[남자1부 단체전 우승] 용인대학교 / 최민선

최민선 대한검도학회 2019 대학검도보 Vol.- No.35

The Effect of Knee Joint Traction Therapy on Pain, Physical Function, and Depression in Patients with Degenerative Arthritis

최민선,이동규 대한물리치료학회 2019 대한물리치료학회지 Vol.31 No.5

Purpose: To identify the effect of knee joint traction therapy on pain, physical function, and depression in patients with degenerative arthritis. Methods: In total, 30 patients with degenerative arthritis were randomly assigned to one of two groups: the experimental group, who underwent knee joint traction therapy, and the control group, who underwent general physical therapy (15 patients per group). Pain was measured using the visual analogue scale (VAS), physical function was measured using the Western ontario and McMaster universities osteoarthritis (WOMAC) index, and depression was measured using the Beck depression inventory (BDI). The VAS, WOMAC score, and BDI score were recorded before and after the 4-week treatment. Results: As a result of comparison within groups, the experimental and control group showed significant difference for VAS, WOMAC and BDI after the experiment (p<0.05). In comparison between the two groups, the experimental group in which knee joint traction was applied showed more significant change in VAS, WOMAC and BDI than the control group (p<0.05). Conclusion: This study showed that knee joint traction therapy was effective in improving pain, physical function, and depression in patients with degenerative arthritis.

국내 마늘 품종 육성 현황 및 연구 방향

최민선,한지원,김지강,김천환,강수현,임태준,조명철 한국종자연구회 2022 종자과학과 산업 Vol.18 No.2

학교자치 실현을 위한 교육 거버넌스 혁신의 과제

최민선 우리교육 2017 우리교육 Vol.268 No.-

적응형 학습 상황에 활용된 학습분석 테크놀로지: 국내외 사례연구를 중심으로

최민선,정재삼 한국교육공학회 2019 한국교육공학회 학술대회발표자료집 Vol.2019 No.1

본 연구의 목적은 국내외 적응형 학습 시스템 사례를 중심으로 각 시스템에 공통적으로 적용된 교수-학습의 이론적 배경과 학습분석 테크놀로지를 살펴보고, 적응형 학습을 위한 교수설계 방향을 제시하는 것이다. 1970년대 이전의 초기 교수이론들은 기본적으로 ‘완전학습(mastery learning)’과 ‘개별화’를 가정하며, 학습자의 특성 분석과 교수의 질(학습과제의 계열화), 그리고 피드백 기능을 강조되고 있다. 이러한 요소는 학습에 대한 심리학적 원리에 기초를 둔 다른 많은 교수이론에도 찾아 볼 수 있으며, 최근 학습분석 테크놀로지를 활용한 적응형 학습 시스템의 학습 모형의 기초로 활용되고 있다. 적응형 학습 플랫폼 개발에 전적으로 헌신하고 있는 에듀테크 기업들의 경우, 서비스 대상은 초등학생부터 중고등학생, 성인까지 다양하지만 인공지능의 최근 급격한 발전에 발맞추어 데이터 수집 · 분석 · 예측을 위한 학습분석 테크놀로지들을 점차 정교화하면서 맞춤형 교육 기회를 제공하는 잠재적 가능성을 제공하고 있다는 공통점이 있다. 적응형 학습 플랫폼에 활용된 학습분석 테크놀로지는 (1)학습자의 로그인 정보와 개인 정보 및 학습 수준을 저장하는 학습자 정보 데이터베이스, (2)학습지식 맵과 영역별, 난이도별 분류된 문항을 저장하는 문제은행 데이터베이스, (3)‘문항반응이론’ 지식을 활용하여 문제은행 데이터베이스에 저장된 문제들 중에서 특정학습자에게 특정 문항을 선택하여 제공하는 추천 시스템 엔진, (4)학습과정에서 발생하는 데이터를 실시간으로 수집, 분석, 처리하는 데이터마이닝 기술, (5)학습결과를 분석하여 예측과 처방을 리포팅하는 시각화 기술 등이 있다. 완전학습과 개별 학습이 빅데이터 기반의 적응형 학습 플랫폼에서 기술적으로 구현이 가능해졌기 때문에 전통적 교수설계 모형, 즉 ADDIE(Analysis, Design, Development, Implementation, & Evaluation) 모형을 보완할 수 있고 ‘데이터 수집, 가공 → 분석→ 예측 → 처방’과 같은 학습분석 단계를 포함하는 새로운 모형이 요구된다.

Essential Oils from the Medicinal Herbs Upregulate Dopamine Transporter in Rat Pheochromocytoma Cells

최민선,최방섭,김상헌,Sok Cheon Pak,장철호,진영원,김영미,김동일,전송희,구병수 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.10

The dopamine transporter (DAT) protein, a component of the dopamine system, undergoes adaptive neurobiological changes from drug abuse. Prevention of relapse and reduction of withdrawal symptoms are still the major limitations in the current pharmacological treatments of drug addiction. The present study aimed to investigate the effects of essential oils extracted from Elsholtzia ciliata, Shinchim, Angelicae gigantis Radix, and Eugenia caryophyllata, well-known traditional Korean medicines for addiction, on the modulation of dopamine system in amphetamine-treated cells and to explore the possible mechanism underlying its therapeutic effect. The potential cytotoxic effect of essential oils was evaluated in PC12 rat pheochromocytoma cells using cell viability assays. Quantification of DAT, p-CREB, p-MAPK, and p-Akt was done by immunoblotting. DAT was significantly reduced in cells treated with 50 lM of amphetamine in a time-dependent manner. No significant toxicity of essential oils from Elsholtzia ciliata and Shinchim was observed at doses of 10, 25, and 50 μg/mL. However, essential oils from A. gigantis Radix at a dose of 100 μg/mL and E. caryophyllata at doses of 50 and 100 μg/mL showed cytotoxicity. Treatment with GBR 12909, a highly selective DAT inhibitor, significantly increased DAT expression compared with that of amphetamine only by enhancing phosphorylation of mitogen-activated protein kinases (MAPK) and Akt. In addition, essential oils effectively induced hyperphosphorylation of cyclic-AMP response elementbinding protein (CREB), MAPK, and Akt, which resulted in DAT upregulation. Our study implies that the essential oils may rehabilitate brain dopamine function through increased DAT availability in abstinent former drug users.

홍삼의 온열 효과와 복약 순응도에 관한 연구

최민선,정재철,박장경,안홍엽,김동일,Choi, Min-Sun,Jeong, Jae-Cheol,Park, Jang-Kyung,Ahn, Hong-Yeop,Kim, Dong-Il 대한한방체열의학회 2009 대한한방체열의학회지 Vol.7 No.1

Purpose: To evaluate thermal effect and medication compliance of red ginseng extract. Methods: Randomized, double-blind, placebo-controlled, cross-over clinical study was performed. Twenty four healthy, married women aged 30-45 years with FSFI score below 25 were randomly divided into two groups; red ginseng group(N=12) and placebo group(N=12). During the first 6-week period (Study1), each group was dosed with red ginseng or placebo twice a day. Before starting the second 6-week period(Study2), a crossover design was chosen with a 2-week break(Washout period). Interchanging two groups after Washout period, red ginseng and placebo were dosed to each group. The efficacy of thermal effect was measured with subjective warm sensation scale and lower abdomen temperature by Digital Infrared Thermographic imaging(DITI) before and after each 6-week period. A medication compliance was assessed after each 6-week period and the correlation medication compliance between Sasang Constitution and subjective warm sensation was analyzed. Results: Overall 23 participants completed the study. In subjective warm sensation scale, after taking placebo, all participants exhibited an improving trend, but there was no significant difference. In lower abdomen temperature by DITI, statistically significant objective thermal effect of red ginseng was also not shown. A medication compliance was higher in Yin constitution(Taeumin, Soeumin), and showed an upward trend with decreasing subjective warm sensation. But no statistically significant difference was exhibited. Conclusion: Statistically significant thermal effect of red ginseng was not shown in this study. We anticipate if a long-term clinical trial is practiced, significant thermal effect of red ginseng will be shown.

Expression of hpa1 Gene Encoding a Bacterial Harpin Protein in Xanthomonas oryzae pv. oryzae Enhances Disease Resistance to Both Fungal and Bacterial Pathogens in Rice and Arabidopsis

최민선,허성기,백남천,고희종,Jung-Sook Lee,오창식 한국식물병리학회 2012 Plant Pathology Journal Vol.28 No.4

Xanthomonas oryzae pv. oryzae causing bacterial leaf blight disease in rice produces and secretes Hpa1 protein that belongs to harpin protein family. Previously it was reported that Hpa1 induced defense responses when it was produced in tobacco. In this study, we expressed hpa1 gene in rice and Arabidopsis to examine the effects of Hpa1 expression on disease resistance to both fungal and bacterial pathogens. Expression of hpa1 gene in rice enhanced disease resistance to both X. oryzae pv. oryzae and Magnaporthe grisea. Interestingly,individual transgenic rice plants could be divided into four groups, depending on responses to both pathogens. hpa1 expression in Arabidopsis also enhanced disease resistance to both Botrytis cineria and Xanthomonas campestris pv. campestris. To examine genes that are upregulated in the transgenic rice plants after inoculation with X. oryzae pv. oryzae, known defense-related genes were assessed, and also microarray analysis with the Rice 5 K DNA chip was performed. Interestingly, expression of OsACS1 gene, which was found as the gene that showed the highest induction, was induced earlier and stronger than that in the wild type plant. These results indicate that hpa1 expression in the diverse plant species, including monocot and dicot, can enhance disease resistance to both fungal and bacterial plant pathogens.

Conformation-specific Antibodies Targeting Aggregated Forms of α-synuclein Block the Propagation of Synucleinopathy

최민선,김태경,안진형,이준성,정병철,안성원,김동인,이민재,묵인희,이상훈,이승재 한국뇌신경과학회 2022 Experimental Neurobiology Vol.31 No.1

Abnormal aggregation of α-synuclein is a key element in the pathogenesis of several neurodegenerative diseases, including Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy. α-synuclein aggregation spreads through various brain regions during the course of disease progression, a propagation that is thought to be mediated by the secretion and subsequent uptake of extracellular α-synuclein aggregates between neuronal cells. Thus, aggregated forms of this protein have emerged as promising targets for disease-modifying therapy for PD and related diseases. Here, we generated and characterized conformation-specific antibodies that preferentially recognize aggregated forms of α-synuclein. These antibodies promoted phagocytosis of extracellular α-synuclein aggregates by microglial cells and interfered with cell-to-cell propagation of α-synuclein. In an α-synuclein transgenic model, passive immunization with aggregate-specific antibodies significantly ameliorated pathological phenotypes, reducing α-synuclein aggregation, gliosis, inflammation, and neuronal loss. These results suggest that conformation-specific antibodies targeting α-synuclein aggregates are promising therapeutic agents for PD and related synucleinopathies.

合歡皮 추출물의 항산화활성 및 혈관계에 미치는 영향에 대한 연구

최민선,김동일,이태균,김은영,류미라 대한한방부인과학회 2004 大韓韓方婦人科學會誌 Vol.17 No.4

Albizzia julibrissin have long been used for clinical therapy associated especially with menopausal symptoms in Korea. To provide a scientific rationale for such use, we have investigated the antioxidant and vasorelaxant effects of Albizzia julibrissin. Antioxidant activity was measured using the , -diphenyl- -picrylhydrazyl (DPPH) radical scavenging and superoxide anion radical scavenging methods. The water extracts of Albizzia julibrissin (AJ-Ex) produced a dose-dependent radical scavenging activity against DPPH and superoxide anion radical. The vasorelaxant effects of Albizzia julibrissin and its possible mechanism of action were investigated on the vasomotor tone of the rat thoracic aorta rings in an organ bath. The extracts produced a dose-dependent transient relaxation in the endothelium-intact rat aorta precontracted with norepinephrine (NE). This relaxant effect was significantly attenuated by removal of the endothelium and also by treatment with such nitric oxide (NO) synthase inhibitor L-NNA (10 M). Neither a prostacycline synthase inhibitor, indomethacin (10 M), nor a muscarinic receptor antagonist, atropine (10 M), altered the AJ-Ex induced endothelium-dependent relaxation. In conclusion, these antioxidant and vasorelaxant effects of the extracts may contribute to the beneficial effects in postmenopausal women. Albizzia julibrissin have long been used for clinical therapy associated especially with menopausal symptoms in Korea. To provide a scientific rationale for such use, we have investigated the antioxidant and vasorelaxant effects of Albizzia julibrissin. Antioxidant activity was measured using the , -diphenyl- -picrylhydrazyl (DPPH) radical scavenging and superoxide anion radical scavenging methods. The water extracts of Albizzia julibrissin (AJ-Ex) produced a dose-dependent radical scavenging activity against DPPH and superoxide anion radical. The vasorelaxant effects of Albizzia julibrissin and its possible mechanism of action were investigated on the vasomotor tone of the rat thoracic aorta rings in an organ bath. The extracts produced a dose-dependent transient relaxation in the endothelium-intact rat aorta precontracted with norepinephrine (NE). This relaxant effect was significantly attenuated by removal of the endothelium and also by treatment with such nitric oxide (NO) synthase inhibitor L-NNA (10 M). Neither a prostacycline synthase inhibitor, indomethacin (10 M), nor a muscarinic receptor antagonist, atropine (10 M), altered the AJ-Ex induced endothelium-dependent relaxation. In conclusion, these antioxidant and vasorelaxant effects of the extracts may contribute to the beneficial effects in postmenopausal women.