소규모 제조업에서 재해발생과 사업장 특성간의 관련성 분석

이건세,김형수,,장성훈,정최경희,오원기,최재욱,이관형,오지영 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 소규모 제조업 사업장의 재해 발생 유무에 따른 사업장 조직 특성을 비교하여 재해 발생과 관련된 요인을 사업장 수준에서 파악하고자 하였다. 방법: 한국산업안전공단이 실시한 2004년도 산업안전 보건 동향조사 자료 중 5인 이상 50인 미만 제조업 1,886개 사업장(가중치를 부여하여 추정한 모집단 사업장은 65,921개)의 재해(산재 및 공상, 경상 포함) 발생 여부와 사업장의 조직 특성(일반적 특성, 고용특성 및 산업안전보건 특성)간 다변량 분석을, 사업장의 일반적 특성은 지역, 산업형태, 업종 등이며, 고용특성은 전체 근로자중에서 생산직 근로자의 분포, 여성근로자의 분포, 1주일 평균 근로시간, 교대근무 등이며, 산업안전보건 특성은 안전관리자/보건관리자의 선임형태, 산업안전보건위원회, 노동조합, 매월 정기안전보건교육시간, 안전보건관리 규정, 안전보건활동 점수, 안전문화 점수 등이다. 결과: 다변량 분석결과 재해가 발생한 사업장이 갖는 특성은 다음과 같았다. 첫째, 사업장의 일반적 특성에서 지역별로는 경인권에 비해 전라권, 산업형태 면에서 원청에 비해 사외협력업체, 업종별로는 전자부품/통신에 비해 코크스/석유정제업, 목재/나무제품업, 음식료품, 조립 금속제품에서 위험도가 높았다. 둘째, 사업장의 고용 특성에서는 전체 구성원 중에서 생산직 근로자가 증가할수록 재해발생 사업장이 유의하게 증가하였으며, 여성근로자의 증가할수록 재해발생 사업장이 유의하게 감소하였다. 주당 근무시간이 증가할수록 재해 발생 사업장이 유의하게 증가하였으며, 교대 근무와 사업장의 재해발생과는 유의한 관련성이 없었다. 셋째, 사업장의 산업안전보건 특성에서는 안전관리자가 전임으로 근무할수록, 산안전보건위원회가 활발히 활동할수록, 노동조합이 설립될수록, 안전보건규정이 갖추어지지 않을수록, 정기보건교육시간이 많을수록, 안전문화수준이 낮을수록 재해발생 사업장이 유의하게 증가하였다. 결론: 소규모제조업에서 사업장의 조직 특성에 따라 사업장 재해율이 다름을 확인할 수 있었으며, 이는 산업재해의 예방을 위해서는 근로자 요인이외에도 사업장 수준에서의 관련요인에 대한 접근이 필요함을 의미한다. Objective: This study evaluated the relationship between injury occurrence and workplace organization in small-sized, manufacturing factories in Korea. Methods: Using data from the 2004 Occupational Safety and Health Survey in Korea, this study compared workplace organizational factors (general characteristics, employee characteristics and health and safety characteristics) with injury occurrence of 1,866 small-sized, manufacturing factories (65,921 population factories after weighting). General characteristics of factories comprised location, type and classification of industry. Employee characteristics comprised proportion of manual workers and female workers, average working hours per week and shiftwork. Health and safety characteristics comprised type of safety and health manager, committee for occupational safety and health, labor union, health and safety regulation, monthly health and safety training time, score of health and safety activity and score of safety culture. Results: The following characteristics of injury-occurrence in small-sized, manufacturing factories were determined by multivariate analysis. In terms of general characteristics, the risk of injury-occurrence was higher in Jeolla area than Gyeongin area in outside associate than other enterprises and in coke, refined petroleum products and nuclear fuel, wood and products of wood, food products and beverages and fabricated metal products, except machinery and furniture industries than television and communication equipment and apparatus industries. In terms of employee characteristics, injury-occurrence significantly increased in factories with greater proportion of manual worker and with a higher rate of working hours per week. But significantly decreased in factories with a higher proportion of female workers. In terms of health and safety characteristics, injury-occurrence significantly increased in factories with a self-appointed safety manager, with unorganized union, with a more active committee for occupational safety and health, with unimplemented health and safety regulation, with longer monthly safety and health training time, and with a lower score of safety culture. Conclusions: This study demonstrated that several factors of workplace organization were significantly related with injury-occurrence in factories. These findings are supposed to raise the need for making effort in workplace organization to improve injury prevention.

Polyethylene glycol 용액(Colyte^(R))을 복용한 후 발생한 Boerhaave 증후군 1예

이관행,기승석,김인숙,김민정,박인호,장세중,하지수,김응수 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Spontaneous esophageal rupture (Boerhaave's syndrome) is a rare case that require early diagnosis and treatment because of its high mortality. The oral administration of osmotically balanced polyethylene-glycol-based electrolyte preparation is a commonly prescribed preparation for cleansing in patients undergoing colonoscopy. Nausea, vomiting and abdominal pain are frequently seen, but serious adverse reactions are rare. Esophageal rupture secondary to severe vomiting, which occurred during colonoscopy preparation using polyethylene gIycoI(PEG) electrolyte solution is extremely rare and only few cases have been published in the literature. We report a case of spontaneous esophageal rupture after routine administration of the PEG before colonoscopy. 대장 정결을목적으로 PEG 사용 후 아주 드물게 발생하는 Boerhaave 증후군 1예를 경험하였기에 보고하는 바이다.

우리나라 주택공간구성에서 보이는 전이적 연속성에 관한 연구

손세관,이수진 中央大學校 建設環境硏究所 1997 環境科學硏究 Vol.8 No.-

The purpose of this study is to grasp the peculiarities of spatial sequence and transition expressed on modern residential space of Korea. For the analyses, 8 famous house designed by Korean architects were selected. Three aspects of spatial sequence such as spatial composition, visual sequence, and visual changes of space were analyzed. In the spatial composition of houses, the linear composition was emphasized to arrtact the sequential visual experience. And the characteristic spatial composition to induce the conversion of direction and the intended sequential movement were used variously. And the inductive walls, change of level of floor and height of ceiling, and various use of corridor or stairs were intentionally emphasized. Change of visual scene according to spatial experience in each stage of spatial connection were also stressed. Based on the above analyses, 14 'patterns' of spatial composition were extracted as a set of language for design of houses.

1990년대 이후 우리나라 주택작품에 나타난 전통성의 현대적 구현에 관한 연구 : 작가, 비평가의 글을 중심으로 Focused on the Writing of Architects and Critics

신경화,이해경,손세관 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(계획계)

The purpose of this study is to analyze the contents of traditionality in houses designed by architects after 1990's. The process is that the article of corresponded house is categorized by conceptual and physical expression, after selecting six houses among houses evaluated expression of tradition by a writer, a critic. The result of analysis is that the traditional expression is differentiating 'che'(채) and a court, Taoism spirit, according natural environment.

Gefitinib in Selected Patients with Pre-Treated Non-Small-Cell Lung Cancer: Results from a Phase IV, Multicenter, Non-Randomized Study (SELINE)

Lee, Kwan-Ho,Lee, Kye-Young,Jeon, Young-June,Jung, Maan-Hong,Son, Choonhee,Lee, Min-Ki,Ryu, Jeong-Seon,Yang, Sei-Hoon,Lee, Jae-Cheol,Kim, Young-Chul,Kim, Sun-Young The Korean Academy of Tuberculosis and Respiratory 2012 Tuberculosis and Respiratory Diseases Vol.73 No.6

Background: This study was designed to analyze the efficacy of gefitinib as a second-line therapy, according to the clinical characteristics in Korean patients with non-small-cell lung cancer (NSCLC). Methods: In this Phase IV observational study, we recruited patients, previously failed first-line chemotherapy, who had locally advanced or metastatic NSCLC, and who were found to be either epidermal growth factor receptor (EGFR) mutation-positive or satisfied 2 or more of the 3 characteristics: adenocarcinoma, female, and non-smoker. These patients were administered with gefitinib 250 mg/day, orally. The primary endpoints were to evaluate the objective response rate (ORR) and to determine the relationship of ORRs, depending on each patient's characteristics of modified intent-to-treat population. Results: A total of 138 patients participated in this study. One subject achieved complete response, and 42 subjects achieved partial response (ORR, 31.2%). The subgroup analysis demonstrated that the ORR was significantly higher in patients with EGFR mutation-positive, compared to that of EGFR mutation-negative (45.8% vs. 14.0%, p=0.0004). In a secondary efficacy variable, the median progression-free survival (PFS) was 5.7 months (95% confidence interval, 3.9~8.4 months) and the 6-month PFS and overall survival were 49.6% and 87.9%, respectively. The most common reported adverse events were rash (34.4%), diarrhea (26.6%), pruritus (17.5%), and cough (15.6%). Conclusion: Gefitinib was observed in anti-tumor activity with favorable tolerability profile as a second-line therapy in these selected patients. When looking at EGFR mutation status, EGFR mutation-positive showed strong association with gefitinib by greater response and prolonged PFS, compared with that of EGFR mutation-negative.

Gefitinib in Selected Patients with Pre-Treated Non-Small-Cell Lung Cancer: Results from a Phase IV, Multicenter, Non-Randomized Study (SELINE)

( Kwan Ho Lee ),( Kye Young Lee ),( Young June Jeon ),( Maan Hong Jung ),( Choon Hee Son ),( Min Ki Lee ),( Jeong Seon Ryu ),( Sei Hoon Yang ),( Jae Cheol Lee ),( Young Chul Kim ),( Sun Young Kim ) 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.73 No.6

Background: This study was designed to analyze the efficacy of gefitinib as a second-line therapy, according to the clinical characteristics in Korean patients with non-small-cell lung cancer (NSCLC). Methods: In this Phase IV observational study, we recruited patients, previously failed first-line chemotherapy, who had locally advanced or metastatic NSCLC, and who were found to be either epidermal growth factor receptor (EGFR) mutation-positive or satisfied 2 or more of the 3 characteristics: adenocarcinoma, female, and non-smoker. These patients were administered with gefitinib 250 mg/day, orally. The primary endpoints were to evaluate the objective response rate (ORR) and to determine the relationship of ORRs, depending on each patient``s characteristics of modified intent-to-treat population. Results: A total of 138 patients participated in this study. One subject achieved complete response, and 42 subjects achieved partial response (ORR, 31.2%). The subgroup analysis demonstrated that the ORR was significantly higher in patients with EGFR mutation-positive, compared to that of EGFR mutation-negative (45.8% vs. 14.0%, p=0.0004). In a secondary efficacy variable, the median progression-free survival (PFS) was 5.7 months (95% confidence interval, 3.9∼8.4 months) and the 6-month PFS and overall survival were 49.6% and 87.9%, respectively. The most common reported adverse events were rash (34.4%), diarrhea (26.6%), pruritus (17.5%), and cough (15.6%). Conclusion: Gefitinib was observed in anti-tumor activity with favorable tolerability profile as a second-line therapy in these selected patients. When looking at EGFR mutation status, EGFR mutation-positive showed strong association with gefitinib by greater response and prolonged PFS, compared with that of EGFR mutation-negative.

상대정맥 증후군의 임상적 고찰

이충기,신세원,이현우,정진홍,이형우,현명수,김명세,강중순,이관호,이삼범 영남대학교 의과대학 1990 Yeungnam University Journal of Medicine Vol.7 No.2

We reviewed 30 cases of superior vena cava syndrome in adult patients who were seen at the Yeungnam University Hospital from January 1985 to June 1990. The results were as follows : 1. The male-to-female ratio was 6.5 : 1, and the most patients were in the age group between the sixth and seventh decades. 2. The most common symptoms were dyspnea (87%) and followed by cough (63%), facial swelling(63%) and chest pain (44%) and the physical signs were dilated neck vein (97%), facial edema(93%) and facial flushing (45%) in order of frequency. 3. The simple chest x-ray findings were superior mediastinal widening (90%), right hilar mass (77%) and pleural effusion (31%). 4. Diagnosis was made by history and physical examination(100%), chest C-T scan (100%), simple chest x-ray (97%), bronchoscopy with biopsy (40%) and so on. 5. 21 cases of patients were confirmed by histology : 14 cases (46%) of bronchogenic ca, 4 cases (14%) of lymphoma, 3 cases (10%) of metastic lung ca. Of bronchogenic ca, small cell ca was 7 cases (23%). squamous cell ca, 5 cases (17%), and unclassified ca was 2 cases (6%). 6. In response of treatment, the clinical improvement was achieved in 18 cases with radiotherapy alone, 1 case with chemotherapy only, and 6 cases with radio-chemotherapy.

Stress related activities of Gardenia Jasminoides in SD Rats and ICR Mice

Cheong Jae Hoon,Lee Geum Seon,Tan-Lee Blendyl Saguan,Yu Gu Young,Han Jeongsup,Kim Eun Seok,Yim Dong Sool,Oh Sei Kwan 대한약학회 2004 大韓藥學會 總會 및 學術大會 Vol.2004 No.2

심장판막대치술시 저온 결정성 심정지액과 상온 혈성 심정지액의 수술후 회복의 비교

이광호,이경민,엄대자,김순열,임현교,배세관 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.32 No.4

Background: Recent interest in the use of normothermic blood cardioplegia is based on theoretical advantages over the traditional method of hypothermic myocardial protection. These reported advantages are a decrease in intraaortic balloon pump use, greater incidence of return to normal sinus rhythm, greater immediate cardiac outputs, and less time weaned from bypass after removal of the aortic cross-clamp. In addition to these advantages, normothermic blood cardioplegia offers the promise to resuscitate the ischemic myocardium and reduce the morbidity and mortality for patients with high-risk disease. This study was designed to compare the effects of cold crystalloid and normothermic blood cardioplegia on the postoperative recovery. Methods: To evaluate the efficacy of cold versus normothermic cardioplegia, forty-four patients scheduled to undergoing valvular replacement surgery were selected to receive intermittent cold(4℃) crystalloid cardioplegia(n=22), group I or continuous normothermic(37℃) blood cardilegia(n=22), group II. Cardiopulmonary bypass(CPB) and aortic cross-clamp(ACC) times were measured during the operation and patients were evaluated postoperatively for serum electrolytes, arterial blood gas analysis, blood pressure, heart rate, complications, ventilator periods and ICU stay. Results: The ACC and CPB times were significantly longer in group II(165.9±44.8 min, 210.9±60.2 min) compared with group I(121.2±38.7 min, 149.7±38.1 min)(p$lt;0.01). Group II patients had significantly higher serum potassium level(5.2±0.8 mEq/L) than group I(4.3±0.4 mEq/L) on the first postoperative day(p$lt;0.01). ICU stay and ventilator period were not significantly different in two groups. There was no significant difference in postoperative complications and mortality rates between two groups. Conclusions: These results suggest that the continuous normothermic blood cardioplegia may be useful in myocardial protection during cardiac operation. (Korean J Anesthesiol 1997; 32: 616∼623)

식도암에서 화학요법 및 방사선 동시치료 효과와 예후인자

이은정,이경희,김태년,김성목,최재혁,정문관,현명수,김병덕,이상엽,김명세 대한소화기학회 2000 대한소화기학회지 Vol.35 No.1

Background/Aims: The prognosis of esophageal cancer has been exceedingly poor. Recently, many studies demonstrated that combined chemotherapy and radiotherapy improved the survival. In this study, we analyzed remission rate, survival rate, recurrance rate, and prognostic factors of the esophageal cancer retrospectively. Methods: Twenty-six patients with esophageal cancer who received chemotherapy with radiotherapy were included in this study. Radiotherapy was undertaken with 180 cGy per day upto 6500 cGy. All patients received two cylces of chemotherapy and the additional 2-4 cycles of maintenance chemotherapy (cisplatin 75 mg/m2 IV on the first day and 5-FU 1,000 mg/m2 for four days) after radiotherapy. Results: For the 26 patients, overall response rate was 61.6%. One year and 2 year survival rate was 66.1% and 41.7%, respectively and median survival was 89 weeks. Recurrence rate was 42.3%. The observed toxicity of this combined modality were nausea in 76.9%, leukopenia in 61.5%, mucositis in 53.9%, pneumonia in 21.3%, and esophageal stenosis in 23.1% of the patients. Conclusions: This combined modality improved the response rate and median survival. Additionally, clinical stage, performance status and the response to treatment were identified as important prognostic factors.