test and commissioning. Among various kinds of the key factors that decisively affected the project, success in the construction and assembly of the major tokamak structure was most important one. Every engineering aspects of each structure were finally confirmed in the integrated commissioning period, and there were no severe troubles and failures prevented the KSTAR device from operating during the commissioning and the first plasma experiments. As a result, all of the experiences and technologies achieved through the KSTAR construction process are expected to be important fundamentals for future construction projects of superconducting fusion devices. This paper summarizes key engineering features of the major structures and of the machine assembly.
인슐린 비의존형 당뇨병 환자에서 혈장 Endothelin-1농도의 변화
신양수,조희충,김원식,국기용,김용화,정종훈,문철웅,배학연,양성훈 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.2
Endothelin(ET) is a 21-residue peptide originally isolated from the cultured porcine endothelial cells. There are at least three genes for endothelin:endothelin-1(ET-1), endothelin-2(ET-2), and endothelin-3(ET-3). Endothelins are present in various human biological fluids including plasma, urine, breast milk, and saliva and have been found elevated plasma ET concentrations in patients with diabetes mellitus, Patients undergoing maintenance hemodialysis due to chronic renal failure, patients with acute myocardial infarction, and patients with subarachnoid hemorrhage. Endothelial cell damage is suspected to occur in diabetic patients and may be one important cause of angiopathy, a major complication in diabetes mellitus. The elevation of ET in diabetic patients may be a marker of, and further exacerbate, their vascular disease. We measured the levels of ET-1 in plasma of 50 patients with non-insulin dependent diabetes mellitus(NIDDM) and 25 normal subjects by radioimmunoassay. The plasma ET-1 concentration (mean±S.D.) in NIDDM was 6.461 A2.510 f㏖/ ㎖, and was significantly higher than in normal subjects (4.567±1.155f㏖/㎖) (P<0.05). The plasma ET-1 concentration (mean±S.D.) in diabetic retinopathy group( 7.15±2.454 f㏖/ml) was significantly elevated than those in otherwise uncomplicated groups (5.348±2.390 f㏖/㎖)(P<0.01). The correlation between any clinical parameters and plasma ET-1 levels in NIDDM was not significant, In conclusion, this study suggest that the elevated levels of ET-1 in diabetic patients may be play a important role in the pathogenesis of diabetic complications.
( Chul Min Park ),( Woon Geon Shin ),( Kyung Wook Hong ),( Ji Won Park ),( Jin Chul Jung ),( Mi Jung Kwon ),( Dae Young Yoon ),( Eun Sook Nam ),( Hak Yang Kim ) The Editorial Office of Gut and Liver 2008 Gut and Liver Vol.2 No.1
Varices that occur at sites other than the esophagogastric area are termed ectopic varices. An ileal varix is a very rare cause of lower gastrointestinal bleeding. Although ileal varices are generally associated with prior intra-abdominal surgery and adhesions, an arteriovenous malformation (AVM) in the ileocecal area can cause ileal varices and bleeding in patients with portal hypertension who have not received previous intra-abdominal surgery, which is due to an intestinal or colonic AVM dilating the collateral veins and further aggravating portal hypertension. Surgical treatment should be considered in patients with massive ectopic variceal bleeding. We report a case of massive ileocecal variceal bleeding associated with an AVM that occurred in a patient with alcoholic liver cirrhosis. (Gut and Liver 2008;2:54-59)
Yang, Chul-Hak,Kim, HyunKyung,Kim, Youngah The Korea Science and Technology Center 1998 BMB Reports Vol.31 No.1
To purify the geranylgeranyl protain transferase type Ⅰ(GGPT-I) efficiently, a gene expression system using the pGEX-4T-1 vector was constructed. The cal1 gene, encoding the βsubunit of GGPT-I, was subcloned into the pGEX-4T-1 vector and co-transformed into E. coli cells harboring the ram2 gene, the α subunit gene of GGPT-I. GGPT-I was highly expressed as a fusion protein with glutathione S-transferase (GST) in E. coli, purified to homogeneity by glutathione-agarose affinity chromatography, and the GST moiety was excised by thrombin treatment. The purified yeast GGPT-I showed a dose-dependent increase in the transferase activity, and its apparent K?? value for an undecapeptide fused with GST (GST-PEP) was 0.66 μM and the apparent K?? value for geranylgeranyl pyrophosphate (GGPP) was 0.071 μM.
Quantitative Assay for the Binding of Jun-Fos Dimer and Activator Protein-1 Site
Yang,Chul-Hak,Jun,Gyo,Hahm,Eun-Ryeong,Lee,Sangkyou,Park,Seyeon,Lee,Dug-Keun The Korea Science and Technology Center 1999 BMB Reports Vol.32 No.6
The Jun and Fos families of eukaryotic transcription factors form heterodimers capable of binding to their cognate DNA enhancer elements. We are interested in searching for inhibitors or antagonists of the binding of the Jun-Fos heterodimer to the activator protein-1 (AP-1) site. The basic-region leucine zipper (bZIP) domain of c-Fos was expressed as a fusion protein with glutathione S-transferase, and allowed to form a heterodimer with the bZIP domain of c-Jun. The heterodimer was bound to glutathione-agarose, to which were added radiolabeled AP-1 uncleotides. After thorough washing, the gel-bound radioactivity was counted. The assay is faster than the coventional electrophoretic mobility shift assay because the gel electrophoresis step and the autoradiography step are eliminated. Moreover, the assay is very sensitive, allowing the detection of picomolar quantities of nucleotides, and is not affected by up to 50% dimethylsulfoxide, a solvent for hydrophobic inhibitors. Curcumin and dihydroguaiaretic acid, recently known inhibitors of Jun-Fos-DNA complex formation, were applied to this Jun-GST-fused Fos system and revealed to decrease the dimer-DNA binding.
Differential Regulation of Reprogramming Transcription Factors in P19 Cells
Byoung-Chul Yang,Hee Kyoung Chung,Hak-Jae Chung,Kyung-Woon Kim,Deug-Woo Han,Jin-Hee An,Myoung-Seob Choi,Jin-Ki Park 한국동물번식학회 2012 Reproductive & Developmental Biology(Supplement) Vol.36 No.2s
Oct4 and Nanog are transcription factors involved in pluripotency of stem cells. In general, Oct4 is up-regulated by Nanog. In previous results, however, Oct4 was differentially regulated by various doses of Nanog in P19 cells. High dose Nanog down-regulated the Oct4 expression. This negative feedback event was performed by DNMT and HDAC through the inhibitor assays (5-AZA-cytidine and trichostatin A). To identify the precise recruited sites for DNMT and HDAC, ChIP assay was performed in differential doses of Nanog. As a result, HDAC1, HDAC2, DNMT3A and Nanog were recruited to CR2, CR3, CR1, and CR4 upon high dose Nanog, respectively. Next, to investigate the differentiation potency of the cells upon high dose Nanog, RT-PCR with specific markers for three germ layers was performed. However, there was no increase for three germ layers in high dose Nanog treated cells except E-cadherin expression. E-cadherin is a specific marker for epithelial cells. Taken together, high dose Nanog induces Oct4 down-regulation and results in differentiating embryonic carcinoma cells to epithelial cell type. These results will be helpful for study on regulation of pluripotency-related genes in embryonic stem cells. * This study was supported by 2012 Post Doctoral Fellowship Program of National Institute of Animal Science, Rural Development Administration, Republic of Korea. This work received grant support from the Agenda Program (No.PJ007577), Rural Development Administration, Republic of Korea.