과민성 장 증후군의 증상 경감을 위한 비약물적 접근 고찰

최명애,김금순,안경주,채영란,최정안,홍해숙,박미정,이경숙,신기수,정재심 대한기초간호자연과학회 2005 Journal of korean biological nursing science Vol.7 No.2

There have been many trials of clinical efficacy of multicomponent and single component treatments for irritable bowel syndrome(IBS). We reviewed effects of non phamacological treatments in the IBS. Though the efficacy of multi-component approaches was unclear, several results suggest that cognitive behavioral therapy was effective in improving gastrointestinal symptoms of IBS. As a single component, cognitive therapy and relaxation with or without biofeedback could improve the symptoms and psychological health of IBS patients. Yoga, meditation, self-help information and hypnotherapy could be applicable to IBS.

비결핵성 마이코박테리아 폐질환의 임상경과

최강현, 한혜숙, 정혜원, 안진영, 이기만, 김미경 충북대학교 의과대학 충북대학교 의학연구소 2011 忠北醫大學術誌 Vol.21 No.2

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茶 침출조건에 따른 Catechin, 무기질 및 Vitamin C 함량 변화

이순재,김미지,윤연희,박규영,최원경,방진숙,부용출 대구효성가톨릭대학교 응용과학연구소 1994 응용과학연구논문집 Vol.3 No.-

본 연구에서는 실제 상용하고 있는 각 차음료가 온도, 시간 및 추출 횟수에 따른 성분의 함량의 차이를 관찰코져 시판되고 있는 한국산 녹차, 우롱차 및 홍차를 대상으로 추출방법을 달리한 후 茶浸出液중의 주요성분인 catechin, vitamin C 및 여러가지 무기질의 함량을 측정하여 다음과 같은 결과를 얻었다. 1. 차침출온도에 따른 침출액중의 catechin과 vitamin C 함량의 차이를 볼 때 온도가 높을수록 많이 추출되었다. 2. 같은 온도라는 침출시간에 따른 차이를 관찰한 결과 시간이 길수록 침출액중의 catechin과 vitamin C의 함량이 증가되었다. 3. 녹차는 우려낸 횟수에 따른 catechin의 함량 차이는 처음에 비하여 2회 추출시약 51%, 3회추출시는 71% 감소하였다. 4. 차의 각 무기원소에 따른 함량을 비교시 Mg은 우롱차가 가장 높고 K, Mn은 녹차가, Zn, Cu 그리고 Fe는 홍차가 가장 높게 나타났다. 5. 녹차, 우롱차의 경우 대체로 무기질의 침출정도가 온도가 높을수록 오히려 감소하는 경향을 나타내었고 홍차는 Mg, K을 제외하고 모두 증가하였다. 6. 각 침출액중의 대부분의 무기질 함량은 추출횟수가 증가할수록 감소하였다. 7. 시료로 사용한 녹차, 우롱차, 홍차의 vitamin C 함량은 녹차, 우롱차, 홍차의 순으로 높게 나타났다. 8. 녹차를 추출한 횟수에 따른 vitamin C 함량은 1회에 비해 2회 추출시 약 36%, 3회 추출시 약 62% 감소되었다. 9. 5g의 녹차를 80℃에서 2분간 침출한 액중에서는 catechin은 100ml당 0.34g, Mg은 2.229mg, Ca은 0.365mg, K은 39.77mg, Zn은 0.037mg, Cu은 0.010mg, Fe는 0.001mg, Mn은 0.581mg이며, vitamin C는 9.65mg이 함유되어 있었다. This study was to compare the ingredients which are contained in usual Korean teas in-depednence on leaching temperature, time and number. The main contents i.e. catechin, vi-tamin C and other minerals extracted from Korean commercial green tea, oolong tea and black tea were measured. The resluts are as follows; According to extracting temperature, the higher temperature made catechin and vitamin C extracted more. For the same leaching temperature, the longer time the more catechin and vitamin C. In case of extracting number, the contents of catechin was decreased a-bout 50% and 70% at second time and third, respectively in comparasion to the first time. For minerals from teas, management(Mg) was most in oolong tea, potassium(K)and manganease(Mn) and in green tea and iron(FEe) was in black tea respectively. Most min-erals from greentea and oolong tea were extracted less as leaching temperature was in-creased. But in black tea minerals other than Mg and K were more at increased tempera-ture. Most minerals in extractions were decreased as leaching number was increased. The content of vitamin C in the experimental samples(tea) was most in green tea, next in oo-long tea and third in black tea. In comparasion with the first extraction vitamin C was de-creased about 35% and 60% at 2nd and 3rd leach, respectively.

STZ 유발 당뇨쥐에서 시간에 따른 생리적 항산화계의 변화

이순재,양정아,김성옥,최정화,신주영,채영미,차복경 대구효성가톨릭대학교 응용과학연구소 1997 응용과학연구논문집 Vol.5 No.-

The purpose of this study was to investigate change of physiological antioxidative system according to the time in streptozotocin-induced diabetic rats. Sprague-Dawley male rats weighing 150±10gm were randomly assigned to one normal and five STZ-induced diabetic groups. Diabetic groups were classified to experimental period. Diabetes was experimentally induced by intravenous injection of 55 mg/kg of body weight of STZ in citrate buffer(PH 4.3) after 6 weeks feeding of three experimental diets. Animals were sacrificed at 0, 3, 6, 12, 18th days of diabetic states. 1. Activity of superoxide dismutase(SOD) in liver was increased in that of diabetic mellitus(DM) groups at 3th day but that of DM groups was not significant from 6th day according to period. Glutathion peroxidase(GPX) was significantly decreased in DM groups from 6th day 2. Reduced glutathione(GSH) contents in liver significantly decreased in diabetic groups from 3rd day compared with those of DM groups according to the period. Oxidized glutathione(GSSG) was higher from 6th day. GSH/GSSG ratio was significantly lower than that of normal group from 3rd day to all experimental period 3. Contents of vitamin E in liver of DM groups were significantly decreased compared with that of normal group from 6th day. 4. Lipid peroxide(LPO) contents in liver of DM groups were significantly increased compared with that of normal group from 3rd day. The present results indicate that STZ-induced diabetic rats were reduced by antioxidative defense system and taken by peroxidate damage in tissue compared with normal group from 3rd day or 6rd day after injection STZ. It lended to acceleration all diabetic groups but no significance according to the experimental time.

결핵성 흉막염 환자에서 폐실질 결핵의 동반 유무에 따른 임상적 특성

이기만, 최강현, 안진영, 정혜원, 김미경, 김성진 충북대학교 의과대학 충북대학교 의학연구소 2012 忠北醫大學術誌 Vol.22 No.1

연구목적; 결핵성 흉막염의 발생과 관련된 인자를 알아보고자하였으며, 방사선학적 소견으로 분류된 일차성 혹은 재활성화에 의한 병변에 따라 양 군 간의 임상적 자료를 비교 분석하고자 하였다. 연구대상 및 방법; 2010년부터 2011년까지 충북대학교병원에 내원하여 결핵성 흉막염으로 진단된 18세 이상의 모든 환자를 대상으로, 폐실질 결핵의 동반양상을 분석하여 활동성여부 및 재활성화 결핵 여부로 나눈 후 각 군 간의 방사선학적 특성, 흉수소견, 기저질환 및 임상적 특성을 비교하였다. 결과; 결핵성 흉막염으로 진단된 대상 환자 37명 중 폐실질 혹은 임파선에 활동성 혹은 비활동성 결핵 소견을 동반한 경우는 27명(27/37, 73%)이고, 활동성 폐실질 결핵의 소견을 동반한 경우는 16명 (43%)이었다. 방사선학적 분석으로 재활성화의 소견을 가진 환자는 18명이고(49%)이고 일차성 결핵 성 흉막염이 발생한 경우로 분석된 환자는 19명(51%)이었다. 재활성화의 경우는 일차성 결핵 환자에 비해 평균나이가 많고(64.6세 및 41.5세, p<0.002) 동반질환 빈도가 높으며(50% 및 5 %, p<0.003), 말초혈액에서의 혈색소치 평균 또한 의미있게 낮았다(11.75 g/dL 및 13.40 g/dL, p<0.014). 결론; 결핵의 재활성화에 의한 결핵성 흉막염은 일차성 결핵 흉막염보다 고령환자 및 면역 저하와 관 련된 동반질환이 있는 경우가 많으며, 빈혈을 동반하는 경우가 많았다.

Identification of Phosphohistone H3 Cutoff Values Corresponding to Original WHO Grades but Distinguishable in Well-Differentiated Gastrointestinal Neuroendocrine Tumors

Kim, Min Jeong,Kwon, Mi Jung,Kang, Ho Suk,Choi, Kyung Chan,Nam, Eun Sook,Cho, Seong Jin,Park, Hye-Rim,Min, Soo Kee,Seo, Jinwon,Choe, Ji-Young,Park, Hyoung-Chul Hindawi 2018 BioMed research international Vol.2018 No.-

<P>Mitotic counts in the World Health Organization (WHO) grading system have narrow cutoff values. True mitotic figures, however, are not always distinguishable from apoptotic bodies and darkly stained nuclei, complicating the ability of the WHO grading system to diagnose well-differentiated neuroendocrine tumors (NETs). The mitosis-specific marker phosphohistone H3 (PHH3) can identify true mitoses and grade tumors reliably. The aim of this study was to investigate the correspondence of tumor grades, as determined by PHH3 mitotic index (MI) and mitotic counts according to WHO criteria, and to determine the clinically relevant cutoffs of PHH3 MI in rectal and nonrectal gastrointestinal NETs. Mitotic counts correlated with both the Ki-67 labeling index and PHH3 MI, but the correlation with PHH3 MI was slightly higher. The PHH3 MI cutoff ≥4 correlated most closely with original WHO grades for both rectal NETs. A PHH3 MI cutoff ≥4, which could distinguish between G1 and G2 tumors, was associated with disease-free survival in patients with rectal NETs, whereas that cutoff value showed marginal significance for overall survival in patient with rectal NETs. In conclusion, the use of PHH3 ≥4 correlated most closely with original WHO grades.</P>

[P10-193] Inhibitory Effects of Anthocyanins on Inflammatory Responses of Adipose Tissue Macrophages

Mi-Ran Choe,Suck-Young Choe,Rina Yu 한국식품영양과학회 2006 한국식품영양과학회 학술대회발표집 Vol.2006 No.10

Cyanidin and Cyanidin-3-O-β-D-glucoside Suppress the Inflammatory Responses of Obese Adipose Tissue by Inhibiting the Release of Chemokines MCP-1 and MRP-2

Choe, Mi-Ran,Kang, Ji-Hye,Yoo, Hoon,Yang, Chae-Ha,Kim, Mi-Ok,Yu, Ri-Na,Choe, Suck-Young The Korean Society of Food Science and Nutrition 2007 Preventive Nutrition and Food Science Vol.12 No.3

Obesity-induced inflammation plays a crucial role in obesity-related pathologies such as type II diabetes and atherosclerosis. Adipose tissue macrophages and the cell-derived proinflammatory chemokines are key components in augmenting inflammatory responses in obesity. Anthocyanins such as cyanidin and $cyanidin-3-O-{\beta}-D-glucoside$ (C3G) are known to elicit anti-inflammatory activities by suppressing the production of proinflammatory mediators such as tumor necrosis factor alpha and nitric oxide in LPS-stimulated macrophages. In the present study, we investigated whether cyanidin and C3G have the potential to suppress the inflammatory responses of adipose cells. Cyanidin and C3G not only suppressed the migration of RAW 264.7 macrophages induced by mesenteric adipose tissue-conditioned medium, but also inhibited the activation of the cells to produce inflammatory chemokines such as monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-related protein-2 (MRP-2) in a dose-dependent manner. Cyanidin and C3G also inhibited the release of MCP-1 and MRP-2 from adipocytes and/or macrophages. These findings suggest that cyanidin and C3G may suppress the inflammatory responses of adipose tissue in obesity.

Selection of nptll Transgenic Sweetpotato Plants Using G418 and Paromomycin

( Young Mi Shin ),( Goh Choe ),( Byoung Chul Shin ),( Gi Bum Yi ),( Pil Yong Yun ),( Ki Young Yang ),( Joon Seol Lee ),( Sang Soo Kwak ),( Kyung Moon Kim ) 한국식물학회 2007 Journal of Plant Biology Vol.50 No.2

Influences of Phosphogypsum Application on Soil Property and Yield and Quality of Onion (Allium cepa L.)

Young-Nam Kim,Ju Young Cho,Young-Eun Yoon,Hyoen Ji Choe,Mi Sun Cheong,Mina Lee,Kwon-Rae Kim,Yong Bok Lee 한국토양비료학회 2021 한국토양비료학회지 Vol.54 No.2

Phosphogypsum (PG) is a by-product obtained in the process of manufacturing phosphoric acid (H₃PO₄). In general, PG is characterized mainly by gypsum, phosphate, sulphate, fluoride etc. Considering the nutritional composition, PG has been globally used as soil fertilizer or amendment in agriculture for decades. This study aimed to investigate effects of PG application on soil properties and yield and quality of onion (Allium cepa L.) and to seek proper rate of PG application in a field. We applied PG into a field with four different levels: 0% (control), 50% (PG50, 104 ㎏ 10a<SUP>-1</SUP>), 100% (PG100, 208 ㎏ 10a<SUP>-1</SUP>), and 150% (PG150, 312 ㎏ 10a<SUP>-1</SUP>). Also, oyster shell (OS) included as a comparable and chemical fertilizer (N-P-K = 8.4-37.9-8.0 ㎏ 10a<SUP>-1</SUP>) was supplied into soil of all treatments. Following onion cultivation for 7 months, there was a significant change in soil pH. Indeed, PG application was more likely to lower pH relative to control. With increase in PG application rate, soil EC increased and the maximum value (1.93 dS m<SUP>-1</SUP>) was found in soil of PG150. In PG100 and PG150, concentration of exchangeable Ca (Ex. Ca) increased by 5% and 10%, respectively, whilst other treatments representing reduction in the Ex. Ca concentration. In addition, PG application affected concentration of water soluble Ca across the soil profile (up to 70 cm depth) and, in particular, the higher the PG application rate the higher the concentration of water soluble Ca. Similarly, water soluble S had same trend with water soluble Ca in the present study. With increase of PG application rate, yield of onion increased but decreased in PG150 which is the highest rate of PG application. Also, the plant’s uptake for N, P, Ca, K, and S affecting yield, resistance to pathogen and pest, and quality of the crop increased in PG50 and PG100. Moreover, concentrations of total amino acids, cysteine and methionine in onion bulbs that are strongly associated to S uptake increased by PG applications. The increased concentrations of amino acids with PG applications might improve yield, quality, and favor of onions. These results suggest that PG supply could have a potential to enhance soil fertility, contributing to improvement of yield and quality of onions. Further studies are needed to maximize efficiency of PG supply in agricultural lands.