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가토모델에서 배양 구강상피를 이용한 근-점막 피판의 형성에 관한 연구
신영민,정헌종,안강민,박희정,성미애,김성민,황순정,김명진,장정원,김성포,양은경,송계영,이종호,Shin, Young-Min,Chung, Hun-Jong,Ahn, Kang-Min,Park, Hee-Jung,Sung, Mi-Ae,Kim, Soung-Min,Hwang, Soon-Jung,Kim, Myung-Jin,Jahng, Jeong-Won,Kim, Sung-P 대한악안면성형재건외과학회 2005 Maxillofacial Plastic Reconstructive Surgery Vol.27 No.3
Purpose : Extensive defect of oral and maxillofacial area is usually reconstructed with composite flap including skin paddle. However, if the defects are lined with only skin components, the mucosa's role in mastication and texture are not restored. Furthermore, stiffness and hair-growing prevent denture rehabilitation and good oral hygiene. This study was performed to overcome the disadvantages of composite soft tissue flaps including the skin and to make a model for myo-mucosal flaps. Materials and methods : Buccal mucosa sized $0.5\times1.0\;cm^2$ from New Zealand rabbit (around 1.5kg) was harvested and cultivated by the modification of Rheinwald and Green's keratinocyte culture method. Cultured mucosa was grafted on the fascia of latismus dorsi as form of mucosal sheet. After 7, 10, 14 days, the myomucosal flap was excised and evaluated under light microscope with H & E and immunohistochemical staining. As control group, harvested buccal mucosa from rabbit was transplanted to gracilis muscle(n=6). Results : From 7 days after prelamination, the basal layer of the grafted mucosa resembled that of normal mucosa. As control group, transplanted mucosa had original shape but there's slight inflammatory reaction. Prelaminated mucosa has 19.8$\pm$4.59 cell layers and some samples have more than 20 layers. The expression rate of PCNA was relatively strong (42.9%$\pm$14.1) at the basal layer of grafted mucosa and the laminin was found at the basal layer. On the contrary, prelaminated mucosa at 10 days showed moderate expression rate of PCNA(32.4%$\pm$4.62). We found the mucosal layer was somehow disappeared and there is strong inflammatory reaction. After 14 days prelamination, the grafted oral keratinocytes were almost disappeared and expression of PCNA was not observed. Conclusion : We can make 75 fold large mucosal($3850mm^2$) sheet from small samples of mucosa $(50mm^2)$. Epithelial sheet that grafted on the fascia of muscle underwent differentiation and proliferation. But after 10, 14 days, there was strong inflammatory reaction and the grafted mucosa was destroyed from surface layer. In rabbit model, transfer of fascio-mucosal flap should be done from 7 to 10 days after prelamination.
법랑모세포종 139증례의 임상소견에 따른 치료방법의 임상 통계학적 분석
신영민(Young-Min Shin),박지훈(Ji-Hoon Park),김진욱(Jin-Wook Kim),권대근(Tae-Geon Kwon),이상한(Sang-Han Lee),김진수(Chin-Soo Kim) 대한구강악안면외과학회 2011 대한구강악안면외과학회지 Vol.37 No.4
Introduction: Ameloblastoma is a benign but locally invasive tumor with a high recurrence rate. The aim of this study was to make an easier diagnosis and treatment planning of ameloblastoma. Materials and Methods: From January 1993 to October 2009, 139 cases from 123 patients, who had been diagnosed with ameloblastoma through radiologic and biopsy in the department of oral and maxillofacial surgery of Kyunpook National University, were selected as the subjects in this study. According to the medical charts, 9 factors (age, gender, location, chief complaints, duration, radiographic findings, size and recurrence) concerned in deciding the treatment method and the relevance between each factor and the treatment methods were examined.(Conservative treatments were marsupialization, enucleation, curettage and lateral decortication. Radical treatments included block excision, resection and hemisection) Results: In the patients under the age of 20, 77.14% had conservative treatments, whereas 22.86% underwent radical treatments. In the patients over the age of 20, 44.23% were treated conservatively treatments, and 55.77% underwent radical treatments. For unilocular types, 28.57% had conservative treatments, whereas 71.43% had radical treatments. For the multilocular types, 66.67% underwent conservative treatments, and 33.33% had radical treatments. For the primary cases, 58.68% were treated conservatively and 41.32% had radical treatments. For the recurrent cases, 16.67% and 83.33% underwent conservative and radical treatments, respectively. Conclusion: There was statistical significance in the factors affecting the treatment methods, such as age, radiographic findings and recurrence.
제주도 숨은물벵뒤 습지 서식 Betaproteobacteria의 종다양성 및 신분류군 분포
신영민 ( Young Min Shin ),김태의 ( Tae Ui Kim ),최아영 ( Ah Young Choi ),전지선 ( Jee Sun Chun ),이상훈 ( Sang Hoon Lee ),김하늘 ( Ha Neul Kim ),이하나 ( Ha Na Yi ),조재형 ( Jae Hyung Jo ),조장천 ( Jang Cheon Cho ),장광엽 ( Kwang 한국환경생물학회 2011 환경생물 : 환경생물학회지 Vol.29 No.3
The species diversity of Betaproteobacteria in the Sumunmulbengdui Wetland Area of Jeju Island was studied using culture based techniques, and candidates for novel taxa were screened. Twenty two novel bacterial strains belonging to Betaproteobacteria were isolated, which could be assigned to 16 genera of 4 families, namely Burkholderiaceae (3 strains), Comamonadaceae (8 strains), Oxalobacteraceae (5 strains), Neisseriaceae (5 strains), and an unassigned group belonging to Burkholderiales (1 strain) based 16S rRNA gene sequences. The genus Chromobacterium contained three candidates of novel species, and each of the genera Burkholderia, Comamonas, Pelomonas and Herbaspirillum contained two candidates respectively. Through the analysis of membrane fatty acid profiles and physiological properties using API 20NE as well as morphological and cultural properties, each of the isolates was found to form potentially novel species. Brief description of 22 potential candidates for new species or subspecies is given accordingly.
HAP기반 네트워크 시뮬레이션을 위한 노드 모빌리티 구성
신영민(Young Min Shin),조관식(Kwan Sik cho),송하윤(Ha Woon Song) 한국정보과학회 2008 한국정보과학회 학술발표논문집 Vol.35 No.2
HAP(High Altitude Platform)은 지표면 17~22㎞위에 있는 성층권 영역에서 운행하는 정지 궤도 공중 플랫폼이며 이것은 인공위성 시스템과 지상의 기반시설(infrastructure)의 장점들을 두루 가지고 있다. 그동안 HAP에 대해서 적절한 플랫폼의 종류, HAP에 할당하는 주파수 대역, 가능한 구조, 시스템 구조들이 다양하게 연구되어 왔다. 그러나 최소의 HAP의 배치로 최대한 많은 지상의 사용자에게 통신을 제공하고 또한 사용자의 이동에 따른 HAP의 움직임을 최소화 하는 등의 HAP의 효율적인 배치에 대한 연구는 많이 이루어지지 않았다. 본 논문에서는 제주도를 노드 모빌리티 지역으로 선정하고 HAP네트워크 시뮬레이션을 위한 노드 모빌리티를 설계, 구현한다. 그 다음 여러 클러스터링 알고리즘 중 K-means 클러스터링 알고리즘을 가지고 앞에서 만든 노드 모빌리티를 사용하여 시뮬레이션 한 후 그 결과가 효율적인 HAP의 배치를 하는 지 살펴보고 분석한다.
신영민(Young-Min Shin),권대근(Tae-Geon KWON) 대한치과의사협회 2015 대한치과의사협회지 Vol.53 No.7
In cleft lip and palate (CLP) patients, there are various degree of residual maxillofacial deformities in adolescent period. Usually, orthoganthic surgery for the cleft patients needs Le Fort I osteotomy and/or mandibular set back surgery. Previous report from other institute had been shown that there is significant relapse after maxillary movement after Le Fort I osteotomy when the surgical advancement of the maxilla was over than 5 or 7mm in average. Recent comphrehensive report showed that most of the relapse was happened within 1 year and the total horizontal relapse of the maxilla was as high as 30% in average. Therefore, overcorrection is needed in maxillary surgery for cleft patients. Another concerns for cleft orthognathic surgery is the anatomical variation in pterygomaxillary region in cleft patients compared to control patients. Patients with CLP had larger and thicker pterygomaxillary dimensions, and the results imply that careful attention to pterygomaxillary anatomy is needed in patients with CLP undergoing Le Fort I surgery. This article reviews the pre and postoperative considering factors for orthognathic surgery for CLP patients.
신영민(Young-Min Shin),최소영(So-Young Cho),김진욱(Jin-Wook Kim),변기정(Ki-Jung Byeon),김진수(Chin-Soo Kim) 대한구강악안면외과학회 2011 대한구강악안면외과학회지 Vol.37 No.1
Polymorphous low-grade adenocarcinomas (PLGA) are distinctive salivary gland neoplasms with a propensity to arise from the minor salivary glands. The most frequent location of PLGA is the palate, even though other locations have been described. Previously used terms for PLGA include lobular carcinoma and terminal duct carcinoma. Although the frequency of the tumor is unknown, the recognition of PLGA as an individual tumor has increased with the establishment of specific histopathological criteria characterizing the PLGA. The first choice of treatment is a wide surgical excision including the subjacent bone if necessary. The prognosis is generally good and the recurrence rate ranges from 17% and 22%. Distant metastases is unusual (9%) but occur mainly in the regional lymph nodes. This is a case report of a 67 year old female patient with PLGA who was treated with a wide excision by layers (2 stage) of the lesion including the surrounding bone. We present this case with a review of the relevant literature.