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      • KCI등재후보

        감마선을 이용한 Metronidazole이 함유된 Poly(vinyl alcohol) 하이드로겔 제조 및 특성

        백재,박종석,정진오,정성인,권희정,안성준,임윤묵 (사)한국방사선산업학회 2016 방사선산업학회지 Vol.10 No.1

        Periodontitis is disease of damaged gum tissue that is not removed the plaque ontoteeth. In case that the symptoms of disease get pain worse, it will have to extract tooth because oftumefy or bleeding at gums so treatment of drug was required to periodontitis. In this study, thehydrogel was prepared by including superior viscous, excellent elastic, and biocompatibility ofPoly(vinyl alcohol, PVA) and antimicrobial drug of Metronidazole (MD). The 15 wt% PVA wasdissolved in deionized water and then prepared PVA solution was irradiated using gamma-ray at25 kGy (10 kGy hr-1). In addition, PVA hydrogel was immersed in each 0.1, 0.25 and 0.5 wt% MDsolution using stirrer for 24 hr. The result of the gelation, 0.5 wt% MD loaded PVA hydrogel (76%)was lower than PVA hydrogel (88.2%). The swelling ration of 0.5 wt% MD loaded PVA hydrogel(294.8%) was higher than PVA hydrogel (105.2%). The compressive strength and thermal propertiesof MD loaded PVA hydrogel was gradually lower. The drug release test of 0.5 wt% MD loadedPVA hydrogel (61%) was higher than 0.1 wt% MD loaded PVA hydrogel (12%). Therefore, MDloaded PVA hygrogel may be a promising tool for periodontitis medicine by gamma-ray.

      • KCI등재

        선량제약치 도입을 위한 원자력발전소 주변 주민의 방사선량 분포 도출

        진용호,김지우,이병민,라현준,김광표 (사)한국방사선산업학회 2022 방사선산업학회지 Vol.16 No.3

        During normal operation of nuclear power plant, liquid and gaseous effluents areemissioned. The International Commission of Radiation Protection (ICRP) suggested setting doseconstraints as quantitative criteria to optimize radiation dose of public. In addition, the International AtomicEnergy Agency (IAEA) suggests that dose constraints would be derived from Representative Person dosedistribution. Currently, research for adaption of ICRP 103 recommendation in Korea is ongoing, and theconcept of dose constraints is expected to be introduced in Korea in the future. Therefore, the object ofthis study is to derive the dose distribution of general public around nuclear power plants prior to settingdose constraints. To achieve this goal, dose distribution was derived through 5 steps, setting source term,setting exposure pathways and scenarios, setting factor for dose assessment, selecting critical groupcandidates, assessing critical group dose and deriving dose distribution. As the first step, source termwas set based on gaseous and liquid effluents emitted from each nuclear power plant for 10 years from2012 to 2021. As the second step, exposure pathways were selected based on KINS regulatory guide 2.2. Exposure scenarios were classified as 1-year-old residents, 10-year-old residents, fishery residents,agricultural residents, commuter, and homemaker, based on occupational characteristics aroundnuclear power plants. As the third step, factors for dose assessment were selected, which includingatmospheric dispersion factor, deposition factor, and habit data. Atmospheric dispersion factor wasassessed based on actual residential location and crop cultivation area using XOQDOQ. In addition, theintake data was set based on 2018 Korea National Health and Nutrition Survey. As a fourth step, criticalgroup candidates were selected based on the actual residence point. Finally, as a fifth step, radiationdose of general were assessed, and the dose distribution of the general public around the nuclear powerplant was derived. The dose of general public was derived from 4.34×10-3~6.65×10-2 mSv yr-1. Doseof general public around sites A, B, C, and D were 4.34×10-3~2.73×10-2 mSv yr-1, 6.15×10-3~6.65×10-2 mSv yr-1, 5.27×10-3~1.50×10-2 mSv yr-1, 1.70×10-2~4.34×10-2 mSv yr-1, respectively. For aparticular site, the dose distribution has 2 peaks, which is judged to be the effect of 14C released in aparticular year. And among the average doses of sites A, B, C, and D, site D was the highest, which isjudged to be due to the highest atmospheric diffusion factor of site D. The dose distribution derived in thisstudy would be the basis data for setting domestic dose constraints in the future.

      • KCI등재

        방사선작업종사자 피폭선량 관리에 대한 연구

        성경정,공창기,동경래 (사)한국방사선산업학회 2020 방사선산업학회지 Vol.14 No.3

        For five years from 2015 to 2019, the cumulative personal exposure dose of radiationworkers and radiation workers across the country was measured to analyze frequency, comparethe average number of radiation workers and radiation workers by year, quarter, age, gender,occupation, radiation workers and radiation workers, and the average number of radiationworkers. It was followed by 2016, 2019, 2018, and 2015. But the year-to-year trend is not visible. In the case of the quarterly average exposure dose, surface dose and heart dose were high in thesecond and third quarters, and low in the first and fourth quarters, but there was no quarterlytrend. Comparing the annual exposure dose by gender and the quarterly exposure dose bygender, it was found that men were received significantly more exposed than women. Comparingthe annual exposure dose by age, the average exposure dose of radiation-related workers overfive years increased with lower age. Comparing the annual exposure dose of each occupationalcategory was analyzed by occupational category, radiologists, nursing staff, doctors, other(research researchers, assistants), dental hygienists, and dentists were shown in the order. Whenthe average exposure dose by radiation-related workers, radiation workers, and others wasanalyzed in quartiles, radiation-related workers and radiation workers were found to be higherthan others. Furthermore, since stochastic effects may occur with long-term exposure to low levelradiation, individual exposure dose data was thoroughly managed and the principle of As Low asReasonably Achievable (ALARA) was implemented when establishing the design of this study.

      • KCI등재
      • KCI등재

        원자력시설 해체 종사자의 방사선피폭 관리를 위한피폭방사선량 관리체계 및 관리 목표치에 대한 연구

        이화정,지승우,김우진,도태관,김도연,김광표 (사)한국방사선산업학회 2018 방사선산업학회지 Vol.12 No.1

        During decommissioning of a nuclear facility, the radiation dose to workers should be managed not to exceed a certain level. The objective of this study was to review decommissioning organization and target doses for management of radiation exposure to workers at nuclear facilities. The review was performed for the 7 nuclear facilities in the US, including commercial nuclear power plants, research and experimental reactor, and other nuclear facilities. For all the facilities, decommissioning organizations were established and given in decommissioning activities report and decommissioning plan. Certain department and associated supervisors were in charge of radiation protection of workers. They had an authority to stop radiation works not to exceed a certain level. In 10 CFR 20, only dose limits not target doses are given. Therefore, each facility set its own target doses and applied it during the facility decommission. The target doses were set 50~100% (25~50 mSv·year-1) level of dose limits for the commercial nuclear power plants and 10~50% (5~25 mSv·year-1) level of dose limits for the research and experimental nuclear plant and other nuclear facilities. It is suggested that 70~90% (14~18 mSv·year-1) level of dose limits is appropriate for near future decommissioning of a commercial nuclear power plant considering target doses for previous decommission of nuclear facilities in other country and management dose limits set for operational nuclear power plants in Korea.

      • 돼지 유래 생체 조직의 이식재 활용을 위한 방사선 조사미생물 제어 평가

        조으리,김정수,최종일,김재훈,성낙윤,송범석,김재경,박종흠,이주운 한국방사선산업학회 2011 방사선산업학회지 Vol.5 No.3

        This study was compared microbiological safety with gamma-irradiated porcinetendon and skin, as materials for the development of xenografts to regenerate damaged tissuesand protect secondary contamination. The porcine tendon and skin were gamma-irradiated afterinoculation of bacteria and virus to evaluate irradiation sensitivity of microorganisms. The resultshowed that the porcine tendon and skin were not different on the sensitivity of microorganismsby gamma irradiation. Bacteria inoculated in the porcine tendon and skin were confirmed that E. coli was the D10 values of 0.32±0.082 and 0.25±0.1 kGy on tendon and skin, and B. subtilis was4.00±0.312 and 3.88±0.3 kGy on gamma irradiation, respectively. Moreover, Virus inoculatedin the porcine tendon and skin was observed that poliovirus (PV) was 6.26±0.332 and 6.88±0.3kGy, and porcine parvovirus (PPV) was 1.75±0.131 and 1.73±0.2 kGy and bovine viraldiarrhoea virus (BVDV) was 3.70±0.212 and 3.81±0.2 kGy on gamma irradiation, respectively. Virus showed higher resistance compared to bacteria on gamma irradiation, but was not detectedCPE (cytopathic effect) by virus both tendon and skin at 25 kGy, a standard dose recommendedfrom IAEA for sterilization of medical products. Therefore, These results were considered thatgamma irradiation could control effectively bacteria and virus to develop safe porcine xenograft,and apply same irradiation doses to all tissues including tendon and skin of porcine.

      • 방사성 히알루론산 합성

        마소영,이동은,박상현 한국방사선산업학회 2014 방사선산업학회지 Vol.8 No.2

        Hyaluronic acid is a disaccharide polymer that consists of glucuronic acid and Nacetylglucosamine,and is a glycosaminoglycan. It is widely distributed in animal connectivetissue, coexisting with chondroitin sulfate. It forms viscous secretions or gel by bonding to proteinin the body, and thus maintains and lubricates tissue structures. In addition, its antibioticproperties are applied to cosmetics and pharmaceuticals. Therefore, it has recently been an objectof great interest at cosmetic and pharmaceutical companies. 125I has a longer half-life (59.4 days)than many other radioisotopes, and is therefore useful to long-term studies. In this study, a facileand efficient procedure for the synthesis of 125I-labeled hyaluronic acid has been designed for invivo imaging and pharmacokinetic studies of hyaluronic acid, which are required for the developmentof new drugs.

      • KCI등재

        원자력시설 해체 시 극저준위방사성폐기물 처분을 위한국내외 방사성폐기물 분류체계 및 인수기준에 대한 연구

        송지영,송교혁,박진호,지승우,도태관,김광표 (사)한국방사선산업학회 2018 방사선산업학회지 Vol.12 No.3

        Waste acceptance criteria (WAC) for disposal of very low level waste (VLLW), which isgenerated in large quantities during decommissioning of nuclear facilities should be developed. Forthe WAC development, it is required to investigate current status to develop WAC for disposal ofVLLW. The objective of the present study was to investigate radioactive waste classification andWAC for disposal of VLLW from decommissioning of nuclear facilities. Each country developed itsown system for the classification of radioactive waste. Therefore, the classification system for radioactivewaste in each country was analyzed to review its WAC of the radioactive waste, which is equivalentto the VLLW in the Korea waste classification system. The category of the VLLW in the wasteclassification systems of the International Atomic Energy Agency (IAEA) and the United Kingdom(UK) was similar to the category of the VLLW in the waste classification systems of Korea. For theUnited States (US), the category of Class A was similar to the VLLW in the Korea system. The IAEAprovided the general guidance for the WAC based on the safety assessment of disposal system. TheUS and the UK developed the WAC based on national radioactive waste disposal policy and characteristicsof disposal facilities and radioactive waste in addition to the IAEA general guidance. Therefore,the WAC for disposal of VLLW in Korea should be developed by considering the nationalradioactive waste disposal policy, characteristics of disposal facilities, and the IAEA guidance. Thisstudy results will contribute to establishment of national management system of radioactive waste.

      • KCI등재

        국내·외 치과촬영에 의한 피폭방사선량 실태조사 현황 분석

        이병민,이민영,남형우,김광표 (사)한국방사선산업학회 2021 방사선산업학회지 Vol.15 No.2

        Dental radiography is an important tool used for diagnosis of cavities, implants, andorthodontics. The usage of dental radiography has increased continuously, which can lead toincrease in the radiation dose for the patient. Therefore, it is necessary to manage the patientdose for medical radiation at the national level continuously and systematically. The objectiveof this study is to analyze the national medical radiation exposures by dental radiography. InKorea, the KCDC conducted a study of radiation exposure by dental radiography in 2019. In thisstudy, the KCDC conducted a study through radiation dose measurement by visiting a medicalinstitution. The age group was classified into 6, 12, and adults, and the types of examination wereselected as intraoral radiography, panorama, and CBCT. The dose area product correspondingto the third quartile for adults was 2,060 mGy·cm2 (CBCT), 227 mGy·cm2 (panorama), and 46mGy·cm2 (intraoral radiography). In other developed countries, it was found that the surveymethod, age, and type of examination for dental radiography were similar to Korea. Radiationdose in Korea was about 39% lower than the other countries in intraoral radiography, and about2.0 times higher in panorama and 2.5 times higher in CBCT. It is because the dental radiographyacquisition methods and devices are different from each country. Periodic nation-wide survey onmedical radiation exposure is necessary to manage the medical radiation exposure. Ultimately, theresults of this study can be used to optimize patient dose and reduce radiation dose.

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