부당경량아에서 발생하는 대사 장애의 기전

김은영,박상기 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S

요추 추간판 질환

유재원,손홍문 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2

Low back pain is a common medical problem and reported overall prevalence is 60-80% of general populations. Most of the low back pain comes from disc degeneration. Degenerative disc disease is broadly defined as "a clinical syndrome characterized by manifestations of disc degeneration and symptoms thought to be related to those changes." Disc degeneration does not necessarily produce symptoms but it is believed to be the aging process of the spine. Despite the extensive research to understand the pathophysiology of disc degeneration, the precise cause and pathophysiology of disc degeneration have not been revealed to date. This article reviews the pathophysiology of lumbar disc disease, especially the intervertebral disc herniation, and relates it to the development of clinical manifestations, including the evaluation as well as the nonoperative and operative management of such problems. 요추간판 질환은 추간판의 퇴행성 변화와 더불어 원인적인 여러인자가 복합되어 발생함에 의해 면밀한 검사가 필요하다. 요추간판 질환은 자연경과에 따라 증상이 호전될 수 있으나 보존적인 치료가 우선되어야하며 증상이 지속될 때에는 수술적인 치료가 필요하다. 수술적 치료의 성공여부는 정확한 적응증과 금기증의 적용 그리고 정확한 시술 등에 의하여 결정된다. 최근 진단기기 그리고 수술환경의 개선과 수술수기 및 척추기기의 개발로 인해 괄목할만한 임상결과를 보이고 있으나 이들의 부작용 또한 무시할 수 없는 실정임을 감안할 때 수술적 치료의 환자선택은 가장 중요하다고 할 수 있으며 수술방법 등은 최근 최소 침습 수술기법 등이 다양하게 이용되고 있으나 술자의 기술 등 여러요인을 고려하여 선택하는 것이 바람직하다고 하겠다.

경부 국소림프절 종대로 나타난 기무라병 I 예

도남용,박성용,김종희 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Kimura's disease is a chronic inflammatory disorder of unknown etiology and characterized by angiolymphoid proliferation which involves the subcutaneous tissue, salivary gland and regional lymph node on neck. On peripheral blood, eosinophilia and elevation of serum IgE are characteristically present. The histopathologic changes consist of follicular lymphoid hyperplasia with interfollicular eosinophils and proliferation of thin-walled blood vessels. We experienced Kimura's disease associated with regional lymph node enlargement on neck, which was treated with mass excision and report it with a review of the literature.

족저건 보강법을 이용한 아킬레스건 파열의 치료

이준영,하상호 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Background and Objectives : We try to evaluate the result of the operative treatment ofAchilles tendon rupture using plantaris tendon augmentation and the functional outcomes related to the cause of injury and rehabilitation methods. Materials and Methods : We studied retrospectively, 28 patients of Achilles tendon rupture treated and followed over l-year, from Januaiy 1995 to August 2001. There were 24 men and 4 women, mean age was 38 years. The repair method of ruptured tendon was pirmary repair with plantahs tendon augmentation. We used Leppilahti method for the clinical evaluation and analyzed patient's satisfaction and subjective strength deficit. Results : In clinical results, we had 11 excellent cases(39%), 10 good cases(36%), 4 fair cases(14%) and 3 poor cases(11%). Nonsports-related rupture had worse result than sports related rupture due to old age and degenerative changes of tendon. The result of short leg cast was similar to that of long leg cast in rehabilitation method, especially, the group starting the weight bearing ambulation within 8 weeks obtained excellent results. Conclusion : We had good result for Achilles tendon rupture treated by primary repair with planths tendon augmentation. This study shows plantahs tendon augmentation was recommended method for primary repair and early rehabilization of Achilles tendon rupture.

류마티스 관절염과 동반된 궤양성 대장염 1예

정종필,김윤아,서강석,김태현,김춘호,박정복,이광욱 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

The gastrointestinal involvement in rheumatoid arthritis may be broad and includes many causes: drug induced colitis, colitis associated with infectious agents, vasculitis in gut, autoimmune disease located in gut. Rheumatoid arthritis is a chronic multisystemic disease of unknown cause. Although a number of mixed autoimmue disease exist, there were rare reports about Ulcerative colitis with Rheumatoid arthritis associated. We report one case of Rheumatoid arthritis patient who diagnosed as Ucerative colitis by colonoscopic and histologic finding with review of literature.

일 고등학교 학생들의 건강증진행위와 관련요인

유상학,김진선 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Background and Objectives: Little is known about the health promoting behaviors of adolescence. The purposes of this study were to identify healthUpromoting behaviors of high school students and to explore the predictors of their health-promoting behaviors. Method: A crossUsectional study was conducted. Data were collected from 751 students in a technical high school located in G city using a structured questionnaire. Results: High school students in this study practice health promoting behaviors relatively well. Among 6 dimensions, students reported the highest score on the interpersonal relationship dimension and the lowest score on the health responsibility dimension. Of 751 respondents, 26.2% was current smokers and 64.6% was current drinkers. Health-promoting behaviors were predicted by selfUeff'icacy, family support, school life adaptation, and gender. Students who reported higher self-efficacy, higher family support, and higher school life adaptation practice more health promoting behaviors than their counterparts. Moreover, boys reported higher health promoting behavior scores than girls, Conclusion: Health promotion programs to increase health responsibility of high school students are need to be developed. There were great needs to develops tobacco cessation and drink control programs. More studies are needed to identify predictors of high school students' health promoting behaviors.

소아 두통의 진단과 치료

노영일 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

청소년기 특발성 척추 측만증의 원인 및 자연사

유재원,손홍문 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Adolescent idiopathic scoliosis(AIS) is a structural lateral curvature of the spine in the adolescent period in otherwise normal children. The diagnosis is obtained through evidence of a lO-degree lateral curvature with vertebral rotation on a standing upright radiograph of the spine, Prevalence studies indicate that 2% to 3% of children have idiopathic scoliosis. The exact etiology of idiopathic scoliosis, however, remains unknown at this time. The general consensus is that there is a hereditary predisposition and its actual cause is multifactohal. Approphate decisions for AIS require thorough knowledge of natural history, Understanding the natural history enables physicians to make thoughtful and appropriate management decisions that will alter the course of the disease in a positive way. The main concerns in the natural history are curve progression, back pain, Pulmonary function, mortality, Psychosocial effects and pregnancy, Previous natural history studies claimed an exaggerated results. Many recent results, however, are comparable to general population other than back pain and cosmetic concerns. 척추 측만증에 대한 원인과 자연사에 대하여 많은 보고가 있지만 아직까지 확실한 단일 원인은 밝혀지지 않았고 원인으로 생각되는 요소가 측만증의 원인인지 아니면 측만증에 의한 이차적인 변화인지 확실하지 않은 경우가 많다. 자연사는 과거의 보고는 요통, 폐기능, 사망률, 임신 등에서 정상인에 비해 좋지 않은 결과를 보인다는 보고가 많았으나 최근 보고는 정상인과 비슷하거나 약간 나쁜 정도의 결과를 보고하고 있다. 앞에서 언급한 내용틀은 일반적인 내용이며 측만증 환자에 대한 치료에 임할때는 측만증의 자연사에 대한 지식과 만곡의 크기, 골격 성숙도, 성 성숙도, 나이 등에 기초한 만곡의 진행 가능성을 충분히 고려하여 각각의 환자에 맞는 치료를 시행하여야 할 것이다.

1세대 Northgate SD-3와 3세대 Donier Compact Delta를 이용한 체외충격파쇄석술의 비교 : 상부 및 중부요관석 243례

고영록,노준,소영석 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2

Objectives: To compare the efficacy of the Dornier Compact Delta lithotriptor with the Northgate SD-3 lithotriptor in the treatment of upper and mid-ureteral stones. Materials and Methods: A total of 243 patients without any previous experience of ESWL were treated for upper and mid-ureteral stones. 121 patients were managed with the Northgate SD-3 lithotriptor which had ultrasonography targeting system and electro hydraulic shock wave source. The other 122 patients were treated with the Dornier Compact Delta equipped with a fluoroscopic focusing system and electromagnetic shock wave source. The locations and sizes of stones, sessions, stone-free rates, auxiliary procedures, and complications of ESWL were reviewed retrospectively. In each group stone-free results were determined by KUB 1 month after the last ESWL and then efficacy quotients (EQ) were obtained. Results: Baseline characteristics were equivalent, including patient ages, sex ratio, stone numbers and locations. Using the Northgate SD-3 lithotriptor, the average sessions and stone-free rates were 1.53 and 86.8%, respectively. Using the Dornier Compact Delta lithotriptor, average sessions and stone-free rate were 1.38 and 92.6 %, respectively. Effectiveness quotient(EQ) in the Northgate SD-3 and the Dornier Compact Delta was 61 and 65, the rates of the auxiliary procedure were 9.1% and 18%. Conclusions: The Dornier Compact Delta lithotripsy resulted in a higher stone-free rate and EQ, although it was associated with a higher rate of pre-ESWL auxiliary procedures than the Northgate SD-3 Lithotripsy.

담낭종양에서 CD24의 역할

임성철,이용,김동출,강길,변익건,박정희,최석민 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

CD24 is a small heavily glycosylated glycosylphosphatidylinosito-linked cell surface protein, which is expressed in hematologic malignancies as well as in a large variety of solid tumors, It appears to function as a ligand of PUselectin, an adhesion molecule that is present in activated platelets and endothelial cells. The authors aimed to evaluate CD24 protein expression in adenoma and adenocarcinoma of gallbladder to correlate to clinicopathologic data. The staining- was evaluated as stainability (negative, weak-, moderate-, strong-positive) and staining' patterns (membranous vs. intracytoplasmic) for statistical analysis. A highly significant association of cytoplasmic CD24 expression with adenocarcinoma compared to the adenoma of gallbladder was demonstrated. The present study demonstrates that CD24 was abundantly expressed on adenocarcinoma rather than on adenoma, but it was not statistically significant, Interrelation between the stainability or intracytoplasmic staining of CD24 and lymph node metastasis was not statistically significant. The authors conclude that CD24 is involved in tumorigenesis of gallbladder mucosa and intracytoplasmic expression of CD24 is an important molecular marker for malignant transformation.