백서 심근경색모델에서 시간경과와 경색의 크기에 따른 심자도의 변화

김미성(Mi Sung Kim),박영선(Young Sun Park),권순길(Sun Gil Kwon),지정훈(Jeong Hoon Ji),신종성(Jong Sung Shin),오광식(Kwang Sik Oh),양용모(Yong Mo Yang),연태진(Tae Jin Youn),김동운(Dong Woon Kim),조명찬(Myeong Chan Cho),이용호(Yong Ho 대한내과학회 2002 대한내과학회지 Vol.62 No.1

Background: Magnetocardiogram (MCG), which records the changes of magnetic fields generated by the heart`s electrical activity, theoritically can provide unique data for clinical application. To date, MCG has been investigated only at a single time point after myocardial infarction (MI) with severe left ventricular dysfunction in rats. The purpose of the present study was to investigate sequential changes of MCG after MI and to evaluate effects of infarct size on MCG. Methods: Acute MI were induced by the permanent ligation of left coronary artery in 22 rats. Magnetic fields were recorded just above a rat with Nb Superconducting Quantum Interference Device (SQUID) gradiometer inside a magnetically shielded room. MCG was measured before and immediately after surgery and it was subsequently recorded at the time points of 1, 4 and 6 hours post operatively. MCG was also measured at 1, 3, 7 and 21 days after surgery. Results: Elevation of ST segment and appearance of pathological Q wave on the MCG were evident immediately after the ligation of coronary artery and persisted to 6 hours after MI. On MCG, ST segment was depressed and T wave was inverted from 1 day after MI. In rats with small-and moderate- sized MI (infarct size〈30%), ST depression returned to near the isoelectric level and Q wave disappeared from 7 days after MI. However, ST depression and Q wave were still present in rats with larger infarct (infarct size≥30%). Conclusion: Evolutional changes of MCG were well-recognized up to 21 days after MI. Furthermore, the infarct size can be expressed by the extent of Q wave and ST segment depression on MCG. Taken together, these data indicate that MCG is a helpful modality for the diagnosis, evaluation of infarct size and follow up after MI.(Korean J Med 62:42-48, 2002)

대량의 각혈로 사망한 장티푸스 1예

한상우,유진홍,권순석,김성훈,박지찬,홍은정,최경성,박용완,장준희,안지원,박유경,강지영,박상미,신완식 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

We experienced a 25 year-old male patient with typhoid fever complicated with massive hemoptysis. Pulmonary complication in typhoid fever is very rare and to our knowledge, there has been no report of hemoptysis as a main cause of death with this disease. We herein report a rare case of typhoid fever.

중학교 학교사고의 역학적 특성

지미영,이성은 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.2

Purpose : This study was conducted to identify the epidemiological characteristics of school accidents in middle school students. Methods : The subjects in this study were the students of a middle school in Gangnung. The study period was one semester, from March 2 to July 15, 1999. Data were collected by one of the authors using a structured questionnaire, and the subjects who had school accidents and visited the school health care office were interviewed. The data was analyzed using the SPSS and SAS programs. Results : The semester incidence rate per 100 students was 31.6 cases. The daily accident rate was 2.8 cases, and the accident incidence density was 2.6 cases per 1,000 students days. The mean of accident incidence was 1.7 per student. The incidence was the highest in June. The most frequent cause of accidents was carelessness, and the accidents were most frequent at recess. Conclusion : It is necessary to conduct the analytic epidemiological study to identify the risk factors of school accidents.

손 제스처 인식을 이용한 3D 영상 네비게이션

지은미,이상호 충북대학교 컴퓨터 정보통신 연구소 2000 컴퓨터정보통신연구 Vol.8 No.1

본 연구에서는 그림 속으로의 여행 기법을 구현하였으며, 마우스 및 키보드를 대신하여 제스처 인식을 사용함으로서 네비게이션이 쉽고 편리해짐을 증명하였다. 그림속으로의 여행 기법은 한 장의 영상으로부터 간단한 방법으로 3차원 애니메이션을 만들 수 있는 기술이다. 본 연구에서는 기존의 Horry 및 Pho가 제안한 방법을 PC가 제안한 방법을 PC상에서 구현하여 2차원 영상을 3차원 네비게이션이 가능한 영상으로 변화하였다. 사용자 인터페이스인 손 모양 제스처의 인식을 크게 3개의 타입으로 개발되었으며 Type-1은 대기(wait)를, Type-2는 2D 상의 각종 방향 지시를, Type-3는 3D 공간상의 위와 아래를 지정할 수 있도록 설계되었다. 개발된 세 타입의 손 제스처는 3D 랜더링된 영상속에서 가상 마우스 및 키보드의 역할을 담당하며, 이러한 손 모양 제스처를 이용함으로서 사용자는 3D 공간상에서 자유롭고 간편하게 투어링이 가능해 졌다. The purpose of this study is to prove that using gesture recognition through implementing the method of 'tour into the picture' makes navigation very convenient and easy compared to navigation using mouse and keyboard. The method of 'tour into the picture' is a simple technique which converts an 2D image into 3D animation. This study shows how to convert 2D image into 3D navigation, implementing the method previously proposed by Horry and Pho on the personal computer. hand-shape gesture recognition which function is as a user interface has been developed into three types : Type-1 means pause: Type-2 means showing directions on 2D : Type-3 is designed to assign upper and lower depth in space. These three types play the role as virtual mouse and keyboard in 3D-rendering image. Above all, using hand-shaped gestures contributes to the ease of user's navigation of 3D space.

농촌지역 노인들의 우울증상에 관련된 요인들의 특성

송미숙,전기홍,송현종,김정은,박승구,신상건,이동훈,정성현,최연주,최완철,최민규,황재철,홍지만 아주대학교 1997 아주의학 Vol.2 No.2

This study was performed to identify risk factors for depression among the elderly in a rural area. A survey was done for the elderly living in Gosam-myenn, Ansung-kun during the period of July 28, 1997 and July 30, 1997. Demographic and sodoeconornic characteristics, and functional and health Status were assessed using a structured questionnaire, and the level of depression was measured by GDS score. The data obtained were analyzed by frequencies, percentage, t-test, ANOVA, and multiple regression, and the results were as follows: 1. The total sample consisted of 133 elderly. Of them, 47 elderly (35.4%) showed significant depressive Symptoms. 2. The GDS score was the highest for the group over 85 years of age (p < 0.05). Those living alone or widowed showed lower GDS score than those living with someone or married (p < 0.05). 3. The GDS score was the highest in the absolutely dependent group, followed by the partially dependent group, and the independent group (p < 0.01). The elderly who perceived their health Status as excellent showed the lowest GDS score. In contrast, those who had more than five chronic diseases showed the highest GDS score. 4. The elderly receiving financial and emotional support from their family or friends showed lower GDS score compared to those without any support. 5. The economically dependent group showed higher GDS score than that of independent group. 6. The elderly who involved in leisure activities showed lower GDS score than those without any involvement. 7. In terms of risk factors for depression, we found that perceived health Status, subjective economic Status, leisure activities, living arrangement and financial support were inversely associated with GDS score, whereas labor support was positively associated with GDS score. Based upon the above findings, this study suggests that these risk factors for depression in the elderly should be taken into consideration for a comprehensive mental health program for the elderly living in the rural area.

폐 아스페루길루스증과 치료적 접근

이미숙,이상오,김은옥,김양수,우준희,류지소 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.4

Roxythromycin-tylosin-furaltadone 합제의 닭 유래 세균에 대한 시험관내 항균효과

김지영,채미경,윤효인,서상희,박배근,김현수,전무형 충남대학교 수의과대학 동물의과학연구소 2003 動物醫科學硏究誌 Vol.11 No.-

In vitro antimicrobial susceptibility of roxythromycin (Rx), tylosin (Tyl), erythromycin (EM) and furaltadone (Fur) was studied, either by the single type or the combinated type of Rx-Tyl-Fur (RTF) against E. co1i (30 strains), Staph. aureus (20 strains) and Mycoplasma gallisepticum (5 strains) that are the major pathogens in poultry farm. The paper disk diffusion and MIC tests were applied. In screening test by paper disk diffusion method, the single types of antibiotics showed the sensitivity against 55 strains of bacteria in order of Fur, EM, Rx and Tyl. The combinated RTF showed the higher rate of sensitivity (80∼83.3% at 64㎍/disk, 60-75% at 32㎍/disk) and wider range of growth inhibiting zone (19.6±3.7-24.8±4.7mm) than those of the single drugs. In MIC test, the sensitivity against the 55 strains appeared in order of Fur. EM, Rx and Tyl as similar to those of paper disk diffusion method. The MIC ranges of RTF were 0.125∼16㎍/ml for E. coli, 0.25∼16㎍/ml for Staph. aureus and 1-8㎍/ml for Myco. gallisepticum, showing evidently lower than those of the single types. The MIC_(50) and MIC_(90) of RTF were estimated l∼4㎍/ml and 8∼16㎍/ml, respectively, and remarkably lower than those of the single drugs.

비장애 아동과 전반적 발달장애 아동에서 회전 후 안구진탕 기간의 비교

김진미,송지원,홍은경,김성희,김경미 대한감각통합치료학회 2005 대한감각통합치료학회지 Vol.3 No.1

Objective : The purpose of this study was to get the mean of duration of post-rotatory nystagmus test in normal children and to differentiate the duration of post-rotatory nystagmus test between normal children and children with pervasive developmental disorder. Method : 84 subjects were between 3 and 5 years of age and consisted of 64 normal children and 20 children with the pervasive developmental disorder. Analysis of the data was done by using t-test and ANOVA. Results : The results were as follows: 1. Range of duration of post-rotatory nyatagmus test in normal children was 5-22second on left and 7-21 second on right and the mean was 12.63 second on left and 12.59 second on right. 2. Range of duration of post-rotatory nystagmus test in children with the pervasive developmental disorder was 3-11 second on both and the mean was 5.65 second on left and 5.60 second on right. 3. There was no significant difference between males and females with normal children in duration of post-rotatory nystagmus test. However, there was a significant difference of the mean duration between 3 and 5 years old normal group. 4. Children with pervasive developmental disorder significantly have relatively lower duration than the duration of post-rotatory nystagmus test of normal children. Conclusions : The results of the study showed significant difference between normal children and children with pervasive developmental disorder in duration of post-rotatory nystagmus test and suggest that they could be applied to the baseline of clinical therapy.

RAW 264.7 세포에서 silica에 의한 유리 라디칼 생성에 미치는 protein kinase 억제제의 영향

심상수,조남영,윤미연,이지윤,김창종 중앙대학교 약학연구소 2002 약학 논총 Vol.16 No.-

To investigate involvement of protein kinase in reactive oxygen species (ROS) and peroxynitrite (PON) generation, we examined effect of protein kinase inhibitors on silica-induced ROS and PON generation in RAW 264.7 cells. Silica dose-dependently increased ROS and PON generation. Protein kinase C inhibitor, bisindolmaleimide and RO32-0432, slightly inhibited silica-induced ROS generation and significantly inhibited PON generation. Tyrosine kinase inhibitor, erbstatin and DHC, significantly inhibited silica-induced ROS generation but not PON generation. Calmodulin antagonist (W-7), calmodulin-dependent protein kinase Ⅱ inhibitor (KN-62) and mitogen-activated protein kinase inhibitor (PD98059) significantly inhibited silica-induced PON generation but not ROS generation. These results suggest that protein kinase C appears to be involved in both ROS and PON generation, tyrosine kinase in ROS generation, and calmodulin antagonist and mitogen-activated protein kinase in PON generation induced by silica in RAW 264.7 cells.

질산화 작용이 있는 Aeromonas hydrophila의 동정 및 특성

엄미나,장재철,유영희,지의상 한국식품영양학회 2000 韓國食品營養學會誌 Vol.13 No.6

폐수처리 중 생물학적 처리에 활용할 수 있는 질소분해 능력을 가진 미생물을 분리하여 동정하고자 경기도내 하천 6지점에서 채취한 시료로부터 50개 균주를 선별하였다. 형태학적, 생화학적 및 배양학적 실험결과 Bergey's mannual of systematic bacteriology의 색인을 통하여 Aeromonas hydrophila로 동정하였다. Aeromonas hydrophila(AH-1). (AH-3), (AH-4), (AH-6) 균이 질산화 능력이 우수하였다. 4개 균주 모두 amoxillin, ampicillin, cephalothin과 ticarcillin에 내성을 나타내었다. 본 실험에서 분리한 .Aeromonas hydrophila의 질산화의 최적조건은 균 농도 1.0×l0exp(6) cells/ml, 배양온도 37℃로 나타났다. For the purpose of the isolation of microorganisms which have the capability of nitrification, we isolated the microorganisms in 6 samples collected from the stream of Kyonggi area. 60 strains were isolated. The selected strain were identified as a Aeromonas hydrophila based on the data obtained from the morphological, biochemical and cultural characteristics defined experiments. Among them Aeromonas hydrophila (AH-1), (AH-3), (AH-4), (AH-6) showed the highest nitrification capability. All isolates were resistant to amoxillin, ampicillin, cephalothin and ticarcillin. Optimum culture conditions of isolates were 37℃ and 1×10exp(8) cells/ml for 4 hours in the nitrate medium.