http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
박인숙,김동섭,최기환,왕소영,임화경,오우용,김소희,강주희,방영주,김주일,Park, In-Sook,Kim, Dong-Seop,Choi, Ki-Hwan,Wang, So-Young,Lim, Hwa-Kyung,Oh, Woo-Young,Kim, So-Hee,Kang, Ju-Hee,Bang, Yung-Jue,Kim, Joo-Il 대한임상약리학회 2002 臨床藥理學會誌 Vol.10 No.2
The enormous cost, intensive time, and constant efforts are required the drug discovery and development of bringing new drug products to the marketplace. The past several years, KFDA approved new drugs developed by local pharmaceutical industries; that is Sunppla, Factive etc. In addition to, investigational new drug application (IND) was established to accelerate new drug development and harmonize with international standards in 2002. At this point of time it is urgent problem to develop ability of reviewing new drug applications (NDAs) scientifically and appropriately to ensure that new drugs are safe and effective. There are many scientific issues embedded in new drug approval process from non-clinical studies to phase 3 clinical trials; 1) sample size, 2) application of end point, 3) statistical method, and etc. However the overall relation between protocols/reports of clinical trials and the characteristics of domestic medical system has fully not been studied. There is also, no references or data for the point to be considered in drug approval process. On this background, the objectives of this study are introduction of guidelines for the requirement for approval or evaluation of safety/efficacy in other countries and presentation how to practice clinical trial for new oncologic products in the present situation of clinical trial. We hope that the guidelines contribute to providing methods of clinical trials and procedures, and evaluating method to develop chemotherapeutic agents.
급성백혈병의 관해수도시 trimethoprim sulfamethoxazole 의 간염예방효과에 관한 연구
최강원(Kang Won Choe),우준희(Jun Hee Woo),방영주(Yung Jue Bang),배현주(Hyun Joo Bae),서철원(Cheol Won Suh),김시영(Si Young Kim),박선양(Seon Yang Park),김병국(Byoung Kook Kim),김노경(Noe Kyeong Kim),김승택(Seung Taik Kim) 대한내과학회 1988 대한내과학회지 Vol.35 No.1
N/A Fifty patients with acute leukemia were studied during remission induction treatment in a prospectively radnomized trial to assess the effect of prophylactic trimethoprim/sulfamethoxazole on infection and fever rate. Twenty-three patients randomly received two single-strength trimethoprim/sulfamethoxazole tablets twice daily and twenty-seven patients did not receive any drugs. There were no significant differences in the duration of granulocytopenia, number of febrile days, or use of parenteral antibiotics. But trimethorpim/sulfamefhoxazole prophylaxis resulted in a reduced incidence of microbiologically documented infections (8 versus eighteen; p<0.05). This was mainly the result of a reduction in the episodes of bacteremia in the treatment group as compared with the contirol group. The number of patients without fever in the treatment group was eight compared to only 2 in the control group (p<0.05). Thus, trimethoprim/sulfamethoxazole prophylaxis during granulocytopenia reduced the incidence of microbiologically docummented infection and had more patients afebrile.
김효진(Hyo Jin Kim),정만표(Man Pyo Jeong),허대석(Dae Seog Heo),방영주(Yung Jue Bang),한성구(Sung Koo Han),심영수(Young Soo Shin),김노경(Noe Kyeong Kim),김건열(Keun Youl Kim),한용철(Young Chol Han),김주현(Joo Hyun Kim),박찬일(Charn Il 대한내과학회 1994 대한내과학회지 Vol.46 No.2
N/A Background: This study was performed to find out the natural history of lung cancer in Korea. Method: Week studied retrospectively 764 patients with pathologically proven lung cancer from January 1980 to December 1984. We analysed the age and sex distribution, initial symptoms before diagnosis, first method yielding histologic diagnosis, cell types of lung cancer, initial stage of lung cancer, schema of overall patients, and survival of lung cancer patients. Result: 1) The overall male to female ratio was 4.7:1, and the age distribution ranged from 21 to 82 years, and the median age of overall patients was 58 years. 2) Histologic classification revealed that the most prevalent type was squamous cell carcinoma (375 cases, 49.1%), followed by small cell carcinama (189 cases, 24.7%), adenocarcinoma (134 cases, 17.5%), and large cell carcinoma (44 cases, 5.8%). 3) In non-small cell lung cancer 88% were stage III, therefore curative operation was done in only 8% of all cases, but in small cell lung cancer 66% were limited disease. 4) Median survival of overall patients was 5.8 months. 5) There was quite difference in survival between stage. In non-small cell long cancer, median survival of stage I was 41 months, median survival of stage II was 13 months and median survival of stage III was 5 months. In small cell lung cancer, median survival of limited disease was 10.4 months and median survival of extended disease was 2.8 months. Conclusion: The prognosis of patients with lung cancer was very grave. In order to increase the survival rate of lung cancer, earlier diagnosis of lung cancer is urgently needed.
허대석,윤영호,정주영,김홍수,김성혜,신상도,김중의,오은경,유철규,방영주,김노경,Heo, Dae-Seog,Yun, Young-Ho,Jeong, Joo-Young,Kim, Hong-Soo,Kim, Sung-Hye,Shin, Sang-Do,Rhee, Joong-Eui,Oh, Eun-Kyung,Yoo, Chul-Gyu,Bang, Yung-Jue,Kim, Noe-K 한국호스피스완화의료학회 1998 한국호스피스.완화의료학회지 Vol.1 No.1
Purpose : Cancer is a common cause for admission to emergency room(ER). Cancer patient present to ER with undiagnosed cancer, acute vague problem of cancer, or treatment related complication. But there is little information on the magnitute of the problems in the Korea. The purposes of our study were to evaluate the appropriateness of care for oncologic emergencies in Korea. Materials and Methods : This study was undertaken of all cancer patients above 15 years old presenting to the Seoul National University Hospital ER, who visited during the period from Oct. 16 to Nov. 15, 1997. ER record was reviewed and ER doctors evaluated patients' reason for visiting ER, appropriateness in patients' utilization of ER, oncology emergency Results : 266 cancer patients(17.4% of total patients) visited ER during this period and 166 cancer patients(62.4%) utilized inappropriately ER. Their average stay is 32.0 hours and 65.8% of them stayed for 6 hours. There were complaints of patients such as pain(44.8%), abdomen distension(9.4%), and dyspnea(7.5%). The most common oncologic emergency in ER during this study were gastrointestinal(34.0%), neurologic(21%), hematologic(8.0%), infectious(7.0%), respiratory(6.0%), and genitourinary(5.0%). Conclusion : For the care of symptoms like pain, most of cancer patients utilize ER inappropriately due to lack of attention from primary health delivery system. For the better care, the palliative medicine should be established in Korea. 목적: 우리나라에서 암환자들이 긴급한 의료문제가 발생한 경우, 어떤 경과를 거쳐 진료를 받고 있는지 자세히 연구된 자료가 없다. 대부분의 1, 2차 의료기관이 암환자진료에 소극적이어서, 사소한 증세조절을 위해서도 3차의료기관의 응급실을 방문해야 하는 등 많은 문제점이 있다. 이에 연구자들은 3차의료기관 응급실을 방문한 암환자들의 적절성여부를 평가하여 암환자의 응급진료상의 문제점을 파악하고자 한다. 방법: 서울대학교 응급실을 방문한 성인암환자들의 응급실방문의 목적, 주증상, 적절성 등을 응급실근무 전공의와 간호사를 통해 조사, 평가하였다. 결과: 1997년 10월 16일부터 11월 15일사이 한달간 서울대학교병원응급실을 방문한 환자중 암환자는 17.4%(266명)를 차지하였다. 이중 응급실이용이 부적절하다고 판단된 환자는 166명(62.4%)이었으며, 이들의 응급실재원 평균시간은 28.7시간이었고, 주증상은 통증이었다. 결론: 통증과 같은 증상조절을 위하여 응급실을 방문하는 암환자의 대부분이 1, 2차의료기관에서도 진료가 가능한 상태로 암환자의 증상조절이 보다 효율적으로 이루어질수 있도록 완화의학 및 의료전달체계의 조속한 확립이 요망된다.
불임환자에서 체외수정시술시 난소내 기질 동맥 Doppler 초음파검사 및 혈청 Glycodelin 측정의 임신 예측인자로서의 임상적 효용성
김선미 ( Sun Mie Kim ),황규리 ( Kyu Ri Hwang ),김진주 ( Jin Ju Kim ),문정애 ( Jung Ae Moon ),방영주 ( Young Joo Bang ),지병철 ( Byung Chul Jee ),구승엽 ( Seung Yup Ku ),서창석 ( Chang Suk Suh ),최영민 ( Young Min Choi ),김정구 ( J 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.3
목적: 불임환자의 체외수정시술 (IVF-ET)시 난소내 기질 동맥의 도플러 초음파검사 및 황체기 자궁내막의 주요 단백질 생산물인 glycodelin (placental protein 14, PP14)의 혈청 농도 측정의 체외수정시술 후 임신 예측인자로서의 임상적 효용성을 평가하고자 하였다. 연구 방법: 2003년 4월부터 2004년 3월까지 서울대학교병원 산부인과 불임클리닉에서 체외 수정시술을 시행받은 정상 난소 반응이 기대되는 불임환자 57명의 57주 Objective: To assess the clinical efficacy of intraovarian artery stromal Doppler ultrasonography and serum glycodelin (placental protein 14, PP14) as prognostic factors of pregnancy in vitro fertilization and embryo transfer (IVF-ET) cycles. Methods: Fif
영어능력 인증제 능력별 교과과정 그리고 대학 교양영어 교육 : 학생과 교사의 인식에 대한 고찰
방영주 한국영어어문교육학회 2004 영어어문교육 Vol.9 No.2
This study aims to illustrate students' and teachers' perceptions towards Certification of English proficiency and proficiency- based curriculum, and to investigate their needs for developing college English program A total of 597 students and 28 teachers participated in the survey. The findings showed that both groups acknowledged the usefulness of the certification of English proficiency and proficiency-based curriculum However, both groups showed a negative response to 'waive test' (testing for the replacement of English required class). They also expressed high level of needs in increasing the number of courses and credit hours, reducing the class size, and improving facilities. Both groups perceived speaking and listening as more important skills, while students showed various preferences for effective language practice activities. The findings of this study suggest that the introduction of certification of English proficiency should be supplemented with follow-ups both in pedagogical aspect and on administrative level.
김동순,심영수,김건열,박인애,조혜제,함의근,한성구,방영주,김준우,한용철 대한내과학회 1987 대한내과학회지 Vol.33 No.6
Eosinophilic granuloma is a rare disease characterized by proliferation of mononuclear cells and admixture of mature eosinophils. Rarely are the lungs the primary site of involvement. We report 2 cases of pulmonary eosinophilic granulama, manifested as diffuse interstitial lung disease coexisting with diabetes insipidus. The diagnosis was verified after open lung biopsy.